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WO2015165019A1 - Dispositif de préparation de frottis, procédé de préparation de frottis et module de séchage de panier de lames de verre - Google Patents

Dispositif de préparation de frottis, procédé de préparation de frottis et module de séchage de panier de lames de verre Download PDF

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Publication number
WO2015165019A1
WO2015165019A1 PCT/CN2014/076412 CN2014076412W WO2015165019A1 WO 2015165019 A1 WO2015165019 A1 WO 2015165019A1 CN 2014076412 W CN2014076412 W CN 2014076412W WO 2015165019 A1 WO2015165019 A1 WO 2015165019A1
Authority
WO
WIPO (PCT)
Prior art keywords
module
slide
sample
smear preparation
working line
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2014/076412
Other languages
English (en)
Chinese (zh)
Inventor
陈良清
向愿
李为公
李学荣
印帅
李乐昌
董丽芳
汪云飞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Mindray Bio Medical Electronics Co Ltd
Original Assignee
Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Mindray Bio Medical Electronics Co Ltd filed Critical Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority to CN202010144880.5A priority Critical patent/CN111337322A/zh
Priority to CN202010144939.0A priority patent/CN111337323A/zh
Priority to CN202010144363.8A priority patent/CN111366429A/zh
Priority to PCT/CN2014/076412 priority patent/WO2015165019A1/fr
Priority to CN202010144366.1A priority patent/CN111337321A/zh
Priority to CN201480074812.9A priority patent/CN105960584A/zh
Priority to CN202010144944.1A priority patent/CN111337324A/zh
Publication of WO2015165019A1 publication Critical patent/WO2015165019A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor

Definitions

  • the invention belongs to the technical field of medical equipment, and in particular relates to a smear preparation device, a smear preparation method and a slide basket drying module.
  • a fully automated blood smear or other tissue smear preparation instrument as a smear preparation device, is generally divided into three important functions of push film preparation, push film and dyeing.
  • some smear preparation devices divide the two functions of pushing and dyeing into two instruments, wherein after the blood smear is completed, manual intervention is required, and the blood smear is completed. Go to the staining instrument.
  • both the labor cost and the risk of the blood smear being damaged are increased, which easily affects the accuracy of the diagnosis result.
  • the object of the present invention is to overcome the deficiencies of the prior art described above, and to provide a smear preparation device, a smear preparation method and a slide basket drying module, which have high reliability in preparing a smear and are advantageous for ensuring the accuracy of the diagnosis result.
  • the technical solution of the present invention is: a smear preparation device comprising a sampling module for extracting a sample, a slide loading module for moving the slide to the working line, a printing module for printing information on the slide, a drip module for dropping a sample onto a slide, a pusher module for smoothing a sample on the slide, a flip module for flipping the slide, and dyeing for dyeing the slide
  • a smear preparation device comprising a sampling module for extracting a sample, a slide loading module for moving the slide to the working line, a printing module for printing information on the slide, a drip module for dropping a sample onto a slide, a pusher module for smoothing a sample on the slide, a flip module for flipping the slide, and dyeing for dyeing the slide
  • the module, the slide loading module, the printing module, the dropping module, the pushing module, the inverting module, and the dyeing module are arranged along the working line.
  • the smear preparation apparatus further includes a cleaning module for cleaning the slide, the cleaning module being disposed along the work line.
  • the smear preparation apparatus further includes a sample drying module for drying the sample on the slide, the sample drying module being disposed along the working line.
  • the smear preparation apparatus further includes a slide output module for carrying a slide basket and outputting the slide basket to a set position.
  • the smear preparation apparatus further includes a slide basket drying module for drying the dyed slide.
  • the drip sample module includes a blood drop needle connected to the sampling module; one side of the blood drop needle is provided with a micro-input for moving a priority sample under the blood drop needle Sample module.
  • the lancet includes a needle body and a guide sleeve, and an elastic structure is disposed between the needle body and the guide sleeve.
