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WO2015198290A1 - Compositions microbicides incolores comprenant un iodophore - Google Patents

Compositions microbicides incolores comprenant un iodophore Download PDF

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Publication number
WO2015198290A1
WO2015198290A1 PCT/IB2015/054845 IB2015054845W WO2015198290A1 WO 2015198290 A1 WO2015198290 A1 WO 2015198290A1 IB 2015054845 W IB2015054845 W IB 2015054845W WO 2015198290 A1 WO2015198290 A1 WO 2015198290A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
iodophore
composition according
iodopovidone
colorless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2015/054845
Other languages
English (en)
Spanish (es)
Inventor
Luis Fernando ORTIZ RAVE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inversiones E Innovaciones Capel Sas
Original Assignee
Inversiones E Innovaciones Capel Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inversiones E Innovaciones Capel Sas filed Critical Inversiones E Innovaciones Capel Sas
Publication of WO2015198290A1 publication Critical patent/WO2015198290A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof

Definitions

  • Iodine and its derivative compounds have been widely used in the prevention and treatment of infections and as an antiseptic. They have a broad spectrum of antimicrobial action in bacteria, viruses, bacterial endospores, fungi and protozoa.
  • One of its mechanisms of action is to reduce the oxygen requirements of aerobic microorganisms, interfering with the respiratory chain by blocking the transport of electrons through electrolytic reactions with enzymes.
  • Preparations containing iodine or iodophore agents acquire brown-violet tones upon contact with the solvent. The intensity of these tones depends on the concentration and polarity of the solvent. When applied, these preparations generate lasting yellow or brown spots on the skin or clothing that are difficult to remove with washing and remain for a long time.
  • US4828569 discloses a detergent composition comprising N-methyl-2-pyrrolidone, gamma butyrolactone, 2-ethyl-l, 3-hexanediol or 4-methyl-l, 3-dioxolan-2-one together with some anionic surfactants or not ionic to remove stains generated by iodopovidone solutions.
  • US4022882 describes a germicidal composition comprising elemental iodine, polyvinylpyrrolidone and hydrazine hydrate to suppress the coloration generated by them, whereby the solution becomes colorless.
  • the bleaching agents according to the present invention are defined as compounds that react as oxidizing agents that convert iodine (colored) to iodide (colorless) ion.
  • the mechanism of action of these bleaching agents is mentioned in US 20080063615 which is incorporated by reference.
  • Bleaching agents according to the invention include methylparaben, propylparaben, sodium thiosulfate, sodium hyposulphite and mixtures thereof.
  • microbicidal compositions of the present invention include an effective amount of an iodophore, at least one bleaching agent and one or more acceptable excipients and / or vehicle. It will be apparent to anyone skilled in the art, that the optimum concentration of it or the active ingredients in the compositions of the invention will depend on several factors such as the type of end user, the type of composition used and the treatment to be performed. In a preferred embodiment, the final concentration of the iodophore in the composition is between 0.1% and 15% (w / v) and the final concentration of bleaching agent is between 0.1% and 10% (w / v).
  • each of the components can be poured into a solid container, add one or more suitable solvents such as water, ethanol, glycerin, polyols, among others, either either alone or mixed, and finally stir constantly until a homogeneous solution is obtained.
  • suitable solvents such as water, ethanol, glycerin, polyols, among others, either either alone or mixed.
  • the solution obtained can be adapted together with excipients or an acceptable vehicle to obtain liquid compositions useful for pharmaceutical, cosmetic and veterinary purposes.
  • the excipients may include one or more surfactants, wetting agents, emollients, antioxidants, surfactants, sequestrants, dispersants, pH regulators and fragrances.
  • acceptable vehicle refers to diluents such as water, alcohols, polyols, glycerin and mixtures thereof, which allows to obtain colorless liquid compositions, either in the form of solution, emulsion, suspension, dispersion or gel.
  • Preferred embodiments of the present invention include colorless solutions of iodopovidone between 0.5% and 12.0% (w / v), colorless solutions of iodine tincture and colorless iodine liquid soap.
  • Example 4 The composition obtained in Example 4 was carried out with microbiological tests with different microorganisms to evaluate its microbicidal activity according to ICONTEC 2455, which is incorporated by reference. The results are illustrated in Table 1.
  • the concentration in mg / L of the sample analyzed must be less than or equal to the concentration of phenol 5%.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne des compositions microbicides liquides incolores qui renferment un iodophore et au moins un agent décolorant qui supprime la coloration produite par l'iode, produisant ainsi une composition incolore qui conserve son spectre d'action.
PCT/IB2015/054845 2014-06-27 2015-06-26 Compositions microbicides incolores comprenant un iodophore Ceased WO2015198290A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CO14139193 2014-06-27
CO14-139193 2014-06-27

Publications (1)

Publication Number Publication Date
WO2015198290A1 true WO2015198290A1 (fr) 2015-12-30

Family

ID=54937477

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/054845 Ceased WO2015198290A1 (fr) 2014-06-27 2015-06-26 Compositions microbicides incolores comprenant un iodophore

Country Status (1)

Country Link
WO (1) WO2015198290A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301145A (en) * 1980-07-28 1981-11-17 Cestari Joseph E Antiseptic skin cream
US4867967A (en) * 1987-06-04 1989-09-19 Crutcher Wilbert L Method for the treatment of pseudofolliculitis barbae
US6025446A (en) * 1995-06-07 2000-02-15 Kulkarni; Arun B. Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same
US20080063615A1 (en) * 2006-09-12 2008-03-13 Macdonald John Gavin Color changing skin sealant
CN101400355A (zh) * 2006-03-14 2009-04-01 Cls制药公司 包含聚维酮碘的眼用组合物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301145A (en) * 1980-07-28 1981-11-17 Cestari Joseph E Antiseptic skin cream
US4867967A (en) * 1987-06-04 1989-09-19 Crutcher Wilbert L Method for the treatment of pseudofolliculitis barbae
US6025446A (en) * 1995-06-07 2000-02-15 Kulkarni; Arun B. Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same
CN101400355A (zh) * 2006-03-14 2009-04-01 Cls制药公司 包含聚维酮碘的眼用组合物
US20080063615A1 (en) * 2006-09-12 2008-03-13 Macdonald John Gavin Color changing skin sealant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200920, 19 October 2015 Derwent World Patents Index; *

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