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WO2016069290A1 - Materiaux dentaires et procédés - Google Patents

Materiaux dentaires et procédés Download PDF

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Publication number
WO2016069290A1
WO2016069290A1 PCT/US2015/055886 US2015055886W WO2016069290A1 WO 2016069290 A1 WO2016069290 A1 WO 2016069290A1 US 2015055886 W US2015055886 W US 2015055886W WO 2016069290 A1 WO2016069290 A1 WO 2016069290A1
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WIPO (PCT)
Prior art keywords
dental material
cured
aqueous solution
contrast ratio
exposure
Prior art date
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PCT/US2015/055886
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English (en)
Inventor
Bradley D. Craig
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3M Innovative Properties Co
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3M Innovative Properties Co
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Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to EP15794372.1A priority Critical patent/EP3212153A1/fr
Priority to US15/521,913 priority patent/US10350297B2/en
Publication of WO2016069290A1 publication Critical patent/WO2016069290A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Definitions

  • Dental restorative composites are used extensively in restorative dentistry. In order to cure deeply, the composite materials need to be transparent enough to allow the light to pass through. However, the need for translucency detrimentally impacts the aesthetic characteristics of these composite materials and leads to an unaesthetic restoration. It is therefore desirable to create a better solution to provide deep curing composite
  • the dental material can include a hardenable resin; an initiator system; a filler; and from about 1 wt% to about 20 wt% zinc compound, based on the weight of the hardenable resin; wherein the contrast ratio of the cured dental material increases by at least about 10 units after continuous exposure to an aqueous solution for 21 days.
  • Some aspects of the present disclosure provide a method of using a dental material.
  • the method can include providing the dental material of the present disclosure and curing the dental material; wherein the contrast ratio of the cured dental material increases by at least 10 units after continuous exposure to an aqueous solution for 21 days.
  • the method can include providing the dental material, wherein the dental material comprises a hardenable resin, an initiator system, a filler and a zinc compound; and curing the dental material to a depth of at least 4 mm.
  • FIG. 1 is a polynomial fit of multiple contrast ratio measurements for photocured experimental resins over time.
  • FIG. 2 is a polynomial fit of multiple contrast ratio measurements for photocured experimental composite pastes over time
  • Hardenable dental restorative composite materials used in larger and deeper increments in the posterior portion of a patient's mouth present a challenge.
  • the composite materials need to be transparent enough to allow the initiating photons of light to pass through the material and to sufficiently interact with the initiator system. This need for translucency has limited the aesthetic characteristics of these deep-curing composite materials.
  • the contrast ratio (or opacity) of these composite materials is low, the contrast ratio (or opacity) of these composite materials does not fully match the contrast ratio (or opacity) and color of the surrounding natural tooth structure. Therefore, the low contrast ratio (or opacity) detrimentally impacts the aesthetic characteristics of these composite materials.
  • the present disclosure generally relates to methods of using a dental material, for example, in restorative procedures.
  • the dental material can include a hardenable resin, an initiator system, a filler and a zinc compound.
  • the method of using the dental material can include providing the dental material and curing the dental material, wherein the contrast ratio (or opacity) of the cured dental material increases by 10 units after continuous exposure to an aqueous solution for 21 days.
  • the aqueous solution includes, but is not limited to water, saliva, artificial saliva or combinations thereof.
  • the contrast ratio is calculated as the ratio of the reflectance through a material on a black substrate to the reflectance through an identical material on a white substrate.
  • the dental material of current application can, for example, develop additional opacity upon continuous exposure to an aqueous solution for a period of time, while the dental material is highly translucent in the uncured state or cured but prior to exposure to the aqueous solution. This allows for deep or "bulk” curing the dental material and the cured dental material can increase opacity to better match natural dentition over time.
  • the dental material described herein comprises a hardenable resin.
  • Suitable resins can include thermosetting resins capable of being hardened to form a polymer network.
  • Suitable resins can include ethylenically unsaturated resins, such as acrylate resins, methacrylate resins, epoxy resins, vinyl resins, and mixtures thereof.
  • the hardenable resin can be made from one or more matrix-forming oligomer, monomer, or polymer, or blends thereof.
  • suitable hardenable resins can include hardenable organic resins having sufficient strength, hydrolytic stability, and non-toxicity to render them suitable for use in the oral environment.
  • hardenable organic resins having sufficient strength, hydrolytic stability, and non-toxicity to render them suitable for use in the oral environment.
  • examples of such resins include acrylate, methacrylate, urethane, carbamoylsiocyanurate, epoxy resins, and mixtures and
  • One class of hardenable resins is materials having free radically active functional groups and includes monomers, oligomers, and polymers having one or more ethylenically unsaturated groups.
