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WO2015199674A1 - Dispositif et procédé potentiométriques sélectifs pour la pioglitazone - Google Patents

Dispositif et procédé potentiométriques sélectifs pour la pioglitazone Download PDF

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Publication number
WO2015199674A1
WO2015199674A1 PCT/US2014/044041 US2014044041W WO2015199674A1 WO 2015199674 A1 WO2015199674 A1 WO 2015199674A1 US 2014044041 W US2014044041 W US 2014044041W WO 2015199674 A1 WO2015199674 A1 WO 2015199674A1
Authority
WO
WIPO (PCT)
Prior art keywords
pioglitazone
selective
ion
polymer membrane
potentiometric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/044041
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English (en)
Inventor
Amr Lotfy Saber HEFNY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Umm Al Qura University
Original Assignee
Umm Al Qura University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Umm Al Qura University filed Critical Umm Al Qura University
Priority to PCT/US2014/044041 priority Critical patent/WO2015199674A1/fr
Publication of WO2015199674A1 publication Critical patent/WO2015199674A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/333—Ion-selective electrodes or membranes
    • G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Definitions

  • the present invention relates to the qualitative and quantitative chemical analysis of drugs, particularly to a potentiometric device and method selective for pioglitazone that may be used detection and measurement of the concentration of the drug for quality control in the manufacture of the drug, etc.
  • a potentiometric sensor is a type of electrochemical sensor that may be used to determine the presence and concentration of substances in a gas or solution. These sensors measure the electrical potential of an electrode when no current is flowing. The signal is measured as the potential difference (voltage) between the working electrode and the reference electrode. The working electrode's potential must depend on the concentration of the analyte in the gas or solution phase. The reference electrode is needed to provide a defined reference potential.
  • Potentiometric sensors typically use an ion selective electrode (ISE).
  • ISE ion selective electrode
  • the voltage between a reference electrode and the ISE exposed to an analyte solution can be measured, and since this voltage is related to the activity of the analyte by the Nernst equation, the unknown concentration of the analyte can be computed.
  • the ISE usually uses a semipermeable membrane or selectively permeable membrane that is selective for the cation or anion of interest.
  • One type of membrane used in an ion selective electrode is a polymer membrane.
  • the polymer membrane includes a polymer matrix, often of poly (vinyl chloride) (PVC), that is doped with an ionophore (an organic ion exchange agent).
  • PVC poly (vinyl chloride)
  • the membrane also may include a plasticizer to keep the polymer soft and amorphous so that the ion of interest can be transported between the aqueous analyte solution and the ionophore embedded in the polymer matrix.
  • the plasticizer may also affect the dielectric constant of the polymer membrane.
  • Plasticized polymers used for ISE membranes are sometimes described as viscous liquids and referred to in the literature as liquid membranes.
  • ionophore used in an ISE is an ion-pair ionophore.
  • the potential measured by an ion-pair sensor electrode is dependent upon the relative attraction and repulsion forces of the ion-pair complex and the ionic species of the analyte of interest.
  • Pioglitazone [( ⁇ )-5-[[4-[2-(5-ethyl-2-yridinyl)ethoxy]phenyl]methyl]-2,4-]
  • thiazolidinedione hydrochloride is an oral anti-hyperglycemic agent that is used in the treatment of type 2 diabetes.
  • a testing method that is quick, simple, and relatively inexpensive for detecting and measuring the concentration of pioglitazone in pharmaceutical manufacture and in biological fluids for ensuring therapeutic levels of the unmetabolized drug is desirable.
  • the potentiometric device and method selective for pioglitazone relates to the detection of pioglitazone in urine, in other liquid biological samples, and in pharmaceutical preparations for quality control testing and the like, and particularly to the use of a potentiometric sensor for potentiometric detection and measurement of the concentration of pioglitazone.
  • the potentiometric sensor includes a plasticized polyvinyl chloride (PVC) matrix membrane having an ionophore impregnated or embedded therein.
  • the ionophore is an iodobismuth anion in which the iodobismuth anion forms a complex with pioglitazone.
  • the polymer membrane is plasticized with either ortho-nitrophenyl octyl ether (NPOE) or dioctyl phthalate (DOP).
  • the potentiometric device and method selective for pioglitazone relates to the detection of pioglitazone in urine, in other liquid biological samples, and in pharmaceutical preparations for quality control testing and the like, and particularly to the use of a potentiometric sensor for potentiometric detection and measurement of the concentration of pioglitazone.
  • the potentiometric sensor includes a plasticized polyvinyl chloride (PVC) matrix membrane having an ionophore impregnated or embedded therein.
  • the ionophore is an iodobismuth anion in which the iodobismuth anion forms a complex with pioglitazone.
  • the polymer membrane is plasticized with either ortho-nitrophenyl octyl ether (NPOE) or dioctyl phthalate (DOP).
  • NPOE ortho-nitrophenyl octyl ether
  • DOP dioctyl phthalate
  • the ionophore is made by adding 2 mL of 0.006 M B1I 3 (bismuth triiodide) to 4 mL of 0.006 M Nal (sodium iodide) to form an iodobismuth anion. Then, 7.2 mL of 0.005 M concentration pioglitazone is added, forming a solid ion-pair complex that precipitates.
  • 40 mg of the bismuth iodate- pioglitazone precipitate just described was combined with 360 mg of ortho-nitrophenyl octyl ether (or 360 mg of dioctyl phthalate) and 170 mg of poly (vinyl chloride) to form a plasticized polymer membrane suitable for use in an ion selective membrane (ISE) in a potentiometric sensor.
  • ISE ion selective membrane
  • the sensor is preferably conditioned by soaking in 0.1 mol/L pioglitazone solution for at least two days prior to use, and then is stored in the same solution.
  • the sensor was then calibrated against known standards to determine the range of the sensor, and tested to determine the effect of pH and the selectivity of the polymer membrane in the presence of interfering cations.
  • the electrode is found to have a Nernstian response to pioglitazone in a concentration range between approximately 1.0 x 10 "9 and 1.0 x 10 "1 mol/L in a pH range of between 3.0 and 7.0.
  • the working electrode is found to show good discrimination toward pioglitazone with respect to most common cations.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Electrochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un dispositif et un procédé potentiométriques sélectifs pour la pioglitazone qui permettent de détecter de la pioglitazone dans l'urine, dans d'autres échantillons biologiques liquides et dans des préparations pharmaceutiques pour l'analyse de contrôle de qualité, et autre, et, en particulier, l'utilisation d'un capteur potentiométrique pour la détection et la mesure potentiométriques de la concentration de pioglitazone. Le capteur potentiométrique comprend une membrane à matrice en poly(chlorure de vinyle) (PVC) plastifiée ayant un ionophore imprégnant celle-ci ou incorporé à l'intérieur de celle-ci. L'ionophore est un anion iodobismuth, l'anion iodobismuth formant un complexe avec la pioglitazone. La membrane polymère est plastifiée soit avec un ortho-nitrophényl octyl éther (NPOE), soit avec du phtalate de dioctyle (DOP).
PCT/US2014/044041 2014-06-25 2014-06-25 Dispositif et procédé potentiométriques sélectifs pour la pioglitazone Ceased WO2015199674A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2014/044041 WO2015199674A1 (fr) 2014-06-25 2014-06-25 Dispositif et procédé potentiométriques sélectifs pour la pioglitazone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2014/044041 WO2015199674A1 (fr) 2014-06-25 2014-06-25 Dispositif et procédé potentiométriques sélectifs pour la pioglitazone

