WO2016048127A1 - Herbicide formulated with glyphosate and amino acids for controlling and/or eliminating weeds, and uses thereof - Google Patents

Abstract

The invention relates to an improved synergistic composition for the control and/or elimination of weeds, characterised in that it comprises: a) between 20 and 72% glyphosate; b) between 15% and 67% of at least one amino acid or a mixture or some or all of the essential amino acids; c) 8% of a diluent; and d) 5% of a surfactant, the total quantity of the components adding up to 100%. The percentages of each component in the composition of the present invention provide a synergistic effect that provides improved effectiveness in the control of weeds, as a result of an increased permeability of the cell membrane, which stimulates the absorption of glyphosate, acting systemically on the weeds, for which reason the subject of the invention is considered novel and inventive because it does solve the problem of the resistance to glyphosate. The composition of the present invention also ensures the control of any type of weed, both monocotyledonous (thin leaf) and dicotyledonous (wide leaf).

Description

Herbicide formulated with glyphosate and amino acids for the control and / or elimination of weeds and uses

Field of the Invention

 The present invention relates to an improved synergistic composition based on glyphosate and amino acids for the control and / or elimination of weeds in agricultural crops, where the amino acids in the composition permeabilize the cell membrane favoring the systemic action of glyphosate thus increasing its effectiveness and increasing the reaction rate.

Background of the invention

 Weeds are plants often described as harmful to crop production systems and also to industrial and commercial processes, since they affect the productive potential of the occupied area or the volume of water handled by man. This damage can be measured as loss of agricultural yield per unit of arable area or also by assessing the impact of the productivity of a commercial enterprise.

The greatest knowledge of weed damage comes from assessments of agricultural crop losses. In general, it is accepted that weeds cause a direct loss of approximately 10% of production agricultural. In cereals, this loss is of the order of more than 150 million tons. However, such losses are not the same in different countries, regions of the world and affected crops. In the 1980s, it was estimated that losses of agricultural production caused by weeds amounted to 7% in Europe and 16% in Africa, while rice cultivation was 10.6%, 15.1% in cane of sugar and 8% in cotton.

 Annual losses caused by weeds in agriculture in developing countries have been estimated at almost 125 million tons of food, enough to feed 250 million people.

Weeds generate competition with crops for the useful space that affects both aerial and underground parts. It is proven that the root development of a plant decreases when it grows in the vicinity of others. The competition for airspace depends on the level of infestation and the speed of growth. The competition for light is different depending on the time of year and the mode of spread of weeds. Competition for soil water depends on the level of weed invasion and transpiratory activity. The competition for nutritional elements is the factor that most influences the crop yield. Weeds extract significant amounts of nutrients that would otherwise be at arrangement of cultivated plants. In addition to competition phenomena, there are other relationships whose manifestation is less clear but that frequently produce very marked depressive effects on crop development. Weeds serve as a refuge for phytophagous insects and phytopathogenic nematodes that spend part of their biological cycle inside or outside cultivated fields, thus facilitating the invasion of the crop and generating considerable damage. The presence of weeds contributes to the spread of fungal diseases.

In developed countries, success in agronomic production in recent decades, is largely due to the use of herbicides. These have revolutionized the agricultural technique of our time and provide a tremendous advance in weed control.

The herbicides in the market are numerous and are classified by their mechanisms of action in 24 groups. However, prolonged use of the same herbicide can cause resistance problems in weeds.

 A herbicide that deserves special attention is the

Glyphosate, whose consumption worldwide is very high as it is applied to numerous crops both in pre-sowing or pre-transplant and later in targeted applications. Its use in soil conservation systems and more recently, in genetically modified crops that support your application, has also increased its use. Given its great use, resistance has been observed in many cases. There are already 12 species of weeds that have resistance to glyphosate. This has proved surprising because of the fact that the resistors have appeared after a long time of use, exceeding 20 years and the use of large quantities of product. Currently there are not only glyphosate resistance but they increase both in number of species and in the number of locations worldwide.