  • a suitable resin can include at least one ethylenically unsaturated monomer (i.e., includes at least one carbon-carbon double bond).
  • Suitable resin systems may include those described in US Patent No. 7,816,423.
  • the hardenable resin can be a material from the class of resins that include cationically active functional groups.
  • a mixture of hardenable resins that include both cationically curable and free radically curable resins may be used.
  • the resin system can include a crystalline component to impart the (e.g. a noncovalent) three-dimensional structure for maintaining the initial preformed shape such as described in International Publication No. WO 2010/057144; U.S. Patent No. 7,674,850 and U.S. Patent No. 7,816,423.
  • This crystalline component may or may not have a reactive group capable of polymerizing (also including
  • the crystalline component can be polymerizable. In some embodiments, the crystalline component can be polymeric (including oligomeric). In some embodiments, the crystalline component can be a polymerizable polymeric material.
  • suitable materials can contain at least one ethylenically unsaturated bond, and are capable of undergoing addition polymerization.
  • suitable materials include mono-, di- or poly-acrylates and methacrylates such as methyl acrylate, methyl methacrylate, ethyl acrylate, isopropyl methacrylate, n-hexyl acrylate, stearyl acrylate, allyl acrylate, glycerol diacrylate, glycerol triacrylate, ethyleneglycol diacrylate, diethyleneglycol diacrylate, triethyleneglycol dimethacrylate, 1,3-propanediol diacrylate, 1,3-propanediol dimethacrylate, trimethylolpropane triacrylate, 1,2,4-butanetriol trimethacrylate, 1 ,4-cyclohexanediol diacrylate, pent
  • Patent No. 4,652,274, and acrylated oligomers such as those of U.S. Patent No. 4,642,126; and vinyl compounds such as styrene, diallyl phthalate, divinyl succinate, divinyl adipate and divinylphthalate. Mixtures of two or more of these free radically hardneable resins can be used if desired.
  • suitable hardenable resins can include polymers with low or reduced polymerization stress, such as described in U.S. Patent Nos. 7,943,680; 8,404,758 and 8,455,565; US Publication No. 2013/0006653; and International Publication Nos. WO2012/003136, WO2012/106083, WO2012/112304, WO2012/112321, WO2012/112350, WO2013/023138, WO2013/028397, WO2013/028401, WO2013/176870, WO 2014/074427, WO 2014/074373 and WO2014/099317.
  • the dental material of the present disclosure can exhibits relatively low or reduced polymerization stress in addition to improved aesthetic characteristics.
  • the dental material is free of TEGDMA.
  • the dental material comprises from about 15% to about 45% by weight of hardenable resin, based on total weight of the dental material.
  • the dental material described herein comprises an initiator system.
  • the initiator system can include one or more initiators and/or a catalyst that enables the composition to be hardened.
  • the initiator can be a photoinitiator.
  • visible and/or near-infrared photoinitiator systems may be used to initiate photopolymerization in compositions including free-radically
  • the initiator system includes at least one photoinitiator active in the spectral region of about 300 nanometers (nm) to about 1200 nm and capable of promoting free radical polymerization and/or crosslinking of ethylenically unsaturated moieties upon exposure to light of suitable wavelength and intensity.
  • photoinitiators can be used. Suitable initiators may include those described in U.S. Patent No. 7,816,423.
  • a monomer can be combined with a three component or ternary photoinitiator system including a sensitizer, an electron donor, and an iodonium salt as disclosed, for example, in U.S. Pat. No. 5,545,676.
  • the composition may include a binary initiator system including a sensitizer (e.g., camphorquinone) and an electron donor (e.g., a secondary or a tertiary alkyl amine compound as disclosed, for example, in U.S. Pat. No. 4,071,424).
  • acylphosphine oxides are of the general formula (Pv)2-P(0)-CO-Pvl , wherein each R individually can be a hydrocarbyl group (e.g., alkyl, cycloalkyl, aryl, and aralkyl), which may be substituted with a halo-, alkyl- or alkoxy- group, or the two R groups may be joined to form a ring along with the phosphorous atom, and wherein Rl is a hydrocarbyl group, an S-, 0-, or N-containing five- or six-membered heterocyclic group, or a -Z-CO-P(0)-(R)2 group, wherein Z represents a divalent hydrocarbyl group (e.g., alkylene or phenylene) having from 2 to 6 carbon atoms.
  • Useful acylphosphine oxides can include those in which the R and Rl groups are phenyl or lower alkyl- or lower alkoxy-substituted phenyl.
  • R and Rl groups are phenyl or lower alkyl- or lower alkoxy-substituted phenyl.
  • lower alkyl and “lower alkoxy” is meant such groups having from 1 to 4 carbon atoms.
