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WO2015138186A3 - Methods and compositions for treating anthracycline-induced cardiomyopathy using neurokinin-1 receptor antagonists - Google Patents

Methods and compositions for treating anthracycline-induced cardiomyopathy using neurokinin-1 receptor antagonists Download PDF

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Publication number
WO2015138186A3
WO2015138186A3 PCT/US2015/018401 US2015018401W WO2015138186A3 WO 2015138186 A3 WO2015138186 A3 WO 2015138186A3 US 2015018401 W US2015018401 W US 2015018401W WO 2015138186 A3 WO2015138186 A3 WO 2015138186A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurokinin
compositions
receptor antagonists
methods
induced cardiomyopathy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/018401
Other languages
French (fr)
Other versions
WO2015138186A2 (en
Inventor
Giselle C. MELENDEZ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wake Forest University Health Sciences
Original Assignee
Wake Forest University Health Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wake Forest University Health Sciences filed Critical Wake Forest University Health Sciences
Publication of WO2015138186A2 publication Critical patent/WO2015138186A2/en
Publication of WO2015138186A3 publication Critical patent/WO2015138186A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The presently disclosed subject matter provides methods and compositions for the treatment of anthracycline-induced cardiomyopathy, particularly doxorubicin- induced cardiomyopathy, using neurokinin-1 (NK-1) receptor antagonists.
PCT/US2015/018401 2014-03-12 2015-03-03 Methods and compositions for treating anthracycline-induced cardiomyopathy using neurokinin-1 receptor antagonists Ceased WO2015138186A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461951605P 2014-03-12 2014-03-12
US61/951,605 2014-03-12

Publications (2)

Publication Number Publication Date
WO2015138186A2 WO2015138186A2 (en) 2015-09-17
WO2015138186A3 true WO2015138186A3 (en) 2015-12-10

Family

ID=54072567

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/018401 Ceased WO2015138186A2 (en) 2014-03-12 2015-03-03 Methods and compositions for treating anthracycline-induced cardiomyopathy using neurokinin-1 receptor antagonists

Country Status (1)

Country Link
WO (1) WO2015138186A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117159571A (en) * 2016-02-04 2023-12-05 Sct二代有限责任公司 Pharmaceutical compositions and uses for combating anthracycline-induced cardiotoxicity
CN116687990A (en) * 2023-07-06 2023-09-05 北京中医药大学 New use of herba Cichorii extract for preventing and treating cardiotoxicity caused by doxorubicin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252714A1 (en) * 2003-01-17 2006-11-09 Berger Stuart A Pharmaceutical compositions and methods for treating multidrug resistant cancer
US20140057861A1 (en) * 2012-08-21 2014-02-27 Genesys Research Institute Compositions and methods for treating or preventing anthracycline induced cardiotoxicity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060252714A1 (en) * 2003-01-17 2006-11-09 Berger Stuart A Pharmaceutical compositions and methods for treating multidrug resistant cancer
US20140057861A1 (en) * 2012-08-21 2014-02-27 Genesys Research Institute Compositions and methods for treating or preventing anthracycline induced cardiotoxicity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MELENDEZ ET AL.: "Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells.", CARDIOVASC RES., vol. 92, no. 3., 1 December 2011 (2011-12-01), pages 420 - 429, XP055103403, ISSN: 0008-6363 *
VO ET AL.: "Cardiovascular events in cancer patients treated with highly or moderately emetogenic chemotherapy: Results from a population-based study.", J CANCER EPIDEMIOL., vol. 21, no. 8, 2012, pages 946 - 12, XP055238887, ISSN: 1687-8558 *

Also Published As

Publication number Publication date
WO2015138186A2 (en) 2015-09-17

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