Currently, the number of resistant weeds is increasing and for this reason there is a growing need to obtain an improved composition that retains the high effectiveness of glyphosate but that solves the resistance problems presented by some species of harmful plants or weeds, as well as the Optimization of your action time.

From the need to find an efficient herbicidal composition, the alternative arises to make a synergistic mixture of glyphosate and amino acids, since amino acids increase the efficiency of glyphosate by opening specific intracellular transport channels that allow better entry of Active ingredients of glyphosate to plant cells. Efforts to improve the effect of the action of the

Glyphosate have been described in Document KR 20140018878, which consists of a synergistic composition containing Penoxsulam and Glyphosate. This document is different since the nature of the compound that is combined with glyphosate and its mechanism of action differ.

There are also numerous documents describing combinations of two or more herbicidal compounds such as CN 103004865 describing a composition consisting of Glyphosate, fluoroglycophene-ethyl and quizalofop-p-ethyl; DE 10351214 describing synergistic combinations of pyridinesulfonyl urea and glyphosate, metolachlor ■ or trifluralin; AU 2012359012 describes a herbicidal composition containing glyphosate with fluroxypyr; AUS Document 2014171321 describes a glyphosate-based herbicidal composition and a pyridine analogue derivative; JP 2014058538 describes a synergistic composition of glyphosate and a derivative of phenoxy alkanic acid; KR 20140018878 describes a synergistic herbicidal composition containing Glyphosate and Penoxsulam. These documents, among others, do not affect the novelty and inventive activity of the present invention since all the compounds used in combination with Glyphosate have mechanisms of action and a synergistic effect different from that of amino acids. On the other hand all the compounds used in combination with glyphosate in the aforementioned documents, are herbicidal compounds.

 PT 1835808 describes a herbicidal composition based on glyphosate and betaine as a surfactant. On the other hand, document MX / a / 2013/004619 describes Glyphosate formulations based on compositions derived from natural metathesis oil, using monounsaturated acids, ester derivatives, imidazolines, amidoamines, betaines, among others, as surfactants. These documents are different from the improved synergistic composition of the present invention because the compounds used in combination with glyphosate are used as surfactants, and their effect does not affect the novelty and inventive activity of the present invention.

The above-mentioned compositions are different from the improved synergistic composition of the present invention for weed control and / or removal comprising: a) 20% to 72% Glyphosate; b) 15% to 67% of at least one amino acid or a mixture of some or all of the amino acids; c) 8% of a diluent; and d) 5% of a surfactant, all this must add up to 100%. The amino acid mixture used may comprise: 1% up to 5% aspartic acid, 0.01% up to 0.5% threonine, 0.01% up to 5% serine, 1% up to 10% glutamic acid, 12% up to 20% glycine, 1% up to 10% Alanine, 0.01% up to 0.5% Cysteine, 0.1% up to 5% Valine, 0.1%, up to 2% Methionine, 0.1% up to 2% Isoleucine, 1% up to 5% Leucine, 0.1% up to 2% Tyrosine, 0.1% up to 2% Phenylalanine, 0.01% up to 0.5% Histidine, 1% up to 10% Lysine, 0.1% up to 0.5% Arginine and 1% up to 10% Proline.

Description of the Invention

 The present invention relates to an improved synergistic composition based on glyphosate and amino acids for the control and / or elimination of weeds in agricultural crops, where the amino acids in the composition permeabilize the cell membrane favoring the systemic action of glyphosate thus increasing its effectiveness and increasing the reaction rate of the active ingredient.

 In a first embodiment the improved synergistic composition of the present invention for weed control and / or removal comprises:

 a) Glyphosate

 b) At least one amino acid or a mixture of some or all amino acids.

 c) A diluent; Y

 d) A surfactant

In a second embodiment the improved synergistic composition of the present invention for weed control and / or removal comprises: a) 20% to 72% glyphosate;

 b) 15% to 67% amino acids of at least one amino acid or a mixture of some or all essential amino acids;

 c) 8% of a diluent; Y

 d) 5% of a surfactant.

