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WO2016024295A1 - Dispositif biomédical pour une tolérance à la dessiccation améliorée de greffons - Google Patents

Dispositif biomédical pour une tolérance à la dessiccation améliorée de greffons Download PDF

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Publication number
WO2016024295A1
WO2016024295A1 PCT/IN2015/050092 IN2015050092W WO2016024295A1 WO 2016024295 A1 WO2016024295 A1 WO 2016024295A1 IN 2015050092 W IN2015050092 W IN 2015050092W WO 2016024295 A1 WO2016024295 A1 WO 2016024295A1
Authority
WO
WIPO (PCT)
Prior art keywords
graft
cap
storage module
outlet port
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/050092
Other languages
English (en)
Inventor
Debasish Pradhan
Salman KAPADIA
Dinesh DIWAKAR
Mangesh Patankar
Afroz Alam MOHAMMAD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Veol Medical Technologies Pvt Ltd
Original Assignee
Veol Medical Technologies Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IN2015/050042 external-priority patent/WO2015186146A1/fr
Application filed by Veol Medical Technologies Pvt Ltd filed Critical Veol Medical Technologies Pvt Ltd
Priority to PCT/IN2015/050112 priority Critical patent/WO2016042579A2/fr
Priority to PCT/IN2015/050201 priority patent/WO2016098126A2/fr
Publication of WO2016024295A1 publication Critical patent/WO2016024295A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/32053—Punch like cutting instruments, e.g. using a cylindrical or oval knife
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/34—Trocars; Puncturing needles
    • A61B17/3468—Trocars; Puncturing needles for implanting or removing devices, e.g. prostheses, implants, seeds, wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00752—Hair removal or transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/005—Auxiliary appliance with suction drainage system

Definitions

  • the present disclosure relates, in general to hair transplantation devices and, more particularly, to a graft (e.g., hair follicle) collection device.
  • a graft e.g., hair follicle
  • An illustrative device comprises a cap and a body.
  • the cap includes a cap inlet port and a cap outlet port in fluid communication with one another.
  • the cap inlet port is configured to engage an inlet tube through which a graft is received.
  • the cap outlet port is in fluid communication with a graft storage volume that is formed at least in part by the cap.
  • the body is coupled to the cap and forms at least a portion of the graft storage volume.
  • the body includes a body inlet port and a body outlet port in fluid communication with one another.
  • the body outlet port is configured to engage a vacuum tube to draw the graft into the graft storage volume.
  • the vacuum tube provides a vacuum pressure that causes a temperature of the graft storage volume to be less than an ambient temperature.
  • An illustrative device comprises a cap and a body.
  • the cap includes a first inlet port and a first outlet port in fluid communication with one another.
  • the first inlet port is configured to engage an inlet tube through which a graft is received.
  • the cap further includes a second inlet port and a second outlet port in fluid communication with one another.
  • the second outlet port is configured to engage a vacuum tube to draw the graft into a graft storage volume.
  • the vacuum tube provides a vacuum pressure that causes a temperature of the graft storage volume to be less than an ambient temperature.
  • the first outlet port is in fluid communication with the graft storage volume that is formed at least in part by the cap.
  • the body is coupled to the cap and forms at least a portion of the graft storage volume.
  • An illustrative method comprises inserting a volume of liquid into a graft storage module that has an inlet port and a vacuum port.
  • the liquid is configured to moisturize a graft.
  • the method also includes attaching a vacuum tube to the vacuum port and applying, via the vacuum tube, a suction to the graft storage module that causes a temperature of the liquid to be less than an ambient temperature.
  • the method further comprises causing, using the suction, the graft to enter into the graft storage module via the inlet port of the graft storage module.
  • FIG. 1A is an isometric view of a graft storage module from an outside perspective in accordance with an illustrative embodiment.
  • Fig. IB is an exploded view of the graft storage module of Fig. 1 in accordance with an illustrative embodiment.
  • Fig. 2 is a cross-sectional view of a graft storage module in accordance with an illustrative embodiment.
  • FIG. 3 is an internal view of a storage chamber of a graft storage module in accordance with an illustrative embodiment.
  • FIG. 4A is an illustration of a graft storage module connected to hoses in accordance with an illustrative embodiment.
  • FIG. 4B is a cross-sectional view of a graft storage module connected to hoses in accordance with an illustrative embodiment.
  • FIGs. 5A-5D illustrate a liquid-filled graft storage module in various orientations in accordance with an illustrative embodiment.
  • Fig. 6 depicts a graft storage module attached to a graft extraction module via a latch in accordance with an illustrative embodiment.
  • FIGS. 7A-7C are illustrations of a single-piece latch in accordance with an illustrative embodiment.
  • Figs. 8A-8C are illustrations of a double-piece latch in accordance with an illustrative embodiment.
  • FIG. 9A and 9B illustrate a latch molded to the graft storage module in accordance with an illustrative embodiment.
  • Fig. 10A is an isometric view of a vertical graft storage module from an outside perspective in accordance with an illustrative embodiment.
  • Fig. 10B is an exploded view of the vertical graft storage module of Fig. 10A in accordance with an illustrative embodiment.
  • FIGs. 11A and 11B are cross-sectional views of a vertical graft storage module in accordance with an illustrative embodiment.
  • FIGs. 12A and 12B are isometric views of a cap of a vertical graft storage module in accordance with an illustrative embodiment.
  • Fig. 13 depicts a spatula in accordance with an illustrative embodiment.
  • FIGs. 14A-14C are illustrations of a spatula in accordance with an illustrative embodiment.
  • FIG. 15 is a flow diagram illustrating a method of storing harvested grafts in accordance with an illustrative embodiment.
  • Graft transplantation is a medical procedure performed for a variety of reasons.
  • the graft can be any suitable graft and can include a harvested graft from a donor (who may also be the recipient of the graft) or may include an artificial graft.
  • a portion of skin can be harvested from a donor and transplanted into the recipient.
  • a hair transplant can be performed using graft transplantation.
  • the hair transplant can be performed by harvesting multiple hair follicles from a donor (e.g., from the back of the recipient's head) and transplanting the hair follicles to a location on the donor (e.g., on the top of the recipient's head).
  • a graft in hair transplantation context is an elongated tissue surgically extracted from the donor site with the help of a punch with at least one hair within it placed almost parallel to the axis of the graft.
  • the tissue of the graft consists of a layer of skin on top followed by dermal tissue and loose fatty tissue. In some cases it may also contain a layer of cutaneous tissue. In other embodiments, any suitable graft may be used.
  • care should be taken to protect and nurture the graft as soon as possible after the graft is harvested and until the graft is transplanted into the recipient.
  • the grafts include stem cells.
