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WO2016031079A1 - Inducteur d'expression d'adénosine triphosphate phosphatase contenant un dérivé phényléthylamine ou de la synéphrine - Google Patents

Inducteur d'expression d'adénosine triphosphate phosphatase contenant un dérivé phényléthylamine ou de la synéphrine Download PDF

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Publication number
WO2016031079A1
WO2016031079A1 PCT/JP2014/072965 JP2014072965W WO2016031079A1 WO 2016031079 A1 WO2016031079 A1 WO 2016031079A1 JP 2014072965 W JP2014072965 W JP 2014072965W WO 2016031079 A1 WO2016031079 A1 WO 2016031079A1
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Prior art keywords
extract
acid
oil
sodium
polyoxyethylene
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Japanese (ja)
Inventor
晃明 桝谷
伊藤　賢一
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Ichimaru Pharcos Co Ltd
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Ichimaru Pharcos Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/04—Preparations for care of the skin for chemically tanning the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to an adenosine triphosphate phosphatase expression inducer containing a phenylethylamine derivative or synephrine, or a cosmetic composition characterized by having an adenosine triphosphate phosphatase expression inducing action.
  • Skin and scalp due to age-related aging, etc., decrease in skin barrier function, skin epidermis function, skin wrinkle formation, reduction in skin tension and gloss, rough skin, or scalp thinning or hair loss It is said to cause etc.
  • Patent Document 1 hyaluronic acid, chondroitin tetrasulfate and soluble collagen are used as skin cosmetics.
  • Patent Document 2 containing at least one kind of extract from Zhuzhou, Zhangzhou, and Shazenshi is already known.
  • jaundice extract and its combination component blood circulation promoter: assembly extract, carrot extract, ginkgo biloba extract, vitamin E and its derivatives, cephalanthin, Minoxidil, carpronium chloride and phthalides, antibacterial agents: octopirox, benzalkonium chloride, zinc pyrithione, salicylic acid and isopropylmethylphenol
  • Patent Document 4 mandarin orange extract It is used for hair nourishing and hair restoration
  • Non-Patent Document 1 adenosine triphosphate phosphatase expression is related to cell adhesion of the skin and scalp.
  • Adenosine triphosphate phosphatase (hereinafter abbreviated as ATPase) is a general term for a group of hydrolases that hydrolyze terminal high energy phosphate bonds of adenosine triphosphate (hereinafter abbreviated as ATP).
  • ATPase adenosine triphosphate phosphatase
  • the material is actively transported like a pump against the electrochemical gradient inside and outside the membrane. Ca 2+ -ATPase is present in the cell membrane, endoplasmic reticulum, and Golgi apparatus, and Ca 2+ released into the cytoplasm is returned to the endoplasmic reticulum and Golgi apparatus by Ca 2+ -ATPase.
  • ATPase, Ca ++ transporting, cardiac muscle, slow twitch 2 (hereinafter abbreviated as ATP2A2) and ATPase, Ca ++ Transporting, Type 2C, Member 1 (hereinafter abbreviated as ATP2C1) are genes encoding Ca 2+ -ATPase ATP2A2 is expressed in the endoplasmic reticulum membrane, and ATP2C1 is expressed in the Golgi membrane.
  • Ultraviolet rays and inflammation are the main stresses in the skin and scalp, and are deeply related to reduced skin barrier function, reduced skin epidermal function, skin wrinkle formation, reduced skin tension and gloss, and rough skin. It has been reported.
  • Non-patent Document 2 In recent years, it has been reported that the expression levels of ATP2A2 and ATP2C1 decrease due to ultraviolet rays and inflammation. Ca 2+ -ATPase is thought to be deeply involved in skin homeostasis, such as reduced skin barrier function, reduced skin epidermal function, skin wrinkle formation, reduced skin tension and gloss, and rough skin It is said that this may be prevented (Non-patent Document 2).
  • an object of the present invention is to provide a novel and useful substance that induces expression of adenosine triphosphate phosphatase or a substance that induces expression of adenosine triphosphate phosphatase as a cosmetic composition.
  • the present inventor has conducted extensive studies on the theme of excellent natural substances that induce the expression of adenosine triphosphate phosphatase.
  • the present inventors have found that it has an action of inducing the expression of adenosine triphosphate phosphatase excellent in phenylethylamine derivatives or synephrine.
  • the present invention provides an adenosine triphosphate phosphatase expression inducer containing a phenylethylamine derivative or synephrine, and further provides a cosmetic composition having the phenylethylamine derivative or synephrine expression inducing action of adenosine triphosphate phosphatase. It came to complete.
  • the “synephrine” used in the present invention is 4- [1-hydroxy-2- (methylamino) ethyl] phenol, chemical formula: C 9 H 13 NO 2 , molecular weight: 167.21, and a synthetic product has already been obtained. Although it is marketed, the extract from a natural product can also be used.
  • the shape of the phenylethylamine derivative or synephrine used in the present invention to be used in producing the adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention is any of liquid, solid, powder, paste, etc. It is possible to select an optimum shape for carrying out the present invention.