  • the working line includes a first working line and a second working line; the slide loading module, the cleaning module, the printing module, the dropping module, the pushing piece module and the turning module are arranged along the first working line,
  • the inverting module is located at an intersection of the first working line and the second working line; the sample drying module and the dyeing module are arranged along the second working line.
  • the first working line is provided with a first linear slide rail, and the first linear slide rail is slidably connected with a pusher cart for carrying a slide;
  • the second working line is provided with a second straight line a slide rail, the second linear slide rail is slidably connected with a robot module for clamping and moving the slide;
  • the first working line and the second working line are arranged perpendicularly or perpendicularly.
  • the smear preparation device further includes a sample auto-injection module, the sample auto-injection module is disposed adjacent to the sampling module; the sample auto-injection module includes a test tube rack feeding component, and the sample is mixed. component.
  • the slide loading module includes a slide storage sub-module for accommodating a slide, a cutter sub-module for pushing the slide from the slide storage sub-module to the working line, and a pair of slides Or the cutter head sub-module performs the limit in place blocking sub-module.
  • the pusher module includes a pusher blade submodule for smearing the sample, and a flipping module for flipping the slide from a flat to an upright.
  • the smear preparation apparatus has a control member for controlling a grip of a robot to manually insert a slide inserted at the sample drying module to the dyeing module.
  • the dyeing module comprises a turntable sub-module, a needle tray module and a dyeing box; the dyeing module has a slide entry station and a slide take-out station, and the slide enters a station, a slide take-out station,
  • the flip module, the sample drying module, and the slide output module are arranged along the same straight line.
  • the slide basket drying module includes a housing provided with a blow port for blowing an air flow and an air suction port for sucking the air flow.
  • the present invention also provides a slide basket drying module comprising a housing provided with a blow port for blowing an air flow and an air suction port for drawing in the air flow.
  • the invention also provides a method for preparing a smear comprising the steps of: laying a slide flat and moving the slide along a working line, and performing the slide on the slide through the cleaning module during the movement of the slide along the working line Cleaning, then printing the sample information on the slide through the printing module, and then dropping the sample collected from the sampling module on the slide through the drop module, and then smoothing the sample of the slide through the push module. Then, the slide piece is turned from the flat state to the erect state by the flipping module, and the inverted slide piece is dyed by the dyeing module.
  • the flipping module flips the slide to tilt and stays for a set length of time during the process of flipping the slide from the flat state to the upright state.
  • the sample information printed on the slide is inspected by the detection module after the sample is printed on the slide and before the sample is dropped on the slide.
  • the smear preparing device, the smear preparing method and the slide basket drying module provided by the invention, the slide loading module, the printing module, the dropping sample module, the pushing piece module, the turning module and the dyeing module are arranged along the working line,
  • the smear preparation device has a compact structure, and the preparation efficiency of the smear is high, and the reliability of preparing the smear is high, which is favorable for ensuring the accuracy of the diagnosis result.
  • FIG. 1 is a schematic perspective view of a smear preparation apparatus according to an embodiment of the present invention
  • FIG. 2 is a schematic perspective view of a smear preparing device according to an embodiment of the present invention
  • FIG. 3 is a schematic view showing the arrangement of each station in the working line of the smear preparing device according to the embodiment of the present invention
  • FIG. 4 is a schematic perspective view of a slide loading module in a smear preparation device according to an embodiment of the present invention
  • FIG. 5 is a schematic plan view of a pusher module in a smear preparation device according to an embodiment of the present invention
  • FIG. 6 is a schematic perspective view of a push-pull module in a smear preparation device according to an embodiment of the present invention
  • FIG. 7 is a schematic perspective view of a sample drying module in a smear preparing device according to an embodiment of the present invention.
  • FIG. 8 is a schematic perspective view of a second slide rail and a robot module in a smear preparation device according to an embodiment of the present invention
  • FIG. 9 is a schematic perspective view showing a three-dimensional assembly of a dyeing module in a smear preparing device according to an embodiment of the present invention.