  • the stem cells can be damaged by desiccation, lack of nutrients, or trauma (e.g., impact, pressure, temperature, etc.). Damage to the stem cells can lead to poor hair growth and less hair shaft caliber of the new hair.
  • the damage to the stem cells is often not perceptible without analyzing the graft using machinery, tests, diagnostics, etc. For example, biological tests in a laboratory are used to determine whether stem cells are damaged. However, in most instances, it is not feasible to test the grafts for stem cell damage before implantation. Accordingly, the grafts should be protected such that as few grafts as possible are damaged.
  • FIG. 1A is an isometric view of a graft storage module from an outside perspective in accordance with an illustrative embodiment.
  • Fig. IB is an exploded view of the graft storage module of Fig. 1 in accordance with an illustrative embodiment.
  • the graft storage module 100 includes a cap 105, a storage chamber 110, a first port 115, a connector 120, at least one groove 125, at least one seal 130, a first hollow tube feature 135, and a cap stop 160.
  • Figs. 1A and IB are meant to be illustrative only and are not meant to be limiting with respect to the size, orientation, scale, or proportions of the illustrated elements.
  • the graft storage module 100 can be used to store the grafts for a time after extraction of the grafts from the donor. After a sufficient amount of grafts have been collected, the graft storage module 100 can be disconnected from tubing, opened, and the contents can be poured out of the graft storage module 100. The grafts can be poured into any suitable container for transplantation into the recipient.
  • An internal storage volume of the graft storage module 100 is defined, at least in part, by the storage chamber 110 and the cap 105. In an illustrative embodiments, the internal storage volume is used to store or house grafts (e.g., hair follicles).
  • a graft extraction module (e.g., the graft extraction module 650 illustrated in Fig. 6) is used to harvest a graft from a donor.
  • the harvested graft can be transported to and stored in the internal storage volume of the graft storage module 100.
  • the internal storage volume is configured to maximize the chances that the harvested grafts will be successfully implanted into the recipient.
  • the cap 105 and the storage chamber 110 are detachable.
  • the storage chamber 110 includes a cap stop 160.
  • the cap stop 160 acts as a stop for the cap 105 as the cap 105 slides over the storage chamber 110.
  • the cap stop 160 can also be used as an ergonomic grip or as a cosmetic detail.
  • the cap stop 160 may not be included.
  • the cap 105 can slide over a surface of the storage chamber 110 that has grooves 125 that receive seals 130.
  • the grooves 125 are located on an internal surface of the cap 105.
  • any suitable sealing mechanism can be used.
  • Fig. IB illustrates the use of two grooves 125 and two seals 130, any suitable number of grooves 125 and seals 130 may be used. For example, one groove 125 and one seal 130 may be used. In another example, three or more grooves 125 and seals 130 may be used.
  • the seals 130 can be any suitable seal.
  • the seals 130 can be O- rings.
  • the seals 130 can include gaskets, clamps, etc.
  • the seals 130 can be elastomeric seals that are an over-molded design.
  • the seals 130 can be permanently attached or removable.
  • the seals 130 can be made of any suitable material that is bio-compatible.
  • the seals 130 can be made of Buna-N (Nitrile), ethylene-propylene, silicone, polyurethane, neoprene, one or more fluorocarbon materials, etc. In an illustrative embodiment, seals 130 are not used.
  • an airtight interference fit between the cap 105 and the storage chamber 110 can be used to seal the cap 105 and the storage chamber 110.
  • the cap 105 can be pushed onto and pulled off of the storage chamber 110.
  • the seals 130 can provide the friction and/or resistance for securing the cap 105 to the storage chamber 110.
  • a vacuum pressure in the internal storage volume can be used to assist in securing the cap 105 to the storage chamber 110.
  • any other suitable arrangement for securing the cap 105 and the storage chamber 110 to one another may be used.
  • the cap 105 and the storage chamber 110 can comprise threads that allow the cap 105 to screw onto the storage chamber 110.
  • clips or clamps may be used.
  • the cap 105 and the storage chamber 110 may be secured together using a snap joint, a Luer Lock, a magnetic interference, etc.
  • FIG. 2 is a cross-sectional view of an illustrated graft storage module in accordance with an illustrative embodiment.
  • the graft storage module 100 includes a cap 105, a storage chamber 110, a first port 115, a connector 120, at least one seal 130, a first hollow tube feature 135, a second hollow tube feature 140, and a retaining filter 145.
  • additional, fewer, and/or different elements may be included in the graft storage module.
  • the connector 120 is connected to a vacuum source.
  • a vacuum tube e.g., flexible vacuum hose 155 illustrated in Fig. 4A
  • Fig. 2 illustrates the connector 120 with a barbed fitting.
  • any suitable connection can be used to connect the vacuum tube to the graft storage module 100.
  • a threaded fitting, a snap connection, a quick disconnect fitting, etc. may be used.
  • the first port 115 can be attached to a graft source.
  • a graft collection tube 150 (as shown in Fig. 4A) is connected to the first port 115 and provides a non-obstructed path for the grafts to travel.
  • the first port 115 is directly connected to a graft extraction module (e.g., without the use of the graft collection tube 150).
  • a harvested graft can be suctioned into the internal storage volume of the graft storage module 100 using the vacuum provided through the connector 120. That is, a vacuum source can be connected to the connector 120, and the vacuum pressure can be used to pull the harvested graft into the first port 115 and through the first hollow tube feature 135, which are fluidly connected.
  • the harvested graft is pulled through the first hollow tube feature 135 and into the internal storage volume.
  • the internal storage volume can store multiple grafts.
  • the internal storage volume can also include a liquid, such as saline.
  • the graft can fall into the liquid in the internal storage volume, in which the graft can remain in storage, for example, while additional grafts are harvested.
  • the storage chamber 110 is marked with graduated markings that can be used to indicate the volume of liquid (and grafts) in the internal storage volume.
  • the first hollow tube feature 135 extends into the internal storage volume.
  • the first hollow tube feature 135 can be centered on the cap 105 and extend into the internal storage volume parallel to the sides of the storage chamber 110. In embodiments in which the sides of the storage chamber 100 are not parallel, the first hollow tube feature 135 can extend along a center axis of the graft storage module that passes through the first port 115 and the connector 120. In alternative embodiments, the first hollow tube feature 135 can be flush with (e.g., not extend beyond) the inner surface of the cap 105. In such embodiments, vacuum pressure from the connector 120 can cause air to flow into the internal storage volume (and out of the internal storage volume via the second hollow tube feature 140 and the connector 120).
  • the air flowing through the first hollow tube feature 135 can prevent the pre-determined amount of liquid within the internal storage volume from entering the first hollow tube feature 135 (and, subsequently, the first port 115, a graft collection tube 150, and/or a graft extraction module).
