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WO2015147008A1 - Système de photographie d'image radiologique, procédé de photographie d'image radiologique et photographie d'image radiologique - Google Patents

Système de photographie d'image radiologique, procédé de photographie d'image radiologique et photographie d'image radiologique Download PDF

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Publication number
WO2015147008A1
WO2015147008A1 PCT/JP2015/058975 JP2015058975W WO2015147008A1 WO 2015147008 A1 WO2015147008 A1 WO 2015147008A1 JP 2015058975 W JP2015058975 W JP 2015058975W WO 2015147008 A1 WO2015147008 A1 WO 2015147008A1
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WO
WIPO (PCT)
Prior art keywords
radiation
image
subject
unit
interest
Prior art date
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Ceased
Application number
PCT/JP2015/058975
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English (en)
Japanese (ja)
Inventor
弘毅 中山
井上　知己
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Fujifilm Corp
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Fujifilm Corp
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Priority to JP2016510396A priority Critical patent/JP6162324B2/ja
Publication of WO2015147008A1 publication Critical patent/WO2015147008A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/502—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of breast, i.e. mammography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/025—Tomosynthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/12—Arrangements for detecting or locating foreign bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
    • A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/54—Control of the diagnostic device
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment

Definitions

  • the present invention relates to a radiation image capturing system, a radiation image capturing method, and a radiation image capturing program.
  • a radiographic imaging apparatus that performs radiography for the purpose of medical diagnosis.
  • Examples of this type of radiographic imaging device include mammography that images the breast of a subject for the purpose of early detection of breast cancer and the like.
  • mammography a technique for performing tomosynthesis imaging in which radiation is applied to a breast of a subject at different angles is known.
  • tomosynthesis imaging a tomographic image is generated by reconstructing from a plurality of radiographic images captured by irradiating a subject with radiation with different angles of incidence on a radiation detection surface within a predetermined range.
  • US Pat. No. 7,831,296 describes that mammography imaging and tomosynthesis imaging are performed with a single breast compression.
  • the present invention provides a radiation image capturing system, a radiation image capturing method, and a radiation image capturing program capable of obtaining an accurate radiation image while reducing a burden on a subject.
  • a first aspect of the present invention is a radiographic imaging system, which generates a radiographic image of a subject based on a radiation source that irradiates the subject with radiation and radiation that is emitted from the radiation source and transmitted through the subject.
  • a radiological image generation unit a site of interest detection unit that detects a site of interest from a first radiographic image of the subject generated by the radiation image generation unit by irradiating the subject with a radiation source at a predetermined incident angle;
  • the radiation source emits radiation a plurality of times with different incident angles in the first incident angle range, and the radiation image generator generates a subject.
  • the radiation source When the region of interest is detected from the first radiation image by performing the first tomosynthesis imaging for acquiring a plurality of radiation images, the radiation source has the first incident angle.
  • a control unit that executes a second tomosynthesis imaging in which a radiation image is generated a plurality of times at different incident angles in a second incident angle range that is larger than the range, and a plurality of radiation images of the subject are acquired by the radiation image generation unit; Is provided.
  • a second aspect of the present invention is a radiographic imaging system that generates a radiographic image of a subject based on a radiation source that irradiates the subject with radiation and radiation that is emitted from the radiation source and transmitted through the subject.
  • a radiological image generation unit a site of interest detection unit that detects a site of interest from a first radiographic image of the subject generated by the radiation image generation unit by irradiating the subject with a radiation source at a predetermined incident angle; Based on the detection result of the part detection unit, the radiation source irradiates the radiation a plurality of times with different incident angles in the first incident angle range, and the radiation image generation unit acquires a plurality of radiation images of the subject.
  • a display unit for performing a recommended display for recommending any of the second tomosynthesis imaging for acquiring a plurality of ray images; and an input unit for inputting a selection result of the first tomosynthesis imaging or the second tomosynthesis imaging. Based on the input from the input unit, the control unit causes the first tomosynthesis imaging or the second tomosynthesis imaging to be executed.
  • the second incident angle range may include a first incident angle range.
  • the first incident angle range and the second incident angle range may be bilaterally symmetric with a predetermined incident angle as a center. .
  • the subject is the subject's breast, and the subject's breast acquired from the radiation image generation unit A tomographic image generation unit that generates a tomographic image of a breast based on the plurality of radiation images, and a display device that displays a tomographic image of the left and right breasts of the subject generated by the tomographic image generation unit
  • the tomographic image generation unit performs the first tomosynthesis imaging.