  • the acylphosphine oxide can be bis(2,4,6-trimethylbenzoyl)phenyl phosphine oxide available under the trade designation IRGACURE 819 from Ciba Specialty Chemicals (Tarrytown, N.Y.).
  • Tertiary amine reducing agents may be used in combination with an acylphosphine oxide.
  • Illustrative tertiary amines useful in the invention include ethyl 4-(N,N- dimethylamino)benzoate and ⁇ , ⁇ -dimethylaminoethyl methacrylate.
  • the dental material comprises from about 0.05% to about
  • the dental material described herein comprises a filler.
  • Fillers for use in the dental material described herein may be selected from a wide variety of conventional fillers for incorporation into resin systems.
  • the filler includes one or more conventional materials suitable for incorporation in compositions used for medical applications, for example, fillers currently used in dental restorative compositions. Fillers may be either particulate or fibrous in nature. Suitable filler may include those described in U.S. Patent No. 7,816,423.
  • the filler can be an inorganic material. It can also be a crosslinked organic material that is insoluble in the polymerizable resin, and is optionally filled with inorganic filler.
  • the filler is generally non-toxic and suitable for use in the mouth.
  • the filler can be radiopaque, radiolucent, or nonradiopaque. Fillers as used in dental applications are typically ceramic in nature.
  • suitable inorganic fillers are naturally occurring or synthetic materials such as quartz, nitrides (e.g., silicon nitride), glasses derived from, for example Ce, Sb, Sn, Zr, Sr, Ba, or Al, colloidal silica, feldspar, borosilicate glass, kaolin, talc, titania, and zinc glass, zirconia-silica fillers; and low Mohs hardness fillers such as those described in U.S. Pat. No. 4,695,251.
  • suitable organic filler particles include filled or unfilled pulverized polycarbonates, polyepoxides, and the like.
  • Preferred filler particles are quartz, submicron silica, and non-vitreous microparticles of the type described in U.S. Pat. No. 4,503,169. Mixtures of these fillers can also be used, as well as combination fillers made from organic and inorganic materials.
  • the surface of the filler particles may be treated with a surface treatment, such as a silane-coupling agent, in order to enhance the bond between the filler and the resin system.
  • a surface treatment such as a silane-coupling agent
  • the coupling agent may be functionalized with reactive curing groups, such as acrylates, methacrylates, and the like.
  • the filler particles used to impart a noncovalent structure can be composed of silica, alumina, zirconia, titania, or mixtures of these materials with each other or with carbon. In their synthesized state, these materials are commonly hydrophilic, due to the presence of surface hydroxyl groups. However, the materials may also be modified by treatment with appropriate agents, such as alkyl silanes, in order to modify this character. For example, the surface of a filler particle may be rendered neutral, hydrophobic, or reactive, depending on the desired properties. Fumed silica may be a compound for imparting self-supporting character, due to its low cost, commercial availability, and wide range of available surface character.
  • Fillers for use in the dental material of the disclosure can be a nanofiller.
  • Suitable nano fillers include either acid reactive or non-acid reactive nano fillers and may include, but are not limited to silica; zirconia; oxides of titanium, aluminum, cerium, tin, yttrium, strontium, barium, lanthanum, zinc, ytterbium, bismuth, iron, and antimony; and combinations thereof. More typical nanofillers may include zirconia (ZrC ); oxides of titanium (e.g., T1O2), and oxides of yttrium (e.g., Y2O3); and other metal oxides with high refractive indices.
  • ZrC zirconia
  • high refractive index means a refractive index of typically at least 1.5, and more typically of at least 2.0. Titania and zirconia are particularly useful nanofillers, as they have very high refractive indices, and will require less weight of material than a lower refractive index material to match the refractive indices appropriately.
  • the nanofillers typically have an average particle size of at most 100 nanometers and more typically at most 50 nanometers. Such nanofillers typically have an average particle size of at least 2 nanometers, more typically at least 5 nanometers, and even more typically at least 10 nanometers.
  • the nanofiller is in the form of nanoclusters, typically at least 80 percent by weight nanoclusters. In other embodiments, the nanofiller is in the form of a combination of nanoparticles and nanoclusters. Often a portion of the surface of the nanofiller is silane treated or otherwise chemically treated to provide one or more desired physical properties. Additional suitable nanofillers are disclosed in U.S. Pat. Nos. 6,387,981; 6,572,693; 6,730,156; and 6,899,948; U.S.
  • the nanofillers of the present disclosure are non-pyrogenic fillers, however pyrogenic fillers can be added as optional additives to the dental compositions.
  • the dental material comprises from about 55% to about 85% by weight filler, based on total weight of the dental material.
  • the dental material described herein comprises a zinc compound.
  • the term "zinc compound” includes, but is not limited, zinc salts, zinc complexes, and solvates (e.g., hydrates), thereof.
