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WO2016015173A1 - Procédé de traitement de tumeur permettant de bloquer le système vasculaire tumoral au moyen d'un nanomatériau et source de rayonnement externe - Google Patents

Procédé de traitement de tumeur permettant de bloquer le système vasculaire tumoral au moyen d'un nanomatériau et source de rayonnement externe Download PDF

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Publication number
WO2016015173A1
WO2016015173A1 PCT/CN2014/000723 CN2014000723W WO2016015173A1 WO 2016015173 A1 WO2016015173 A1 WO 2016015173A1 CN 2014000723 W CN2014000723 W CN 2014000723W WO 2016015173 A1 WO2016015173 A1 WO 2016015173A1
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WO
WIPO (PCT)
Prior art keywords
tumor
nanomaterial
cancer
nanomaterials
energy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2014/000723
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English (en)
Chinese (zh)
Inventor
王春儒
甄明明
王太山
舒春英
张国强
邹头君
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Fullcan Bio-Technology Co Ltd
Original Assignee
Beijing Fullcan Bio-Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Fullcan Bio-Technology Co Ltd filed Critical Beijing Fullcan Bio-Technology Co Ltd
Priority to PCT/CN2014/000723 priority Critical patent/WO2016015173A1/fr
Publication of WO2016015173A1 publication Critical patent/WO2016015173A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds

Definitions

  • a third object of the present invention is to provide a method for treating tumors based on the above-described nanomaterials which can specifically block tumor blood vessels.
  • FIG. 1 is a schematic diagram of nanomaterial-specific destruction of tumor vascular endothelial cells, in which black particles refer to nanomaterials that satisfy the properties of the present invention, that is, can undergo deformation (rapid expansion or explosion); green particles refer to those that do not satisfy the present invention. Nanoparticles of the nature; the purple fraction refers to the action of the nanomaterials leading to apoptosis of tumor vascular endothelial cells.
  • the tumor treatment method provided by the invention utilizes nano materials to block tumor blood vessels with high selectivity, has strong specificity, large power, direct and rapid, and is safe and efficient, and has little damage to normal tissues, and is a promising new type of tumor treatment. method.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une application d'un nanomatériau pour la préparation d'un agent de blocage du système vasculaire tumoral, ledit nanomatériau ayant toutes les propriétés suivantes : (1) la surface est hydrophile; (2) la surface a de l'électronégativité; (3) la taille du nanomatériau est de 50 à 250 nm, et le matériau est rigide, de telle sorte qu'il n'a pas tendance à traverser le trou dans la paroi d'un vaisseau tumoral et à rester bloqué dans ledit trou; (4) le nanomatériau peut absorber l'énergie de rayonnement externe, et convertir celles-ci à l'intérieur en énergie thermique, et à accumuler ladite énergie thermique, amenant la structure morphologique dudit nanomatériau à un changement sensible. Pendant le traitement, le nanomatériau de l'invention est injecté dans un organisme porteur de tumeur, un rayonnement est ensuite appliqué à la section tumorale, amenant le nanomatériau à absorber l'énergie de rayonnement et sa température interne à augmenter rapidement; lorsque la température a augmenté jusqu'à un certain niveau, la structure morphologique du nanomatériau change (explosion ou expansion phénoménal de volume), amenant ainsi la structure morphologique ou la fonction des cellules endothéliales vasculaires tumorales à changer, par destruction du système vasculaire de la tumeur.
PCT/CN2014/000723 2014-07-29 2014-07-29 Procédé de traitement de tumeur permettant de bloquer le système vasculaire tumoral au moyen d'un nanomatériau et source de rayonnement externe Ceased WO2016015173A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/000723 WO2016015173A1 (fr) 2014-07-29 2014-07-29 Procédé de traitement de tumeur permettant de bloquer le système vasculaire tumoral au moyen d'un nanomatériau et source de rayonnement externe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/000723 WO2016015173A1 (fr) 2014-07-29 2014-07-29 Procédé de traitement de tumeur permettant de bloquer le système vasculaire tumoral au moyen d'un nanomatériau et source de rayonnement externe

Publications (1)

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WO2016015173A1 true WO2016015173A1 (fr) 2016-02-04

