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WO2016061709A1 - Mems à conception bionique et procédés pour l'acquisition multiple d'informations sensorielles de pression artérielle selon la théorie tcm - Google Patents

Mems à conception bionique et procédés pour l'acquisition multiple d'informations sensorielles de pression artérielle selon la théorie tcm Download PDF

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Publication number
WO2016061709A1
WO2016061709A1 PCT/CN2014/000926 CN2014000926W WO2016061709A1 WO 2016061709 A1 WO2016061709 A1 WO 2016061709A1 CN 2014000926 W CN2014000926 W CN 2014000926W WO 2016061709 A1 WO2016061709 A1 WO 2016061709A1
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WIPO (PCT)
Prior art keywords
pressure
pulse
bionic
information
finger
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Ceased
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PCT/CN2014/000926
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English (en)
Inventor
Xin Niu
Xuezhi Yang
Tingli NIU
Liangxiao MA
Yu Lu
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Priority to PCT/CN2014/000926 priority Critical patent/WO2016061709A1/fr
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Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A61B5/02055—Simultaneously evaluating both cardiovascular condition and temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/02416—Measuring pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/02444—Details of sensor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6843—Monitoring or controlling sensor contact pressure

Definitions

  • TCM physicians take several part of artery pulse by place physicians′finger on the skin where the artery pulse could be felt, they call this kind of pulse taking as full pulse taking.
  • the pulse taking locations include radial artery (CunKou) , carotid artery (RenYing) and Dorsal Pedal Artery (FuYang) .
  • TCM physicians only take CunKou as the main pulse taking place, which named typical pulse taking or simply default named pulse taking.
  • the application of typical pulse taking method could accelerate the diagnosis speed and partially avoid the ethical dilemma in diagnosis. While by the same time, the simplification on pulse taking method also causes inevitably decline of the diagnosis information integrity and accuracy.
  • the pulse taking diagnosis require patients sit quiet and face to face with TCM physician, patients stretch both his forearms out horizontally and the height of forearms are equal to the heart.
  • the location of Cun, Guan and Chi are adjacent area, each have 9mm-20mm long, according to TCM theory, the length in Cun, Guan and Chi location, each are equal to 1/20 of the subject′s inner forearm′s length.
  • the invention including the integrated sensors probes band, and corresponding terminal.
  • the integrated sensors probes band including bionic fingers, ECG fabric electrodes, Photoplethysmograph (PPG) probes and impedance blood diagram fabric electrodes, each provide corresponding signal, together with the power source, micro motor, the MEMs designed primary information calculation and wireless telecommunication block also located on the bands, makes the band physically independent and easy to wear. Different external designs are made for different part such as CunKou, RenYing and FuYang. The device also designed compatible for additional abdomen pressure detector for belly diagnosis. See fig. 1.
  • the terminal is designed to display real time data and corresponding diagnosis conclusion. It has telecommunication block to acquire the information from integrated sensor probe bands, the auto-analysis function based on TCM theory and experiences to calculate the result, including syndrome pattern recognition, physical condition tendency anticipation and herbs prescription.
  • the terminal could be phone, iPad or tablet PC.
  • the directly acquired information includes pulse condition on CunKou, RenYing, FuYang and abdomen , coupled II lead ECG, PPG and impedance rheogram.
  • CunKou, RenYing and FuYang That′s the core information that capable to evaluate the physical condition in overall, dialectic the balance between Yin and Yang, cold and warm, outer skin or inner organs, all suggest the macroscopic and functional condition and tendency. But by accurate measure by this bionic device, the conclusion could not only output quantify express the long time dim feelings received by TCM physicians, But also calculate the secondary diagnosis information such as the PWV in multiple body part by correlation. Theoretically the incremental tendency could be in exponential order in maximum by adding each real time information dimension. But for the diagnosis convenience, only the one have diagnosis value been programmed to display.
