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WO2015114655A3 - Modified release tablet of pregabalin - Google Patents

Modified release tablet of pregabalin Download PDF

Info

Publication number
WO2015114655A3
WO2015114655A3 PCT/IN2015/000032 IN2015000032W WO2015114655A3 WO 2015114655 A3 WO2015114655 A3 WO 2015114655A3 IN 2015000032 W IN2015000032 W IN 2015000032W WO 2015114655 A3 WO2015114655 A3 WO 2015114655A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified release
release tablet
pregabalin
stomach
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/000032
Other languages
French (fr)
Other versions
WO2015114655A2 (en
Inventor
Nilesh Patel
Umesh Setty
Ashish Sehgal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intas Pharmaceuticals Ltd
Original Assignee
Intas Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intas Pharmaceuticals Ltd filed Critical Intas Pharmaceuticals Ltd
Publication of WO2015114655A2 publication Critical patent/WO2015114655A2/en
Publication of WO2015114655A3 publication Critical patent/WO2015114655A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to a modified release tablet comprising pregabalin with at least one low-density excipient, at least one swelling agent and at least one gelling agent, wherein the modified release tablet substantially maintains its hydrodynamic balance and physical integrity for the time period during which the drug is released into the stomach.
PCT/IN2015/000032 2014-01-21 2015-01-20 Modified release tablet of pregabalin Ceased WO2015114655A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN198/MUM/2014 2014-01-21
IN198MU2014 IN2014MU00198A (en) 2014-01-21 2015-01-20

Publications (2)

Publication Number Publication Date
WO2015114655A2 WO2015114655A2 (en) 2015-08-06
WO2015114655A3 true WO2015114655A3 (en) 2016-01-28

Family

ID=53757862

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000032 Ceased WO2015114655A2 (en) 2014-01-21 2015-01-20 Modified release tablet of pregabalin

Country Status (2)

Country Link
IN (1) IN2014MU00198A (en)
WO (1) WO2015114655A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106606495A (en) * 2015-10-27 2017-05-03 四川海思科制药有限公司 Pregabalin sustained-release tablet medicinal composition and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070269511A1 (en) * 2005-11-02 2007-11-22 Warner-Lambert Company Llc Solid pharmaceutical compositions containing pregabalin
US20100255067A1 (en) * 2007-11-23 2010-10-07 Lupin Limited Controlled Release Pharmaceutical Compositions of Pregabalin
WO2012035559A2 (en) * 2010-09-17 2012-03-22 Panacea Biotec Ltd Sustained release pharmaceutical compositions comprising pregabalin
US20130149253A1 (en) * 2010-08-03 2013-06-13 Dominique Meergans Oral dosage form of pregabalin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070269511A1 (en) * 2005-11-02 2007-11-22 Warner-Lambert Company Llc Solid pharmaceutical compositions containing pregabalin
US20100255067A1 (en) * 2007-11-23 2010-10-07 Lupin Limited Controlled Release Pharmaceutical Compositions of Pregabalin
US20130149253A1 (en) * 2010-08-03 2013-06-13 Dominique Meergans Oral dosage form of pregabalin
WO2012035559A2 (en) * 2010-09-17 2012-03-22 Panacea Biotec Ltd Sustained release pharmaceutical compositions comprising pregabalin

Also Published As

Publication number Publication date
IN2014MU00198A (en) 2015-08-28
WO2015114655A2 (en) 2015-08-06

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