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WO2015130840A3 - Treatment of resistant lesions - Google Patents

Treatment of resistant lesions Download PDF

Info

Publication number
WO2015130840A3
WO2015130840A3 PCT/US2015/017595 US2015017595W WO2015130840A3 WO 2015130840 A3 WO2015130840 A3 WO 2015130840A3 US 2015017595 W US2015017595 W US 2015017595W WO 2015130840 A3 WO2015130840 A3 WO 2015130840A3
Authority
WO
WIPO (PCT)
Prior art keywords
lesions
treatment
resistant
resistant lesions
healing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/017595
Other languages
French (fr)
Other versions
WO2015130840A2 (en
Inventor
Anthony Phillips
Scott BANNAN
Grove MATSUOKA
Bradford DUFT
David EISENBUD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inflammx Therapeutics Inc
Original Assignee
CoDa Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CoDa Therapeutics Inc filed Critical CoDa Therapeutics Inc
Priority to CA2940648A priority Critical patent/CA2940648A1/en
Priority to EP15755058.3A priority patent/EP3110455A4/en
Publication of WO2015130840A2 publication Critical patent/WO2015130840A2/en
Publication of WO2015130840A3 publication Critical patent/WO2015130840A3/en
Priority to US15/247,853 priority patent/US20170056468A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Connexin protein modulation methods and compositions are provided for the healing of resistant lesions, including lesions on subjects with multiple venous leg ulcers or multiple diabetic foot ulcers, and other responder subjects. Also provided are kits and articles of manufacture comprising a connexin protein modulating agent, for example, a connexin 43 modulating agent for use in the healing of resistant lesions.
PCT/US2015/017595 2014-02-25 2015-02-25 Treatment of resistant lesions Ceased WO2015130840A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2940648A CA2940648A1 (en) 2014-02-25 2015-02-25 Treatment of resistant lesions
EP15755058.3A EP3110455A4 (en) 2014-02-25 2015-02-25 Treatment of resistant lesions
US15/247,853 US20170056468A1 (en) 2014-02-25 2016-08-25 Treatment of resistant lesions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461944566P 2014-02-25 2014-02-25
US61/944,566 2014-02-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/020786 Continuation-In-Part WO2015139047A2 (en) 2014-02-25 2015-03-16 Treatment of resistant lesions

Publications (2)

Publication Number Publication Date
WO2015130840A2 WO2015130840A2 (en) 2015-09-03
WO2015130840A3 true WO2015130840A3 (en) 2015-11-05

Family

ID=54009775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/017595 Ceased WO2015130840A2 (en) 2014-02-25 2015-02-25 Treatment of resistant lesions

Country Status (3)

Country Link
EP (1) EP3110455A4 (en)
CA (1) CA2940648A1 (en)
WO (1) WO2015130840A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12054724B2 (en) 2018-04-10 2024-08-06 President And Fellows Of Harvard College AAV vectors encoding clarin-1 or GJB2 and uses thereof
AU2020357740A1 (en) * 2019-09-30 2022-04-28 Eli Lilly And Company Adeno-associated virus (AAV) systems for treatment of genetic hearing loss
US12129287B2 (en) 2020-09-14 2024-10-29 President And Fellows Of Harvard College Recombinant adeno associated virus encoding clarin-1 and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100279921A1 (en) * 2007-12-11 2010-11-04 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments
US20130079388A1 (en) * 1999-01-27 2013-03-28 Coda Therapeutics, Inc. Formulations comprising antisense nucleotides to connexins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156896B2 (en) * 2013-03-15 2015-10-13 Coda Therapeutics, Inc. Wound healing compositions and treatments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130079388A1 (en) * 1999-01-27 2013-03-28 Coda Therapeutics, Inc. Formulations comprising antisense nucleotides to connexins
US20100279921A1 (en) * 2007-12-11 2010-11-04 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ARNOLD, S ET AL.: "Prospective, Multicenter Study Of Managing Lower Extremity Venous Ulcers", ANNALS OF VASCULAR SURGERY, vol. 8, no. 4, July 1994 (1994-07-01), pages 356 - 362, XP005940154, [retrieved on 20150602], DOI: doi:10.1007/BF02132997 *
BRYANT, R.: "Acute & Chronic Wounds; Current Management Concepts: Chapter 4: Hound Healing Physiology", REFERENCE & RESEARCH BOOK NEWS ., 2011, XP008184658, [retrieved on 20150602] *
HINES, JR., MD , EA .: "The Differential Diagnosis Of Chronic Ulcer Of The Leg.", CIRCULATION, vol. 27, no. 5, May 1963 (1963-05-01), pages 989 - 996, XP055234982, ISSN: 0009-7322, [retrieved on 20150602] *
MOSTOW, E ET AL.: "Effectiveness Of An Extracellular Matrix Graft (OASIS Wound Matrix) In The Treatment Of Chronic Leg Ulcers: A Randomized Clinical Trial.", JOURNAL OF VASCULAR SURGERY, vol. 41, no. 5, 2005, pages 837 - 843, XP004916563, ISSN: 0741-5214, [retrieved on 20150602] *
See also references of EP3110455A4 *
SHEEHAN, P ET AL.: "Percent Change In Wound Area Of Diabetic Foot Ulcers Over A 4-Week Period Is A Robust Predictor Of Complete Healing In A 12-Week Prospective Trial", DIABETES CARE, vol. 26, no. 6, 2003, pages 1879 - 1882, XP055234978, [retrieved on 20150602] *
SUSSMAN ET AL.: "Wound Care: A Collaborative Practice Manual For Health Professionals", WOUND MEASUREMENT AND PREDICTION OF HEALING, 2012, Philadelphia, XP008184648, [retrieved on 20150602] *

Also Published As

Publication number Publication date
CA2940648A1 (en) 2015-09-03
WO2015130840A2 (en) 2015-09-03
EP3110455A4 (en) 2017-10-11
EP3110455A2 (en) 2017-01-04

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