  • the zinc compound may be polymerizable or non- polymerizable.
  • the zinc compound is substantially (e.g., fully) or at least partially soluble in the hardenable resin.
  • the dental material is free of zinc oxide.
  • the zinc compound is a salt (or a complex) of a carboxylic acid, i.e., an acid which includes a -C(0)OH group.
  • Such a carboxylic acid may include one or more polymerizable groups (e.g., ethylenically unsaturated groups such as acrylate or methacrylate groups), such that the carboxylic acid is an unsaturated carboxylic acid.
  • the unsaturated carboxylic acid used in the current application can be monobasic or polybasic unsaturated carboxylic acid.
  • Suitable monobasic unsaturated carboxylic acid can include, but not limited to acrylic acid and methacrylic acid.
  • the carboxylic acid may be substituted with one or more polar or hydrophilic groups (including heteroatoms), such that the zinc compound derived from such a carboxylic acid is also relatively polar or hydrophilic.
  • polar groups include ether and polyether groups.
  • a non- limiting example of a carboxylic acid substituted with polar groups is 2-(2-methoxy-l-methylethoxy)acetic acid.
  • the carboxylic acid from which the zinc compound is derived has a pKa of at least about 3.5, at least about 4.0, at least about 4.5, at least about 5.0, or at least about 5.5.
  • the zinc compound is a zinc salt of acrylic acid or methacrylic acid (i.e., zinc acrylate or zinc dimethacrylate).
  • the zinc compound has a molecular weight of less than about 500 g/mol, less than about 450 g/mol, less than about 400 g/mol, less than about 350 g/mol, less than about 300 g/mol, less than about 250 g/mol, less than about 200 g/mol.
  • the zinc compound is a zinc salt of a mineral acid such as for example, nitric or sulfuric acid (i.e., zinc nitrate or zinc sulfate).
  • the zinc compound is a salt (or complex) of a phosphoric acid derivative (e.g., a mono- or diester of phosphoric acid such as mono- or di-HEMA phosphate).
  • the zinc compound is selected from the group consisting of zinc acrylate, zinc methacrylate, ethylenediaminetetraacetic acid disodium zinc salt, zinc sulfate, and zinc nitrate.
  • the dental material comprises from about 1 wt%, 5 wt%, 10 wt%, 20 wt%, or a range between and including any two of these values of zinc compound, based on the weight of the hardenable resin. In some embodiments, the dental material comprises from about 0.15 wt%, 0.75 wt%, 1.5 wt%, 2.25 wt%, 3 wt%, 4.5 wt% , 5 wt%, 9 wt%, 10 wt%, or a range between and including any two of these values of zinc compound, based on total weight of the dental material.
  • the dental material comprising the resin, the initiator system, the filler and the zinc compound of the present disclosure can be cured.
  • the cured dental material has an initial contrast ratio (or opacity), which is measured after dental material is cured, but prior to exposure to an aqueous solution.
  • the initial contrast ratio (or opacity) of cured dental material prior to exposure to the aqueous solution is no more than about 50, about 40, about 30, about 20, or about 10.
  • the initial contrast ratio (or opacity) of cured dental material prior to exposure to the aqueous solution is about 50, about 40, about 30, about 20, or about 10 or a range between and including any two of these values.
  • the contrast ratio (or opacity) of the cured dental material of the present disclosure increases upon exposure to an aqueous solution. This allows the cured dental material of the current application to match opacity and color of the surrounding natural tooth structure, thus providing a better aesthetic characteristic.
  • the contrast ratio (or opacity) of the cured dental material increases by at least about 10 units, about 20 units, about 30 units, about 40 units, or about 50 units after continuous exposure to an aqueous solution at 37 °C for 21 days.
  • the contrast ratio (or opacity) of cured dental material after continuously exposure to an aqueous solution at 37 °C for 21 days is more than about 50, about 60, about 70, about 80, or about 90.
  • the contrast ratio (or opacity) of the cured dental material of the present disclosure generally increases initially upon exposure to an aqueous solution, reaches a maximum value, and then generally stabilizes over time. In other words, the contrast ratio (or opacity) increase of the cured dental material upon exposure to the aqueous solution is substantially irreversible.
  • the dental material of the present disclosure can be cured. After cured, the dental material can be exposed to an aqueous solution.
  • the contrast ratio (or opacity) of the cured dental material increases by at least 10 units after continuous exposure to an aqueous solution for 21 days.
  • a dental material including a hardenable resin, an initiator system, a filler, and a zinc compound can be cured.
  • the dental material is at least partially hardened (e.g., cured) by exposing it to radiation to cause activation of the initiator system.
  • the dental material can be completely cured in the mouth by irradiating it with a dental curing light.
