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WO2016073846A1 - Méthodes de traitement des ckd utilisant des prédicteurs de rétention de fluide - Google Patents

Méthodes de traitement des ckd utilisant des prédicteurs de rétention de fluide Download PDF

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Publication number
WO2016073846A1
WO2016073846A1 PCT/US2015/059456 US2015059456W WO2016073846A1 WO 2016073846 A1 WO2016073846 A1 WO 2016073846A1 US 2015059456 W US2015059456 W US 2015059456W WO 2016073846 A1 WO2016073846 A1 WO 2016073846A1
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Prior art keywords
subject
risk
etra
fluid retention
atrasentan
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Inventor
Donald K. KOHAN
Hiddo J. LAMBERS HEERSPINK
Dick De Zeeuw
Blai COLL
Dennis ANDRESS
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AbbVie Inc
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AbbVie Inc
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Priority to CN201580072599.2A priority Critical patent/CN107106522A/zh
Priority to BR112017009668A priority patent/BR112017009668A2/pt
Priority to AU2015342929A priority patent/AU2015342929A1/en
Priority to EP15857776.7A priority patent/EP3215138A4/fr
Priority to JP2017523974A priority patent/JP2017534634A/ja
Priority to CA2966756A priority patent/CA2966756A1/fr
Priority to MX2017005884A priority patent/MX2017005884A/es
Publication of WO2016073846A1 publication Critical patent/WO2016073846A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Definitions