  • the corresponding prescription and other assistant recuperate method are ready-made when all the sensory information are digitalized and quantified. The more information collected, the more accuracy the conclusion would be.
  • the prescription on herbs and needles will be coupled by the dialectic result.
  • the herbs and needles rectification need physicians to apply. So the simplified version of this device for family use are only suit for healthy evaluation and the recuperate method application.
  • incompressible fluid are suitable for hydraulic pressure conduction, water are suggested to apply.
  • interval (Lt) of the microprobe are approximately designed as 0.1mm, which is also the intervene of the sensory cells in human finger tip. This design could simulate the discrimination threshold in human finger tip and provide high bio-fidelity information for TCM physician in diagnosis process. See fig. 2.
  • Each finger encompassed inside the band been equipped with one micro motor for finger pressure adjust, simulate the force TCM physician used to apply.
  • the default pressure values are designed in 4 different level: ′′light/normal/heavy/hard′′ .
  • the micro motor inside each bionic fingers are designed to adjust hydraulic pressure in finger tip while in detection, while the overall pressure sensors buried in the multilayer chip packages will sense the hydraulic pressure, based on the hydraulic pressure conduction principle, the pressure where the overall sensor acquired are equal to the pressure that bionic fingers added on the detection place, according to TCM theory, three marks are set for four different pressure range recognition.
  • the device by apply the full hard ware function are designed to aid TCM physician, while the simplified version could be just bands for CunKou, convenient to apply at home and other place.
  • the device If the device detected the unhealthy signals more than twice, or detected severe dangerous condition such as ventricular fibrillation, it will send signals for health warning and provide possible reason for users to take caution.
  • spatiality represents the needed pressure added by micro motor to acquire the most fitted pressure.
  • the most fitted pressure represents the pressure when the greatest pressure difference is suggested and creates the biggest wave form in display.
  • the pressure value will be compared with the settled value that classified by level of light/normal/heavy/hard. If the pressure value is less than the settled ′′light′′ level, the spatiality of this pulse is float. If the pressure value is in the range between the ′′light′′ level and the ′′normal′′ value, then the spatiality of this pulse is normal. If the pressure value is in the range between the ′′normal′′ level and the ′′heavy′′ value, then the spatiality of this pulse is heavy. If the pressure value is heavier than the settled ′′heavy′′ level, the spatiality of this pulse is hard. See fig. 3.
  • Rhythmicity including rapid (7-9 beat per breath process, HR 120 ⁇ 140 b/min) , fast (5-7 beat per breath process, HR 100 ⁇ 120 b/min) , normal (4-5 beat per breath process, HR 65 ⁇ 100 b/min) , slow (3-4 beat per breath process, HR 55 ⁇ 65 b/min) , sluggish (2-3 beat per breath process, HR ⁇ 55 b/min) .
  • Rush fast or rapid but occasion slow unpredictably
  • knotted slow or normal but occasion sluggish unpredictbly
  • intermittent slow or normal but occasion sluggish regularly
  • Formability especially represent pulse wide, and others like cross-section pressure curve. Depend on the micro probe on bionic fingers to acquire. See fig. 4 .
  • Intensity exclusively represent the overall pressure waveform detected by each bionic fingers see fig. 4.
  • the pressure wave form in different pulse type corresponding different but not exclusive shape.
  • typical intensity character such as thready, fluency and so on will be recognized. This is a compare complex work but had been done by years of wave form couple and analysis.
  • the corresponding software had been registered in China. (register No: 2009SR019286; Serial number: 0146285; Name: Bode TCM 2008 integrated diagnosis software V1,0----′′ ⁇ TCM2008 ⁇ V1.0′′ )
  • the 28 typical pulses and their combination types will be recognized in high accuracy and capable to quantify each attribution.
  • the bands designed to detect the multiple information are specially designed to fit the body part.
  • the inner part of bands is elastic to fit the wrist while the outer part of bands is inelastic to support steady hydraulic pressure inside the bionic fingers.