  • the content of the phenylethylamine derivative or synephrine used in the present invention in the adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention is within a range where it can be confirmed that it has an adenosine triphosphate phosphatase expression inducing action.
  • it is generally set in the range of 0.01 mg / g to 200 mg / g (the denominator indicates the weight of the preparation).
  • the range is preferably from 0.1 mg / g to 20 mg / g, and most preferably from 200 ⁇ g / g to 10 mg / g.
  • the adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention can be used, for example, in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, Pills, tablets, powders, granules, solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc.
  • Suitable forms for use 1) pharmaceuticals, 2) quasi drugs, 3) topical or Skin cosmetics for the whole body (for example, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, hair removal Agents, shaving treatments, after-shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, etc.
  • basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, hair removal Agents, shaving treatments, after-shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, etc.
  • the adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention include the components and additives exemplified below within the range that does not impair the effects of the present invention, if necessary, in addition to the above essential components.
  • Various preparations can be produced by arbitrarily selecting and using these, and the content in the preparation is not particularly limited, but a concentration range of usually 0.0001 to 50% is preferable.
  • oily bases examples include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexene Higher fatty acids such
  • liquid paraffin mineral oil
  • heavy liquid isoparaffin heavy liquid isoparaffin
  • light liquid isoparaffin ⁇ -olefin oligomer
  • polyisobutene hydrogenated polyisobutene
  • polybutene squalane
  • Olive-derived squalane squalene
  • petroleum jelly solid paraffin and other carbides
  • candelilla wax carnauba wax, rice wax, waxy wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline Waxes
  • palm wax petrolatum, Fischer-Tropsch wax
  • polyethylene wax ethylene propylene copolymer
  • palm oil, palm oil, palm kernel oil, safflower oil olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow
  • moisturizers / feel improvers water (ordinary water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionic water, electrolytic acidic ionic water, ionic water, cluster water) ), Glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol , Hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, polyols such as ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (ethoxydiglycol) Glycol alkyl ethers such as ethylene glycol monoethyl ether, ethylene glycol mono
  • the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant.
  • an anionic surfactant a nonionic surfactant
  • a cationic surfactant a cationic surfactant
  • an amphoteric surfactant a polymer surfactant.
  • HLB of surfactant It can use from about 1 low thing to about 20 high thing, It is also preferable to combine what has low and high HLB.
  • preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amine and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate;
  • Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsophila extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypro Cellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose,
  • Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as diacetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as dieth
  • Antioxidants include ⁇ -lipoic acid, salts of ⁇ -lipoic acid, and derivatives of ⁇ -lipoic acid; tocopherol derivatives such as tocopherol (vitamin E), tocotrienol, tocopherol acetate; BHT, BHA; propyl gallate, etc.
  • Gallic acid derivatives include vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite Salts: thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred.
  • Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like.
  • Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.
  • Antiseptic and antibacterial agents include hydroxybenzoic acid and its salts or esters such as methylparaben, ethylparaben, propylparaben, butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-diols such as diols; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides , Quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, No
  • chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable.
  • edetate ethylenediaminetetraacetate
  • HEDTA3Na EDTA3Na
  • EDTA4Na hydroxyethylethylenediaminetriacetate
  • pentetate diethylenetriaminepentaa
  • pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.
  • powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (for example, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and super Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultraf
  • Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.
  • sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt
  • potassium chloride aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chlor
  • ultraviolet absorbers examples include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester.
  • Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropy
  • Benzophenone series External line absorber 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy-5- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- 3,4-dimethoxyphenyl)
  • hydantoin derivatives phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphor Preferred are sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and derivatives thereof, oryzanol and derivatives thereof.