  • a one-way valve can be placed within the first hollow tube feature 135 that allows grafts to enter the internal storage volume, but prevents the liquid from entering the graft collection tube 150.
  • the one-way valve can be implemented within the connection between the graft collection tube 150 and the first port 115. The use of a one-way valve retains a negative pressure between the one-way valve and the vacuum source, thereby improving the response time of the system.
  • the vacuum applied to the connector 120 is applied continuously. That is, in such embodiments, vacuum is applied to the connector 120 while grafts are stored in the internal storage volume and/or while grafts are being harvested. In alternative embodiments, the vacuum is applied to transport the grafts into the internal storage volume and is shut off in between harvesting of the individual grafts. Switching on and off of the vacuum can be manual or automatic using any suitable method.
  • the connector 120 is fluidly connected to the second hollow tube feature 140.
  • the second hollow tube feature 140 extends into the internal storage volume.
  • the second hollow tube feature 140 can be centered on the storage chamber 110 and extend into the internal storage volume parallel to the sides of the storage chamber 110. In embodiments in which the sides of the storage chamber 100 are not parallel, the second hollow tube feature 140 can extend along the center axis of the graft storage module that passes through the first port 115 and the connector 120.
  • the first hollow tube feature 135 and the second hollow tube feature 140 extend into the internal storage volume substantially along the same central axis of the graft storage module 100.
  • the first hollow tube feature 135 and the second hollow tube feature 140 do not extend along a central axis and/or are not parallel to the sides of the storage chamber 110.
  • the opening of the first hollow tube feature 135 and the retaining filter 145 are located along the central axis even though the first hollow tube feature 135 and the second hollow tube feature 140 do not connect to the cap 105 and the storage chamber 110 along the central axis.
  • the first hollow tube feature 135 and the second hollow tube feature 140 extend into the internal storage volume substantially along the same central axis of the graft storage module 100.
  • the first hollow tube feature 135 and the second hollow tube feature 140 do not touch one another. Rather, the first hollow tube feature 135 and the second hollow tube feature 140 are spaced apart.
  • the first hollow tube feature 135 and the second hollow tube feature 140 are spaced apart enough to allow a graft to flow through the first hollow tube feature 135 and into liquid within the internal storage volume.
  • the first hollow tube feature 135 and the second hollow tube feature 140 are spaced apart by 10 millimeters (mm).
  • first hollow tube feature 135 and the second hollow tube feature 140 are spaced apart by less than 10 mm or greater than 10 mm.
  • first hollow tube feature 135 and the second hollow tube feature 140 can be spaced apart by 6 mm, 8 mm, 9 mm, 9.5 mm, 10.5 mm, 11 mm, 12 mm, 14 mm, etc.
  • the separation between the first hollow tube feature 135 and the second hollow tube feature 140 is chosen to be greater than the length of the longest graft that is intended to be harvested.
  • Fig. 3 is an internal view of a storage chamber of a graft storage module in accordance with an illustrative embodiment. In alternative embodiments, additional, fewer, and/or different elements may be used.
  • the second hollow tube feature 140 can include a retaining filter 145.
  • the retaining filter 145 can be configured to prevent grafts from entering into the second hollow tube feature 140.
  • the retaining filter 145 includes slits along the second hollow tube feature 140. The slits can be shaped and sized such that the grafts cannot fit within the slits.
  • the retaining filter 145 separates and retains the grafts inside the internal storage volume. In some instances, the retaining filter 145 allows excess fluid (e.g., air, liquid, saline, etc.) to drain through the flexible vacuum hose 155, for example, to an external collection bottle.
  • the grafts are harvested using a graft extraction module that punches grafts out of the donor's tissue.
  • the length of the grafts can be determined by the thickness of the skin from which the grafts are harvested. In an illustrative embodiment, the length of the grafts can be between 6 mm and 8 mm.
  • the grafts can be 6 mm long, 6.5 mm long, 7 mm long, 7.5 mm long, 8 mm long, etc.
  • the grafts can be shorter than 6 mm or longer than 8 mm.
  • hair can protrude from the graft.
  • the length of the hair can be as long as a hair can grow. In some instances, the hair is shaven close to the skin. In other embodiments, the hair is trimmed prior to extraction to be approximately 2 mm to 5 mm above the surface of the skin.
  • the diameter of the grafts depends on the size of the punch or cutting member of the graft extraction module (or other method/tool used to harvest the graft).
  • the grafts can be from 0.8 mm in diameter to 1.2 mm in diameter.
  • the diameter of the grafts can be 0.8 mm, 0.9 mm, 1.0 mm, 1.1 mm, 1.2 mm, etc.
  • the grafts can be less than 0.8 mm in diameter or greater than 1.2 mm in diameter.
  • the thickness of the slits of the retaining filter 145 is one half of the diameter of the grafts.
  • the thickness of the slits can be from 0.4 mm thick to 0.6 mm thick.
  • the slits can be 0.4 mm thick, 0.5 mm thick, 0.55 mm thick, 0.6 mm thick, etc.
  • the slits can be less than 0.4 mm thick or greater than 0.6 mm thick.
  • the retaining filter 145 can include a filtering element other than slits.
  • a mesh filter or a screen can be used.
  • a retaining filter 145 can be selected to minimize the air flow resistance through the retaining filter 145. In the embodiments illustrated in Figs.
  • the retaining filter 145 is permanently fixed to the second hollow tube feature 140.
  • the retaining filter 145 can be removable.
  • the retaining filter 145 can be removably attached to the second hollow tube feature 140 via threads, a snap connection, a quick disconnect, etc.
  • FIG. 4A is an illustration of a graft storage module connected to hoses in accordance with an illustrative embodiment.
  • FIG. 4B is a cross-sectional view of a graft storage module connected to hoses in accordance with an illustrative embodiment.
  • additional, fewer, and/or different elements may be used.
  • a graft collection tube 150 can be attached to the cap 105 via the first port 115. As illustrated in Fig. 4B, the graft collection tube 150 can be received by the first port 115 and the first port 115 can surround a portion of the graft collection tube 150.
  • the outer diameter of the graft collection tube 150 and the inner diameter of the first port 115 can be sized such that there is sufficient friction between the graft collection tube 150 and the first port 115 to secure the graft collection tube 150 to the first port 115.
  • a push-style connection is used. That is, the graft collection tube 150 is pushed into the first port 115 to connect the graft collection tube 150 and the first port 115.
  • any suitable connection style may be used.
  • the connection between the graft collection tube 150 and the first port 115 can include threads, a snap, a compression fitting, etc.
  • the connection between the graft collection tube 150 and the first port 115 can be glued, fused, over molded, etc.