  • the dental material can be cured to a depth of at least 4 mm.
  • the dental material can be exposed to an aqueous solution.
  • the contrast ratio (or opacity) of the cured dental material increases upon exposure to the aqueous solution.
  • the contrast ratio (or opacity) of cured dental material after continuously exposure to the aqueous solution for 21 days is more than about 50, about 60, about 70, about 80, or about 90.
  • Embodiment 1 is a dental material comprising:
  • contrast ratio of the cured dental material increases by at least about 10 units after continuous exposure to an aqueous solution for 21 days.
  • Embodiment 2 is the dental material of any of embodiment 1 , wherein the initial contrast ratio of cured dental material prior to exposure to the aqueous solution is no more than about 50.
  • Embodiment 3 is the dental material of any of embodiments 1 to 2, wherein the initial contrast ratio of cured dental material prior to exposure to the aqueous solution is no more than about 40.
  • Embodiment 4 is the dental material of any of embodiments 1 to 3, wherein the initial contrast ratio of cured dental material prior to exposure to the aqueous solution is no more than about 30.
  • Embodiment 5 is the dental material of any of embodiments 1 to 4, wherein the initial contrast ratio of cured dental material prior to exposure to the aqueous solution is from about 20 to about 40.
  • Embodiment 6 is the dental material of any of embodiments 1 to 5, wherein the contrast ratio of cured dental material after continuous exposure to the aqueous solution for 21 days is more than about 50.
  • Embodiment 7 is the dental material of any of embodiments 1 to 6, wherein the contrast ratio of cured dental material after continuous exposure to the aqueous solution for 21 days is more than about 60.
  • Embodiment 8 is the dental material of any of embodiments 1 to 7, wherein the contrast ratio of cured dental material increases by at least about 20 units after continuous exposure to the aqueous solution for 21 days.
  • Embodiment 9 is the dental material of any of embodiments 1 to 8, wherein the contrast ratio of cured dental material increases by at least about 30 units after continuous exposure to the aqueous solution for 21 days.
  • Embodiment 10 is the dental material of any of embodiments 1 to 9, wherein the contrast ratio of cured dental material increases by at least about 40 units after continuous exposure to the aqueous solution for 21 days.
  • Embodiment 11 is the dental material of any of embodiments 1 to 10, wherein the contrast ratio of cured dental material increases by at least about 50 units after continuous exposure to the aqueous solution for 21 days.
  • Embodiment 12 is the dental material of any of embodiments 1 to 11, wherein the zinc compound is polymerizable.
  • Embodiment 13 is the dental material of any of embodiments 1 to 12, wherein the zinc compound is made from a hydrophilic acid or an acid with pKa at least about 3.5.
  • Embodiment 14 is the dental material of any of embodiments 1 to 13, wherein the zinc compound is a salt of a carboxylic acid.
  • Embodiment 15 is the dental material of any of embodiments 1 to 14, wherein the carboxylic acid is an unsaturated carboxylic acid.
  • Embodiment 16 is the dental material of any of embodiments 1 to 15, wherein the unsaturated carboxylic acid is selected from the group consisting of acrylic acid and methacrylic acid.
  • Embodiment 17 is the dental material of any of embodiments 1 to 16, wherein the zinc compound is a salt of a phosphoric acid.
  • Embodiment 18 is the dental material of any of embodiments 1 to 17, wherein the zinc compound is selected from zinc nitrate, zinc sulfate, zinc methacrylate, and combinations thereof.
  • Embodiment 19 is the dental material of any of embodiments 1 to 18, wherein the zinc compound is zinc methacrylate.
  • Embodiment 20 is the dental material of any of embodiments 1 to 19, wherein the aqueous solution is saliva.
  • Embodiment 21 is the dental material of any of embodiments 1 to 20, wherein the initiator system is a photoinitiator system.
  • Embodiment 22 is the dental material of any of embodiments 1 to 21, wherein the dental material is free of TEGDMA.
  • Embodiment 23 is the dental material of any of embodiments 1 to 22, wherein the contrast ratio increase of the cured dental material upon exposure to the aqueous solution is substantially irreversible.
  • Embodiment 24 is a method of using a dental material comprising:
  • contrast ratio of the cured dental material increases by at least 10 units after continuous exposure to an aqueous solution for 21 days.
  • Embodiment 25 is a method of using a dental material comprising:
  • the dental material comprises a hardenable resin, an initiator system, a filler and a zinc compound
  • Embodiment 26 is the method of any of embodiment 25, wherein the contrast ratio of cured dental material after continuous exposure to an aqueous solution for 21 days is more than about 50.
  • Resin and paste samples were formed into 1 mm thick by 25.4 mm diameter disks and cured by exposing them to illumination from an LED array (455 nm wavelength, 850 mW/cm 2 intensity) for 20 seconds on one side of the disk.