  • a first tomographic image having a resolution in the depth direction of the first resolution is generated based on the acquired radiographic image of one breast, and based on the radiographic image of the other breast acquired by the second tomosynthesis imaging.
  • a second tomographic image having a second resolution whose resolution in the depth direction is higher than the first resolution is generated, and further, a radiological image acquired in the first incident angle range among the radiographic images of the other breast
  • the display unit Based on the first tomographic image, the display unit generates a first tomographic image of one breast, a second tomographic image of the other breast, and a third tomographic image. At least one of the tomographic images may be displayed.
  • the display device may switchably display the second tomographic image and the third tomographic image of the other breast.
  • the display device displays the first tomographic image and the second tomographic image, and then the second tomographic image.
  • the image and the third tomographic image may be displayed in a switchable manner.
  • the display device displays a tomographic image of the breast and another tomographic image having a different resolution from the tomographic image. A predetermined mark indicating whether or not switching is possible may be displayed.
  • the display device cannot switch a tomographic image of one breast obtained by the first tomosynthesis imaging by a predetermined mark. This means that the other tomographic image obtained by the second tomosynthesis imaging may be switched by a predetermined mark.
  • a radiographic imaging method wherein a radiographic image of a subject is generated based on a radiation source that emits radiation toward the subject and radiation that is emitted from the radiation source and transmitted through the subject.
  • a radiation image capturing method of a radiation image capturing apparatus including a radiation image generating unit, wherein a radiation source irradiates a subject at a predetermined incident angle and the first of the subject generated by the radiation image generating unit If the region of interest is detected from the first radiation image by the region-of-interest detection step and the region-of-interest detection step does not detect the region of interest from the first radiation image, the radiation source has a different incident angle in the first incident angle range.
  • the first tomosynthesis imaging in which a plurality of radiation images of the subject are acquired by the radiation image generation unit, and a region of interest detection step is performed.
  • the radiation source emits radiation a plurality of times with different incident angles in a second incident angle range that is larger than the first incident angle range, thereby generating a radiation image.
  • a control step of executing second tomosynthesis imaging in which a plurality of radiographic images of the subject are acquired by the unit.
  • An eleventh aspect of the present invention is a radiographic image capturing method for generating a radiographic image of a subject based on a radiation source that irradiates the subject with radiation and radiation that is emitted from the radiation source and transmitted through the subject.
  • a radiographic imaging method of a radiographic imaging device including a radiographic image generation unit, wherein the region of interest detection unit irradiates a subject with a predetermined incident angle and generates the radiographic image generation unit Detecting a region of interest from the first radiographic image of the subject and the display unit causes the radiation source to vary the incident angle within the first incident angle range based on the detection result of the region of interest detection unit.
  • a second tomosynthesis imaging in which a plurality of radiation images of the subject are acquired by the radiation image generation unit, or a radiation source that is larger than the first incident angle range.
  • the unit performs a recommended display for recommending either the first tomosynthesis imaging or the second tomosynthesis imaging based on the detection result of the region-of-interest detection unit, and the input unit performs the first tomosynthesis imaging or the second tomosynthesis imaging.
  • a step of causing the control unit to execute the first tomosynthesis imaging or the second tomosynthesis imaging based on the input by the input unit.
  • a radiographic image capturing program comprising: a computer; a region-of-interest detection unit of the radiographic image capturing system according to any one of the first to ninth aspects of the present invention; It is for functioning as a control unit.
  • the radiographic imaging apparatus 10 is configured to perform radiation (for example, X-rays) using the breast N of the subject W as a subject in the standing state where the subject W is standing. ), For example, mammography.
  • radiation for example, X-rays
  • the front side close to the subject W when the subject W faces the radiographic image capturing apparatus 10 at the time of imaging will be described as the front side of the radiographic image capturing apparatus 10.
  • the back side away from the subject W when the subject W faces the radiographic image capturing apparatus 10 will be described as the rear side of the radiographic image capturing apparatus 10.
  • the left-right direction of the subject W when the subject W faces the radiation image capturing apparatus 10 will be described as the apparatus left-right direction of the radiation image capturing apparatus 10. Refer to the arrows in FIGS. 1 and 2 for the front side, the rear side, and the left-right direction of the difference of the radiographic imaging device 10.
  • the imaging target of the radiographic image capturing apparatus 10 is not limited to the breast N, and may be, for example, other parts of the human body, non-human organisms or objects (inorganic substances).