  • the graft collection tube 150 is molded to the cap 105 as a single unit.
  • the inside diameter of the graft collection tube 150 can be selected to be the same size or slightly larger than the diameter of the harvested grafts.
  • the inside diameter of the graft collection tube 150 can be selected to be large enough that the harvested grafts can travel through the graft collection tube 150, but not so large that the vacuum applied to suction the grafts through the graft collection tube 150 is not strong enough to cause the graft to be pulled through the graft collection tube 150.
  • the inside diameter of the graft collection tube 150 can be up to 10% wider than the width of the harvested grafts.
  • the graft collection tube 150 can be 1%, 2%, 5%, 7%, or 10% wider than the harvested grafts.
  • the graft collection tube 150 can be greater than 10% wider than the harvested grafts.
  • the graft collection tube 150 is around 50% wider than the harvested grafts.
  • the graft collection tube 150 is 35%, 40%, 45%, 50%, 55%, 60%, 65%, etc. wider than the harvested grafts.
  • a rotary punch can be used to harvest grafts with a diameter of 1 mm.
  • the graft collection tube 150 can have an inside diameter of 1 mm.
  • the graft collection tube 150 can have an inside diameter of 1.1 mm or 1.05 mm.
  • the length of the graft collection tube 150 can be any suitable length. In some embodiments, the length of the graft collection tube 150 is chosen to be as short as possible or convenient. In some instances, as the graft travels through the graft collection tube 150 via vacuum pressure, air flows between the inside wall of the graft collection tube 150 and the graft. The airflow can dry out the graft. Additionally, the longer that the graft collection tube 150 is, the further the graft travels and slides against the graft collection tube 150. Friction between the graft collection tube 150 and the graft can damage the graft. Accordingly, in some embodiments, shortening the length of the graft collection tube 150 can reduce the amount of desiccation of the grafts. In alternative embodiments, the first port 115 can be directly connected to a graft extraction module, thereby eliminating the graft collection tube 150.
  • the inside diameter of the first hollow tube feature 135 is the same as the inside diameter of the graft collection tube 150.
  • the relative inside diameters of the first hollow tube feature 135 and the graft collection tube 150 can be chosen such that the harvested grafts can be suctioned through the graft collection tube 150 and into the first hollow tube feature 135 without damaging the harvested graft.
  • the inside diameter of the first hollow tube feature 135 is larger than the inside diameter of the graft collection tube 150.
  • the inside surfaces of the graft collection tube 150 and/or the first hollow tube feature 135 can include a lubrication material.
  • the inside surfaces of the graft collection tube 150 and/or the first hollow tube feature 135 can be coated with a hydrophobic or hydrophilic coating.
  • a hydrophobic or hydrophilic coating can reduce sticking of the graft and/or other biologic material to the surfaces of the graft collection tube 150 and/or the first hollow tube feature 135.
  • the coating can also reduce the friction between the graft and the graft collection tube 150 and/or the first hollow tube feature 135, thereby reducing damage of the graft.
  • the coating can further prevent (or reduce) clotting of the blood of the graft, thereby increasing the chance that the graft will be successfully transplanted.
  • the surfaces of the first hollow tube feature 135 and/or the second hollow tube feature 140 are textured with an anti-sticking property. For example, nano-texturing may be used.
  • the inside diameter of the second hollow tube feature 140 can be the same as the inside diameter of the first hollow tube feature 140 and/or the graft collection tube 150. In alternative embodiments, the inside diameter of the second hollow tube feature 140 can be the same as the inside diameter of the flexible vacuum hose 155.
  • Fig. 4B illustrates the flexible vacuum hose 155 connected to the storage chamber 110 via a barbed fitting, in alternative embodiments, any suitable connection can be used to connect the vacuum tube to the graft storage module 100. For example, a threaded fitting, a snap connection, a quick disconnect, etc. may be used.
  • Figs. 5A-5D illustrate a liquid-filled graft storage module in various orientations in accordance with an illustrative embodiment.
  • Figs. 5A-5D illustrate the liquid level in the graft storage module 100 in positions ranging from vertical (Fig. 5A) through horizontal (Fig. 5D).
  • the liquid level can be chosen such that, regardless of orientation, the liquid level 170 does not reach the opening of the second hollow tube feature 140.
  • saline or other liquid
  • excess liquid within the internal storage volume is suctioned through the second hollow tube feature.
  • the second hollow tube feature 140 can protrude into the internal storage volume by a length of between 30 mm and 60 mm.
  • the second hollow tube feature 140 can protrude into the internal storage volume by 30 mm, 35 mm, 40 mm, 45, mm, 50 mm, 55 mm, 60 mm, etc.
  • the second hollow tube feature 140 can protrude into the internal storage volume by less than 30 mm or by more than 60 mm.
  • the length of the second hollow tube feature 140 includes the length of the retraining filter 145. In alternative embodiments, the length of the second hollow tube feature 140 does not include the length of the retaining filter 145.
  • the first hollow tube feature 135 can protrude into the internal storage volume by a length of between 30 mm and 60 mm.
  • the first hollow tube feature 135 can protrude into the internal storage volume by 30 mm, 35 mm, 40 mm, 45, mm, 50 mm, 55 mm, 60 mm, etc.
  • the first hollow tube feature 135 can protrude into the internal storage volume by less than 30 mm or by more than 60 mm.
  • the liquid used within the internal storage volume can be any suitable liquid to preserve the grafts in a healthy state.
  • the liquid can be water.
  • the liquid can be a saline solution.
  • the liquid can be a saline solution with added compounds.
  • the additional compounds can i nclude nutrients for the grafts, moisturizers, etc.
  • the liquid may include biological matter (e.g., skin, blood, etc.) that is incident to the harvesting of the grafts.
  • the cap 105 and the storage chamber 110 can be made of any suitable bio- compatible materials. In some embodiments, at least a portion of at least one of the cap 105 or the storage chamber 110 is transparent or translucent to allow a clinician to view the liquid and/or the grafts collected in the internal storage volume.
  • the cap 105 and/or the storage chamber 110 can be made of polycarbonate, glass, stainless steel, etc.
  • the shape of the cap 105 and the storage chamber 110 are illustrated as being cylindrical, any suitable shape can be used.
  • the cross-sectional shape of the cap 105 and the storage chamber 110 can be circular, elliptical, octagonal, rectangular, square, or any other geometric or non-geometric shape.
  • the inside diameter and the length of the storage chamber 110 can be selected to allow enough liquid to be stored in the internal storage volume to preserve the health of the grafts without the level of the liquid reaching the opening of the second hollow tube feature 140.
  • the inside diameter of the storage chamber 110 (and/or the cap 105) can be 25 mm.
