WO2015147698A2 - Procédé de réchauffement de liquides de rinçage et de préparations d'infusion et de perfusion (et variantes) dispositif pour mettre en oeuvre le procédé (et variantes) - Google Patents
Procédé de réchauffement de liquides de rinçage et de préparations d'infusion et de perfusion (et variantes) dispositif pour mettre en oeuvre le procédé (et variantes) Download PDFInfo
- Publication number
- WO2015147698A2 WO2015147698A2 PCT/RU2015/000165 RU2015000165W WO2015147698A2 WO 2015147698 A2 WO2015147698 A2 WO 2015147698A2 RU 2015000165 W RU2015000165 W RU 2015000165W WO 2015147698 A2 WO2015147698 A2 WO 2015147698A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- thermostat
- infusion
- electric heater
- coolant
- heated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1413—Modular systems comprising interconnecting elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3633—General characteristics of the apparatus related to heating or cooling thermally insulated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/364—General characteristics of the apparatus related to heating or cooling by chemical reaction
Definitions
- the invention can be used in medicine for heating washing fluids, infusion and transfusion preparations. State of the art
- a known method of heating flushing fluids, infusion and transfusion preparations with electric flowing heating devices Heat is supplied to the heated preparations through the wall of the tube of the heated section of the infusion system or through the wall of the disposable flexible cassette connected to it.
- the Astotherm plus flow-through apparatus [1] was selected, which heats the preparations poured into the blood of patients to 36, 39, 41, or 43 ° C.
- This device contains a built-in electric heater, a microprocessor that performs the functions of a temperature controller, as well as an alphanumeric display.
- An electric heater is installed in the holder of the heated section of the tube of the infusion system.
- the holder has the form of a segment of a cylindrical pipe with a spiral groove on the outer surface.
- Known flow apparatus Ranger [2] which allows you to heat up to 41 ° C blood and flushing fluids, which are used in surgical practice.
- This device also contains an integrated microprocessor-controlled electric heater and an alphanumeric display.
- There is a groove in the housing of the Ranger for installing a flexible disposable cartridge for the infusion system.
- the length of the unheated portion of the tube of the infusion system, ending with a venipuncture needle, is 1.3 for Astotherm plus and 2.3 meters for Ranger.
- the volume of the drug enclosed in them is 10.4 and 18.5, and with a diameter of 6.8 mm it reaches 36.7 and 65.0 milliliters. It follows that at the beginning of each infusion therapy procedure, the indicated volumes of cold preparations are infused to patients.
- the intensity of the cooling of the drug in the considered section of the tube of the infusion system depends on several factors. Such factors are: the speed of the drug in the tube of the infusion system, the speed of movement of the surrounding air, as well as its temperature. If the drug is administered intensively, in the area of the infusion system under consideration, it cools slightly. At low infusion rates, its temperature may drop by several degrees. Therefore, the Ranger apparatus is used only at high and medium infusion rates, and the Astotherm plus heating device is equipped with an “active insulating sheath”.
- the Hotline system [3] heats the tube section located on the patient side. This section is the central channel of a one-way three-way highway, washed by warm water.
- the middle channel of the line is connected to the pressure pump, and the outer one to the water vessel equipped with a built-in electric heater. Using warm water, infusion and transfusion preparations, as well as flushing liquids, are heated to 38, 40 or 42 ° C.
- the Hotline system does not have a control microprocessor, and instead of an alphanumeric display, LEDs are used. In the cavities of the Hotline system, the growth of pathogenic bacteria is possible, therefore they are subject to periodic disinfection.
- Any procedure for infusion of a drug heated by a method adopted as an analogue is dangerous for the patient.
- a threatening situation occurs in the event of an accident in the electrical network or in case of failure of the electronics of the heating apparatus.
- the risk is increased if the drug, initially having a low temperature, is poured at a high speed. Continuation of such a procedure may result in "unintentional" hypothermia.
- a decrease in the level of the drug in the container leads to a gradual decrease in the rate of its entry into the patient’s blood.
- Another factor that reduces the rate of infusion is the reaction of the patient's vascular system.
- a decrease in the flow rate of the drug leads to an increase in its temperature. The reaction of the patient’s body is obvious - he will spend energy, which he just does not have in this situation.
- Any known heating apparatus emits electrical impulses. These devices typically have built-in defibrillation protection.
- the electrical cord of any known warming device makes it difficult to access a patient’s location. In addition, the power cord complicates sanitization.
- thermostat a device that provides a constant temperature in the study of the physical and chemical properties of substances.
- the thermostat is a vessel, part of the cavity of which, carefully isolated from the surrounding space, is filled with coolant.