  • FIG. 10 is a perspective view of a three-dimensional assembly of a middle glass basket drying module according to an embodiment of the present invention.
  • FIG. 11 is a perspective view of a three-dimensional assembly of a middle slide output module according to an embodiment of the invention.
  • a smear preparation device provided by an embodiment of the present invention can be used for smear preparation of blood, body fluid and the like.
  • the above smear preparation apparatus includes a sampling module for extracting a sample, a slide loading module 3 for moving a slide to a working line, a printing module 4 for printing information on a slide, and a sample for dropping the sample a drop module 5 of the slide, a pusher module 6 for smoothing the sample on the slide, a flip module 64 (not shown) for flipping the slide, and for the slide a dyeing module 9 for dyeing, the slide loading module 3, the printing module 4, the dropping module 5, the pushing module 6, the inverting module 64 and the dyeing module 9 are arranged along the working line, and the structure is compact, and the smear is The preparation efficiency is high, the reliability of preparing the smear is high, and the accuracy of the diagnosis result is ensured.
  • the sampling module is the sampling station
  • the slide loading module 3 is the slide loading station
  • the printing module 4 is the printing station
  • the dropping module 5 is the printing station.
  • the pushing station is the turning station
  • the turning module 64 is the turning station
  • the dyeing module 9 is the dyeing station.
  • the glass slides in this embodiment are not limited to glass materials, and other suitable materials may be used, which are all within the protection scope of the present invention.
  • the smear preparation apparatus further includes a cleaning module (not shown) for cleaning the slide, the cleaning module being disposed along the working line, and the cleaning module is a cleaning station.
  • the cleaning module is a cleaning station.
  • the slide can be cleaned by the cleaning module before printing the sample information, for example, by blowing, or the like.
  • the smear preparation apparatus further includes a sample drying module 8 for drying a sample on a slide, and the sample drying module 8 can be used for drying a sample such as a blood film.
  • the sample drying module 8 is arranged along the working line, and the sample drying module 8 is a slide drying station to dry the blood sample in time.
  • the smear preparing device further includes a slide output module 10 for carrying a slide basket and outputting the slide basket to a set position, and the slide output module 10
  • the slide output station is the place.
  • the smear preparation device further includes a slide basket drying module for drying the dyed slide, and the slide basket drying module 12 is a slide basket drying. Station.
  • the drop module 5 includes a lancet 501, and the lancet 501 is connected to the sampling module 1; one side of the lancet 501 is provided for
  • the priority sample is moved to the micro-injection module 2 below the lancet 501.
  • the micro-injection module 2 can directly move the test tube placed by the operator in the direction of the lancet 501, and at the same time, the lancet 501 can also move in the direction of the test tube placed by the operator, since it is not necessary to draw blood through the sampling module 1. , can reduce the need for blood samples, thus achieving micro and priority injection.
  • the same blood drop 501 can be shared by batch injection and micro-preferred injection.
  • the lancet 501 includes a needle body and a guide sleeve, and an elastic structure is disposed between the needle body and the guide sleeve to prevent the lancet 501 from rigidly impacting the glass. sheet.
  • the working line includes a first working line 101 and a second working line 102; the slide loading module 3, the cleaning module, the printing module 4, the dropping module 5, and the pushing
  • the sheet module 6 and the inversion module 64 are arranged along the first working line 101, the inversion module 64 is located at the intersection of the first working line 101 and the second working line 102; the sample drying module 8 and the dyeing module 9 Arranged along the second working line 102, the first working line 101 and the second working line 102 are arranged perpendicularly to each other or arranged in a straight line or at other suitable angles.
  • the first working line 101 is provided with a first linear slide rail 111 , and the first linear slide rail 111 is slidably connected with a pusher cart for carrying a slide.
  • the second working line 102 is provided with a second linear slide 112, and the second linear slide 112 is slidably connected with a robot module 113 for clamping and moving the slide; the first working line 101 and the The second working lines 102 are arranged perpendicularly or vertically.
