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WO2016004911A8 - A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition - Google Patents

A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition Download PDF

Info

Publication number
WO2016004911A8
WO2016004911A8 PCT/CZ2015/000076 CZ2015000076W WO2016004911A8 WO 2016004911 A8 WO2016004911 A8 WO 2016004911A8 CZ 2015000076 W CZ2015000076 W CZ 2015000076W WO 2016004911 A8 WO2016004911 A8 WO 2016004911A8
Authority
WO
WIPO (PCT)
Prior art keywords
cocrystal
pharmaceutical composition
mandelic acid
ivabradine hydrochloride
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CZ2015/000076
Other languages
French (fr)
Other versions
WO2016004911A1 (en
Inventor
Ondrej Dammer
Veronika SLADKOVA
Eliska SKOREPOVA
Gregor Sedmak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zentiva KS
Original Assignee
Zentiva KS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva KS filed Critical Zentiva KS
Publication of WO2016004911A1 publication Critical patent/WO2016004911A1/en
Publication of WO2016004911A8 publication Critical patent/WO2016004911A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a new solid form of ivabradine hydrochloride and (R)-mandelic acid of formula (II) hi the molar ratio of 1:1. The method of preparing the above mentioned cocrystal consists in mixing or grinding the individual components in the presence of a solvent The present invention also relates to a polymorphically stable pharmaceutical composition and a granulate, which contains the cocrystal and a pharmaceutically acceptable excipient.
PCT/CZ2015/000076 2014-07-10 2015-07-10 A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition Ceased WO2016004911A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ2014-478A CZ305436B6 (en) 2014-07-10 2014-07-10 Solid form of ivabradine hydrochloride and (R)-mandelic acid and pharmaceutical composition thereof
CZPV2014-478 2014-07-10

Publications (2)

Publication Number Publication Date
WO2016004911A1 WO2016004911A1 (en) 2016-01-14
WO2016004911A8 true WO2016004911A8 (en) 2016-05-19

Family

ID=53765011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2015/000076 Ceased WO2016004911A1 (en) 2014-07-10 2015-07-10 A cocrystal of ivabradine hydrochloride and (r)-mandelic acid and its pharmaceutical composition

Country Status (2)

Country Link
CZ (1) CZ305436B6 (en)
WO (1) WO2016004911A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020112941A2 (en) * 2018-11-27 2020-06-04 Teva Czech Industries S.R.O Solid state forms of lumateperone salts and processes for preparation of lumateperone and salts thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (en) 1991-09-27 1993-11-12 Adir Cie NOVELS (BENZOCYCLOALKYL) ALKYLAMINES, THEIR PREPARATION PROCESS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2868777B1 (en) 2004-04-13 2006-05-26 Servier Lab NOVEL PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ITS SALTS OF ADDITION TO A PHARMACEUTICALLY ACCEPTABLE ACID
FR2882553B1 (en) 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE BETA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882555B1 (en) 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882554B1 (en) 2005-02-28 2007-05-04 Servier Lab IVABRADINE HYDROCHLORIDE BETA D-CRYSTALLINE FORM, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2882556B1 (en) 2005-02-28 2007-05-04 Servier Lab CRYSTALLINE GAMMA D FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891827B1 (en) 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE DELTAD FORM OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2891826B1 (en) 2005-10-11 2007-12-28 Servier Lab CRYSTALLINE FORM 6 OF IVABRADINE HYDROCHLORIDE, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
EP2097383B1 (en) 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
RU2473544C2 (en) * 2007-05-30 2013-01-27 Инд-Свифт Лабораториз Лимитед Method of producing ivabradine hydrochloride and polymorphs thereof
CN101774969B (en) 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 Ivabradine sulfate and method for preparing type I crystal thereof
SI23290A (en) 2010-02-12 2011-08-31 Krka D.D., Novo Mesto New forms of ivabradine hydrochloride
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
ES2465596T3 (en) * 2010-06-14 2014-06-06 Ratiopharm Gmbh Pharmaceutical composition containing ivabradine with modified release
WO2013017582A1 (en) * 2011-08-02 2013-02-07 Sandoz Ag Acetone solvate of ivabradine hydrochloride
EP2589594A1 (en) 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
CZ305096B6 (en) * 2013-10-02 2015-04-29 Zentiva, K.S. The solid form of Ivabradine hydrochloride and (S) -mandelic acid and its pharmaceutical composition

Also Published As

Publication number Publication date
CZ2014478A3 (en) 2015-09-16
WO2016004911A1 (en) 2016-01-14
CZ305436B6 (en) 2015-09-16

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