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WO2015120220A1 - Systèmes pour traiter les microbulles sur des dispositifs médicaux comportant des bobines, et produits ainsi obtenus - Google Patents

Systèmes pour traiter les microbulles sur des dispositifs médicaux comportant des bobines, et produits ainsi obtenus Download PDF

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Publication number
WO2015120220A1
WO2015120220A1 PCT/US2015/014738 US2015014738W WO2015120220A1 WO 2015120220 A1 WO2015120220 A1 WO 2015120220A1 US 2015014738 W US2015014738 W US 2015014738W WO 2015120220 A1 WO2015120220 A1 WO 2015120220A1
Authority
WO
WIPO (PCT)
Prior art keywords
coils
micro
wettability
medical devices
post
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/014738
Other languages
English (en)
Inventor
Erik T. Engelson
David Ferrera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Blockade Medical LLC
Original Assignee
Blockade Medical LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blockade Medical LLC filed Critical Blockade Medical LLC
Publication of WO2015120220A1 publication Critical patent/WO2015120220A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214—Coils or wires
    • A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00526—Methods of manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00831—Material properties

Definitions

  • the field of the invention generally relates to medical devices for the treatment of vascular abnormalities.
  • the instant disclosure embraces apparatus that placed within the vasculature, including the brains of mammals, and ways to make such devices safer.
  • Detachable #479 Platinum alloy micro-coils have found broad utility in the endovascular closure of cerebral aneurysms. Aneurysms are packed with micro-coils to slow blood flow within the aneurysms, to encourage tissue ingrowth into the micro-coil matrix, and ultimately to stabilize the aneurysm against rupture. Some manufacturers utilize an electrolytically-detachable, stainless steel linkage between the microcoil and the delivery wire.
  • Sterile micro-coils are packaged in a dry state, and are hydrated with sterile saline prior to delivery into the body.
  • the ability to fully hydrate (exclude all air) from the micro-coil is a function of the wettability of the micro-coil surface, among other factors. Introduction of tiny air bubbles into the vasculature of the body is undesirable. Therefore, it is a goal to minimize the number of air bubbles that might be trapped within the micro-coil, or any related medical device, system, or apparatus having such risks.
  • a process for treating medical devices comprising, in combination; at least a post-manufacture, prepackaging surface treatment to increase wettability of the device surface.
  • a process for treating medical devices wherein said medical device is a metallic coil wound from wire having a circular cross-section and further comprising a platinum alloy.
  • the platinum alloy comprises about 8% tungsten.
  • an improved system to mitigate bubble formation in and on micro-coils comprising, in combination; providing a means for increasing the wettability of the surfaces of said micro-coils.
  • an improved system to mitigate bubble formation in and on micro-coils comprising, in combination; providing a means for increasing the wettability of the surfaces of said micro-coils, the means being a plasma treatment step.
  • a post-assembly, prepackaging and sterilization plasma treatment step applied to micro-coils and delivery wire assemblies which improves cleanliness and wettability of said devices in-situ.
  • a post-assembly, prepackaging and sterilization plasma treatment step applied to medical devices other than micro-coils and delivery wire assemblies.
  • medical devices include intravascular stents.
  • Cerebrovascular embolization may be accomplished through the transcatheter deployment of one or several embolizing agents in an amount sufficient to halt internal blood flow at a desired location within a blood vessel.
  • embolic agents Several types have been approved for neurovascular indications including glues, liquid embolics, occlusion balloons, occlusion plugs, platinum and stainless steel micro-coils (with and without attached fibers), and polyvinyl alcohol particles.
  • Micro-coils are the most commonly employed device for embolization of neurovascular lesions, with micro-coiling techniques employed in the majority of procedures involving cerebral aneurysms and for many cases involving permanent vessel sacrifice/occlusion.
  • Neurovascular stents are also sometimes utilized for cerebral aneurysm treatment. Other devices such as flow diversion implants or flow disruptor implants are used in certain types of aneurysms.
  • vascular abnormalities may benefit from treatment with delivery of vascular implants.
  • Aortic aneurysms are commonly treated with stent grafts.
  • a variety of stents are used for the treatment of atherosclerotic, and other diseases of the vessels of the body. Little progress has been made with respect to increased wettability and improved cleanliness of the stainless steel detachment zones for microcoils. This longstanding need is addressed in the present inventions.
  • the present inventor has discovered that increases to the wettability of medical devices, particularly those used to address cerebral aneurysms, has dual positive impacts, namely to minimize unwanted introduction of air bubbles into the vasculature and to likewise improve the efficiency and consistency of electrolytic detachment.
  • each physical element disclosed should be understood to encompass a disclosure of the action which that physical element facilitates.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Neurosurgery (AREA)
  • Surgical Instruments (AREA)

Abstract

L'augmentation de la mouillabilité de surfaces de dispositifs médicaux intravasculaires réduit les bulles d'air éventuellement introduites et libérées dans le système vasculaire, et améliore également la régularité et l'efficacité du détachement électrolytique, en particulier avec les micro-bobines utilisées pour traiter les anévrismes cérébraux.
PCT/US2015/014738 2014-02-07 2015-02-06 Systèmes pour traiter les microbulles sur des dispositifs médicaux comportant des bobines, et produits ainsi obtenus Ceased WO2015120220A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461937314P 2014-02-07 2014-02-07
US61/937,314 2014-02-07

Publications (1)

Publication Number Publication Date
WO2015120220A1 true WO2015120220A1 (fr) 2015-08-13

Family

ID=53778466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/014738 Ceased WO2015120220A1 (fr) 2014-02-07 2015-02-06 Systèmes pour traiter les microbulles sur des dispositifs médicaux comportant des bobines, et produits ainsi obtenus

Country Status (1)

Country Link
WO (1) WO2015120220A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080142038A1 (en) * 2006-12-15 2008-06-19 Bausch & Lomb Incorporated Surface treatment of medical devices
US20110060402A1 (en) * 2006-04-28 2011-03-10 Medtronic, Inc. Wettable ePTFE Medical Devices
US8202292B2 (en) * 2008-10-13 2012-06-19 Stryker Corporation Vaso-occlusive coil delivery system
WO2013006298A2 (fr) * 2011-07-07 2013-01-10 The Regents Of The University Of California Revêtement en serpentin spiralé bioactif

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110060402A1 (en) * 2006-04-28 2011-03-10 Medtronic, Inc. Wettable ePTFE Medical Devices
US20080142038A1 (en) * 2006-12-15 2008-06-19 Bausch & Lomb Incorporated Surface treatment of medical devices
US8202292B2 (en) * 2008-10-13 2012-06-19 Stryker Corporation Vaso-occlusive coil delivery system
WO2013006298A2 (fr) * 2011-07-07 2013-01-10 The Regents Of The University Of California Revêtement en serpentin spiralé bioactif

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