  • ASTM-D2805-95 test method was modified to measure the contrast ratio (or opacity) of the disks.
  • Y-tristimulus values for the disks were measured on an Ultrascan XE Colorimeter (Hunter Associates Laboratory, Reston, Va.) with a 0.953-cm aperture using separate white and black backgrounds. The D65 Illuminant was used with no filters for all measurements. A 10 degree angle of view was used.
  • CR values were obtained for each disk after cure. After obtaining an initial CR, the disk was submersed in deionized water at 37 °C. Periodically, the disk was removed from the water and dried with a paper towel, the CR re-obtained, and disk re-submersed back in the 37 °C water. In this manner, the changes in CR for the disk as a function of the length of time exposed to water could be monitored. Depth of Cure (DOC) Test Method
  • the depth of cure was determined by filling a 4-mm diameter stainless steel mold cavity with the composite (paste), covering the top and bottom of the mold with sheets of polyester film, pressing the sheets to provide a leveled composition surface, placing the filled mold on a white background surface, irradiating the dental composition for 20 seconds using a dental curing light (EPILAR FreeLight2 or EPILAR S-10, available from 3M ESPE Dental Products), separating the polyester films from each side of the mold, gently removing (by scraping) materials from the bottom of the sample (i.e., the side that was not irradiated with the dental curing light), and measuring the thickness of the remaining material in the mold.
  • the reported depths are the actual cured thickness in millimeters divided by 2.
  • Diametral tensile strength of a cured composition was measured in this test.
  • An uncured test sample composition was injected into a 4-mm (inside diameter) glass tube and the tube was capped with silicone rubber plugs. The tube was compressed axially at approximately 2.88 kg/cm 2 pressure for 5 minutes.
  • the sample was then light cured for 80 seconds by exposure to a XL 1500 dental curing light (3M ESPE, St. Paul, MN), followed by irradiation for 90 seconds in a Kulzer UniXS curing box (Heraeus Kulzer GmbH, Germany).
  • the test sample was cut with a diamond saw to form disks about 2.3 mm thick, which were stored in distilled water at 37 °C for about 24 hours prior to testing. Selected samples were stored in distilled water for extended periods (i.e., >24 hours) prior to testing, to study the effect of water exposure on the diametral tensile strength of the cured disks (vide infra).
  • AFM-1 is an addition-fragation monomer which can be prepared as described in U.S. Patent Appl. Publication No. 2012/0208965 at paragraph [0078] (Example 1);
  • BHT refers to butylated hydroxytoluene (2,6-di-tert-butyl-4-methylphenol), CAS
  • BisEMA-6 refers to ethoxylated (6 mole ethylene oxide) bisphenol A dimethacrylate as further described in U.S. Patent No. 6,030,606, available from Sartomer Co., Inc. (Exton, PA) as "CD541";
  • BisGMA refers to 2,2-bis[4-(2-hydroxy-3- methacryloyloxypropoxy)phenyl]propane (also referred to as bisphenol A diglycidyl ether methacrylate), CAS Reg. No. 1565-94-2;
  • BZT refers to 2-(2'-hydroxy-5'-methacryloxyethylphenyl)-2H-benzotriazole, CAS Reg. No. 96478-09-0, available from Ciba, Inc. (Tarrytown, NY) as "TINUVIN R 796", also available from Sigma-Aldrich Corp. (St. Louis, MO);
  • CPQ camphorquinone
  • DPIHFP diphenyliodonium hexafluorophosphate
  • CAS Reg. No. 58109-40-3 available from Johnson Matthey, Alfa Aesar Division (Ward Hill, MA);
  • DMDMA refers to 1,12-dodecanediol dimethacrylate, CAS Reg. No. 72829-09- 5;
  • EDMAB refers to ethyl 4-dimethylaminobenzoate, CAS Reg. No. 10287-53-3;
  • ERGP-IEM refers to 2-propenoic acid, 2-methyl-, l,l'-[l,3-phenylenebis[oxy- 2, 1 -ethanediyloxy[ 1 -(phenoxymethyl)-2, 1 -ethanediyl]oxycarbonylimino-2, 1 -ethanediyl]] ester, CAS Reg. No. 1353886-10-8, which can be prepared as described at paragraph [0222] of U.S. Patent Appl. Publication No. 2013/0109777;
  • PROCRYLAT refers to 2,2-bis-4-(3-methacryloxypropoxy)phenyl)propane dimethacrylate, CAS Reg. No. 27689-12-9;
  • TEGDMA refers to triethyleneglycol dimethacrylate, CAS Reg. No. 109-16-0, available from Sartomer Co., Inc. (Exton, PA);
  • UDMA refers to diurethane dimethacrylate, CAS Reg. No. 41137-60-4, available under the trade designation “ROHAMERE 6661-0” from Rohm America LLC (Piscataway, NJ); also available from Dajac Laboratories (Trevose, PA);
  • YbF3 M refers to ytterbium fluoride, 100 nm particle size, available from Sukgyung AT Co. Ltd., (Korea);
  • S/T Silica/Zirconia Clusters refers to silane-treated silica-zirconia nanocluster filler, which can prepared as described in U.S. Patent No. 6,730,156 at column 25, lines 50-63 (Preparatory Example A) and at column 25, line 64 through column 26, line 40 (Preparatory Example B) with minor modifications.