  • the radiographic image capturing apparatus 10 may be an apparatus that captures the breast N of the subject W when the subject W is sitting on a chair (including a wheelchair) or the like. Any device may be used as long as the breast N of the subject W can be separately photographed while the upper body of the examiner W is standing.
  • the radiographic image capturing apparatus 10 includes a measurement unit 12 having a substantially C-shaped side view provided on the front side of the apparatus, and a base unit 14 that supports the measurement unit 12 from the rear side of the apparatus. .
  • the measurement unit 12 compresses the breast N between the imaging surface 22 on which the planar imaging surface 20 that contacts the breast N of the subject W in the standing position is formed and the imaging surface 20 of the imaging table 22. And a holding part 28 that supports the imaging table 22 and the compression plate 26. Note that a member that transmits radiation is used for the compression plate 26.
  • a sensor (not shown) for detecting the relative position of the compression plate 26 with respect to the imaging table 22 (particularly, the imaging surface 20) is provided inside the holding unit 28.
  • the radiographic imaging apparatus 10 can detect the thickness of the breast with this sensor.
  • the measuring unit 12 includes a radiation source 30 such as a tube (see FIG. 4), a radiation irradiation unit 24, and a support unit 29.
  • the radiation irradiation unit 24 irradiates inspection radiation from the radiation source 30 toward the imaging surface 20.
  • the support unit 29 is separated from the holding unit 28 and supports the radiation irradiation unit 24.
  • the measurement unit 12 is provided with a rotation shaft 16, and the measurement unit 12 can rotate with respect to the base unit 14.
  • the rotation shaft 16 is fixed to the support portion 29, and the rotation shaft 16 and the support portion 29 rotate integrally.
  • Each of the rotating shaft 16 and the holding portion 28 is provided with a gear, and the holding portion 28 and the rotating shaft 16 are connected and rotated integrally by switching between the meshing state and the non-meshing state of the gears. And the rotation shaft 16 can be switched to the state of being separated from the holding portion 28 and idling.
  • the transmission / non-transmission switching of the rotational force of the rotating shaft 16 is not limited to this gear, and various machine elements can be used.
  • the holding unit 28 supports the imaging table 22 and the radiation irradiation unit 24 by separating the imaging surface 20 and the radiation irradiation unit 24 by a predetermined interval.
  • the holding unit 28 also holds the compression plate 26, and the interval between the compression plate 26 and the imaging surface 20 changes as the compression plate 26 slides on the holding unit 28.
  • the imaging surface 20 with which the breast N abuts is made of, for example, carbon from the viewpoint of radiation transparency and strength.
  • a radiation detector 42 for detecting radiation that has passed through the breast N and the imaging surface 20 is disposed inside the imaging table 22.
  • the radiographic image capturing apparatus 10 generates image information indicating a radiographic image based on the radiation detected by the radiation detector 42, and generates a radiographic image by an image processing unit (see FIG. 4) described later. Detailed description of the generation of the radiation image will be described later.
  • the radiographic imaging device 10 of the present exemplary embodiment irradiates the breast N as a subject with different incident angles (changes) with respect to the detection surface of the radiation detector 42 within a predetermined range. It is an apparatus that can perform imaging at different incident angles.
  • the incident angle refers to an angle formed by the normal line of the detection surface of the radiation detector 42 and the radiation axis.
  • the detection surface of the radiation detector 42 is a surface substantially parallel to the imaging surface 20.
  • the radiographic image capturing apparatus 10 irradiates the breast N with a plurality of times by changing the incident angle with respect to the detection surface of the radiation detector 42 within a predetermined range.
  • This is a device that performs so-called tomosynthesis imaging.
  • a predetermined range in which the incident angle in tomosynthesis imaging is varied is referred to as an “incident angle range”.
  • Specific examples of the incident angle range include a range of ⁇ 10 degrees or ⁇ 20 degrees with respect to the normal line of the detection surface of the radiation detector 42.
  • the position of the radiation irradiator 24 is moved from the angle ⁇ by a predetermined angle ⁇ , and the positions of the radiation irradiator 24 are n locations (imaging locations) P1 to Pn. Shooting is performed.
  • incident angle the incident angle of radiation with respect to the normal direction of the detection surface of the radiation detector 42 is referred to as “incident angle”.
  • the imaging at each imaging location may be performed while moving the radiation irradiation unit 24 continuously.
  • the radiation irradiation unit 24 is irradiated with radiation from the radiation irradiation unit 24 to the breast N when it reaches each imaging position without stopping while moving the radiation irradiation unit 24. Also good.