  • the first working line 101 and the second working line 102 are arranged in a “T” shape, and the inversion module 64 is located at the intersection of the first working line 101 and the second working line 102, wherein The sample drying module 8 and the dyeing module 9 are disposed on the left and right sides of the inversion module 64.
  • the slide loading module 3, the cleaning module, the printing module 4, the dropping module 5, and the pushing module 6 are located on the same side of the inversion module 64.
  • the smear preparation device further includes a sample auto-injection module 114, the sample auto-injection module 114 is disposed adjacent to the sampling module 1 , and the sample auto-injection module 114
  • the test tube rack can be sent to the sampling module 1;
  • the sample autosampler module 114 includes a test tube rack feed member, and a sample mixing member.
  • the slide loading module 3 serves as a sheet storage and distribution module including a slide storage sub-module 31 for accommodating a slide for using the slide from the The slide storage sub-module 31 is pushed to the bit sub-module 33 of the working line, the in-position blocking sub-module 32 for limiting the slide or the bit sub-module 33.
  • the pusher module 6 includes a pusher blade submodule 61 for smoothing the sample, and a flip module 64 for flipping the slide from the flat to the upright.
  • the smear preparation apparatus has a control member for controlling a grip of a robot to manually insert the slide inserted at the sample drying module 8 to the dyeing module 9.
  • the control member can cause the robot to grip the slide at the sample drying module 8.
  • the control unit can be a button or the like.
  • the sample drying module 8 has a first receiving groove 81 and a second receiving groove 82 for receiving the slide coated with the sample, and the inside of the first receiving groove 81 and the second receiving groove 82 can flow out a dry air flow to dry the sample.
  • the second receiving groove 82 can be used as a slide for manually inserting. Through the control component, the robot module 113 can take a slide in the second receiving groove 82 and put it into the dyeing station.
  • the first receiving groove 81 and the second receiving groove 82 correspond to the first drying station and the second drying station, respectively.
  • the dyeing module 9 includes a turntable sub-module, a needle tray module and a dyeing box; the dyeing module 9 has a slide entering station 901 (dyeing station 1) and a slide.
  • the station 902 (dyeing station 4) is taken out, and the slide entering station 901, the slide take-out station 902, the flipping module 64, the sample drying module 8, and the slide output module 10 are arranged along the same straight line, thus, one The robot that can move in a straight line can move the slide to each corresponding station.
  • the slide basket drying module 12 includes a housing 120 provided with a blowing port 1201 for blowing out airflow and an air inlet 1202 for sucking airflow, such that It can form a better convection effect, which is beneficial to the rapid drying of the slide in the slide basket 11.
  • the housing 120 can have two air flow passages, that is, one air outlet passage and one air suction passage.
  • An outlet fan may be provided at the outlet passage, and an intake fan may be provided at the suction passage.
  • the two ends of the circulation passage are respectively a blowing port 1201 and an air suction port 1202, and a circulation fan may be disposed in the circulation passage or/and the air outlet 1201 or/and the suction opening 1202.
  • all the working positions can be designed as two working lines that intersect perpendicularly, including: the first working line 101 from the right side of the smear preparation device to the left side (pushing piece) Work line), a second working line 102 (dyeing and output working line) that intersects the push line perpendicularly.
  • the push line there are loading, printing, dripping, pushing and flipping work positions from left to right.
  • the slide output, blood film drying and blood film unfolding are distributed from front to back on the dyeing and output working line. , flip, staining station 1 (slide insert), staining station 4 (slide removal).
  • the two station lines intersect at the flip station and switch the slide placement state (horizontal to vertical) at the flip station.
  • This layout can ensure that the whole machine can always be in an accurate position control state under the premise that the functions can be realized, and the number of times of the slides can be minimized, and the slides are solved during the operation of the instrument. Card failure.
  • the station design is on the two working station lines, it also plays an important role in reducing the volume of the whole machine.
