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WO2016031071A1 - Cathéter médical - Google Patents

Cathéter médical Download PDF

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Publication number
WO2016031071A1
WO2016031071A1 PCT/JP2014/072825 JP2014072825W WO2016031071A1 WO 2016031071 A1 WO2016031071 A1 WO 2016031071A1 JP 2014072825 W JP2014072825 W JP 2014072825W WO 2016031071 A1 WO2016031071 A1 WO 2016031071A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter tube
groove
catheter
medical
medical catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/072825
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English (en)
Japanese (ja)
Inventor
前田　真法
清隆 森
秋山　省一
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Usci Japan Ltd
Original Assignee
Usci Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usci Japan Ltd filed Critical Usci Japan Ltd
Priority to JP2016545211A priority Critical patent/JPWO2016031071A1/ja
Priority to PCT/JP2014/072825 priority patent/WO2016031071A1/fr
Publication of WO2016031071A1 publication Critical patent/WO2016031071A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters

Definitions

  • the present invention relates to a medical catheter that is inserted into a blood vessel, liver, bile duct, or other luminal tissue or organ in a living body for use, and in particular, relatively without adversely affecting the living body.
  • shunt PTA percutaneous angioplasty
  • Such a shunt PTA uses a medical catheter provided with a balloon on the distal end side of the catheter tube.
  • the catheter tube is inserted into a blood vessel under the guidance of a guide wire, and the balloon is allowed to reach a shunt stenosis or the like.
  • the balloon is inflated and deformed, and the constricted portion of the shunt blood vessel is expanded from the inside to expand, thereby allowing blood in the shunt to flow smoothly.
  • a contrast medium is used using an angiography apparatus.
  • an X-ray opaque marker portion provided at the balloon placement portion of the catheter tube was guided.
  • Non-Patent Document 1 discloses a catheter tube to be inserted into a blood vessel, and a shadow tube that is the same length as the catheter tube and is fixed to the proximal end of the catheter tube.
  • a method using a medical catheter having the following has been proposed.
  • the shadow catheter on the outer surface is moved along the marking indicating the blood vessel running.
  • the balloon of the catheter tube that moves in the blood vessel following the shadow catheter is made to reach the target site, and as a result, “the balloon tip is guided to the target site easily and accurately”.
  • Non-Patent Document 1 it is assumed that the catheter tube in the blood vessel moves following the movement of the shadow catheter, and the tip of the shadow catheter reaches the outer surface side of the target site. As a result, it is indirectly considered that the tip of the catheter tube has reached the target site, but since the catheter tube in the blood vessel cannot actually be confirmed directly, the position of the catheter tube is sufficiently accurate. It is hard to say that it can be grasped.
  • this method requires a time-consuming and time-consuming and quick and easy operation because it is necessary to mark the blood vessel traveling route along the shadow catheter on the outer surface of the blood vessel into which the catheter tube is inserted. The treatment could not be realized.
  • An object of the present invention is to solve such problems of the prior art, and an object of the present invention is to provide an X-ray angiography apparatus and an X-ray contrast medium that may adversely affect a living body.
  • a medical catheter that can accurately reach a predetermined site of a catheter tube inserted into a luminal organ in a living body without using an agent under a relatively simple facility There is to do.
  • the medical catheter according to the present invention is a medical catheter that is used by being inserted into a luminal tissue or organ in a living body, and reaches the medical catheter through the living tissue at least at one of the medical catheters.
  • An elastic wave marker portion that reflects an elastic wave in a manner different from other portions is provided.
  • the medical catheter may include a tubular catheter tube inserted into a luminal tissue or organ, and the elastic wave marker portion may be provided in at least one place in the extending direction of the catheter tube.
  • the elastic wave marker portion is an ultrasonic marker portion that reflects ultrasonic waves in a manner different from other portions.
  • At least one of the elastic wave marker portions is formed by one or more grooves recessed from the outer peripheral surface of the catheter tube and / or one or more protrusions protruding from the outer peripheral surface. It is preferable to configure.