All this must add up to 100%.

The amino acid mixture containing the improved synergistic composition of the present invention may contain: a) 1% to 5% aspartic acid,

^' b) 0.01% up to 0.5% Threonine,

 c) 0.01% up to 5% Serine,

 d) 1% up to 10% Glutamic Acid,

 e) 12% up to 20% Glycine,

 f) 1% to 10% of Alanine,

g ⁾ 0.01% up to 0.5% Cysteine,

 h) 0.1% up to 5% Valine,

 i) 0.1% up to 2% ethionine,

j ⁾ 0.1% up to 2% Isoleucine,

 k) 1% up to 5% Leucine,

 1) 0.1% up to 2% Tyrosine,

 m) 0.1% up to 2% Phenylalanine,

 n) 0.01% up to 0.5% Histidine,

 o) 1% up to 10% Lysine,

 P) 0.1% up to 0.5% Arginine and

q ⁾ 1% to 10% Proline. In the present invention, the% corresponds to the percentage by weight unless otherwise indicated.

The diluent is selected from water or inert diluents.

The surfactant is selected from a diethylene glycol, polyoxyethylene alcohol, polyoxyethylene alkylphenol, polyethylene glycol and / or mixtures thereof.

The percentages of each component in the composition of the present invention provide a synergistic effect that generates greater effectiveness and a faster effect on weed combat, guaranteeing control of the most common weeds that affect agricultural crops, thanks to the fact that When the specific transport systems of the amino acids are activated, a greater permeability of the cell membrane is promoted, which favors the absorption of glyphosate, which is systemic in the weeds. Due to the above, it is considered that this formulation is new and inventive because it increases the effectiveness of glyphosate, thus helping to avoid resistance.

El, glyphosate is an isopropylamine salt of N- (phosphonomethyl) glycine, with a molecular weight of 228.18 g / mol. It is a non-selective broad spectrum herbicide, which is absorbed by the leaves and not by the roots of the plants and is then translocated to the roots and underground vegetative organs, causing the total death of the weeds emerged. It can be applied to the leaves, injected into logs and stems or sprinkled on stumps as a forest herbicide. Glyphosate is a systemic action herbicide. This can be used for post-emergent control of annual and perennial weeds in agricultural, industrial, roads and railways, among others.

 The mechanism of action of glyphosate is due to the inhibition of the biosynthesis of aromatic amino acids in plants (tryptophan, phenylalanine and tyrosine) through the inhibition of the enzyme 5-enolpiruvil-siquimato-3- phosphate synthetase (EPSPS), with that the production of protein, hormones and other metabolites is reduced; which leads to preventing the development of the plant (weed). Decontrol in catalysis by the EPSPS enzyme in the penultimate step in the pathway of the siquimato, also reduces the biosynthesis of other compounds such as tetrahydrofolate, ubiquinone and vitamin K in plants.

 Glyphosate is used for the destruction of weeds of corn, beans, wheat, citrus, tomato, vine, sorghum and potato crops, among others.

The mixture of amino acids present in the improved synergistic composition of the present invention makes it highly effective, since it permeabilizes the cell membrane favoring the absorption of glyphosate in the plant. In addition, it has a powerful transporting and chelating effect, which acts in the mobilization, transport and absorption by the plant of other substances that can be added or mixed in its application. This in turn leads to the optimization of the action of glyphosate.