  • This disclosure relates generally to methods of treating chronic kidney disease (CKD) based on predictors of fluid retention. Further, this disclosure relates to methods of treating diabetic nephropathy based on predictors of fluid retention.
  • CKD chronic kidney disease
  • diabetic nephropathy based on predictors of fluid retention.
  • albuminuria as measured by the decrease in the urinary albumin-to-creatinine ratio (UACR), for patients receiving effective doses of RAAS inhibitors like Angiotensin-Converting Enzyme inhibitors (ACEi) or Angiotensin Receptor Blockers (ARBs), is associated with a decrease in the incidence of "hard outcome” renal events like doubling of serum creatinine, time to End-Stage Renal Disease (ESRD) and death.
  • ACEi Angiotensin-Converting Enzyme inhibitors
  • ARBs Angiotensin Receptor Blockers
  • ETRAs Endothelin Receptor Antagonists
  • ET A and ET B receptors are known to cause fluid retention. Fluid retention is a common side effect associated with previously studied ETRAs.
  • the observed rate of edema with some previously studied ETRAs resulted in discontinuation of their development for albuminuria or other disease states. Therefore, a balance between desired renoprotection and clinical safety is sought when using ETRAs in a manner that lowers urinary protein excretion while limiting the incidence of peripheral edema and fluid retention.
  • ETRA darusentan was studied for the treatment of resistant hypertension.
  • a pivotal double-blind study by Weber (Weber, M., et al., Lancet, 374: 1423-31 (2009)), which was conducted in multiple sites worldwide, enrolled 379 individuals with a systolic blood pressure above 140 mmHg who were receiving full doses of at least three blood- pressure-lowering drugs including a diuretic.
  • Patients were randomized to receive either placebo or darusentan (50 mg, 100 or 300 mg) taken once daily.
  • darusentan After 14 weeks of treatment, the addition of darusentan was associated with a non- dose-dependent reduction in systolic and diastolic clinic seated blood pressures of about 10 mmHg and 5 mmHg, respectively, compared with placebo treatment. Edema and/or fluid retention was reported in 27% of patients on darusentan and 14% of patients on placebo in the study. Although only four patients (2%) in the combined darusentan treatment groups had to discontinue participation in the study because of fluid retention or peripheral edema, five patients taking darusentan experienced cardiac-related serious adverse events (two patients had myocardial infarction, one patient had atrial fibrillation and two patients had incident congestive heart failure). One sudden death event occurred in the placebo group.
  • Bosentan therapy was associated with early worsening of congestive heart failure (CHF) within the first 4-8 weeks in the ENABLE and REACH-1 trials and this was thought to be a consequence of fluid retention.
  • CHF congestive heart failure
  • darusentan tended to worsen CHF when given at higher doses.
  • Atrasentan is a highly potent and selective ETRA that was previously studied for the treatment of prostate cancer. After a detailed evaluation of pre-clinical results, atrasentan was evaluated for the treatment of residual albuminuria. The key objective was to balance systemic effects, which can lead to a significant unacceptable side effects like edema, and efficacy effects on urinary albumin creatinine ratio (UACR). Subsequently, atrasentan was studied in patients with residual albuminuria associated with diabetic nephropathy.
  • the disclosure presents methods of treating chronic kidney disease with an ETRA, such as atrasentan or another selective ET A receptor antagonist, by measuring one or more of eGFR, blood pressure, HbA1 c, or HOMA-product in a subject suffering from chronic kidney disease; determining, based on the measurement(s), risk of fluid retention if an ETRA were administered to the subject; and administering the ETRA to the subject if the risk is at an acceptable level.
  • an ETRA such as atrasentan or another selective ET A receptor antagonist
  • the present disclosure presents methods of treating diabetic nephropathy with an ETRA, such as atrasentan or another ETRA that is a selective ET A receptor antagonist, by measuring one or more of eGFR, blood pressure, HbA1c, or HOMA- product in a subject suffering from diabetic nephropathy; determining, based on the measurement(s), risk of fluid retention if an ETRA were administered to the subject; and administering the ETRA to the subject if the risk is at an acceptable level.
  • an ETRA such as atrasentan or another ETRA that is a selective ET A receptor antagonist
  • the present disclosure also presents a method of treating chronic kidney disease, diabetic nephropathy or both with endothelin receptor antagonist (ETRA) comprising administering a RAS inhibitor to a subject in need of treatment for chronic kidney disease, diabetic nephropathy or both; measuring one or more of eGFR, blood pressure, HbA1 c, or HOMA-product in the subject; determining, based on the measurement, risk of fluid retention if an ETRA were administered to the subject in addition to the RAS inhibitor; and administering the ETRA to the subject if the risk is at an acceptable level.
  • ETRA endothelin receptor antagonist
  • the RAS inhibitor has been administered to the subject for at least four weeks before the measuring step, and/or the subject has been administered a maximum tolerated labeled daily dose (MTLDD) of a RAS inhibitor for at least four weeks before the measuring step.
  • MLDD maximum tolerated labeled daily dose
  • the foregoing methods can also further comprise the step of adjusting an amount or a frequency of a diuretic already administered to the subject based on the measuring step, and determining the risk of administering the ETRA to the subject based on the measuring step and the adjusting of the diuretic
  • the risk is risk of fluid retention after two weeks of administering the ETRA to the subject.
  • the risk of fluid retention is risk of the subject having a weight gain of greater than or equal to 2 kg after administering the ETRA to the subject for two weeks, and/or risk of the subject having a hemoglobin reduction of greater than or equal to 1.3 g/dL after administering the ETRA to the subject for two weeks.
  • the ETRA can be a selective ET A receptor antagonist, such as atrasentan or a pharmaceutically acceptable salt thereof.
  • An acceptable risk can be determined by a clinician who weighs the risk of fluid retention against the subject's need for the therapy.
  • the level of risk can be determined manually or automatically such as using an algorithm that calculates a fluid retention risk level using eGFR, blood pressure, HbA1 c, and/or HOMA-product as inputs.
  • the level of risk can be determined based on one parameter or on a combination of parameters. For example, the risk level can be determined based on two or more of eGFR, blood pressure, HbA1c, or HOMA- product, or based on eGFR, HbA1 c or both.
  • the foregoing methods further comprise obtaining a biological sample (for example, urine or blood) from the subject and measuring one of the parameters (for example, eGFR or HbA1c) using the biological sample.
  • the measurement(s) are compared to predetermined values of eGFR, blood pressure, HbA1 c, or HOMA-product which correlate to an acceptable risk of fluid retention.
  • Predetermined values can be acceptable risk level values, unacceptable risk level values, or both.
  • the clinician when the clinician determines the risk of fluid retention is unacceptable based on the measurement(s) of eGFR, blood pressure, HbA1 c, or HOMA- product, the ETRA therapy is not be administered.
  • the clinician may adjust the therapy administered to the subject so that an unacceptable risk of fluid retention becomes an acceptable risk, such as by prescribing a diuretic, increasing a dose of a diuretic (such as an amount or frequency), which is already taken by the subject, or changing the diuretic taken by the subject.