  • the inside diameter of the storage chamber 110 can be less than or greater than 25 mm.
  • the inside diameter of the storage chamber 110 can be 10 mm, 15 mm, 20 mm, 30 mm, 35 mm, 40 mm, etc.
  • the inside length of the internal storage volume is 100 mm.
  • the inside length of the internal storage volume can be less than or greater than 100 mm.
  • the inside length of the internal storage volume can be 80 mm, 90 mm, 95 mm, 105 mm, 110 mm, 120 mm, etc.
  • the graft collection tube 150 may be made of any suitable bio-compatible material.
  • the graft collection tube 150 can be transparent or translucent to allow a clinician to view the graft (or other material) in the graft collection tube 150.
  • the graft collection tube 150 is rigid.
  • the graft collection tube 150 can be made of, for example, polycarbonate or stainless steel.
  • the graft collection tube 150 is flexible or semi-flexible.
  • the graft collection tube 150 can be made of a thermoplastic elastomer, polyvinyl chloride, polyether ether ketone (PEEK), polyurethane, silicone, nylon, poly ethylene, poly phenyl sulphone, glass, ceramic, composite materials such as glass reinforced plastic or carbon composites, etc. Because grafts are suctioned through the graft collection tube 150 using vacuum, the graft collection tube 150 is rigid enough not to collapse under the vacuum pressure.
  • Fig. 6 depicts a graft storage module attached to a graft extraction module via a latch in accordance with an illustrative embodiment. In alternative embodiments, additional, fewer, and/or different elements may be used.
  • the graft storage module 100 can be oriented in any direction while maintaining a pre-determined amount of liquid in the internal storage volume.
  • the graft storage module 100 can be attached to a graft extraction module 650.
  • the graft extraction module 650 can be any suitable device, and the graft extraction module 650 illustrated in Fig. 6 is illustrative only. In alternative embodiments, the graft storage module 100 can be attached to any suitable device.
  • the graft storage module 100 can be attached to the graft extraction module 650 via a latch 600. In some embodiments, the latch 600 can be a clip. Figs.
  • FIGS. 7A-7C are illustrations of a single-piece latch in accordance with an illustrative embodiment.
  • Figs. 8A-8C are illustrations of a double-piece latch in accordance with an illustrative embodiment.
  • additional, fewer, and/or different elements may be used.
  • the latch 600 can be used to prevent misplacing the graft storage module 100 or prevent the graft storage module 100 from freely moving around and becoming a distraction to clinicians.
  • the clip-like latch 600 allows the graft storage module 100 to be located along a convenient location of the graft extraction module 650. That is, in some instances, the latch 600 can secure the graft storage module 100 at a plurality of locations along the graft extraction module 650.
  • Fig. 7A is an isometric view of a single-piece latch 600.
  • Fig. 7B is a top view of the single-piece latch 600.
  • Fig 7C is a side view of the single-piece latch 600.
  • the single-piece latch 600 can be made of a single piece of material, such as plastic, metal, or a composite.
  • the single-piece latch 600 can be molded from polycarbonate or can be machined from billet aluminum or stainless steel.
  • Fig. 8A is an isometric view of a double-piece latch 600.
  • Fig. 8B is a top view of the double-piece latch 600.
  • Fig 8C is a side view of the double-piece latch 600.
  • the double-piece latch 600 can be formed by two pieces joined in the middle. The two pieces can be joined using any suitable method, such as by welding, with adhesives, with rivets, with screws, etc.
  • the two pieces can be made of any suitable material, such as plastic, metal, or a composite. For example, the pieces can be made of polycarbonate, aluminum, stainless steel, etc.
  • One C-shaped end of the latch 600 can be configured to be secured around at least a portion of the graft storage module 100.
  • the other C-shaped end of the latch 600 can be configured to be secured around at least a portion of the graft extraction module 650 or any other suitable device or fixation point.
  • the C-shaped ends can clip onto the respective device.
  • the C-shaped ends can be manufactured such that the C-shaped ends provide an optimum stiffness to its jaws for secure holding of the graft extraction module 650, the graft storage module 100, etc.
  • both of the C-shaped ends are identical.
  • the C-shaped ends can be differently shaped from one another (e.g., be different sizes).
  • one of the C-shaped ends corresponds to the size and shape of the graft storage module 100
  • the size and shape of the other C-shaped end corresponds to the size and shape of the graft extraction module 650.
  • one end of the latch 600 can be permanently secured and/or molded into either the graft storage module 100 or the graft extraction module 650 (or any other suitable device).
  • one end of the latch 600 is permanently secured and/or molded to the graft storage module 100 and the other end of the latch 600 is permanently secured and/or molded to the graft extraction module 650 (or any other suitable device).
  • FIGs. 9A and 9B illustrate a latch molded to the graft storage module in accordance with an illustrative embodiment. In alternative embodiments, additional, fewer, and/or different elements may be used.
  • Fig. 9A is an isometric view of the graft storage module 100 with a molded latch 600
  • Fig. 9B is a cross- sectional side view of the graft storage module 100 with a molded latch 600.
  • a graft storage module 100 with the molded latch 600 can be economical to manufacture and can prevent misplacing the latch 600.
  • a vacuum source can be attached to the connector 120, which can cause a vacuum pressure to be in the internal storage volume and the graft collection tube 150.
  • Any suitable amount of vacuum can be applied at the connector 120.
  • the pressure at the connector 120 can be in the range of 200 millimeters of mercury (mm Hg) to 700 mm Hg.
  • the pressure at the connector 120 can be 200 mm Hg, 300 mm Hg, 400 mm Hg, 450 mm Hg, 500 mm Hg, 550 mm Hg, 600 mm Hg, 700 mm Hg, etc.
  • the pressure at the connector 120 can be less than 200 mm Hg or greater than 700 mm Hg.
  • the amount of vacuum pressure used can be chosen by a clinician based on the size of the graft storage module 100 (and/or its various components), the size of the various tubes, the size of the grafts, the size and type of the graft extraction module used, the particular conditions of the patient, the particular atmospheric conditions, the preference of a clinician, etc.
  • the vacuum pressure used can be chosen such that the amount of suction applied at the harvesting location overcomes tissue adherence of the graft below the follicular bulb.
  • the internal storage volume can include a liquid under vacuum pressure. As air is vacuumed out of the internal storage volume, the temperature of the internal storage volume (and, therefore, the temperature of the liquid and the grafts) can be decreased by 8° C to 10° C.
  • the temperature of the internal storage volume can be 8° C, 8.5° C, 9° C, 9.5° C, 10° C, etc. lower than the ambient temperature (e.g., about 23° C). In alternative embodiments, the temperature of the internal storage volume can be less than 8°C lower than the ambient temperature or greater than 10° C lower than the ambient temperature.