  • the detector in carotid artery are designed as coupled PPG and impedance blood diagram
  • the bionic finger are removable unilateral distributed and are removable
  • the band are designed more elastic and flexible to avoid uncomfortable feelings.
  • the integrated sensor probe band on foots are similar to the wrist part, while more strong and tight.
  • the information transporting method could be either USB port or wireless transporting. Both have two modes: real time information mode and full wave form mode.
  • the former data are concise in package but enough for diagnosis; the later mode need flow rate at least 76 KB bandwidth to realize real time transforming.
  • the data transport process are shown in fig 5.
  • the overall signal channel in the bionic finger are including: 64 micro sensors for pulse wide ⁇ the signal are acquired by a calculator and output the pulse wide value.
  • the whole pressure wave hydraulic pressure sensor embedded in multi-chip water proof packages, the inner layer are designed to makes primary signal processing. The spatiality, rhythmicity, formability, and intensity in every pulse cycle will be generated. And adding the location and time of P, Q, R, S, T point in standard two lead ECG, the SaO2 value in PPG, and the waveform integral value in both PPG and impedance blood diagram.
  • the complete set of device have 11 bionic fingers in sum, 2*3 in radial artery, 1 in carotid artery and 2*2 in dorsal pedal artery, each need 8 byte volume.
  • 4 PPG probe for each needs 2 bit for SaO2 and 2bit for waveform integral value.
  • 4 impedance blood diagram probe, each needs 2 bit for wave form integral value record.
  • the whole packed set of the device could provide pure digitalized diagnosis information for inside a data frame, the frame including frame head and frame data, all adding up less than 1 kb volume, if the graphic signals are acquired, the volume will be 76 KB in estimate.
  • the digital information data When the information group synchronously acquired by the terminal software, the digital information data will be translate into the language and terms which could be understand by TCM physicians. Then correlation process on the synchronously acquired information will calculate the information such as the whole physical condition in meridians and collaterals, the artery stiffness represented by pulse wave velocity (PWV) in multiple region ;
  • PWV pulse wave velocity
  • Fig. 4 the layout of pressure sense part and visualized signal type in bionic finger
  • Fig. 5 the information type in acquirement and transmission process
  • Fig. 7 The location method of integrated sensors probes band
  • Fig. 8 the layout of the adjust method in precise location
  • the fig 1 in the middle suggest the whole appearance while the dotted circle are transparent the band to show the layout of the sensors and probes.
  • 101 represent the model when the device are fully equipped.
  • 102-105 are local layout.
  • 102 show three bionic fingers press on CunKou in three different locations
  • 103 show the layout of RenYing pulse detection design
  • 104 are the FuYang part design.
  • the bionic fingers in RenYing design are replaced by PPG and impedance blood graph to avoid blood deficiency in brain blood supplication.
  • 201 represent one possible appearance of bionic finger.
  • 202 represent the 64 micro pressure probe array lay inside the tip of bionic finger, each for sensation the cyclical pulse wave.
  • the interval space Lt are simulate the threshold discrimination in human finger tips, prefer designed as 0.1mm.
  • 301, 302, 303 column schematically suggest light, normal, heavy level on pressure exerting by bionic fingers.
  • 304 represent cross section of artery in diastolic period while 305 represent cross section of artery in systolic period.
  • 306 represent the wave form often happened in healthy people where the best fit pressure always appeared nearby the pressure range of normal level.
  • Fig 4 shows the spatiality attribution resulted as 401 suggest are sensed by micro sensors array 403 displayed.
  • the overall pressure is acquired by the whole hydraulic pressure conducted to chip 404 to form the wave form like 402 suggest.
  • 600 is the integrated sensors probes band
  • 601 is the windows for location on both band and the bionic fingers
  • 602 is the impedance plethysmography sensor
  • 603 conductive fabric for II lead ECG
  • 604 suggest the bionic fingers for pressure and temperature acquirement
  • 605 is the Photoplethysmograph (PPG) probes.
