[go: up one dir, main page]

WO2015106378A1 - Microsonde mems médicale multifonctionnelle - Google Patents

Microsonde mems médicale multifonctionnelle Download PDF

Info

Publication number
WO2015106378A1
WO2015106378A1 PCT/CN2014/070554 CN2014070554W WO2015106378A1 WO 2015106378 A1 WO2015106378 A1 WO 2015106378A1 CN 2014070554 W CN2014070554 W CN 2014070554W WO 2015106378 A1 WO2015106378 A1 WO 2015106378A1
Authority
WO
WIPO (PCT)
Prior art keywords
microprobe
laser
probe
multifunctional medical
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2014/070554
Other languages
English (en)
Chinese (zh)
Inventor
刘胜
徐涌
戴宜全
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WUXI WISDOM TECHNOLOGY CO Ltd
Wuhan Finemems Inc
Original Assignee
WUXI WISDOM TECHNOLOGY CO Ltd
Wuhan Finemems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by WUXI WISDOM TECHNOLOGY CO Ltd, Wuhan Finemems Inc filed Critical WUXI WISDOM TECHNOLOGY CO Ltd
Priority to PCT/CN2014/070554 priority Critical patent/WO2015106378A1/fr
Publication of WO2015106378A1 publication Critical patent/WO2015106378A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0534—Electrodes for deep brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes

Definitions

  • the invention relates to a medical micro-probe with multiple functions, which is mainly used for clinical diagnosis and neuroprosthetic support interconnection, and can also be used for neural signal feedback control research. Background technique
  • the present invention aims to provide a microprobe as a research platform, incorporating transdermal drug delivery, microelectrodes for shock stimulation and brain reaction potential signal collection, spectral efficacy tracking, tip pressure and stress strain measurement, etc. Technology, supporting the scientific quantitative research of acupuncture. Summary of the invention
  • a multifunctional medical MEMS microprobe is characterized in that an optical fiber and a micro flow tube are arranged inside the hollow needle tube, and a micro electrode and a micro flow tube outlet are formed on the side of the needle tip, and a flexible interconnection line and a control chip are arranged at the tail of the probe. Or the neuroprosthetic control system is interconnected while the fiber is connected to the fiber optic coupler at the tail.
  • the hollow needle tube may be used singly or in an array, and the material may be silicon or silicon dioxide, metal, or polymer.
  • the optical fiber is placed inside the hollow needle tube, and the front end is cemented with the front end of the needle, and is sharpened together to serve as a laser exit port.
  • the microfluidic tube is placed inside the needle tube for drug delivery, wherein a plurality of drug outlets are formed on the side of the needle tip, and a small amount of sustained release agent may also be stored at the outflow port.
  • the microelectrode is fixed to the outer side of the front end of the needle, and may be one or more for contacting a neuron to achieve nerve stimulation or sensing a nerve pulse signal, and may also be used to form an electric field at a local cell site for electrical breakdown.
  • the fiber coupler can be compatible with a single fiber single-wavelength laser access or a plurality of lasers with different wavelengths of laser input to realize laser input to the probe.
  • the light source may be a femtosecond laser, a picosecond laser, an infrared laser, a krypton laser or the like according to application requirements.
  • a phase retarder can be added before the laser coupler is connected to modulate the appropriate stimulated Raman input light or diagnostic light to achieve spectral focusing.
  • microprobe of the invention has important application value in transdermal administration, microelectrode and the like:
  • the main problems of oral administration are the degradation of the gastrointestinal tract and the first-pass effect of the liver.
  • Intravenous injection has a painful effect and requires medical personnel to operate.
  • Micro-probe arrays assisted transdermal administration can significantly increase the transdermal rate and absorption of macromolecular drugs, enabling efficient and painless administration.
  • the probe of the present invention has the functions of spectrum analysis of infrared spectrum or Raman spectrum, and the spectrum of the diseased cells and normal cells. The difference can identify the location of the lesion and the treatment of the lesion.
  • laser acupuncture can also be used with different lasers.
  • the micro-neural electrode at the front end of the micro-probe can extract neural signals and provide a control communication platform for the disabled, such as Parkinson's, epilepsy, blind people, etc., which is the key to study the human neural feedback signal and connect the intelligent prosthesis. bridge.
  • cell membrane lipid opening that is, electroporation
  • Raman spectroscopy is particularly effective for identifying cancer cells, and simultaneously binds to probe microtubules.
  • Drug macromolecules are electroporated in cells. In this case, it is easy to enter the interior of the cell, thereby achieving a combination of chemotherapy and electroporation therapy to improve the efficiency of treating cancer and to achieve local treatment.
  • the invention provides a novel neural probe and probe array.
  • the invention can be fabricated by an existing MEMS process such as electrochemical etching, and has low cost, high precision, longer probe and more assembly.
  • the electrodes are subjected to electric shock and feedback to form a three-dimensional electrode array having three-dimensional spatial resolution capability, and at the same time, a micro-flow tube drug delivery function is realized.
  • the experiments that have been completed show that the probe made based on the present invention succeeds when the mouse is in an artificial noise environment.
  • the pulse response potential signals of the two auditory neurons in the brain of the mouse were collected, as shown in Fig. 1 and 2. As can be seen from the figure, the probe has sufficient sensitivity to distinguish different neuronal response signals.
  • the invention has the beneficial effects that the probe of the invention can combine diagnosis, pathogenic spectrum identification, therapeutic effect monitoring, neural pulse communication and various treatment means, and can be applied to different applications. It is especially suitable for transdermal drug delivery, nerve pulse signal acquisition and shock input, neuroprosthetic interconnection, pathogen cell spectrum analysis and identification, and electrical breakdown therapy.
  • Fig.1 Pulse response potential signal of two auditory neurons in the brain of mice
  • Figure 3 is a schematic view of the structure of the present invention.
  • a multifunctional medical MEMS microprobe As shown in Fig. 1, a multifunctional medical MEMS microprobe, the microprobe tube 5 and the inner fiber 1 are cemented together and sharpened to obtain a microprobe tip.
  • the microelectrode 2 and the microfluidic tube outlet 3 are formed on the outer wall of the front end of the probe, wherein the electrode signal is led out through the gold plating wire in the outer wall groove of the needle tube for external control chip or intelligent prosthesis control system (not shown), and the electrode is
  • the application needs to be used as a neuron stimulation interconnect or to create a breakdown electric field at the local cells; the microfluidic tube outlet is used to contact the medicament in the microfluidic tube 4 or the sustained release medicament pre-existing in the orifice with the affected area.
  • the laser coupler 6 can meet the laser access of different wavelengths, wherein the laser can be a femtosecond laser, a picosecond laser, an infrared laser, a holmium laser, etc., and the selection is determined by the actual medical application.
  • Raman spectroscopy is used to identify diseased tissue, two different wavelengths of laser light can be coupled into the probe fiber, and one of the lasers can be first connected to the phase retarder before coupling, and the phase retarder can be adjusted in the probe.
  • the wavelength of the input light required for stimulated Raman scattering is generated in the fiber to achieve spectral focusing to improve spectral resolution.
  • the probe can be used for the collection of the optical signal generated by the excitation.
  • an avalanche diode, a photoelectric imaging probe, and the like are connected after the laser coupler, so that the space congestion caused by the accessories such as the lens can be greatly avoided.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Surgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Radiation-Therapy Devices (AREA)
  • Finger-Pressure Massage (AREA)

