[go: up one dir, main page]

WO2015120372A3 - Compositions et méthodes d'inhibition de ezh2 pour traiter des maladies cardiovasculaires - Google Patents

Compositions et méthodes d'inhibition de ezh2 pour traiter des maladies cardiovasculaires Download PDF

Info

Publication number
WO2015120372A3
WO2015120372A3 PCT/US2015/014989 US2015014989W WO2015120372A3 WO 2015120372 A3 WO2015120372 A3 WO 2015120372A3 US 2015014989 W US2015014989 W US 2015014989W WO 2015120372 A3 WO2015120372 A3 WO 2015120372A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
treatment
cardiovascular diseases
inhibit ezh2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/014989
Other languages
English (en)
Other versions
WO2015120372A2 (fr
Inventor
Zheng-Gen Jin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Rochester
Original Assignee
University of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Rochester filed Critical University of Rochester
Priority to US15/114,947 priority Critical patent/US20160340674A1/en
Publication of WO2015120372A2 publication Critical patent/WO2015120372A2/fr
Publication of WO2015120372A3 publication Critical patent/WO2015120372A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des compositions et des méthodes pour traiter et/ou prévenir une maladie cardiovasculaire. Dans un mode de réalisation, cette invention concerne des compositions et des méthodes permettant de réduire le niveau de EZH2 et/ou sa production et/ou son activité.
PCT/US2015/014989 2014-02-10 2015-02-09 Compositions et méthodes d'inhibition de ezh2 pour traiter des maladies cardiovasculaires Ceased WO2015120372A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/114,947 US20160340674A1 (en) 2014-02-10 2015-02-09 Compositions and Methods to Inhibit EZH2 for the Treatment of Cardiovascular Diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461937672P 2014-02-10 2014-02-10
US61/937,672 2014-02-10

Publications (2)

Publication Number Publication Date
WO2015120372A2 WO2015120372A2 (fr) 2015-08-13
WO2015120372A3 true WO2015120372A3 (fr) 2015-11-05

Family

ID=53778617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/014989 Ceased WO2015120372A2 (fr) 2014-02-10 2015-02-09 Compositions et méthodes d'inhibition de ezh2 pour traiter des maladies cardiovasculaires

Country Status (2)

Country Link
US (1) US20160340674A1 (fr)
WO (1) WO2015120372A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017201585A1 (fr) * 2016-05-26 2017-11-30 Genea Ip Holdings Pty Ltd Modulateurs de dux4 pour la régulation de la fonction musculaire
KR101916652B1 (ko) * 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018013929A1 (fr) 2016-07-15 2018-01-18 Tufts Medical Center Composés et méthodes pour améliorer la fonction du système immunitaire.
CA3044691A1 (fr) 2016-10-26 2018-05-03 Genea Biocells USA (Holdings), Inc. Generation amelioree de cellules de lignee musculaire et leurs utilisations therapeutiques
WO2019115472A1 (fr) * 2017-12-11 2019-06-20 Fondazione Istituto Firc Di Oncologia Molecolare (Ifom) Inhibiteurs de polycomb et leurs utilisations
WO2019150309A1 (fr) * 2018-02-02 2019-08-08 Hammack Scott Modulateurs de gpr68 et leurs utilisations pour le traitement et la prévention de maladies
WO2019161364A1 (fr) * 2018-02-19 2019-08-22 The General Hospital Corporation Méthodes et compositions pour le traitement d'une maladie vasculaire
KR102810863B1 (ko) * 2018-06-03 2025-05-20 엑셀시오 파마테크 랩스 비-밀집 심근증 치료 방법
AU2019409868A1 (en) * 2018-12-21 2021-07-08 The Walter And Eliza Hall Institute Of Medical Research Methods of treating inflammation
CN114028397A (zh) * 2021-02-01 2022-02-11 徐州医科大学 Gsk126作为ezh2抑制剂在制备预防和/或治疗缺血性脑卒中药物中的应用
US20240350508A1 (en) * 2021-08-25 2024-10-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of ezh2 inhibitors for the treatment of aortic valve stenosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110286990A1 (en) * 2008-10-31 2011-11-24 University Of Rochester Methods of diagnosing and treating fibrosis
US20130345200A1 (en) * 2010-05-07 2013-12-26 Glaxosmithkline Llc Indoles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140095073A (ko) * 2011-11-04 2014-07-31 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 치료 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110286990A1 (en) * 2008-10-31 2011-11-24 University Of Rochester Methods of diagnosing and treating fibrosis
US20130345200A1 (en) * 2010-05-07 2013-12-26 Glaxosmithkline Llc Indoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DRGER ET AL.: "The expression of the inducible nitric oxide synthase is epigenetically suppressed by the histone methyltransferase enhancer of zeste homolog 2 in human endothelial cells", ESC CONGRESS, vol. 365, 2013, XP055234491, Retrieved from the Internet <URL:http://congress365.escardio.org/Session/11234> [retrieved on 20150321] *

Also Published As

Publication number Publication date
WO2015120372A2 (fr) 2015-08-13
US20160340674A1 (en) 2016-11-24

Similar Documents

Publication Publication Date Title
WO2015120372A3 (fr) Compositions et méthodes d&#39;inhibition de ezh2 pour traiter des maladies cardiovasculaires
IL264049A (en) Compounds, preparations and methods for treating the disease
WO2015148863A3 (fr) Méthodes liées à crispr/cas et compositions pour le traitement de la drépanocytose
WO2015073587A3 (fr) Complexes membrane synthétique- récepteur
WO2016066744A3 (fr) Composés agonistes de gip et procédés associés
WO2016011222A3 (fr) Polynucléotides circulaires
IL264156A (en) Compounds, preparations and methods for treating the disease
WO2017095944A8 (fr) Procédés et compositions se rapportant à des chondrisomes provenant de produits sanguins
WO2015168532A3 (fr) Compositions et procédés de modulation de l&#39;expression de pkk
WO2015077503A8 (fr) Composés inhibiteurs de l&#39;autotaxine
WO2016011306A3 (fr) Modifications de terminal de polynucléotides
EP3675859A4 (fr) Composés, compositions et méthodes pour le traitement d&#39;une maladie
WO2016105525A3 (fr) Nouvelles pyrimidines en tant qu&#39;inhibiteurs d&#39;egfr et procédés de traitement de troubles
WO2015200790A3 (fr) Compositions et procédés pour réguler la rénalase dans le traitement de certaines maladies et de certains troubles
WO2016077639A3 (fr) Thérapies nanovésiculaires
EP3182989A4 (fr) Méthodes et compositions destinées à prévenir et à traiter une maladie
EP3102220C0 (fr) Compositions de complément alimentaire synergique pour la prévention, le traitement ou la régulation de troubles inflammatoires
HK1251566A1 (zh) 作为hdac1/2抑制剂的呱啶衍生物
HK1259441A1 (zh) 包含btk抑制剂的制剂/组合物
WO2015143447A3 (fr) Méthodes de traitement de troubles neurologiques
WO2016004413A3 (fr) Inhibiteurs de la gls1 pour le traitement de maladies
MX2019000677A (es) Células miméticas de células b.
MY178971A (en) Triaminopyrimidine compounds useful for preventing or treating malaria
PH12017500563A1 (en) Stabilized adrenomedullin derivatives and use thereof
PH12016501326A1 (en) (s)-3&#39;-methyl-abscisic acid and esters thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15746759

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 15114947

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 15746759

Country of ref document: EP

Kind code of ref document: A2