  • ascorbic acid Ascorbic acid, ascorbic acid phosphate sodium salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, ascorbic acid fatty acid ester such as ascorbic acid tetraisopalmitate, ascorbic acid ethyl ether
  • Ascorbic acid alkyl ethers such as ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfates, ascorbic acid derivatives such as tocopheryl phosphate ascorbyl; kojic acid, ellagic acid, tranexamic acid and the like Derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butyl resorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, Nishikawayanagi Eki , It is mentioned as saxifrage extract, and the like plant extract
  • Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; ⁇ , Vitamin E such as ⁇ , ⁇ , and ⁇ -tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters
  • Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable.
  • Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, ⁇ -oryzanol, cephalanthin, vitamin E and derivatives such as tocopherol / nicotinic acid tocopherol, ⁇ -oryzanol, nicotinic acid and nicotinamide / benzyl nicotinate Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride Flavonol derivatives, stigmasterol or stigmasteranol and
  • hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.
  • retinols such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, ⁇ - or such as hydroxycapric acid, long chain ⁇ -hydroxy fatty acid, long chain ⁇ -hydroxy fatty acid cholesteryl ⁇ -hydroxy acids and derivatives thereof; ⁇ -aminobutyric acid, ⁇ -amino- ⁇ -hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein and other antioxidant / active oxygen scavengers;
  • Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract,retea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, braces Extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawara-momogi extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiw
  • antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like.
  • exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like.
  • antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate.
  • Examples of the refreshing agent include menthol and methyl salicylate.
  • the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid.
  • enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.
  • Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.
  • Orange No. 204 Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205
  • Organic pigments such as zirconium, barium or aluminum lake such as yellow No. 4, yellow No. 5, yellow No. 202, yellow No. 203, green No. 3 and blue No.
  • cosmetic ingredient standards cosmetic ingredient-specific formulation standards, Japan Cosmetic Industry Association ingredient name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug ingredient standards, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as listed ingredients, in known combinations, blending ratios and blending amounts.
  • Test 1 Adenosine triphosphate phosphatase expression inducing action
  • the present inventor evaluated the adenosine triphosphate phosphatase expression inducing action using a quantitative PCR method.
  • "Test method and evaluation method” Normal human epidermal keratinocytes (manufactured by Kurashiki Boseki Co., Ltd.) are cultured to sub-confluence, further cultured for 48 hours, and then added with the sample “invention product or control (comparative control)” for 6 hours and 12 hours. did.
  • RNA extraction kit QIAGEN
  • cDNA was synthesized using the obtained RNA as a template and PrimeScript RT reagent Kit (Takara Bio).
  • ATP2A2 was evaluated using a sample collected 6 hours after the addition
  • ATP2C1 was evaluated using a sample collected 12 hours after the addition.
  • SYBR Premix Ex Taq (Takara Bio Inc.)
  • Thermal Cycler Dice Real Time System (Takara Bio Inc.) were used.
  • ⁇ -Actin gene As an internal standard, the expression level of ⁇ -Actin gene, which is a housekeeping gene, was quantified, and the relative expression level with respect to ⁇ -Actin was calculated and used as the expression level of ATP2A2 gene and ATP2C1 gene. Qiagen ATP2A2, ATP2C1, and ⁇ -Actin were used as PCR primers. "sample” In addition, the sample used for the test by adding 20 ⁇ of synephrine of the present invention (manufactured by Sigma Aldrich Japan GK). As a control (comparison control), a 70% 1,3-butylene glycol aqueous solution was prepared under the same conditions and used in the test.
  • Adenosine triphosphate phosphatase expression inducer A gauze or liniment cloth is impregnated with a prescription solution in which appropriate amounts of synephrine, antibiotics, anti-inflammatory agents and the like are mixed, and attached to the wound. Alternatively, the synephrine-containing aqueous solution may be directly sprayed locally and covered with gauze or the like.
  • Soybean seed natto fermentation liquid 0.5 13.Hydroxyethyl chitosan solution 0.5 14.
  • Trehalose solution 0.5 15.Hydrolyzed silk solution 0.5 16.
  • Antibacterial / preservative benzalkonium chloride
  • Fragrance proisoned water
  • the present invention finds an excellent adenosine triphosphate phosphatase expression inducing action on phenylethylamine derivatives or synephrine, and an adenosine triphosphate phosphatase expression inducer containing phenylethylamine derivatives or synephrine, and further, phenylethylamine derivatives or synephrines.
  • a cosmetic composition having an adenosine triphosphate phosphatase expression-inducing action can be provided.