  • the inner surface of the groove and / or the outer surface of the protrusion is formed as a flat surface or a curved surface.
  • the groove wall surface of the groove and / or the protrusion side surface of the protrusion is a tapered surface inclined with respect to the outer peripheral surface of the catheter tube in a cross section orthogonal to the extending direction of the groove and / or protrusion. It is preferable to do.
  • the groove and / or the protrusion extend in a direction inclined with respect to the extending direction of the catheter tube or in a direction perpendicular to the extending direction.
  • such a groove and / or the protrusion is provided on at least a part of a half-circumferential region on one side of the outer peripheral surface of the catheter tube and a half-circular portion on the other side located behind the half-circular region on the one side. It is preferable to form each at least part of the region. Further, here, a plurality of the groove portions and / or the plurality of protrusion portions are arranged adjacent to each other, and a dense region is formed, and the plurality of groove portions and / or the plurality of protrusion portions are spaced from each other. It is preferable to provide a dispersion region formed side by side.
  • the said elastic wave marker part of at least one place can also be comprised by including the material from which an elastic modulus and / or density differ from the said other part.
  • at least one portion of the elastic wave marker portion may be made of a material having a different elastic modulus and / or density from the other portion in the extending direction of the catheter tube itself.
  • the other portion is made of a material having a different elastic modulus and / or density, and is formed of a coating portion that covers at least a portion of the outer peripheral surface of the catheter tube in the circumferential direction.
  • the medical catheter described above has an inflatable deformable balloon disposed at least one place in the longitudinal direction of the catheter tube so as to surround the catheter tube from the outer peripheral side, Alternatively, the elastic wave marker portion is arranged at a close location at a certain distance along the extending direction of the catheter tube from the arrangement location, and the elastic wave marker portion is used as a luminal organ in a living body. It is preferable that the position display portion of the balloon inserted into the.
  • the balloon is more preferably configured to include microbubbles.
  • the medical catheter further includes a guide wire that is inserted into a luminal organ in a living body and guides the catheter tube in the luminal organ.
  • the medical catheter is preferably an intravascular treatment catheter in which the catheter tube is inserted into a blood vessel in a living body.
  • an elastic wave that reflects an elastic wave such as an ultrasonic wave that reaches the medical catheter through a living tissue in at least one place among the medical catheters in a manner different from the other parts By providing a marker portion for use, it is easy to use an ultrasonic diagnostic apparatus, etc., which is cheaper and smaller than an X-ray angiography apparatus.
  • the position can be grasped directly. Accordingly, a predetermined portion of the catheter tube to be inserted into a luminal organ in a living body can be accurately obtained under relatively simple equipment without using an X-ray angiography apparatus and an X-ray contrast medium.
  • the target part can be reached.
  • FIG. 2 is a partially enlarged side view schematically showing a part of a balloon placement portion of a catheter tube included in the medical catheter of FIG. 1.
  • FIG. 3 is a side view schematically showing a part of FIG. 2 further enlarged. It is the photograph which shows the image which displayed the medical catheter of FIG. 1 on the display using an ultrasonic diagnostic apparatus, and its schema.
  • FIG. 4 is a longitudinal sectional view taken along line IV-IV in FIG. 3. It is a longitudinal cross-sectional view which shows the modification of a groove part and a projection part.
  • FIG. 4 is a transverse sectional view taken along line VI-VI in FIG. 3.
  • a medical catheter 1 is mainly a catheter tube 2 such as a circular tube that can be bent and formed of, for example, polyethylene, nylon, or polyethylene terephthalate (PET), as illustrated in FIG.
  • the catheter tube 2 is inserted into a vascular tissue or organ in the form of a blood vessel, a liver, a bile duct or other tubular or bag-like body in the living body, for example, under the guidance of a known guide wire (not shown) during the operation. It is what is done.
  • the medical catheter 1 shown in the figure has a balloon 3 that is inflated and deformed at a predetermined location in the luminal organ in the vicinity of the distal end portion of the catheter tube 2 to be inserted into the luminal tissue or organ.