The present invention then consists of a synergistic mixture of glyphosate and amino acids, increasing the chemical efficiency of glyphosate, thanks to the permeability and mobility promoted by amino acids, as well as the reduction of resistance in glyphosate weeds due to a greater and more effective exposure to the asset. The present invention also relates to the methods of application of the composition, which can be spray, atomization, dispersion, coating or pouring; depending on the expected results and the present circumstances, as well as the use of the composition for the control- and / or elimination of any type of weeds, especially, Cyperus rotundus L., Cynodon dactylon (L.) Pers, Echinochloa crus- galli (L.) P. Beauv, Echinochloa hill (L.) Link, Eleusine indica (L.) Gaerth, Sorghum halepense (L.) Pers, Impera cylindrical (L.) Raeuschel, Eichhornia crassipes (Mart.) Solms, Portulaca oleraceae L., Chenopodium album L., Digitaria sanguinalis (L.), Scop, Convolvulus arvensis L., Avena fatua L. and related species, Amaranthus hybridus L., Amaranthus spinosus L., Cyperus esculentus L., Paspalum conjugatum Berg, Rottloellia cochinchinensis (Lour.) .D. Clayton, Ipomoea dissecta, Amaranthus albus, Raphanus raphanistrum, Sicyos angulata, Encella mexicana, Helianthus annus, Malva moschata, Datada stramonium, Ixophorusunis etus, Cynodon niemfuensis, Amaranthus retoflexus, Chenopodium albus and Malva parviflora. Typical concentration rates for application are between 0.1 and 1000 ppm of active components. Application rates may vary depending on the limitations present such as the nature of the soil, the type of application, the type of crop, the type of weeds and the climate. The application rates per hectare are in general 1 to 10Og of active components per hectare, preferably 20 to 500g of active ingredient per hectare. The application dose of the improved synergistic composition of the present invention is generally from 0.5 to 12L per hectare. The application of the invention can be carried out by mixing the components thereof within the container, flask or container of the applicator or, applying each of the components separately by performing the mixture directly in the field.

Examples

The following examples are intended to illustrate the invention, not to limit any variation by those skilled in the art, fall within the scope thereof. Example 1

An improved synergistic composition is prepared to remove weeds by mixing in a container with agitation: 72% Glyphosate; 15% of at least one amino acid or a mixture of some or all amino acids; 8% of a diluent and 5% of a surfactant, until complete homogenization, weighing and packaging. It can be applied by sprinkling, atomization or direct application to weeds. With doses of 0.5 to 12L per hectare with an average efficiency of 95% to 100% in a period of 2 to 5 days.

Example 2

An improved synergistic composition is prepared to remove weeds comprising Glyphosate, at least one amino acid or a mixture of some or all amino acids, at a concentration of 1 to 10OOppm of active components, preferably 45 to 600ppm of active components, with doses of 0.5 to 12L per hectare with an average efficiency of 95% to 100% over a period of 2 to 5 days.

Example 3

The following example shows the efficacy of treatment with three compositions, a composition only with glyphosate, a composition of glyphosate with amino acids and only water.

 The following table shows the effects at 1 and 5 days after the application of the compositions.

 Advantages

 1. - The mixture of amino acids in the composition makes it highly effective since it permeabilizes the cell membrane of the plants allowing greater absorption and transport of glyphosate to their roots, increasing the effectiveness of glyphosate and helping to reduce its resistance to active substance due to faster and more intense exposure to glyphosate.

 2. - The composition is used to control any type of weeds, especially Cyperus rotundus

L., Cynodon dactylon (L.) Pers, Echinochloa crus-galli (L.) P. Beauv, Echinochloa hill (L.) Link, Eleusine indica (L.) Gaerth, Sorghum halepense (L.) Pers, Imperaba cylindrical (L.) Raeuschel, Eichhornia crassipes (Mart.) Solms, Portulaca oleraceae L., Chenopodium album L., Digitaria sanguinalis (L.) _f Scop, Convolvulus arvensis L., Avena fatua L. and related species, Amaranthus hybridus L., Amaranthus spinosus L., Cyperus esculentus L., Paspalum conjugatum Berg, Rottloellia cochinchinensis (Lour.) WD Clayton, Ipomoea dissecta, Amaranthus albus, Raphanus raphanistru, Sicyos angulata, Encelia mexicana, Helianthus annus, Malva moschata _f Datada stramonium, Ixophorusunis etus, Cynodon niemfuensis, Amaranthus retoflexus, Chenopodium albus. Malva parviflora.