- the test substance placed in the working area of the thermostat, is in thermal contact with the coolant and has its temperature.
- the isothermal conditions in the working area of the thermostat are provided by a built-in electric heater with a precision temperature regulator.
- An electric heater built into another type of thermostat used differently - they melt the coolant. After melting the coolant, the electric heater turns off. Subsequently, the temperature in the working area of the thermostat does not change - it is equal to the melting point of the coolant.
- thermostats The stability of the thermal regime of the thermostat is provided due to the heat released during crystallization of the coolant.
- Known thermostats the constant temperature in which provides the process of evaporation of the coolant.
- thermostats with a melted or evaporated coolant the effect that occurs during the implementation of phase transitions of the first kind is used.
- the temperature of the system in which the aggregate transformation of the substance occurs does not change until the transition is complete.
- Astotherm plus and Ranger devices are the simplest flow-through infusion thermostats with built-in electric heaters and temperature regulators. Thermal insulation of the considered devices is not perfect
- the power of their electric heaters is 450 - 900 watts. This power is an order of magnitude higher than the amount of energy that is needed to heat the preparations to a given temperature.
- the claimed group of inventions is aimed at solving two technical problems associated with a single inventive concept.
- the first of the tasks is aimed at solving three problems associated with heating flushing fluids, infusion and transfusion preparations.
- One of these problems is the low therapeutic and economic efficiency of using drugs heated in a known manner.
- Another problem is that any known heating apparatus is potentially dangerous for patients.
- the first technical problem is solved by improving the known method of heating flushing fluids, infusion and transfusion preparations.
- a common feature of the known and both variants of the proposed method is that when they are used, a flow infusion thermostat (hereinafter - thermostat) and an electric heater are used.
- a flow infusion thermostat hereinafter - thermostat
- an electric heater are used.
- the following is an example of the use of a new method for intravenous administration of a drug to a patient.
- a new one in the first embodiment of the proposed method consists in the use of an electric heater located far from the patient.
- a thermostat is used, in the removable part of which the coolant is contained.
- the heat carrier is an alloy of macromolecular substances having a melting point in the range of 25 - 45 ° C.
- the removable part of the thermostat is pushed onto an electric heater, which melts the coolant, after which the melt is overheated by 3-5 degrees.
- the removable part of the thermostat is transferred to the infusion system, then its heated section is placed in the working area of the thermostat.
- the drug begins to heat due to the heat released during solidification of the melt. After 1 - 2 minutes, the temperature in the working area of the thermostat drops to the melting point of the coolant. Accordingly, the temperature of the drug rises in the heated area of the infusion system. Set the desired infusion rate. Subsequently, the heat balance in the working area of the thermostat is maintained due to the heat released during solidification of the melt.
- the second variant of the proposed method perform similar actions.
- a substance having a boiling point in the range of 36 to 45 ° C. is used as a heat carrier.
- the coolant is evaporated with an electric heater, and the resulting steam is overheated by 3-5 degrees. Subsequently, the drug is heated due to the heat released during condensation of the steam.
- the second technical problem is aimed at eliminating the shortcomings of the device selected as the closest analogue.
- a common feature of the proposed device and its analogue is that both of them contain thermostats and electric heaters.
- the proposed device from the analogue differs in that the electric heater is located outside the thermostat.
- the thermostat contains a removable part with a closed cavity filled with coolant.
- the coolant of the thermostat of the device made according to the first embodiment has a melting temperature selected in the range from 25 to 45 ° C.
- the coolant of the thermostat of the device made according to the second embodiment has a boiling point selected in the range from 36 to 43 ° C.
- the electric heater is located in a closed cavity of the thermostat filled with coolant.
- the technical result achieved is: 1) to ensure the safety of the use of heated preparations, and 2) to increase the therapeutic and economic effectiveness of such procedures.
- the electric power of the proposed device is an order of magnitude lower than the power of known heating devices. 3. Personnel safety is ensured by the fact that the electric heater is powered by a step-down transformer.
- the device has a simple design. In mass production, its price will be 15 - 20 times lower than the cost of the well-known universal heating apparatus.
- the device does not contain substances hazardous to the health of patients, medical personnel and the environment.
- the thermostat does not have wires connecting it to an electrical outlet, which facilitates access to the patient, and also simplifies sanitization.
- FIG. 1 shows an infusion stand with an infusion system and a thermostat
- FIG. 2 a fragment of a block of electric heaters
- FIG. 3 longitudinal section of the thermostat assembly (option 1); in FIG. 4 - longitudinal section of the removable part of the thermostat; in FIG. 5 - attached to the cover of the thermostat shown in FIG. 3, a holder with heated sections of the tube of the infusion system
- FIG. 6 is a longitudinal section of a thermostat assembly (option 2);
- FIG. 7 is a section AA of the thermostat shown in FIG. 6.