  • a Y-shaped connector 4 that branches in a Y-shape from the base end portion is provided at the base end portion disposed outside the living body on the opposite side of the base plate.
  • the balloon 3 is shown in an inflated and deformed state.
  • the cylindrical portion 4 a on one side of the Y-shaped connector 4 is used for supplying a fluid to the balloon 3 for inflating and deforming the balloon 3, and the cylindrical portion 4 b on the other side is used for the catheter tube 2.
  • a guide wire inserted into a luminal tissue or organ passes therethrough.
  • these balloon 3 and Y-shaped connector 4 are not essential components for the present invention.
  • the catheter tube 2 when the catheter tube 2 is inserted into a luminal tissue or organ in a living body, the position of the predetermined portion of the catheter tube 2 in the luminal tissue or organ is determined.
  • the catheter tube passes through the living tissue from the ultrasonic diagnostic apparatus or the like outside the living body in at least one place in the extending direction of the catheter tube 2.
  • An ultrasonic marker portion 5 for reflecting the ultrasonic wave reaching 2 in a different manner from the other portions is provided.
  • the ultrasonic marker portion 5 is provided with a groove 6 recessed from the outer peripheral surface 2 a of the catheter tube 2, and It is composed of a protrusion 7 protruding from the outer peripheral surface 2 a of the catheter tube 2 adjacent to the groove 6.
  • the ultrasonic marker portion 5 provided with the groove portion 6 and the protrusion portion 7 reflects in a different direction from the other outer peripheral surface portion of the catheter tube 2 that does not have an uneven shape, and is thus reflected as such.
  • the ultrasonic marker portion 5 including, for example, the groove portion 6 and the projection portion 7 can be displayed darker than the other portions, as illustrated in FIG. .
  • the medical catheter 1 can be used for patients and medical personnel. There is a risk of radiation exposure to the person, and it is not necessary to use an expensive and large-sized X-ray imaging apparatus or an X-ray contrast agent that may cause side effects.
  • the medical catheter 1 can be manufactured very easily simply by forming the groove 6 and the protrusion 7 in the catheter tube 2 by, for example, laser processing, cutting with a cutter or a drill, sandblasting, or rolling. Therefore, the medical catheter 1 to be manufactured in the future can be used as the medical catheter 1 as well as the medical catheter 1 by performing simple processing on the existing medical catheter.
  • the ultrasonic marker portion is a protrusion portion. It is also possible to have only one or more groove portions without, or only one or more protrusion portions without the groove portion. Therefore, the protrusion 7 in the illustrated embodiment is not necessarily provided.
  • each groove 6 is inclined with respect to the outer peripheral surface 2a of the catheter tube 2 and faces each other as shown in a cross-sectional view across the groove 6 and the protrusion 7 in FIG. It can have an inner surface constituted by a pair of groove wall surfaces 6a and a groove bottom portion 6b located at the deepest position continuously to the groove wall surfaces 6a.
  • each protrusion 7 is composed of a protrusion side surface 7a that is inclined with respect to the outer peripheral surface 2a of the catheter tube 2, and a protrusion top portion 7b that connects the protrusion side surfaces 7a to each other. It may have an outer surface.
  • the groove wall surface 6 a forming the inner surface of the groove portion 6 and the protrusion side surface 7 a and the protrusion top portion 7 b forming the outer surface of the protrusion portion 7 are both tapered surfaces formed as flat surfaces.
  • Both the inner surface of the groove portion 6 and the outer surface of the projection portion 7 can be tapered surfaces having a curved surface that is concave or convex in the radial direction of the catheter tube 2 as shown in FIG.
  • the inner surface of the groove 6 can be a curved surface
  • the outer surface of the projection 7 can be a flat surface.
  • the inner surface of the groove 6 can be a flat surface
  • the outer surface of the projection 7 can be a curved surface.
  • the groove bottom portion 6b of the groove 6 is a corner where the opposing groove wall surfaces 6a and 6b intersect, but as shown in FIG. 6 (d).