  • a temperature indicator is attached to the graft storage module 100 that indicates the temperature of the internal storage volume. Any suitable temperature indicator can be used.
  • a cooling system is incorporated into the graft storage module 100 to maintain the temperature of the internal storage volume at a setpoint, which may be chosen by the clinician. Any suitable cooling system may be used.
  • the cooling system can provide cool air to the internal storage chamber, thereby cooling the liquid.
  • the cooling system ca n provide cool saline to the internal storage chamber, thereby displacing some of the liquid already in the internal storage chamber.
  • a cooling jacket can surround (at least a portion of) the graft storage system 100.
  • a cooling fluid e.g., gas or liquid
  • a cooling fluid passes through the internal storage volume.
  • a closed-loop system can circulate cooling fluid through the internal storage volume via one or more tubes (e.g., tubes perpendicular or parallel to the first hollow tube feature 135 and the second hollow tube feature 145).
  • grafts are harvested and have a temperature of about 37° C (body temperature) and are stored in the liquid in the internal storage volume. The grafts are then cooled to about 8° C to 10° C below ambient temperature until they are implanted in the recipient, when the grafts warm back up to about 37° C.
  • a vertical graft storage module 1000 can be used to collect harvested grafts in place of the graft storage module 100.
  • FIG. 10A is an isometric view of a vertical graft storage module from an outside perspective in accordance with an illustrative embodiment.
  • Fig. 10B is an exploded view of the vertical graft storage module of Fig. 10A in accordance with an illustrative embodiment.
  • Figs. 11A and 11B are cross-sectional views of a vertical graft storage module in accordance with an illustrative embodiment.
  • Figs. 12A and 12B are isometric views of a cap of a vertical graft storage module in accordance with an illustrative embodiment.
  • An illustrative graft storage module 1000 includes a cap 1005, a storage chamber 1010, a first port 1015, a connector 1020, at least one groove 1025, at least one seal 1030, a first hollow tube feature 1035, a retaining filter 1045, a graft collection tube 1050, and a spatula 1075.
  • additional, fewer, and/or different elements may be used.
  • Figs. 10A and 10B are meant to be illustrative only and are not meant to be limiting with respect to the size, orientation, scale, or proportions of the illustrated elements.
  • the internal storage volume of the graft storage module 1000 is defined, at least in part, by the storage chamber 1010 and the cap 1005.
  • the size and materials of construction of the cap 1005 and the storage chamber 1010 can be the same as those discussed above with regard to the cap 105 and the storage chamber 110 of the graft storage module 100.
  • the cap 1005 and the storage chamber 1010 are detachable. As shown in the embodiment illustrated in Fig. 10B, the cap 1005 can slide over a surface of the storage chamber 1010 that has grooves 1025 that receive seals 1030.
  • the grooves 1025 and seals 1030 can be similar in form and function as grooves 125 and seals 130 discussed above in regard to graft storage module 100.
  • the grooves 1025 are located on an internal surface of the cap 1005.
  • any suitable sealing mechanism can be used.
  • Fig. 10B illustrates the use of two grooves 1025 and two seals 1030, any suitable number of grooves 1025 and seals 1030 may be used.
  • one groove 1025 and one seal 1030 may be used.
  • three or more grooves 1025 and seals 1030 may be used.
  • the seals 1030 can be any suitable seal.
  • the seals 1030 can be O-rings.
  • the seals 1030 can include gaskets, clamps, etc.
  • the seals 1030 can be made of any suitable material that is bio-compatible.
  • the seals 1030 can be made of Buna-N (Nitrile), ethylene-propylene, silicone, polyurethane, neoprene, one or more fluorocarbon materials, etc.
  • the cap 1005 can be pushed onto and pulled off of the storage chamber 1010.
  • the seals 1030 can provide the friction and/or resistance for securing the cap 1005 to the storage chamber 1010.
  • a vacuum pressure in the internal storage volume can be used to assist in securing the cap 1005 to the storage chamber 1010.
  • any other suitable arrangement for securing the cap 1005 and the storage chamber 1010 to one another may be used.
  • the cap 1005 and the storage chamber 1010 can include threads that allow the cap 1005 to screw onto the storage chamber 1010.
  • clips or clamps may be used.
  • the connector 1020 is connected to a vacuum source, such as the vacuum source discussed above with respect to the graft storage module 100.
  • Figs. 10A, 10B, 11A, and 11B illustrate the connector 1020 with a barbed fitting.
  • any suitable means for connecting the vacuum tube to the graft storage module 1000 may be used.
  • a threaded fitting, a snap connection, a quick disconnect fitting, etc. may be used.
  • the connector 1020 can include a retaining filter 1045.
  • the retaining filter 1045 includes a plurality of filtering elements. The plurality of filtering elements can be the same or different from one another.
  • the retaining filter 1045 can be configured to prevent grafts from entering into the connector 1020.
  • the retaining filter 1045 can be any suitable filter for preventing grafts from passing through the retaining filter 1045.
  • the retaining filter 1045 can have any of the properties discussed above with regard to retaining filter 145. As illustrated in Figs. 11A and 11B, the retaining filter 1045 can be flush with the inside surface of the cap 1005. In alternative embodiments, the retaining filter 1045 can be recessed into the cap 1005 or protrude from the cap 1005.
  • the retaining filter 1045 can include perforations, a screen, a mesh, etc.
  • the retaining filter 1045 is a micro filter. In some embodiments, the retaining filter 1045 can be removable/replaceable. In alternative embodiments, the retaining filter 1045 is integrated into the cap 1005.
  • the retaining filter 1045 does not prevent liquid from entering into the connector 1020, which may be under a vacuum pressure. Accordingly, if the graft storage module 1000 is tipped such that the liquid within the internal storage volume contacts the retaining filter 1045, the liquid may be suctioned into the connector 1020. Thus, to prevent suctioning the liquid into the connector 1020, the graft storage module 1000 may be kept in a substantially upright and vertical orientation to prevent the liquid from contacting the retaining filter 1045.
  • the first port 1015 can be attached to a graft source.
  • a graft collection tube 1050 is connected to the first port 1015.
  • a harvested graft can be suctioned into the internal storage volume of the graft storage module 1000 using the vacuum provided through the connector 1020. That is, a vacuum source can be connected to the connector 1020, and the vacuum pressure can be used to pull the harvested graft into the first port 1015 and through the first hollow tube feature 1035.
  • the first hollow tube feature 1035 is part of the graft collection tube 1050.
  • the graft collection tube 1050 is inserted into the first port 1015 and into the internal storage volume such that the graft collection tube 1050 protrudes into the internal storage volume.