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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
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  • Medicinal Chemistry (AREA)
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  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　La présente invention concerne un nouvel inducteur d'expression d'adénosine triphosphate phosphatase, utile, et une composition cosmétique fonction d'un effet inducteur d'expression d'adénosine triphosphate phosphatase ; un inducteur d'expression d'adénosine triphosphate phosphatase contenant un dérivé phényléthylamine ou de la synéphrine et une composition cosmétique fonction d'un effet inducteur d'expression d'adénosine triphosphate phosphatase d'un dérivé phényléthylamine ou de synéphrine.　
PCT/JP2014/072965 2014-08-28 2014-09-02 Inducteur d'expression d'adénosine triphosphate phosphatase contenant un dérivé phényléthylamine ou de la synéphrine Ceased WO2016031079A1 (fr)

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JP2014-173823 2014-08-28
JP2014173823A JP2016047806A (ja) 2014-08-28 2014-08-28 フェニルエチルアミン誘導体又はシネフリン含有アデノシン三リン酸フォスファターゼ発現誘導剤

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001019607A (ja) * 1999-07-06 2001-01-23 Kanebo Ltd 皮膚化粧料
JP2007106697A (ja) * 2005-10-13 2007-04-26 Sederma Sa 新規なチラミン誘導体及びその製造方法、並びに該誘導体を含む化粧用組成物、若しくは皮膚用医薬組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001019607A (ja) * 1999-07-06 2001-01-23 Kanebo Ltd 皮膚化粧料
JP2007106697A (ja) * 2005-10-13 2007-04-26 Sederma Sa 新規なチラミン誘導体及びその製造方法、並びに該誘導体を含む化粧用組成物、若しくは皮膚用医薬組成物

Non-Patent Citations (3)

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Title
N. MAYUZUMI ET AL.: "Effects of ultraviolet B irradiation, proinflammatory cytokines and raised extracellular calcium concentration on the expression of ATP2A2 and ATP2C1", BRITISH JOURNAL OF DERMATOLOGY, vol. 152, no. 4, April 2005 (2005-04-01), pages 697 - 701 *
NA-YOUNG HONG ET AL.: "p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 418, 28 January 2012 (2012-01-28), pages 720 - 724, XP028462007, DOI: doi:10.1016/j.bbrc.2012.01.085 *
TERUAKI MASUYA ET AL.: "Phenylethylamine Yudotai Gan'yu Mandarin Orange Kahi Chushutsubutsu no Hito Hyohi Kozo Kyoka Kino to sono Mechanism Kaiseki", ABSTRACTS OF 134TH ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN 2, 5 March 2014 (2014-03-05), pages 88 *

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