  • the groove wall surfaces 6a and 6b that are separated from each other at the groove bottom position may be formed in a flat surface shape that connects the mutual surfaces.
  • the projection top part 7b of the projection part 7 can also have a flat surface shape as shown in FIGS. 5 and 6B or a corner part shape not shown.
  • the groove wall surface 6a of the groove portion 6 is formed so that the groove wall surfaces 6a facing each other as they approach the groove bottom are mutually effective for the purpose of effectively reflecting ultrasonic waves irradiated from outside the living body in different directions from other parts. It is preferable to incline in the approaching direction, and the inclination angle ⁇ 1 is 30 ° to 90 ° with respect to the extending direction of the catheter tube 2 (the left-right direction in FIGS. 5 and 6).
  • the projection side surface 7a of the projection portion 7 is inclined so that the projection side surface 7a approaches each other as it approaches the projection top portion 7b, and the inclination angle ⁇ 2 is inclined in the extending direction of the catheter tube 2. On the other hand, it is preferably 30 ° to 90 °.
  • the maximum depth Dg of the groove 6 is preferably 20 ⁇ m to 200 ⁇ m as measured along the radial direction of the catheter tube 2 from the position of the outer peripheral surface of the catheter tube 2.
  • the maximum depth Dg of the groove 6 is preferably 10% to 70% with respect to the thickness of the tubular catheter tube 2 from the viewpoint of securing the required tensile strength of the catheter tube 2.
  • the width Wg of the opening at the position of the outer peripheral surface of the groove 6 is preferably 50 ⁇ m to 500 ⁇ m when measured in the direction perpendicular to the groove 6.
  • the width Wp of the protrusion 7 at the position of the outer peripheral surface is preferably 10 ⁇ m to 100 ⁇ m as measured in the direction orthogonal to the protrusion 7, and the maximum protrusion height Hp of the protrusion 7 Is preferably 0 ⁇ m to 100 ⁇ m as measured along the radial direction of the catheter tube 2 from the position of the outer peripheral surface of the catheter tube 2.
  • the maximum depth Dg and the opening width Wg of the groove 6 described above the width Wp of the protrusion 7 and the maximum protrusion height Hp are too small, the visibility of the groove 6 or the protrusion 7 due to ultrasonic waves is reduced. When an image is displayed using an ultrasonic diagnostic apparatus, there is a possibility that it cannot be confirmed sufficiently clearly.
  • the groove 6 and / or the protrusion 7 are inclined with respect to the extending direction of the catheter tube 2 (left and right direction in FIG. 3), or with respect to the extending direction as shown in FIG. It can extend in a vertical direction.
  • the respective groove portions 6 and / or protrusions 7 may be continuously extended around the entire outer periphery 2a of the catheter tube 2; 7, the outer peripheral surface 2a of the catheter tube 2 is arranged on the one side (for example, front side) half circumference region Ah1 located on the upper side of FIG. 7 and on the other side located on the lower side. It is preferable that the groove 6 and / or the protrusion 7 are formed in at least a part of each of the half-circumferential regions Ah1 and Ah2 on one side and the other side thereof. .
  • each catheter tube of a plurality of medical catheters can be In a state where they are arranged side by side, all of a plurality of medical catheters can be collectively processed by laser processing in a direction crossing the catheter tube from each of the front side and the back side. Can do. Therefore, the groove 6 and / or the protrusion 7 can be easily formed as compared with the case where the groove 6 or the protrusion 7 is formed over the entire circumference.
  • the observation from outside the living body by the ultrasonic diagnostic apparatus does not require that the groove 6 and the protrusion 7 are formed over the entire circumference of the catheter tube 2, and as described above, the circumference of the outer circumferential surface 2a. It is possible to carry out sufficiently effectively by being formed at positions opposite to each other in the direction.
  • the groove 6 and / or the protrusion 7 is formed in each of the half-circumferential region Ah1 on one side (for example, the front side) and the half-circular region Ah2 on the other side (for example, the back side), these grooves 6
  • the length of the protrusion 7 along the circumferential direction of the outer circumferential surface 2a of the catheter tube 2 is preferably 10% to 100% with respect to the total circumferential length of the outer circumferential surface 2a of the catheter tube 2.