  • the graft collection tube 1050 is inserted into the first port 1015 and does not protrude into the internal storage volume.
  • the first hollow tube 1035 can be attached to the cap 1005.
  • the internal storage volume of the graft storage module 1000 can also include a liquid, such as saline.
  • the graft after the graft is pulled through the hollow tube feature 1035, the graft can fall into the liquid in the internal storage volume, in which the graft can remain in storage, for example, while additional grafts are harvested.
  • the first hollow tube 1035 protrudes below a surface of the liquid.
  • damage to the graft can be minimized by having the first hollow tube feature 1035 protrude below the surface of the liquid because, as the graft enters into the liquid, the graft can be surrounded (at least in part) in a bubble. That is, the vacuum pressure suctions air and the graft out of the first hollow tube feature 1035 simultaneously.
  • the bubble can dissipate or float away from the graft, thereby gently entering the graft into the liquid.
  • the first hollow tube feature 1035 does not protrude below a surface of the liquid and the graft can fall into the liquid.
  • the size of the first hollow tube feature 1035, the first port 1015, and the graft collection tube 1050 can be chosen in the same fashion as the first hollow tube feature 135, the first port 115, and the graft collection tube 150 as discussed above in regard to the graft storage module 100.
  • the vacuum applied to the connector 1020 is applied continuously. That is, in such embodiments, vacuum is applied to the connector 1020 while grafts are stored in the internal storage volume and/or while grafts are being harvested. In alternative embodiments, the vacuum is applied to transport the grafts into the internal storage volume and is shut off in between harvesting of the individual grafts. Switching on and off of the vacuum can be manual or automatic using any suitable method.
  • Fig. 13 depicts a spatula in accordance with an illustrative embodiment. An illustrative spatula includes a perforated discus 1305 and a handle grip 1310. In alternative embodiments, additional, fewer, and/or different elements may be used.
  • the spatula 1075 can be used to strain the harvested grafts collected in the internal storage volume from the liquid used to protect the grafts.
  • the spatula 1075 can be located within the internal storage volume, with the perforated discus 1305 resting on the top surface of the bottom of the storage chamber 1010. In alternative embodiments, the perforated discus 1305 can be suspended above the bottom of the storage chamber 1010.
  • the grafts can enter the liquid above the perforated discus 1305.
  • a clinician (or any suitable device) can grasp or otherwise secure the handle grip 1310, which extends vertically from the perforated discus 1305, and lift the spatula 1075 up and off of the bottom of the internal storage volume.
  • the perforations in the perforated discus 1305 can allow the liquid to flow through the perforated discus 1305, but prevent the grafts from flowing through the perforated discus 1305.
  • the perforations can be sized similar to the retaining filter 145, which is discussed above with regard to the graft storage module 100.
  • the spatula 1075 can be lifted, the grafts are strained from the liquid and rest on the top surface of the perforated discus 1305.
  • the perforated discus 1305 can be sized such that the graft cannot fall between a sidewall of the storage chamber 1010 and the perforated discus 1305.
  • the spatula 1075 can be made of any suitable bio-compatible material such as rubber, plastic, metal, stainless steel, aluminum, polycarbonate, etc.
  • a spatula (e.g., spatula 1475) similar to the spatula 1075 can be adapted for use in the graft storage module 100.
  • Figs. 14A-14C are illustrations of a spatula in accordance with an illustrative embodiment.
  • Fig. 14A illustrates a spatula 1475 with a perforated discus 1405, a handle grip 1410, and a through holel415.
  • Fig. 14B is an exploded view of the spatula 1475 assembled with the graft storage module 100.
  • Fig. 14C is a cross-sectional view of the spatula 1475 in the graft storage module 100.
  • additional, fewer, and/or different elements may be used.
  • the spatula 1475 has a through hole 1415 in the perforated discus 1405.
  • the perforations in the perforated discus 1405 can be the same as the perforations in the perforated discus 1305.
  • the through hole 1415 allows the second hollow tube feature 140 to pass through the perforated discus 1305.
  • the diameter of the through hole can be the same as (or slightly larger than) the outside diameter of the second hollow tube feature 140.
  • the spatula 1475 can strain harvested grafts from the liquid when the spatula 1475 is raised out of the storage chamber 110.
  • liquid is inserted into a graft storage module, such as the graft storage module 100 or the graft storage module 1000.
  • the liquid can be inserted into the graft storage module in any suitable manner.
  • the liquid can be suctioned through a graft collection tube and into an internal storage volume of the graft storage module (e.g., through the cap of the graft storage module).
  • the liquid can be inserted into the graft storage module by pouring the liquid, injecting the liquid from a syringe, etc.
  • the liquid is saline.
  • the amount of liquid can be pre-determined (e.g., measured) and be dependent on the size of the graft storage module.
  • the graft storage module is assembled.
  • assembling the graft storage module includes fixing (e.g., by sliding) the cap onto the storage chamber.
  • assembling the graft storage module includes placing the spatula into the storage chamber.
  • assembling the graft storage module includes fixing a filter to the graft storage module, fixing one or more seals (e.g., O- rings) to the graft storage module, etc.
  • an inlet hose is attached to the graft storage module.
  • the graft collection tube as described above, is connected to the first port of the graft storage module.
  • operation 1515 can comprise attaching the graft storage module (e.g., via the first port) directly to a graft extraction module.
  • the method illustrated in Fig. 15 includes mounting the graft storage module.
  • a clip or latch can be used to secure the graft storage module to another device or mounting point.
  • the graft storage module is attached to a graft extraction device using a latch.
  • a vacuum hose is attached to the graft storage module.
  • the vacuum hose can be attached to the connector of a graft storage module.
  • suction is applied to the graft storage module. For example, vacuum pressure is applied via the vacuum hose by operating a valve, operating a panel or other user interface of a vacuum control system, etc.
  • a graft is harvested from a donor.
  • the harvested graft can include one or more hair follicles.
  • Harvesting the graft can be performed using any suitable method.
  • a graft extraction module is used to core out a graft.
  • the harvested graft is stored in the graft storage module. Suction from the vacuum hose is used to cause the harvested graft to travel through a collection tube (if one is used) and enter the storage chamber.
  • the cap of the graft storage module is removed.
  • operation 1540 is performed after several grafts have been harvested and stored in the graft storage module.
  • operation 1540 includes turning off the vacuum applied to the graft storage module.
  • operation 1540 includes disconnecting one or more of the tubes connected to the graft storage module.
  • the harvested grafts are collected from the graft storage module.
  • collecting the harvested grafts includes pouring out the liquid (in which the harvested grafts are suspended) from the storage chamber. The liquid can be poured out into another vessel, such as a tray.
  • collecting the harvested grafts includes straining the grafts from the liquid (e.g., via the spatula).