  • 606 is the micro motor for adjust hydraulic pressure in bionic finger.
  • the left part are designed with more margin for velcro or other stick material, so when round up to the wrist, the stick part could pass through the conductor tissue to makes the fix more firm for the pressure detection and manipulation.
  • band window is 7cm, the length is 5cm, covered by transparency thin flexible material when applied by TCM physicians or cover nothing if for personal use.
  • the conductive fabrics beside the band window are impedance blood diagram electrodes, two close to the verge are supply electrodes and the inner side conductors are detector.
  • the conductive fabric for II lead ECG when both bands on wrist are applied.
  • the bionic fingers are designed to simulate the size of human finger.
  • the application method is show in fig. 6 ⁇ fig. 9.
  • the part of Conductive fabric in ECG detection part are elastic so the location of bionic finger will be proper located on the right pulse location; then stick the end of inner part to the outboard of band.
  • the region of stick part is located beyond the domain of Conductive fabric so the entire band will firmly located on the wrist.
  • the method to locate the RenYing and FuYang position are the same.
  • the primary signal After the all the band have located well, then open power source, the primary signal will be shown, check the signal by sifting to the full wave form mode, if no wave is missing or deformed, then we can turn on the detection process to makes information collection.
  • the micro motors in each finger will automatically add pressure and by the same time, sensing the wave amplitude, it will automatically record the pressure until the first time pulse wave had been clearly sensed and displayed over basic amplitude, define the pressure as the float value and record the pulse wave for 30 seconds. Then pressure adding process continue until for the first time the wave amplitude acquired by pressure sensors begin to decrease, then antomatically record the static hydraulic pressure and the wave form again for 60 seconds.
  • the hydraulic pressure now is the most fit pressure and the waveform are the standard pulse waveform; then check if the best fit pressure are over the ′′hard′′ level, if not, then the motor will continue add pressure to additional fixed pressure value to acquire pulse wave form in heavy and hard pressure region, each for 30s, the wave form in heavy way would be acquired.
  • the pressure After the pressure adding reached to the limit, the pressure start to decrease.
  • the pressure return to the most fit pressure (remember the pressure may not be the same with the one acquired in pressure adding process, that may reflect some kind of physical information in TCM theory. ) , record for another 60s, then continue the decrease process until the wave form just reached to the basic amplitude level, record the wave form again for 30s.
  • the ECG, PPG and impedance blood graph are simultaneously make recoding.
  • the original wave form will be restored and send to the chip for analysis where the spatiality, rhythmicity, formability and intensity attribution will be acquired in digital value, the information could be viewed if additional display panel are installed, but this kind of information are hard to understand, the data group will be packed and transported into the terminal where the programme will decipher the numeric information into term and language description.
  • additional physiological information could be shown including multiple PWV value, CO, blood distribution.
  • the device is suitable for TCM physician in remote diagnosis.
  • the information needed are just visual, auditory, tactile sensing, by adding the pulse sensing the acquired information, all TCM needed will be acquired to makes diagnosis.
  • the method could been modified to apply a bionic hand to regenerate the pulse waving by the tele-transported pulse signal.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
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  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention concerne un dispositif bionique destiné à l'acquisition multiple d'informations sensorielles de pression artérielle selon la théorie TCM, qui recueille des impulsions dans l'artère radiale, l'artère carotide, l'artère dorsale du pied et l'abdomen, combinées à une mesure non invasive supplémentaire, afin de rendre des conclusions et des prescriptions dialectiques. La conduction de pression hydraulique est appliquée dans le dispositif et de l'eau est utilisée de manière préférentielle. La sonde du dispositif comprend des doigts bioniques pour la forme d'onde de pression d'impulsion; un réseau à 64 micro-sondes pour quantifier la largeur d'impulsion; un tissu conducteur pour un ECG à II fils; un rhéogramme d'impédance; un PPG. Des groupes d'informations sont acquis et analysés simultanément pour produire de multiples groupes d'informations de diagnostic à des fins de combinaison et de dialectique. Le dispositif est susceptible d'envoyer des données et un résultat dialectique en temps réel à un terminal sans fil pour étayer un télé-diagnostic. S'il est appliqué dans un cadre familial, une alerte de santé pourrait suggérer aux personnes que des données anormales sont trouvées de façon répétée.