  • the sample auto-injection module 114 is mainly composed of an injection sub-module and a sampling sub-module, and can automatically perform sample collection processing on a closed test tube that is continuously or discontinuously arranged on the test tube rack.
  • the injection sub-module and the sampling sub-module structure are relatively independent, and can be used according to different application environments (such as using an automatic blood smear preparation instrument alone or using a fully automatic blood smear preparation instrument on a fully automatic assembly line) It is very convenient to install and disassemble without affecting the integrity of the sampling sub-module function.
  • the automatic blood smear preparation instrument can be quickly configured into different scenarios, and independent or high-speed, automatic re-checking functions can be realized as needed.
  • the micro-injection module 2 can also be used as an open injection module. When the sample size is relatively small, or after a push-push is initiated, it is necessary to preferentially intervene to process a certain sample, and the micro-injection module 2 can be used.
  • the micro-injection module 2 can automatically collect and process a single sample placed in the tube adapter. It can include sample feed and sample unloading functions.
  • the sampling needle used for sample collection and the lancet 501 used by the drip-type module 5 use the same needle, which can minimize the requirement for the sample size; and because the same needle is used, the sample is used. The short distance of transportation can effectively reduce the deformation effect of the sample on the tangible cells of the sample during transportation in the instrument.
  • the slide loading module 3 (slide storage and distribution module) is mainly composed of a slide box module 31, a cutter sub-module 33, and an in-position blocking sub-module 32, and can be loaded into the user here.
  • the horizontal slide of the stack is automatically loaded by the slide storage and distribution module to the pusher carriage of the pusher module 6 one by one according to the sample requirements.
  • the slide box can be designed with a relatively independent structure, but is different from the easy-to-remove structure. Under normal working conditions, the slide box is locked by a special locking mechanism.
  • the accuracy of the relative position of the slide box and the slide distribution guide can be reliably ensured, and the slide box of the easy-disassembled structure is prevented from being shaken by external disturbance, and the slide distribution failure is caused.
  • the operator can easily remove the slide box by opening a special locking mechanism for independent disassembly.
  • the printing module 4 can use a thermal transfer method to print pre-set information (possibly number, time, type, etc.) of the user on the frosted area of the slide for identifying the slide.
  • the ribbon and the slide are stationary, and the print head is moved relative to the ribbon to achieve absolute rest of the ribbon and the slide, maximally avoiding the breakage of the ribbon during printing due to ribbon and slide movement.
  • the drop sample module 5 is mainly divided into a sample suction sub-module and a blood drop sub-module.
  • the lancet 501 adopts a structure in which the guide sleeve is elastic. The lancet 501 is moved downward, and when the slide is touched, the lancet 501 is restricted from moving downward. Because the guide sleeve has an elastic structural design, the fixed bracket of the lancet 501 can continue to move downward. A small buffer distance. In this way, the blood drop needle 501 can be used for dripping blood without very precise position control, that is, the bottom end surface of the blood drop needle 501 can always contact the surface of the slide surface, and the shape of the blood drop on the surface of the slide surface can be consistent.
  • the pusher module 6 is mainly divided into a pusher car sub-module 62, a pusher blade sub-module 61, a blade cleaning sub-module 63, and a flip module 64.
  • a pusher car sub-module 62 utilizes the power of its own motion to achieve the fixation and release of the slide on the trolley.
  • the flip module 64 adopts a single-piece flip structure, which realizes a simple structure and reliable flipping.
  • the slide is first flipped at a small angle, waiting for the preset time of the system, and then flipped to the vertical position. This can effectively solve the problem of blood stasis caused by the blood film being too thick after the completion of the push film.
  • the manipulator module 113 serves as a main bearing mechanism for the dyeing and output working line, and realizes the slide output, the blood film drying, the blood film unfolding detection, the turning, the dyeing in the vertical placement state of the slide. Transfer between bit 1 (slide placement), staining station 4 (slide removal). Slide output station, slide drying station (blood film drying station), push station (blood film unfolding inspection station), flip station, dyeing station 4, dyeing station 1
  • the linear design allows the robot to easily perform all station movements in a straight line.