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PCT/CN2014/000723 Ceased WO2016015173A1 (fr) 2014-07-29 2014-07-29 Procédé de traitement de tumeur permettant de bloquer le système vasculaire tumoral au moyen d'un nanomatériau et source de rayonnement externe

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WO (1) WO2016015173A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108217626A (zh) * 2017-12-29 2018-06-29 华中科技大学 一种实现内包金属富勒烯快速分离的方法
CN112546069A (zh) * 2020-12-04 2021-03-26 河南精检生物科技有限公司 阻断病变细胞营养供给的纳米碳材料及其制备方法和应用

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WO2008048074A1 (fr) * 2006-10-20 2008-04-24 Seoul National University Industry Foundation NANOPARTICULE D'OR CœUR-COQUILLE CONTENANT DES NANOPARTICULES MAGNÉTIQUES, S'UTILISANT COMME AGENT DE CONTRASTE T2 D'IRM, DIAGNOSTIC ET TRAITEMENT DU CANCER
WO2012121528A2 (fr) * 2011-03-04 2012-09-13 Samsung Life Public Welfare Foundation Nanocomposite magnétique spécifique du cancer de la thyroïde et son utilisation
CN103191427A (zh) * 2013-04-19 2013-07-10 郑州大学 富勒烯及其衍生物在射频或微波照射下作为制备治疗皮肤病或肿瘤药物中的应用
CN103316341A (zh) * 2013-06-26 2013-09-25 郑州大学 富勒烯-纳米金复合材料及其制备方法与应用
CN103861103A (zh) * 2014-01-24 2014-06-18 中国科学院长春光学精密机械与物理研究所 一种上转换纳米粒子与金纳米棒复合的纳米粒子及其制备方法和应用
CN103893764A (zh) * 2012-12-25 2014-07-02 国家纳米科学中心 药物载体及其制备方法和药物组合物及其应用
CN104127873A (zh) * 2014-07-29 2014-11-05 中国科学院化学研究所 一种由纳米材料和外加辐射源组成的实现肿瘤血管阻断的肿瘤治疗药物
CN104127872A (zh) * 2014-07-29 2014-11-05 中国科学院化学研究所 金属富勒烯单晶纳米颗粒在制备特异性肿瘤血管阻断剂中的应用

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008048074A1 (fr) * 2006-10-20 2008-04-24 Seoul National University Industry Foundation NANOPARTICULE D'OR CœUR-COQUILLE CONTENANT DES NANOPARTICULES MAGNÉTIQUES, S'UTILISANT COMME AGENT DE CONTRASTE T2 D'IRM, DIAGNOSTIC ET TRAITEMENT DU CANCER
WO2012121528A2 (fr) * 2011-03-04 2012-09-13 Samsung Life Public Welfare Foundation Nanocomposite magnétique spécifique du cancer de la thyroïde et son utilisation
CN103893764A (zh) * 2012-12-25 2014-07-02 国家纳米科学中心 药物载体及其制备方法和药物组合物及其应用
CN103191427A (zh) * 2013-04-19 2013-07-10 郑州大学 富勒烯及其衍生物在射频或微波照射下作为制备治疗皮肤病或肿瘤药物中的应用
CN103316341A (zh) * 2013-06-26 2013-09-25 郑州大学 富勒烯-纳米金复合材料及其制备方法与应用
CN103861103A (zh) * 2014-01-24 2014-06-18 中国科学院长春光学精密机械与物理研究所 一种上转换纳米粒子与金纳米棒复合的纳米粒子及其制备方法和应用
CN104127873A (zh) * 2014-07-29 2014-11-05 中国科学院化学研究所 一种由纳米材料和外加辐射源组成的实现肿瘤血管阻断的肿瘤治疗药物
CN104127872A (zh) * 2014-07-29 2014-11-05 中国科学院化学研究所 金属富勒烯单晶纳米颗粒在制备特异性肿瘤血管阻断剂中的应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108217626A (zh) * 2017-12-29 2018-06-29 华中科技大学 一种实现内包金属富勒烯快速分离的方法
CN108217626B (zh) * 2017-12-29 2019-11-22 华中科技大学 一种实现内包金属富勒烯快速分离的方法
CN112546069A (zh) * 2020-12-04 2021-03-26 河南精检生物科技有限公司 阻断病变细胞营养供给的纳米碳材料及其制备方法和应用

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