  • Fig. 1 depicts changes in UACR, body weight, hemoglobin, and hematocrit from baseline through 12 weeks of atrasentan or placebo administration.
  • Fig. 2 depicts changes in body weight, hemoglobin, and hematocrit based on whether the subject showed a greater than 30% response in UACR.
  • administer refers to any manner of providing a drug (such as, atrasentan or a pharmaceutically acceptable salt thereof) to a subject or patient.
  • routes of administration can be accomplished through any means known by those skilled in the art. Such means include, but are not limited to, oral, buccal, intravenous, subcutaneous, intramuscular, transdermal, by inhalation and the like.
  • an “effective amount” or a “therapeutically effective amount” of an active agent is meant a nontoxic but sufficient amount of the active agent to provide the desired effect.
  • the amount of active agent that is “effective” will vary from subject to subject, depending on the age and general condition of the individual, the particular active agent or agents, and the like. Thus, it is not always possible to specify an exact “effective amount.” However, an appropriate “effective amount” in any individual case may be determined by one of ordinary skill in the art using routine experimentation.
  • pharmaceutically acceptable such as in the recitation of a “pharmaceutically acceptable excipient,” or a “pharmaceutically acceptable additive,” is meant a material that is not biologically or otherwise undesirable, i.e., the material may be incorporated into a pharmaceutical composition administered to a patient without causing any undesirable biological effects.
  • subject refers to an animal.
  • the animal is a mammal, including a human or non-human.
  • patient and subject may be used interchangeably herein.
  • treating and “treatment” refer to reduction in severity and/or frequency of symptoms, elimination of symptoms and/or underlying cause, prevention of the occurrence of symptoms and/or their underlying cause, and improvement or remediation of damage.
  • “treating” a patient involves prevention of a particular disorder or adverse physiological event in a susceptible individual as well as treatment of a clinically symptomatic individual by inhibiting or causing regression of a disorder or disease.
  • Observations in body weight changes and hemoglobin changes may be used as surrogate markers for changes in fluid retention.
  • Table 1 is reproduced in part from de Zeeuw D, et al., The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy. J Am Soc Nephrol 25: 1083-1093, 2014, which is hereby incorporated by reference in its entirety. Values within Table 1 are mean ⁇ standard deviation unless stated otherwise.
  • Table 2 depicts changes over measured/calculated parameters over time.
  • SD Mean (SD) Mean (SD) Mean (SD) or median or median or median Baseline 50 671 78 878 83 826
  • Table 2 shows that body weight increased by approximately 1 kg after 2 weeks of treatment compared with a decrease of approximately 1 kg in the placebo group. Although weight declined 1-2 kg during the 30-day recovery period in the atrasentan-treated groups, weight was unchanged in the placebo group. Hemoglobin (Hb) decreased by approximately 1 g/dl in both atrasentan groups after 2 weeks of treatment, and these reductions persisted throughout the treatment period. Hb normalized by 30 days after treatment discontinuation, suggesting that the atrasentan-associated decrease in Hb was caused by hemodilution. Despite the gain in weight in patients who received atrasentan, no significant change was observed in B-natriuretic peptide (BNP). Changes in the diuretic dose were similar were similar among treatment groups throughout the study (4%, 5%, and 8% for the placebo, 0.75 mg/day, and 1.25 mg/day groups, respectively).
  • BNP B-natriuretic peptide
  • Table 3 shows a list of potential independent baseline predictors of changes in weight and hemoglobin after two weeks of atrasentan therapy.
  • Atrasentan (0.75 vs. placebo) 0.8 (0.3-1.3) 0.001 3.0 (1.0-8.5) 0.04
  • Atrasentan (1.25 vs. placebo) 1.3 (0.8-1.7) ⁇ 0.001 6.6 (2.3-18.6) ⁇ 0.001 eGFR(10ml_/min/1.73m 2 ) -0.2 (-0.3- -0.1) 0.002 0.7 (0.4-1.0) 0.007
  • Systolic BP (10 mmHg) 0.1 (0.0-0.3) 0.05 -
  • Atrasentan (0.75 vs. placebo) -0.7 (-0.9- -0.5) ⁇ 0.001 -
  • Atrasentan (1.25 vs. placebo) -1.0 (-1.2- -0.8) ⁇ 0.001 5.6 (2.5-12.7) ⁇ 0.001 eGFR(10ml_/min/1.73m 2 ) 0.1 (0.1 -0.2) ⁇ 0.001 0.6 (0.2-0.9) 0.001
  • BP blood pressure
  • eGFR estimated glomerular filtration rate
  • HbA1c glycated hemoglobin
  • HOMA homeostatic model assessment.
  • the following covariates were included in the initial backward selection model: treatment assignment, age, gender, body weight, Hb, eGFR, albuminuria, systolic blood pressure (BP), eGFR, log transformed homeostatic metabolic assessment (HOMA) product, log-transformed B- type natriuretic peptide (BNP), thiazide and loop-diuretic use.
  • Systolic blood pressure and atrasentan dose were not included in the final logistic regression models for body weight and hemoglobin, respectively.
  • Table 3 confirms that baseline predictors of weight gain after 2 weeks of atrasenttan treatment include an atrasentan dose of 0.75 or 1.25 mg/day versus placebo, lower eGFR, higher glycated hemoglobin (HbA1 c), higher systolic BP, and lower HOMA product.
  • HbA1 c glycated hemoglobin
  • systolic BP systolic BP
  • HOMA product For each 10 mL/min lower baseline eGFR, body weight was higher by 0.2 (0.1-0.3) kg. For each percentage lower HbA1 c, body weight increased 0.2 (0.1-0.4) kg.
  • body weight was higher by 0.1 (0.0-0.3) kg.
  • Logistic regression analysis of factors predicting a greater or equal to 2 kg weight gain shows the odds for a greater or equal to 2 kg weight gain were 3.0 (1.0-8.5) and 6.6 (2.3-18.6) times higher for atrasentan 0.75 and 1.25 mg/day groups, respectively.
  • Figure 1 Panel A. Determinants in the logistic regression were similar to those in the linear regression model.
  • Table 3 also discloses the baseline predictors of Hb change after 2 weeks of atrasentan treatment included an atrasentan dose of 0.75 or 1.25 mg/day versus placebo, eGFR, Hb, and weight.
  • Logistic regression analysis of factors predicting a greater or equal to 1.3 g/dl fall in Hb (upper qartile of distribution of combined atrasentan 0.75 and 1.25 mg/day groups) showed an increase in the odds of 5.6 (2.5-12.7) fold with atrasentan 1.25 mg/day versus placebo (but no significant association with 0.75 mg/day group) and 0.6 (0.2-0.9) fold for each 10 ml/min lower baseline eGFR. Small but significant associations with baseline weight and Hb were also observed. Baseline BNP was not associated with changes in body weight or Hb.
  • risk of fluid retention if an ETRA, such as atrasentan, were administered to a subject can be predicted based on measuring one or more of eGFR, blood pressure, HbA1 c, or HOMA-product.
  • a clinician can use the measurement to determine if the risk of fluid retention for a particular subject is acceptable before the ETRA is prescribed or administered.
  • Table 4 shows the correlation between changes in hemoglobin and weight with urinary albumin to creatinine ratio change after 2 weeks of placebo or atrasentan treatment.
  • the atrasentan dose and eGFR were predictors of week 2 changes in hemoglobin. Moreover, baseline hemoglobin and body weight predicted week 2 changes in hemoglobin. [0049] Weak correlations were observed between week 2 changes in body weight and hemoglobin with changes in albuminuria. R 2 values ranged between 0.005 and 0.07 suggesting that only 0.5% to 7% of the variability in albuminuria response is explained by changes in body weight. No correlation was detected between changes in UACR and body weight. And no correlation was seen between change in UACR and body weight at week 2 in subjects taking placebo or atrasentan 0.75 or 1.25 mg/day. R 2 values show that 4% to 6.9% of the variability in the albuminuria response was accounted for by the response in Hb.