  • the length of the groove 6 to the protrusion 7 is preferably set to 300 ⁇ m to 4500 ⁇ m.
  • the circumferential length of the groove 6 and / or the protrusion 7 is about 0.3 mm as 10% of the tube diameter of 1.0 mm in the shortest case. In the longest case, the entire circumference can be 1.5 mm in tube diameter. Even when the circumferential length of the groove 6 and / or the protrusion 7 is short, the surface on which the groove 6 and / or the protrusion 7 is processed is always directed toward the side irradiated with the ultrasonic waves. By doing so, the groove 6 and / or the protrusion 7 can effectively function as the ultrasonic marker portion 5.
  • the circumferential length of the groove 6 and / or the protrusion 7 is too long, there is a concern that the strength of the catheter tube may locally decrease or increase at the location where the ultrasonic marker portion 5 is provided. On the other hand, if the circumferential length of the groove 6 and / or the protrusion 7 is too short, the visibility of the groove 6 and / or the protrusion 7 as the ultrasonic marker portion 5 may be reduced.
  • the plurality of grooves 6 and / or the plurality of protrusions 7 are adjacent to each other as illustrated in FIGS. It is preferable to provide a dense region Fd that is aligned with each other and a dispersion region Fs in which the plurality of groove portions 6 and / or the plurality of protrusions 7 are spaced apart from each other at a predetermined interval.
  • the formation position of the groove 6 and / or the protrusion 7 can have different meanings in the dense region Fd and the dispersion region Fs.
  • an ultrasonic marker portion 15 including a material having a different elastic modulus and / or density from other portions can be provided.
  • the outer peripheral surface of the catheter tube 12 is coated with a material having a larger or smaller elastic modulus than other tube portions by spraying, painting, or other processing methods, and the outer periphery thereof.
  • a coating portion 16 is formed to cover at least a part of the circumferential direction of the surface, in FIG.
  • the ultrasonic waves are reflected in different directions by the ultrasonic marker portions 15 made of materials having different elastic moduli and / or densities, the portion provided with the ultrasonic marker portions 15 in the living body The position in can be effectively grasped.
  • the elastic modulus means volume elastic modulus or Young's modulus. This can be calculated from the result of a tensile test.
  • the elastic modulus of the catheter tube 12 corresponding to “other portion” here is generally about 0.2 MPa to 7 MPa, whereas the elastic modulus of a portion made of a material having a different elastic modulus is different from that of the other portion.
  • the elastic modulus is made large or small in the range of 0.01% to 1%, more preferably in the range of 0.1% to 0.5%. More specifically, the portion made of a material having a different elastic modulus can be set to 0.01 MPa to 0.1 MPa, specifically assuming that the elastic modulus of the other portion is different from that described above. Is 0.03 MPa to 0.05 MPa.
  • the material of the catheter tube 12 corresponding to the “other part” is generally PTEE, polyethylene, polypropylene, nylon or the like, whereas the elasticity constituting the ultrasonic marker part 15 is used.
  • the material having a different modulus and / or density can be a rubber material having a smaller elastic modulus than other portions, a metal material having a larger elastic modulus than other portions, or the like.
  • the ultrasonic marker portion 15 made of a material having a different elastic modulus can have a larger or smaller elastic modulus than the other portions.
  • the ultrasonic marker portion 15 having a low elastic modulus is displayed as a black streak on the catheter tube 12 displayed in white when viewed with an ultrasonic diagnostic apparatus. Since the sonic marker portion 15 is displayed as white stripes, it may be slightly inferior in visibility. Further, since the ultrasonic marker portion 15 having a large elastic modulus hardens the portion where the catheter tube 12 is provided, the bendability and kink resistance (hardness to buckle) may be impaired.