- the proposed device includes a thermostat having a removable and stationary parts.
- the removable part 1 of the thermostat (Fig. 1 - Fig. 4, Fig. 6, Fig. 7) is made in the form of a thermally insulated vessel, and the stationary part is the cover 2 of this vessel (Fig. 1, Fig. 3, Fig. 5, Fig. 6).
- the cover 2 In the cover 2 there is a compartment 3 for a board with a circuit for controlling the temperature of the drug, and on its outer surface there is a platform 4 with LEDs.
- the temperature control circuit board and the LEDs that display it are not shown in the drawings.
- a through hole 5 is made in the lid 2 (Fig. 3, Fig. 5), intended for the input and output of the tube 6 of the heated section of the infusion system.
- thermostat with vacuum thermal insulation. Instead of vacuum, a synthetic material having low thermal conductivity can be used.
- thermostat has a sealed cavity filled with coolant.
- coolant of the thermostat of the device made according to the first embodiment, an alloy of high molecular substances was used. The composition of the alloy depends on the purpose of the heating device. So, if it is necessary to carry out infusion in a hypothermic mode, a coolant is used that has a melting point below (or equal to) 27 ° C.
- FIG. 6 shows a thermostat made according to the second variant: the closed cavity of its removable part 1 is filled with liquid 9 coolant and its vapor 10.
- a holder 1 1 of the tube 6 of the heated section of the infusion system is attached to the cover 2 of the thermostat.
- the holder 1 1 is a segment of a cylindrical pipe with a longitudinal groove 12, through holes 13 and a spiral groove on the outer surface.
- the outer diameter of the tube 6 of the heated section of the infusion system used in the operation of the device is 6.8 or 4.0 millimeters. In accordance with established practice, the length of the tube 6 is 5.7 or 4.9 meters, and at low rates of infusion, standard infusion systems are used (the length of the tube 6 is 1.5 meters).
- a heated section of the infusion system can be a disposable flexible cartridge 14 (Fig. 6, Fig. 7).
- the composition of the proposed device includes an electric heater unit, remote from the patient. Elements 15 (Fig. 2) of the electric heater block are mounted on the table 16. Elements 15 are connected to a step-down transformer connected to the electric network and disconnected from it by simple automation.
- a disposable "passive" heat-insulating cover (not shown in the drawings).
- the cover is used to isolate the portion of the infusion tube located between the thermostat and the patient. Apply a cover at low infusion rates, as well as at low ambient temperatures.
- the first variant of the proposed method is as follows.
- the heated section of the tube 6, as well as the unheated section with a venipuncture needle, are passed through the opening 5 of the cover 2 and the longitudinal groove 12.
- the tube 6 is placed in the spiral groove of the holder 1 1 (Fig. 5), after which the infusion system is filled.
- the removable part 1 of the thermostat is transferred to the table of electric heaters (Fig. 2).
- the detachable part 1 of the thermostat is put on the elements 15 of one of the electric heaters.
- the coolant 8 is melted, and the melt is overheated by 3-5 degrees.
- the removable part 1 of the thermostat is transferred to the infusion system.
- the detachable part 1 of the thermostat is pushed onto the holder 1 1 - thereby the heated sections of the tube 6 wound thereon are brought into thermal contact with the molten coolant 8.
- the coolant 8 begins to cool, and the contents of the thermostat working area become hot. After 1 - 2 minutes, the temperature in the working zone of the thermostat drops to the melting point of the coolant, as evidenced by the green LED on.
- 1.3 meters of the heated tube 6, ending with a venipuncture needle are wound from the holder 1 1. Venipuncture is performed and the set infusion rate is set.
- the heated preparation cools the coolant 8, but its temperature does not change. The heat balance in the working area of the thermostat is maintained due to the heat released during solidification of the melt.
- the thermal regime in the working area of the removable part 1 of the thermostat is leveled with air circulating through the openings 13.
- the amount of solid coolant 8 in the thermostat gradually increases.
- the solidification of the coolant 8 is completed at the location of the end of the tube 6 of the heated section of the infusion system. After that, the temperature in the working area of the thermostat drops, as evidenced by the yellow LED and a sound signal. If the procedure must be continued, a removable part 1 of another thermostat with a molten coolant is put on a holder 1 1 with a heated section of the infusion system.
- the proposed device equally reliably heats the drugs entering it at any speed.
- the phase transition process accelerates (or slows down) accordingly.
- the amount of heat released always corresponds to the amount that the preparation carries away.