  • the silanization was performed in water at a pH adjusted to ⁇ 8.5 with NH 4 OH and the nanocluster filler was obtained by spray drying;
  • S/T 20 nm Silica refers to silane-treated silica nanoparticle filler having a nominal particle size of approximately 20 nanometers, which can be prepared as described in U.S. Patent No. 6,572,693 at column 21, lines 63-67 (Nano-sized particle filler, Type #2);
  • S/T Nanozirconia refers to silane-treated zirconia nanoparticle filler, which can be prepared from the zirconia sol described in U.S. Patent No. 8,647,510 at column 31 lines 51-60 (Example 6).
  • the zirconia sol is added to an equivalent weight of 1-methoxy- 2-propanol containing 3-methacryloxypropyltrimethoxysilane (1.1 mmol of 3- methacryloxypropyltrimethoxysilane per gram of nanozirconia to be surface treated).
  • the mixture is heated to ⁇ 85 °C for 3 hours with stirring.
  • S/T Nanozirconia is isolated by removing solvents via gap drying.
  • S/T Nanozirconia may also be prepared as described in U.S. Patent No. 7,649,029 beginning at column 19, line 39 through column 20, line 41 (Filler I), except for the substitution of 3-methacryloxypropyltrimethoxysilane for the blend of Silquest A- 174 and A-1230, and further removing the solvents via gap drying.
  • S/T Filler refers to zirconia- silica filler (which can be prepared as described in
  • metal-containing additives were purchased from commercial suppliers such as Sigma-Aldrich (St. Louis, MO), Johnson Matthey, Alfa Aesar Division (Ward Hill, MA), TCI America (Portland, OR), or Chem Service (West Chester, PA) and were used as received: zinc methacrylate ("ZnMA”, CAS Reg. No. 13189-00-9), calcium methacrylate (“CaMA”, CAS Reg. No. 16809-88-4), sodium methacrylate (“NaMA”, CAS Reg. No. 5536-61-8), aluminum methacrylate ("AIM A”, CAS Reg. No.
  • YMA yttrium methacrylate
  • ZrMA zirconium methacrylate
  • MgMA magnesium methacrylate
  • Zn(N0 3 ) 2 6H 2 0, CAS Reg. No. 10196-18-6 zinc sulfate, zinc oleate (CAS Reg. No. 557-07-3), ethylenediaminetetraacetic acid disodium zinc salt tetrahydrate (Na 2 Zn(EDTA)-4H 2 0, CAS Reg. No.
  • Zinc oxide (1.9941 g) was digested into 2-(2-methoxy-l-methylethoxy)acetic acid (7.326 g, "MMEAA", prepared as described in U.S. Patent No. 8,236,277 beginning at column 11, line 1, through column 12, line 2). The mixture was heated at 100 °C under vacuum until water evolution ceased ( ⁇ 1 -2 hours).
  • HEMA-phosphate (26.0 g, which may be prepared as a mixture of mono-, di-, tri-HEMA phosphate and tetra-HEMA pyrophosphate in the manner described at columns 24-25 of U.S. Pat. No. 7,632,098 for "HEMA-P"; bis(methacryloxyethyl)phosphate available from Nippon Kayaku (Japan) under the trade designation KAYAMER PM-2 may also be used).
  • the mixture was heated at 100 °C under vacuum until water evolution ceased (-1-2 hours).
  • Photocurable stock resins (Resins A-C) were prepared by hand mixing the components shown in Table 1 to form a uniform mixture.
  • Table 1 Photocurable Stock Resin Formulations, Resins A-C
  • Resin 1 which included 20 wt.% ZnMA, was placed into a small metal mold between two polyester sheets and the resin irradiated with a dental curing light (EPILAR S-10, available from 3M ESPE Dental Products) for 20 seconds.
  • a dental curing light EPILAR S-10, available from 3M ESPE Dental Products
  • Two disks (each ⁇ 8 mm diameter x ⁇ 1 mm thick) were prepared in this manner. Both of the disks were translucent and colorless after curing.
