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WO2015191636A3 - Xanthine oxidase inhibitors and methods of use - Google Patents

Xanthine oxidase inhibitors and methods of use Download PDF

Info

Publication number
WO2015191636A3
WO2015191636A3 PCT/US2015/034971 US2015034971W WO2015191636A3 WO 2015191636 A3 WO2015191636 A3 WO 2015191636A3 US 2015034971 W US2015034971 W US 2015034971W WO 2015191636 A3 WO2015191636 A3 WO 2015191636A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
xanthine oxidase
oxidase inhibitors
inhibitors
xanthine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2015/034971
Other languages
French (fr)
Other versions
WO2015191636A2 (en
Inventor
Changyi Chen
Jian-ming LU
Qizhi Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of WO2015191636A2 publication Critical patent/WO2015191636A2/en
Publication of WO2015191636A3 publication Critical patent/WO2015191636A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase.
PCT/US2015/034971 2014-06-09 2015-06-09 Xanthine oxidase inhibitors and methods of use Ceased WO2015191636A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462009810P 2014-06-09 2014-06-09
US62/009,810 2014-06-09
US201462060515P 2014-10-06 2014-10-06
US62/060,515 2014-10-06

Publications (2)

Publication Number Publication Date
WO2015191636A2 WO2015191636A2 (en) 2015-12-17
WO2015191636A3 true WO2015191636A3 (en) 2016-03-10

Family

ID=54834545

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/034971 Ceased WO2015191636A2 (en) 2014-06-09 2015-06-09 Xanthine oxidase inhibitors and methods of use

Country Status (1)

Country Link
WO (1) WO2015191636A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105753774A (en) * 2016-03-31 2016-07-13 常州大学 Synthesis method for 2-hydroxyl-3-nitro-4-formylpyridine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803225A (en) * 1983-12-06 1989-02-07 Fisons, Plc Dihydroxy-phenethylamino compounds useful as pharmaceuticals
US5399577A (en) * 1991-05-01 1995-03-21 Taiho Pharmaceutical Co., Ltd. Isoxazole derivatives and salts thereof
US6121303A (en) * 1992-10-23 2000-09-19 Orion-Yhtyma Oy Pharmacologically active catechol derivatives
US6169092B1 (en) * 1996-07-12 2001-01-02 Bayer Aktiengesellschaft 3-Ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803225A (en) * 1983-12-06 1989-02-07 Fisons, Plc Dihydroxy-phenethylamino compounds useful as pharmaceuticals
US5399577A (en) * 1991-05-01 1995-03-21 Taiho Pharmaceutical Co., Ltd. Isoxazole derivatives and salts thereof
US6121303A (en) * 1992-10-23 2000-09-19 Orion-Yhtyma Oy Pharmacologically active catechol derivatives
US6169092B1 (en) * 1996-07-12 2001-01-02 Bayer Aktiengesellschaft 3-Ureido-pyridofurans and -pyridothiophenes for the treatment of inflammatory processes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE PubChem 5 December 2007 (2007-12-05), Database accession no. 22112903 *
LU ET AL.: "3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a Potent Inhibitor of Xanthine Oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout", BIOCHEM PHARMACOL., vol. 86, no. 9, 2013, pages 22 *

Also Published As

Publication number Publication date
WO2015191636A2 (en) 2015-12-17

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