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Abstract

Cette divulgation concerne des méthodes de traitement des néphropathies chroniques et des néphropathies diabétiques utilisant des prédicteurs de rétention de fluide pour réduire au minimum le risque d'effets secondaires. Les méthodes décrites sont particulièrement utiles dans les traitements impliquant des antagonistes du récepteur de l'endothéline, et plus particulièrement, l'atrasentan et ses sels pharmaceutiquement acceptables.
PCT/US2015/059456 2014-11-07 2015-11-06 Méthodes de traitement des ckd utilisant des prédicteurs de rétention de fluide Ceased WO2016073846A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201580072599.2A CN107106522A (zh) 2014-11-07 2015-11-06 使用液体潴留的预测因子治疗ckd的方法
BR112017009668A BR112017009668A2 (pt) 2014-11-07 2015-11-06 métodos de tratamento da ckd utilizando predictores de retenção de fluidos
AU2015342929A AU2015342929A1 (en) 2014-11-07 2015-11-06 Methods of treating CKD using predictors of fluid retention
EP15857776.7A EP3215138A4 (fr) 2014-11-07 2015-11-06 Méthodes de traitement des ckd utilisant des prédicteurs de rétention de fluide
JP2017523974A JP2017534634A (ja) 2014-11-07 2015-11-06 体液貯留の予測因子を使用してｃｋｄを処置する方法
CA2966756A CA2966756A1 (fr) 2014-11-07 2015-11-06 Methodes de traitement des ckd utilisant des predicteurs de retention de fluide
MX2017005884A MX2017005884A (es) 2014-11-07 2015-11-06 Metodos para el tratamiento de la erc, utilizando predictores de la retencion de liquidos.