  • One of the disks was left dry in air under ambient conditions as a control, while the other disk was submersed into deionized water at 37 °C. After 4 days, water-exposed disk was removed and evaluated. The water-exposed disk was white and opaque in appearance. In contrast, the control disk remained substantially unchanged from its original appearance immediately after cure.
  • the opacity change due water exposure was determined to be substantially irreversible: heating the water-exposed disk at 100 °C for 2 hours resulted in no reduction in opacity.
  • the cured disk of Resin 5 displayed an initial CR of 42.60 (prior to water exposure), a CR of 67.54 after 3 days of water exposure, a CR of 96.88 after 17 days of water exposure, a CR of 97.14 after 19 days of water exposure, and a CR of 97.09 after 21 days of water exposure. Even after exposure to 37 °C water for 158 days, the CR of the cured resin disk from Resin 5 was 89.08 (data not shown). In contrast, cured resins which included methacrylates of other metals (e.g., Resins 9A-9F) did not display significant increases in opacity with water exposure.
  • methacrylates of other metals e.g., Resins 9A-9F
  • Zinc additives with hydrophilic ligands/anions may be used with good effect (e.g., Na2Zn(EDTA)-containing Resin 11, as well as Resins 15-18), while the effect zinc compounds with relatively non-polar groups (zinc oleate-containing Resin 12) are less effective.
  • Comparison of the cured resin disks derived from Resin 13 and Resin 14 show that, increasing the loading of a given zinc compound (e.g., Zn(MEEAc) 2 ) in a particular resin system can provide a substantially increased ability of the corresponding cured resin to opacify with water exposure.
  • a given zinc compound e.g., Zn(MEEAc) 2
  • the pastes could be readily be light cured at a depth greater than 4 mm.
  • the diametral tensile strengths of cured experimental pastes were evaluated. As shown in Table 8, the tensile strengths of the cured experimental pastes were comparable to that of a control, and thus displayed sufficient strength to be used in an oral environment. Notably, the tensile strength of the cured pastes did not degrade after extended exposure to water/opacificatication (e.g., Paste 9).

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Dental Preparations (AREA)

Abstract

La présente invention concerne un matériau dentaire et un procédé d'utilisation du matériau dentaire. Le matériau dentaire peut comprendre une résine durcissable ; un système initiateur ; une charge ; et d'environ 1 % en poids à environ 20 % en poids d'un composé de zinc, sur la base du poids de la résine durcissable. Le rapport de contraste du matériau dentaire durci augmente d'au moins environ 10 unités après un contact continu avec une solution aqueuse pendant 21 jours.
PCT/US2015/055886 2014-10-31 2015-10-16 Materiaux dentaires et procédés Ceased WO2016069290A1 (fr)

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US20120208965A1 (en) 2011-02-15 2012-08-16 3M Innovative Properties Company Addition-fragmentation agents
WO2012112321A2 (fr) 2011-02-15 2012-08-23 3M Innovative Properties Company Compositions dentaires comprenant un mélange de monomère d'isocyanurate et de monomère de tricyclodécane
WO2012112350A2 (fr) 2011-02-15 2012-08-23 3M Innovative Properties Company Compositions dentaires comprenant un agent de fragmentation d'addition éthyléniquement insaturé
WO2012112304A1 (fr) 2011-02-15 2012-08-23 3M Innovative Properties Company Agents d'addition-fragmentation
US8455565B2 (en) 2011-05-18 2013-06-04 3M Innovative Properties Company Disulfide monomers comprising ethylenically unsaturated groups suitable for dental compositions
US20130006653A1 (en) 2011-06-30 2013-01-03 3M Innovative Properties Company Methods using multi-dimensional representations of medical codes
WO2013023138A1 (fr) 2011-08-11 2013-02-14 3M Innovative Properties Company Composition dentaire, ses procédés de préparation et d'utilisation
WO2013028397A2 (fr) 2011-08-23 2013-02-28 3M Innovative Properties Company Compositions dentaires contenant des agents d'addition-fragmentation
WO2013028401A1 (fr) 2011-08-23 2013-02-28 3M Innovative Properties Company Agents d'addition-fragmentation
WO2013176870A1 (fr) 2012-05-25 2013-11-28 3M Innovative Properties Company Pointe d'application et système de distribution d'un matériau dentaire
WO2014074373A1 (fr) 2012-11-12 2014-05-15 3M Innovative Properties Company Compositions dentaires comprenant des agents d'ajout et de fragmentation
WO2014074427A1 (fr) 2012-11-12 2014-05-15 3M Innovative Properties Company Agents d'addition-fragmentation
WO2014099317A1 (fr) 2012-12-17 2014-06-26 3M Innovative Properties Company Oligomères d'addition-fragmentation

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