  • the ultrasonic marker portion 15 containing a material having a different elastic modulus is provided on the outer peripheral surface of the catheter tube 12 by coating a material having a different elastic modulus, but the illustration is omitted.
  • the ultrasonic marker portion 15 can also be provided by coating the inner peripheral surface of the catheter tube 12, and a part of the catheter tube 12 itself is replaced with a material having a different elasticity and / or density ratio. By doing so, the ultrasonic marker portion 15 including materials having different elastic moduli and / or densities can be provided.
  • a tube made of a material having different elastic modulus and / or density can be joined and provided in the middle of the catheter tube 12.
  • the medical catheters 1 and 11 as described above are provided with the ultrasonic marker portions 5 and 15 in at least one place of the catheter tubes 2 and 12, thereby inserting the catheter tubes 2 and 12 into the luminal organ.
  • an ultrasonic wave is radiated from outside the living body using an ultrasonic diagnostic apparatus, it is possible to accurately determine where the portion provided with the ultrasonic marker portions 5 and 15 is currently located in the luminal tissue or organ. Can be confirmed.
  • ultrasonic marker portions 5 and 15 are applied to the medical catheters 1 and 11 provided with the balloon 3 as shown in the drawing, it is generally impossible to grasp the position in the luminal tissue or organ. This is very advantageous because the position of the balloon 3 can be accurately confirmed with the display function of the ultrasonic marker portions 5 and 15.
  • the ultrasonic marker portions 5 and 15 described above for example, the catheter tube portion inside the flexible thin film balloon 3 provided at the distal end portion of the catheter tube 2 or the like.
  • the ultrasonic marker portion 5 is provided at a location close to the balloon 3 by a predetermined distance Ls1, Ls2. 15 can function as a position display portion of the balloon 3 in the living body.
  • the ultrasonic marker portions 5 and 15 are provided in the catheter tube portion inside the balloon 3, it is a portion that widens the actually narrowed blood vessel portion. It is preferable to provide the ultrasonic marker portions 5 and 15 over the entire length of the balloon length Lb, which has a constant diameter. Thereby, it can be reliably displayed by the ultrasonic diagnostic apparatus. Further, in order to emphasize and display the both end positions of the balloon length Lb of the balloon 3, for example, an area in the vicinity of the both end positions, for example, 0.5 mm to 2 mm from each of the both end positions toward the center in the longitudinal direction.
  • the grooves and the like are densely or to dispose a material that absorbs more ultrasonic waves.
  • the distance Ls1 and the distance Ls2 can be equal to each other, or can be different from each other. it can.
  • an ultrasonic marker portion 5 in which grooves and / or protrusions are densely provided is provided in the vicinity of the balloon 3.
  • the medical catheter 1 provided with such a balloon 3 although the illustration is omitted, it is possible to provide the above-described groove and / or protrusion on the balloon 3 itself.
  • the medical catheters 1 and 11 according to the embodiments of the present invention are particularly used as an intravascular treatment catheter for performing a shunt PTA or the like in which the catheter tubes 2 and 12 are inserted into blood vessels in the living body. It is valid.
  • the balloon 3 itself has a groove and / or protrusion. Ultrasonic marker portions 5 and 15 such as can be provided.
  • a guide wire (not shown) is passed through the blood vessel of the arm of an artificial dialysis patient who has shunted due to diabetic nephropathy or the like, and the tip is positioned beyond the stenosis of the shunt.
  • the medical catheters 1 and 11 are inserted into the blood vessel under the guidance of the guide wire.
  • the position of the balloon 3 at the distal end of the catheter tube 2 inserted into the blood vessel cannot normally be confirmed from outside the human body.
  • the location of the balloon 3 or By providing the ultrasonic marker portions 5 and 15 in the vicinity thereof by irradiating ultrasonic waves from outside the human body using an ultrasonic diagnostic apparatus or the like, for example, ultrasonic waves are displayed on an image displayed outside the human body.
  • the marker portions 5 and 15 can be clearly displayed, and the position of the balloon 3 can be confirmed accurately. Therefore, here, the balloon 3 can be sent to the shunt stenosis portion with high accuracy and placed there under visual recognition from the outside.