Publications (1)

Publication Number Publication Date
WO2015199674A1 true WO2015199674A1 (fr) 2015-12-30

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Family Applications (1)

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PCT/US2014/044041 Ceased WO2015199674A1 (fr) 2014-06-25 2014-06-25 Dispositif et procédé potentiométriques sélectifs pour la pioglitazone

Country Status (1)

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WO (1) WO2015199674A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090266719A1 (en) * 2004-11-08 2009-10-29 Shen-Kan Hsiung Potentiometric Urea Sensor Based on Ion-Selective Electrode
US20130270125A1 (en) * 2012-04-14 2013-10-17 Endress + Hauser Conducta Gesellschaft Fur Mess- Und Regeltechnik Mbh + Co. Kg Potentiometric Sensor Apparatus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090266719A1 (en) * 2004-11-08 2009-10-29 Shen-Kan Hsiung Potentiometric Urea Sensor Based on Ion-Selective Electrode
US20130270125A1 (en) * 2012-04-14 2013-10-17 Endress + Hauser Conducta Gesellschaft Fur Mess- Und Regeltechnik Mbh + Co. Kg Potentiometric Sensor Apparatus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MOSTAFA ET AL.: "Characteristics of new composite-and classical potentiometric sensors for the determination of pioglitazone in some pharmaceutical formulations", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, vol. 48, no. 1, 2008, pages 57 - 61, XP024098162 *
SABER ET AL.: "Highly selective determination of pioglitazone in urine and pharmaceutical formulations by novel PVC-membrane sensors", INT. J. ELECTROCHEM. SCI, vol. 9, no. Iss. 8, 2014, pages 4374 - 4383, XP055249549, [retrieved on 20140519] *
SABER ET AL.: "Liquid chromatographic and potentiometric methods for determinations of clopidogrel", JOURNAL OF FOOD AND DRUG ANALYSIS, vol. 16, no. 2, 2008, pages 11 - 18, XP055249550 *

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