  • the sample drying module 8 may also be referred to as a blood film drying module to perform the function of drying the slide on the slide, and at the same time, providing an interface to the unstained slide as an external input in the entire machine interface.
  • a blood film drying module to perform the function of drying the slide on the slide, and at the same time, providing an interface to the unstained slide as an external input in the entire machine interface.
  • the sample drying module 8 serves as both a blood film drying module and an externally input unstained glass slide in the whole structure, and simplifies the structure of the whole machine without reducing the function of the instrument, thereby realizing the streamlining of the whole machine.
  • the module controls the relative humidity of the drying medium, the drying temperature and the flow rate of the drying medium, which greatly improves the drying speed, and completely solves other products in the market due to low ambient temperature and low air humidity.
  • the module proposes a blowing drying method in which the dry air flow flows along the direction in which the sample (blood film) is deployed, which can ensure that the cell shape does not change under the drying of the micro airflow, and solves other products in the air drying process.
  • the resulting cellular deformation gives the problem of a wrong diagnosis.
  • the staining module 9 dyes the slides that have been pushed by the user according to a pre-selected staining process. Mainly divided into: turntable sub-module, needle plate module and blocking sub-module 32, dyeing box.
  • the rotating plate module together with the dyeing box, provides the location required for the dyed slides and completes the dyeing process.
  • the needle plate module carries all the adding and discharging needles, and all the needles are inserted and lifted off the dyeing box along with the up and down movement of the dial to realize the liquid filling and discharging of the dyeing liquid.
  • the dyeing module 9 adopts a disc structure in structure, and realizes a compact structure.
  • the use of a dial with all the liquid-filling and liquid-discharging needles as a whole prevents the problem of requiring a set of power mechanisms for each of the dyeing stations.
  • the dyeing box uses the friction between the dyeing box and the turntable on the turntable, and is transferred along with the turntable.
  • the blocking mechanism is used to control the time point of the dyeing box transfer, and the user-defined coloring process is realized.
  • the slide output module 10 is mainly a slide basket loading sub-module 115, a slide basket feeding sub-module 116, a slide drying sub-module (a slide basket drying module 12) and a slide.
  • the basket unloading sub-module 117 includes loading, slide basket transport, slide storage, and slide basket drying.
  • the slide basket loading sub-module 115 can be designed with a double belt feeding mechanism, and can accurately detect and display the number of slide baskets available inside the instrument, and can load the slide basket at any time and continuously, and alarm when the number is insufficient. Meet the needs of users to add slide baskets under any circumstances.
  • the application of the freely retractable finger mechanism enables the number of empty slide baskets to be increased by 50% without taking up space.
  • the application of the slide basket pressing mechanism in the slide basket feeding sub-module 116 ensures the movement precision of the slide basket and improves the reliability of the slide collection.
  • the slide basket drying module 12 is dried by blowing hot air on the slide, and the water on the surface of the slide is evaporated by heating, and the moisture is taken away by the flowing air to achieve the drying effect.
  • the air outlet 1201 has a large area, and a plurality of slides can be placed at one time to provide work efficiency.
  • the slide basket drying module 12 is designed with a blow port 1201 and an air suction port 1202 so that the slide basket passage is between the air outlet 1201 and the air passage of the suction port 1202.
  • the slide basket drying module 12 blows a constant temperature, a constant speed of strong wind from the air outlet 1201, and at the same time, the flow rate from the suction port 1202 is much larger than the flow rate of the air outlet 1201.
  • the fan draws air and creates effective convection at the slide basket.
  • the drying time is greatly reduced under the influence of temperature and air convection.
  • the embodiment further provides a slide basket drying module 12, comprising a casing 120, the casing 120 is provided with a blowing port 1201 for blowing airflow and a suction for sucking airflow. Tuyere 1202. In this way, a better convection effect can be formed, which facilitates rapid drying of the slide in the slide basket.