  • saline is added to a storage chamber of a graft storage module.
  • the cap to the graft storage module is secured to the top of the storage chamber.
  • the cap and the storage chamber are sealed using O-rings that seat in grooves of the storage chamber.
  • the cap and the storage chamber are made of transparent polycarbonate.
  • the cap and the storage chamber are cylindrical in shape.
  • a first hollow tube feature extends along an internal axis from the cap and a second hollow tube feature extends along the internal axis from the storage chamber. Attached to the end of the second hollow tube feature is a filter.
  • the fi rst hollow tube feature and the second hollow tube feature are separated by 10 mm.
  • the inside end surface of the cap and the inside end surface of the storage chamber are 100 mm apart.
  • a punch is used in a graft extraction module to extract cylindrically shaped grafts that each include at least one hair follicle.
  • the inside diameter of the punch is 1 mm.
  • a graft collection tube is attached to the output of the punch.
  • the inside diameter of the graft collection tube is 1.5 mm.
  • the graft collection tube is attached to a first port of the graft storage module.
  • the inside diameter of the first hollow tube feature (and the second hollow tube feature) is 1.5 mm.
  • the filter at the end of the second hollow tube feature has slits that are 0.5 mm wide.
  • the con nector of the graft storage module is connected to a vacuum source.
  • the pressure supplied by the vacuum source is 500 mm Hg.
  • Hair follicles are harvested from a donor source using the punch.
  • the hair follicles are suctioned away from the punch, through the graft collection tube, and through the first hollow tube feature.
  • the hair follicles fall into the liquid.
  • the vacuum pressure is turned off, and the graft collection tube and the vacuum tube are disconnected from the graft storage module.
  • the cap is pulled off of the storage chamber, and the contents of the storage chamber are poured out for implantation of the grafts into a recipient.
  • a spatula is placed inside of a storage chamber.
  • Saline is added to the storage chamber.
  • the cap to a graft storage module is secured to the top of the storage chamber and the graft storage module is kept in an upright position (i.e., with the cap above the storage chamber).
  • the cap and the storage chamber are sealed using O-rings that seat in grooves of the storage chamber.
  • the cap and the storage chamber are made of transparent polycarbonate.
  • the cap and the storage chamber comprise a cylindrical shape.
  • a first hollow tube feature extends down from the cap and protrudes into a volume defined by the storage chamber. The first hollow tube feature extends below the surface of the saline.
  • a punch is used in a graft extraction module to extract cylindrically shaped grafts that each include at least one hair follicle.
  • the inside diameter of the punch is 1 mm.
  • a graft collection tube is attached to the output of the punch.
  • the inside diameter of the graft collection tube is 1.5 mm.
  • the graft collection tube is attached to a first port of the graft storage module.
  • the inside diameter of the first hollow tube feature is 1.5 mm.
  • the connector of the graft storage module is connected to a vacuum source.
  • the pressure supplied by the vacuum source is 500 mm Hg.
  • the clinician can adjust the amount of vacuum supplied by the vacuum source to be any pressure less than 760 mm Hg.
  • Hair follicles are harvested from a donor source using the punch.
  • the hair follicles are suctioned away from the punch, through the graft collection tube, and through the first hollow tube feature.
  • the hair follicles are expelled from the first hollow tube feature into the liquid.
  • the vacuum pressure is turned off, and the graft collection tube and the vacuum tube are disconnected from the graft storage module.
  • the spatula is used to strain the grafts from the liquid.
  • the spatula has perforations with diameters of 0.5 mm.
  • the spatula is lifted up and out of the liquid, and the grafts rest on the top surface of the spatula.
  • the grafts are then implanted into a recipient.
  • any two components so associated can also be viewed as being “operably connected,” or “operably coupled,” to each other to achieve the desired functionality, and any two components capable of being so associated can also be viewed as being “operably couplable,” to each other to achieve the desired functionality.
  • operably couplable include but are not limited to physically mateable and/or physically interacting components and/or wirelessly interactable and/or wirelessly interacting components and/or logically interacting and/or logically interactable components.

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Abstract

L'invention concerne un exemple de dispositif qui comprend un capuchon et un corps. Le capuchon comprend un orifice d'entrée de capuchon et un orifice de sortie de capuchon en communication fluidique l'un avec l'autre. L'orifice d'entrée de capuchon est conçu pour mettre en prise un tube d'entrée, à travers lequel est reçu un greffon. L'orifice de sortie de capuchon est en communication fluidique avec un volume de stockage de greffon qui est formé au moins en partie par le capuchon. Le corps est accouplé au capuchon et forme au moins une partie du volume de stockage de greffon. Le corps comprend un orifice d'entrée de corps et un orifice de sortie de corps en communication fluidique l'un avec l'autre. L'orifice de sortie de corps est conçu pour mettre en prise un tube à vide pour amener le greffon dans le volume de stockage de greffon. Le tube à vide fournit une pression à vide qui amène une température du volume de stockage de greffon à être inférieure à une température ambiante.
PCT/IN2015/050092 2014-08-13 2015-08-13 Dispositif biomédical pour une tolérance à la dessiccation améliorée de greffons Ceased WO2016024295A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IN2015/050112 WO2016042579A2 (fr) 2014-09-18 2015-09-16 Dispositif biomédical de récupération de greffons
PCT/IN2015/050201 WO2016098126A2 (fr) 2014-12-15 2015-12-15 Plateau à greffon

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
IN2611MU2014 2014-08-13
IN2612/MUM/2014 2014-08-13
IN2612MU2014 2014-08-13
IN2611/MUM/2014 2014-08-13
IN2987/MUM/2014 2014-09-18
IN2987MU2014 2014-09-18
IN4012/MUM/2014 2014-12-15
IN4011MU2014 2014-12-15
IN4012MU2014 2014-12-15
IN4011/MUM/2014 2014-12-15
IN4161/MUM/2014 2014-12-26
IN4161MU2014 2014-12-26
PCT/IN2015/050042 WO2015186146A1 (fr) 2014-06-05 2015-06-05 Systèmes de transplantation de cheveux et procédés pour leur utilisation
INPCT/IN2015/050042 2015-06-05

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PCT/IN2015/050091 Ceased WO2016024294A1 (fr) 2014-08-13 2015-08-13 Dispositif biomédical pour implanter des greffons

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KR101861504B1 (ko) * 2018-01-11 2018-05-28 신한종 고정대가 부착된 모발 이식용 핸드피스
WO2023250452A2 (fr) * 2022-06-24 2023-12-28 The General Hospital Corporation Systèmes et procédés pour la préparation d'un site de transplantation destiné à recevoir des greffes folliculaires et pour la réalisation de greffes folliculaires

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