PCT/CN2014/000926 2014-10-21 2014-10-21 Mems à conception bionique et procédés pour l'acquisition multiple d'informations sensorielles de pression artérielle selon la théorie tcm Ceased WO2016061709A1 (fr)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107157454A (zh) * 2017-06-26 2017-09-15 四川脉卫科技有限公司 一种中医脉诊用仿生医生手指系统及信号采集方法
CN107714029A (zh) * 2017-11-20 2018-02-23 北京工业大学 一种心电远程监护系统
CN109215774A (zh) * 2018-11-19 2019-01-15 郑博 实时远程脉诊系统
CN114005345A (zh) * 2021-11-13 2022-02-01 沈阳天仁合一科技有限公司 脉诊仪医护端
US11540762B2 (en) 2014-10-30 2023-01-03 West Affum Holdings Dac Wearable cardioverter defibrtillator with improved ECG electrodes
CN116269246A (zh) * 2023-05-24 2023-06-23 深圳市中医院 一种互联网远程仿生脉诊仪器及应用方法
US11745006B2 (en) 2014-10-30 2023-09-05 West Affum Holdings Dac Wearable cardiac defibrillation system with electrode assemblies having pillow structure
CN117961947A (zh) * 2024-04-01 2024-05-03 合肥综合性国家科学中心人工智能研究院(安徽省人工智能实验室) 多重传感与反馈刺激的仿生机器手
CN119400381A (zh) * 2025-01-06 2025-02-07 湖南博极生命科技有限公司 一种智能设备辅助的中医信息采集与处理系统

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CN103426351A (zh) * 2013-07-11 2013-12-04 牛欣 可远程复现的心动脉应脉诊训练装置及方法
CN103750823A (zh) * 2014-01-13 2014-04-30 孙冰 一种利用智能终端远程切脉的脉诊仪及其方法

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11540762B2 (en) 2014-10-30 2023-01-03 West Affum Holdings Dac Wearable cardioverter defibrtillator with improved ECG electrodes
US11745006B2 (en) 2014-10-30 2023-09-05 West Affum Holdings Dac Wearable cardiac defibrillation system with electrode assemblies having pillow structure
CN107157454A (zh) * 2017-06-26 2017-09-15 四川脉卫科技有限公司 一种中医脉诊用仿生医生手指系统及信号采集方法
CN107714029A (zh) * 2017-11-20 2018-02-23 北京工业大学 一种心电远程监护系统
CN109215774A (zh) * 2018-11-19 2019-01-15 郑博 实时远程脉诊系统
CN109215774B (zh) * 2018-11-19 2023-08-04 郑博 实时远程脉诊系统及其工作方法
CN114005345A (zh) * 2021-11-13 2022-02-01 沈阳天仁合一科技有限公司 脉诊仪医护端
CN114005345B (zh) * 2021-11-13 2024-03-26 沈阳天仁合一科技有限公司 脉诊仪医护端
CN116269246A (zh) * 2023-05-24 2023-06-23 深圳市中医院 一种互联网远程仿生脉诊仪器及应用方法
CN116269246B (zh) * 2023-05-24 2023-07-25 深圳市中医院 一种互联网远程仿生脉诊仪器及应用方法
CN117961947A (zh) * 2024-04-01 2024-05-03 合肥综合性国家科学中心人工智能研究院(安徽省人工智能实验室) 多重传感与反馈刺激的仿生机器手
CN119400381A (zh) * 2025-01-06 2025-02-07 湖南博极生命科技有限公司 一种智能设备辅助的中医信息采集与处理系统

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