  • the air outlet 1201 can face the top of the slide basket, and the air inlet 1202 can face the side wall of the slide basket.
  • the housing 120 can have two air flow passages, that is, one air outlet passage and one air suction passage. At least one air outlet fan may be disposed at the air outlet passage, and at least one air suction fan may be disposed at the air suction passage.
  • the slide basket drying module 12 allows the slide basket passage to be between the air outlet 1201 and the air passage of the suction port 1202.
  • the slide basket drying module 12 blows a constant temperature, a constant speed of strong wind from the air outlet 1201, and at the same time, the flow rate from the suction port 1202 is much larger than the flow rate of the air outlet 1201.
  • the fan draws air and creates effective convection at the slide basket.
  • the drying time is greatly reduced under the influence of temperature and air convection.
  • an embodiment of the present invention further provides a method for preparing a smear, which can be applied to the above smear preparation device, and the smear preparation method comprises the following steps, and the sampling module 1 and the slide are arranged.
  • the flipping module 64 flips the slide to tilt and stays for a set length of time, so that the sample is dried to a certain extent and then turned into a standing state to ensure Diagnostic accuracy.
  • the sample information printed on the slide is inspected by the detection module after the sample is printed on the slide and before the sample is dropped on the slide.
  • the front end of the smear preparation device may be a sample auto-injection module 114, where the user puts the sample to be tested, or the other workstation device (such as a cascade pipeline) automatically transmits the sample.
  • the functions including tube injection, test tube presence, barcode scanning, sample mixing, and puncture aspiration are completed.
  • the micro/open injection module can be used for aspiration, which ensures that the tablet can be dyed at a lower sample size.
  • the sample auto-injection module 114 and the micro/open sampling module respectively transmit the sample information collected by the sample to the drip sample module 5 for processing to extract the sample characteristics related to the push film for subsequent push.
  • the right side of the smear preparation device can be a slide storage and distribution module, where the user loads a stack of horizontal slides, and the slide storage and distribution module automatically loads the slides one by one according to the sample requirements.
  • the pusher car of the pusher module 6 is fixed in the horizontal state on the trolley.
  • a special slide cleaning station is designed, and a special cleaning module is used to clean the free foreign matter on the surface of the slide surface, so that when the slide is printed, there is no surface free foreign matter in the printing area. Minimizes the failure of printing due to the quality of the surface of the slide.
  • the slide is then moved along the trolley of the pusher module 6 along with the trolley to the left side of the smear preparation device.
  • the trolley in this embodiment first arrives at the printing position, and cooperates with the slide information printing module 4 to complete the printing of the sample information; after confirming that the printing operation is successfully completed, the blood dropping station is reached again; and the sample automatic sampling module is matched with the dropping module 5 114 or the sample collected by the micro/open injection module is dropped onto the slide; reaching the push position, according to the sample characteristics extracted by the drop module 5, the push parameters are intelligently adjusted, so that the sample is applied to the glass in an optimal state. On-chip, the push action is completed; then, the slide is finally flipped from the horizontal state to the vertical state by the flip module 64 of the push module 6.
  • the manipulator module 113 on the left side of the smear preparation device runs through the front and rear direction of the whole instrument, and connects the flipping position of the slide in the vertical state, the blood film drying position, the dyeing station 1, the dyeing station 4, and the slide output position.
  • the robot module 113 transfers the slides that have completed the push to the blood film drying module at the inversion position of the pusher module 6, and the sample is sufficiently dried in the blood film drying module to ensure that the blood film does not fall off during the subsequent dyeing process.
  • the robot module 113 rotates the slides of the sample dried to the dyeing box in the station 1 of the dyeing module 9, each of which corresponds to a dyeing box.
  • the slides are dyed in the dyeing box according to the dyeing process set by the user (the dyeing process can be customized by the user within a certain range), and the instrument automatically absorbs and discharges the dyeing solution for each dyeing box, thereby realizing the staining of the slides. .