  • the fluid is sent from the cylindrical part 4a of the Y-shaped connector 4 of the medical catheters 1 and 11 to the balloon 3, and the balloon 3 is inflated and deformed to expand and expand the shunt stenosis part from the inside. Can be made.
  • the fluid supplied to such a balloon 3 is a liquid containing microbubbles.
  • the microbubbles when supplied into the living body, the microbubbles reflect the ultrasonic wave by the irradiation of ultrasonic waves from outside the living body, and the part where the microbubbles exist is Since it can be displayed on the ultrasonic diagnostic apparatus, for example, when the balloon 3 positioned in the shunt stenosis is inflated and deformed, it can be confirmed whether the balloon 3 is inflated and deformed as expected. . Thereby, it is possible to quickly cope with an unintended situation such as leakage of liquid from the balloon 3.
  • Such microbubbles are fine particles having a diameter of about 2 ⁇ m to 3 ⁇ m, in which a gas such as air is contained in a phospholipid film together with a stabilizer such as perflubutane, and those already known should be used.
  • a gas such as air
  • a stabilizer such as perflubutane
  • the liquid containing this include a contrast agent for ultrasonic diagnosis, specifically, sonazoid (registered trademark, manufactured by Daiichi Sankyo Co., Ltd.), levovist (registered trademark, manufactured by Bayer Yakuhin Co., Ltd.), and the like. it can.
  • transformation as mentioned above can be acquired by forming balloon 3 itself with the material containing a microbubble.
  • the balloon 3 can be manufactured by coating the surface with a drug containing microbubbles.
  • the ultrasonic marker portions 5 and 15 described above may also reflect elastic waves other than ultrasonic waves in a manner different from other portions, and depending on the diagnostic device used, the ultrasonic waves may be reflected. It is also possible to use an elastic wave marker portion that targets an elastic wave other than the above and has a reflection mode of the elastic wave different from other portions.

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  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

Cathéter médical (1, 11) mis en oeuvre par insertion dans des tissus luminaux et dans un organe d'un organisme vivant, et réalisé par la disposition, au moins sur une partie du cathéter médical (1, 11), d'une section de marquage (5, 15) pour ondes élastiques permettant la réflexion, différenciée vers d'autres sections, des ondes élastiques qui traversent un tissu vivant et atteignent le cathéter médical (1, 11).
PCT/JP2014/072825 2014-08-29 2014-08-29 Cathéter médical Ceased WO2016031071A1 (fr)

Priority Applications (2)

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JP2016545211A JPWO2016031071A1 (ja) 2014-08-29 2014-08-29 医療用カテーテル
PCT/JP2014/072825 WO2016031071A1 (fr) 2014-08-29 2014-08-29 Cathéter médical

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PCT/JP2014/072825 WO2016031071A1 (fr) 2014-08-29 2014-08-29 Cathéter médical

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WO2016031071A1 true WO2016031071A1 (fr) 2016-03-03

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018134299A (ja) * 2017-02-23 2018-08-30 ニプロ株式会社 バルーンカテーテル
JP2020130883A (ja) * 2019-02-25 2020-08-31 日本ゼオン株式会社 Ｉａｂｐ用バルーンカテーテル
WO2020175462A1 (fr) * 2019-02-26 2020-09-03 一般社団法人細胞シート再生医療推進機構 Tube interne, cathéter et procédé de fabrication de tube interne
US20210244674A1 (en) * 2017-12-08 2021-08-12 Takeshi Ohdaira Therapeutic method
CN115813440A (zh) * 2020-02-11 2023-03-21 荆州市中心医院(长江大学附属荆州医院) 一种介入的多点检查装置
JP2024519021A (ja) * 2021-05-17 2024-05-08 ボストン サイエンティフィック サイムド，インコーポレイテッド 医療システム、デバイス、および関連する方法

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US20040019311A1 (en) * 2000-12-21 2004-01-29 Justin Crank Infusion devices and method
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