 3.- The composition can be applied by mixing all the components inside the container, bottle or container of the applicator or apply each of the components separately by performing the mixture directly in the field.

Claims

Claims "Having described the invention as above, the contents of the following Claims are claimed as property." 1. An improved synergistic composition for the control and / or removal of weeds characterized in that it comprises: a) 20% to 72% glyphosate;  b) 15% to 67% amino acids of at least one amino acid or a mixture of some or all essential amino acids;  c) 8% of a diluent; Y  d) 5% of a surfactant.  All this must add up to 100%. 2. A composition according to claim 1, characterized in that the amino acid mixture it contains may contain: a) 1% to 5% aspartic acid,  b) 0.01% up to 0.5% Threonine,  c) 0.01% up to 5% Serine,  d) 1% up to 10% Glutamic Acid,  e) 12% up to 20% Glycine,  f) 1% to 10% of Alanine,  g) 0.01% up to 0.5% Cysteine,  h) 0.1% up to 5% Valine, i) 0.1% up to 2% Methionine, j) 0.1% up to 2% Isoleucine,  k) 1% up to 5% Leucine,  1) 0.1% up to 2% Tyrosine,  m) 0.1% up to 2% Phenylalanine,  n) 0.01% up to 0.5% Histidine,  o) 1% up to 10% Lysine,  p) 0.1% up to 0.5% Arginine and  q) 1% to 10% Proline. 3. A composition according to claim 1, characterized in that the% corresponds to the percentage by weight. 4. A composition according to claim 1, characterized in that the diluent is selected from water or inert diluents. 5. A composition according to claim 1, characterized in that the surfactant is selected from a diethylene glycol, polyoxyethylene alcohol, polyoxyethylene alkylphenol, polyethylene glycol and / or mixtures thereof. 6. A composition according to claim 1, characterized in that it is used for the control and / or removal of any type of weed especially Cyperus rotundus L. , Cynodon dactylon (L.) Pers, Echinochloa crus-galli (L.) P. Beauv, Echinochloa hill (L.) Link, Eleusine indica (L.) Gaerth, Sorghum halepense (L.) Pers, Impered cylindrical (L. ) Raeuschel, Eichhornia crassipes (Mart.) Solrns, Portulaca oleraceae L., Chenopodium album L. , Digitaria sanguinalis (L.), Scop, Cor / voii / uius arvensis L. , Avena fatua L. and related species, Amaranthus hybridus L., Amaranthus spinosus L., Cyperus esculentus L., Paspalum conjugatum Berg, Rottloellia cochinchinensis (Lour.) WD Clayton _r Ipomoea dissecta, Amaranthus albus, Raphanus raphanistrum, Sicyos angulata, Encelia Mexican, Helianthus annus, Malva moschata, Datada stramonium, Ixophorusunis etus, Cynodon niemfuensis _r Amaranthus retoflexus, Chenopodium albus, Malva parviflora. 7. A composition according to claim 1, characterized in that the mixture of amino acids permeabilizes the cell membrane of plants allowing greater absorption and has a powerful transporting and chelating effect, which acts in the mobilization and transport of glyphosate to the root of the same, reducing resistance to glyphosate by Better and more efficient exposure to the active substance. 8. A composition according to claim 1, characterized in that it can be applied by mixing all the components inside the container, bottle or container of the applicator or apply each of the components separately by mixing directly in the field. 9. A composition according to claim 1, characterized in that it can be applied at a concentration of 1 to 1000 ppm of active components, preferably 45 to 600 ppm of active components, with doses of 0.5 to 12 L per hectare with an efficiency 95% to 100% average over a period of 2 to 5 days.