Abstract

La présente invention concerne une microsonde MEMS médicale multifonctionnelle, la microsonde étant en forme de tube creux ; l'aiguille creuse (5) comprenant, agencés dans celle-ci, une fibre optique (1), un tube microfluidique (4), et des micro-électrodes (2) et des sorties de tube microfluidique (3) fabriquées sur les côtés de l'embout d'aiguille ; l'arrière de la sonde comportant un câble d'interconnexion flexible raccordé à une puce de commande ou un système de commande de prothèse neurale, et la fibre optique (1) étant raccordée à l'arrière d'un raccord de fibre optique (6). La microsonde comporte à la fois des fonctions de diagnostic, de discrimination spectrale de pathogène, de surveillance d'efficacité thérapeutique, de communication d'impulsions nerveuses, et de différents traitements, et est particulièrement adaptée pour utilisation dans l'administration transdermique, l'acquisition de signal d'impulsions nerveuses et d'entrée de choc électrique, l'interconnexion de prothèse neurale, l'analyse spectrale et la discrimination de cellules pathogènes et la thérapie électrique de la dépression.
PCT/CN2014/070554 2014-01-14 2014-01-14 Microsonde mems médicale multifonctionnelle Ceased WO2015106378A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/070554 WO2015106378A1 (fr) 2014-01-14 2014-01-14 Microsonde mems médicale multifonctionnelle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2014/070554 WO2015106378A1 (fr) 2014-01-14 2014-01-14 Microsonde mems médicale multifonctionnelle

Publications (1)

Publication Number Publication Date
WO2015106378A1 true WO2015106378A1 (fr) 2015-07-23

Family

ID=53542258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/070554 Ceased WO2015106378A1 (fr) 2014-01-14 2014-01-14 Microsonde mems médicale multifonctionnelle

Country Status (1)