- Actions similar to those listed above are performed if the device is operated with an electric heater located in the cavity of the thermostat filled with coolant.
- the second variant of the proposed method is carried out in a similar manner.
- another variant of the heating device is used.
- Liquid electric coolant 9 is evaporated by its electric heater, and the steam 10 being formed is overheated by 3-5 degrees.
- the drug is heated due to the heat released during the condensation of the coolant vapor.
- inventions can be used in resuscitation, surgery, obstetrics, gynecology, in the treatment of infectious diseases, in therapy, as well as in veterinary medicine.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Le dispositif comprend un thermostat à infusion et un réchauffeur électrique qui se présente comme un bloc isolé. La partie amovible (1) du thermostat comprend une cavité creuse qui est rempli d'un caloporteur (8). On utilise en tant que caloporteur (8) un alliage de substances à haut poids moléculaire. Le point de fusion du caloporteur est égal à la température jusqu'à laquelle est chauffée la préparation. 5 minutes avant le début de la procédure, on chauffe le caloporteur (8) avec un réchauffeur électrique éloigné du patient. Après quoi, on place dans la partie amovible (1) du thermostat une partie chauffée du tuyau (6) du système d'infusion. Pendant l'infusion la préparation est chauffée grâce à la chaleur qui se dégage lors du durcissement de la masse en fusion. La température de la préparation préchauffée à n'importe quelle vitesse d'infusion est égale au point de fusion du caloporteur (8) qui reste inchangée depuis le début et jusqu'à la fin de la procédure. L'invention permet d'assurer la sécurité des procédures, d'améliorer lesur efficacité thérapeutique et économique.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2016141345A RU2662427C2 (ru) | 2014-03-24 | 2015-04-13 | Способ подогрева инфузионных и трансфузионных препаратов, а также промывочных жидкостей. Термостат для осуществления способа |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014110912/14A RU2014110912A (ru) | 2014-03-24 | 2014-03-24 | Способ подогрева инфузионного или трансфузионного препарата и устройство для его осуществления |
| RU2014110912 | 2014-03-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2015147698A2 true WO2015147698A2 (fr) | 2015-10-01 |
| WO2015147698A3 WO2015147698A3 (fr) | 2015-11-26 |
Family
ID=54196530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/RU2015/000165 Ceased WO2015147698A2 (fr) | 2014-03-24 | 2015-04-13 | Procédé de réchauffement de liquides de rinçage et de préparations d'infusion et de perfusion (et variantes) dispositif pour mettre en oeuvre le procédé (et variantes) |
Country Status (2)
| Country | Link |
|---|---|
| RU (2) | RU2014110912A (fr) |
| WO (1) | WO2015147698A2 (fr) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5420962A (en) * | 1993-10-25 | 1995-05-30 | Bakke; Allan P. | Convection blood warming system with disposable flattened tube envelope having vent incorporating a hydrophobic filter |
| US6788885B2 (en) * | 2000-09-01 | 2004-09-07 | Michael Mitsunaga | System for heating instillation or transfusion liquids |
| US6608968B2 (en) * | 2001-11-23 | 2003-08-19 | Allan P Bakke | Convection blood warming system with disposable flattened tube envelope incorporating paperboard “needle” for inserting envelope between heating plates and employing active and passive insulation of outlet flow path to provide normothermic fluid at zero to 600 milliliters per minute |
| EP1721626B1 (fr) * | 2004-02-17 | 2016-02-17 | Genshirou Ogawa | Dispositif chauffeur de liquide d'infusion |
| RU54513U1 (ru) * | 2005-12-26 | 2006-07-10 | Ооо Нпп Уникон | Аппарат для подогрева инфузионных лекарственных средств |
| RU72303U1 (ru) * | 2007-10-23 | 2008-04-10 | Государственное образовательное учреждение высшего профессионального образования Нижегородский государственный технический университет | Парогенератор со свинцовым теплоносителем или его сплавами |
| RU134794U1 (ru) * | 2013-05-20 | 2013-11-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Устройство для подогрева жидкостей и лекарственных растворов, используемых при инфузионной терапии |
-
2014
- 2014-03-24 RU RU2014110912/14A patent/RU2014110912A/ru not_active Application Discontinuation
-
2015
- 2015-04-13 RU RU2016141345A patent/RU2662427C2/ru not_active IP Right Cessation
- 2015-04-13 WO PCT/RU2015/000165 patent/WO2015147698A2/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015147698A3 (fr) | 2015-11-26 |
| RU2016141345A3 (fr) | 2018-04-26 |
| RU2016141345A (ru) | 2018-04-26 |
| RU2014110912A (ru) | 2015-09-27 |
| RU2662427C2 (ru) | 2018-07-25 |
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