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US201462077108P 2014-11-07 2014-11-07
US62/077,108 2014-11-07

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AU (1) AU2015342929A1 (fr)
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CA (1) CA2966756A1 (fr)
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2018153513A1 (fr) 2017-02-27 2018-08-30 Idorsia Pharmaceuticals Ltd Combinaisons d'un dérivé de 4-pyrimidinesulfamide avec des principes actifs pour le traitement de maladies liées à l'endothéline
WO2019106066A1 (fr) 2017-11-30 2019-06-06 Idorsia Pharmaceuticals Ltd Combinaison d'un dérivé de 4-pyrimidinesulfamide avec un inhibiteur de sglt-2 pour le traitement de maladies liées à l'endothéline
WO2023227490A1 (fr) 2022-05-22 2023-11-30 Idorsia Pharmaceuticals Ltd Aprocitentan pour le traitement de l'hypertension

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WO2016049234A1 (fr) 2014-09-23 2016-03-31 Icahn School Of Medicine At Mount Sinai Systèmes et méthodes de traitement d'un trouble psychiatrique
EP4076652B1 (fr) 2019-12-17 2025-12-03 Chinook Therapeutics, Inc. Sel pharmaceutiquement acceptable d'atrasentan destiné à être utilisé dans un procédé de traitement de la néphropathie à iga
CN118262911B (zh) * 2024-03-12 2024-08-20 广东省人民医院 一种糖尿病患者dme风险评估模型及早期筛查系统

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JP7520951B2 (ja) 2017-02-27 2024-07-23 イドルシア・ファーマシューティカルズ・リミテッド ４－ピリミジンスルファミド誘導体の結晶形
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WO2018153513A1 (fr) 2017-02-27 2018-08-30 Idorsia Pharmaceuticals Ltd Combinaisons d'un dérivé de 4-pyrimidinesulfamide avec des principes actifs pour le traitement de maladies liées à l'endothéline
WO2018154101A1 (fr) 2017-02-27 2018-08-30 Idorsia Pharmaceuticals Ltd Formes cristallines du dérivé 4-pyrimidinesulfamide aprocitentan
US11787782B2 (en) 2017-02-27 2023-10-17 Idorsia Pharmaceuticals Ltd Combinations of a 4-pyrimidinesulfamide derivative with active ingredients for the treatment of endothelin related diseases
JP2023027305A (ja) * 2017-02-27 2023-03-01 イドーシア ファーマシューティカルズ リミテッド ４－ピリミジンスルファミド誘導体の結晶形
US12144811B2 (en) 2017-11-30 2024-11-19 Idorsia Pharmaceuticals Ltd Combination of a 4-pyrimidinesulfamide derivative with an SGLT-2 inhibitor for the treatment of endothelin related diseases
WO2019106066A1 (fr) 2017-11-30 2019-06-06 Idorsia Pharmaceuticals Ltd Combinaison d'un dérivé de 4-pyrimidinesulfamide avec un inhibiteur de sglt-2 pour le traitement de maladies liées à l'endothéline
WO2023227490A1 (fr) 2022-05-22 2023-11-30 Idorsia Pharmaceuticals Ltd Aprocitentan pour le traitement de l'hypertension

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BR112017009668A2 (pt) 2017-12-26
JP2017534634A (ja) 2017-11-24
CN107106522A (zh) 2017-08-29
MX2017005884A (es) 2017-06-26
EP3215138A4 (fr) 2018-11-21
CA2966756A1 (fr) 2016-05-12
EP3215138A1 (fr) 2017-09-13
AU2015342929A1 (en) 2017-05-25

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