Country Link
WO (1) WO2015106378A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105708546A (zh) * 2016-04-05 2016-06-29 鞍山英杰华科技有限公司 一种激光手术刀笔
CN109567786A (zh) * 2019-01-23 2019-04-05 国家纳米科学中心 一种植入式柔性神经微电极梳的处理方法
CN112516462A (zh) * 2020-11-24 2021-03-19 深圳罗兹曼国际转化医学研究院 光电联合器械和光动力治疗仪
CN116036457A (zh) * 2022-10-31 2023-05-02 深圳市恒康泰医疗科技有限公司 生物光子序流耦合及调控系统与针灸诊疗装置
CN116223865A (zh) * 2023-01-04 2023-06-06 上海泽丰半导体科技有限公司 Mems悬臂探针及制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5458597A (en) * 1993-11-08 1995-10-17 Zomed International Device for treating cancer and non-malignant tumors and methods
US20050137671A1 (en) * 2003-12-23 2005-06-23 Lili Liu His bundle mapping, pacing, and injection method and lead
CN1662187A (zh) * 2002-06-19 2005-08-31 塞隆医疗设备公司 电极针
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
CN101516286A (zh) * 2006-07-28 2009-08-26 特偲芙医药公司 限制神经传导的切割装置和系统
CN102014746A (zh) * 2008-05-02 2011-04-13 Sri国际公司 基于光学显微针的光谱仪
CN102755691A (zh) * 2012-06-19 2012-10-31 吉林大学 高灵敏医用微针阵列电极

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5458597A (en) * 1993-11-08 1995-10-17 Zomed International Device for treating cancer and non-malignant tumors and methods
CN1662187A (zh) * 2002-06-19 2005-08-31 塞隆医疗设备公司 电极针
US20050137671A1 (en) * 2003-12-23 2005-06-23 Lili Liu His bundle mapping, pacing, and injection method and lead
US20070276318A1 (en) * 2006-05-26 2007-11-29 Mit, Llp Iontosonic-microneedle applicator apparatus and methods
CN101516286A (zh) * 2006-07-28 2009-08-26 特偲芙医药公司 限制神经传导的切割装置和系统
CN102014746A (zh) * 2008-05-02 2011-04-13 Sri国际公司 基于光学显微针的光谱仪
CN102755691A (zh) * 2012-06-19 2012-10-31 吉林大学 高灵敏医用微针阵列电极

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105708546A (zh) * 2016-04-05 2016-06-29 鞍山英杰华科技有限公司 一种激光手术刀笔
CN109567786A (zh) * 2019-01-23 2019-04-05 国家纳米科学中心 一种植入式柔性神经微电极梳的处理方法
CN112516462A (zh) * 2020-11-24 2021-03-19 深圳罗兹曼国际转化医学研究院 光电联合器械和光动力治疗仪
CN116036457A (zh) * 2022-10-31 2023-05-02 深圳市恒康泰医疗科技有限公司 生物光子序流耦合及调控系统与针灸诊疗装置
CN116036457B (zh) * 2022-10-31 2023-09-12 深圳市恒康泰医疗科技有限公司 生物光子序流耦合及调控系统与针灸诊疗装置
CN116223865A (zh) * 2023-01-04 2023-06-06 上海泽丰半导体科技有限公司 Mems悬臂探针及制备方法

Similar Documents

Publication Publication Date Title
Fekete Recent advances in silicon-based neural microelectrodes and microsystems: a review
Lu et al. Polymer fiber probes enable optical control of spinal cord and muscle function in vivo
CN103167892B (zh) 基于液晶聚合物的电极-光极神经接口及其制造方法
Szostak et al. Neural interfaces for intracortical recording: requirements, fabrication methods, and characteristics
Vitale et al. Fluidic microactuation of flexible electrodes for neural recording
Zhao et al. Nanoelectronic coating enabled versatile multifunctional neural probes
Cheung Implantable microscale neural interfaces
Stark et al. Diode probes for spatiotemporal optical control of multiple neurons in freely moving animals
Zhang et al. Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue
US11160489B2 (en) Wireless optofluidic systems for programmable in vivo pharmacology and optogenetics
US10617300B2 (en) Injectable and implantable cellular-scale electronic devices
WO2015106378A1 (fr) Microsonde mems médicale multifonctionnelle
CN102793973B (zh) 帕金森氏病治疗装置
US10694951B2 (en) Probe structure for physiological measurements using surface enhanced Raman spectroscopy
US20240057943A1 (en) Multilayer and bouquet fiber-based neural probes and methods of making and uses thereof
Missey et al. Organic electrolytic photocapacitors for stimulation of the mouse somatosensory cortex
Hart et al. Biological considerations of optical interfaces for neuromodulation
Tooker et al. Microfabricated polymer-based neural interface for electrical stimulation/recording, drug delivery, and chemical sensing-development
CN104287960B (zh) 光纤针灸针
Dadarlat et al. Widespread activation of awake mouse cortex by electrical stimulation
CN104287959B (zh) 光纤针灸针诊疗和探测成像系统
Kim et al. Micro‐Coil Neuromodulation at Single‐Cell and Circuit Levels for Inhibiting Natural Neuroactivity, Neutralizing Electric Neural Excitation, and Suppressing Seizures
Rubehn et al. Polymer-based shaft microelectrodes with optical and fluidic capabilities as a tool for optogenetics
Balogh-Lantos et al. Focal infrared stimulation modulates somatosensory cortical activity in mice: evidence for TRPV1 ion channel involvement
US10694950B2 (en) Probe structure for physiological measurements using surface enhanced Raman spectroscopy

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14878504

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14878504

Country of ref document: EP

Kind code of ref document: A1