  • the dyed finished slide along with the dyeing box will be transferred from the dyeing station 1 to the dyeing station 4 in the dyeing module 9.
  • the robot module 113 takes the dyed slide from the dyeing box from the dyeing station 4, and the dye box automatically enters the next dyeing cycle.
  • the robot module 113 transfers the slides from the dyeing station 4 of the dyeing module 9 to the bottom sealed, hollowed-out slide basket 11 on the slide output module 10, one by one, with a gap arranged.
  • the slide output module 10 counts the loaded slides in the slide basket. When the slide basket 11 is full or the entire push print process is completed, the slide output module 10 transports the slide basket 11 to the slide output. At the drying mechanism of the slide basket drying module 12 of the module 10, the drying mechanism blows a strong temperature at a constant temperature and a constant speed to dry the dyed slide. After a fixed time of strong wind drying, all the slides were sufficiently dried.
  • the slide output module 10 pushes the slide together with the slide basket 11 onto the unloading platform of the slide output module 10, at which time the entire push dyeing process is completed.

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Abstract

La présente invention concerne le domaine technique des dispositifs médicaux. L'invention concerne un dispositif de préparation de frottis, un procédé de préparation de frottis et un module de séchage de panier de lames de verre. Le dispositif de préparation de frottis comprend un module de support de lame de verre, un module d'impression, un module de goutte à goutte d'échantillon, un module de frottis, un module de retournement et un module de coloration, lesdits modules étant tous agencés le long d'une ligne de travail. Le procédé de préparation de frottis consiste à : poser la lame de verre à plat et déplacer la lame de verre le long d'une ligne de travail; nettoyer la lame de verre à l'aide d'un module de nettoyage; imprimer des informations d'échantillon par utilisation du module d'impression; faire un goutte à goutte de l'échantillon par utilisation du module de goutte à goutte d'échantillon; faire un frottis de l'échantillon par utilisation du module de frottis; retourner la lame de verre par utilisation du module de retournement pour passer de l'horizontale à la verticale; et colorer la lame de verre par utilisation du module de coloration. Le module de séchage de panier de lames de verre comprend un boîtier doté d'une entrée d'air et d'une sortie d'air. La combinaison du dispositif de préparation de frottis, du procédé de préparation de frottis et du module de séchage de panier de lames de verre de la présente invention permet au dispositif de préparation de frottis de présenter une structure compacte et également d'obtenir une efficacité élevée et une fiabilité élevée de préparation de frottis, des résultats de diagnostic précis pouvant ainsi être obtenus.
PCT/CN2014/076412 2014-04-28 2014-04-28 Dispositif de préparation de frottis, procédé de préparation de frottis et module de séchage de panier de lames de verre Ceased WO2015165019A1 (fr)

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CN202010144880.5A CN111337322A (zh) 2014-04-28 2014-04-28 涂片制备装置、涂片制备方法
CN202010144939.0A CN111337323A (zh) 2014-04-28 2014-04-28 涂片制备装置、涂片制备方法
CN202010144363.8A CN111366429A (zh) 2014-04-28 2014-04-28 涂片制备装置、涂片制备方法
PCT/CN2014/076412 WO2015165019A1 (fr) 2014-04-28 2014-04-28 Dispositif de préparation de frottis, procédé de préparation de frottis et module de séchage de panier de lames de verre
CN202010144366.1A CN111337321A (zh) 2014-04-28 2014-04-28 涂片制备装置和涂片制备方法
CN201480074812.9A CN105960584A (zh) 2014-04-28 2014-04-28 涂片制备装置、涂片制备方法和玻片篮干燥模块
CN202010144944.1A CN111337324A (zh) 2014-04-28 2014-04-28 涂片制备装置和涂片制备方法

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CN120891213A (zh) * 2025-09-30 2025-11-04 长治医学院附属和平医院 一种心内科血液取样检测装置

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