  • the radiation irradiation unit 24 may be moved to each imaging location, and then temporarily stopped, and the radiation irradiation unit 24 may irradiate the breast N with radiation. .
  • radiation is irradiated from the radiation irradiation unit 24 to the breast N, and after stopping, the radiation irradiation unit 24 is moved again. Also good.
  • the radiographic imaging apparatus 10 of the present embodiment performs tomosynthesis imaging in two types of incident angle ranges.
  • a small (narrow) incident angle range which is an example of the first incident angle range of the disclosed technology, of two types of incident angle ranges is referred to as a “small incident angle range”.
  • a large (wide) incident angle range which is an example of the second incident angle range of the disclosed technique is referred to as a “large incident angle range”.
  • Values such as the incident angle range are stored in advance in the memory 43B in the control unit 46, for example.
  • both the small incident angle range and the large incident angle range are symmetric with respect to the predetermined incident angle, and the predetermined incident angles in the small incident angle range and the large incident angle range are the same.
  • the small incident angle range is included in the large incident angle range.
  • the predetermined incident angle is set as the angle in the normal direction of the detection surface of the radiation detector 42.
  • the small incident angle range is included in the large incident angle range.
  • FIGS. 2 and 3 respectively show the posture of the radiographic image capturing apparatus 10 and the position of the radiation irradiating unit 24 when tomosynthesis imaging is performed. As shown in FIGS. 2 and 3, tomosynthesis imaging is performed by tilting the support portion 29 that supports the radiation irradiation portion 24.
  • the breast N of the subject W is irradiated with a plurality of (n) times of radiation. Therefore, in order to suppress the exposure dose, the dose of radiation for one time is lowered, and for example, normal two-dimensional imaging with n total times (irradiating the subject with radiation from a fixed position without moving the radiation source 30) The same dose of radiation as in normal shooting) is applied.
  • the radiographic imaging apparatus 10 of the present embodiment performs both CC (Cranio & Caudal: head-to-tail direction) imaging and MLO (Mediolateral-Oblique) imaging on the breast N. It is a device that can.
  • CC imaging the orientation of the holding unit 28 is adjusted with the imaging surface 20 facing the vertical direction with respect to the ground, and the radiation irradiating unit 24 is perpendicular to the normal of the imaging surface 20 (that is, 0).
  • the posture of the support portion 29 is adjusted to the position of degree. Thereby, radiation is irradiated from the radiation irradiation unit 24 to the breast N from the head side to the foot side of the subject W in the standing position, and CC imaging is performed.
  • the posture of the holding unit 28 is adjusted in a state in which the imaging table 22 is rotated by 45 ° or more and less than 90 ° compared to the case of performing CC imaging.
  • Positioning is performed with the axilla of the subject W applied to the front side wall corner 22A.
  • radiation is irradiated from the radiation irradiation unit 24 to the breast N from the axial center side of the body of the subject W to the outside, and MLO imaging is performed.
  • a chest wall surface 25 is formed on the surface of the imaging table 22 on the front side of the apparatus so that the chest portion below the breast N of the subject W contacts when the imaging is performed.
  • the chest wall surface 25 is formed in a flat shape.
  • FIG. 4 shows a block diagram of an example of the configuration of the radiation image capturing system 6 of the present embodiment.
  • the radiographic image capturing system 6 of this embodiment includes a radiographic image capturing device 10, an image processing device 50, and a display device 80.
  • the radiographic imaging device 10 includes a radiation irradiation unit 24, a radiation detector 42, an operation panel 44, a control unit 46, and a communication I / F (interface) unit 48.
  • the control unit 46 has a function of controlling the operation of the entire radiographic imaging apparatus 10.
  • the control unit 46 includes a CPU (Central Processing Unit) 43A, a memory 43B including a ROM (Read Only Memory) and a RAM (Random Access Memory), a non-volatile storage unit including an HDD (Hard Disk Drive), a flash memory, and the like. 43C.
  • the control unit 46 includes an image processing unit 45 and a region-of-interest detection unit 47.
  • the image processing unit 45 and the region-of-interest detection unit 47 include the CPU 43A, the memory 43B, and It is partially contained in the storage unit 43C and the like.
  • the control unit 46 is connected to the radiation irradiation unit 24, the radiation detector 42, the operation panel 44, and the communication I / F unit 48.
  • the control unit 46 When the control unit 46 receives an irradiation instruction from the operator using the exposure switch displayed on the instruction input unit 84, the radiation provided in the radiation irradiation unit 24 according to the imaging menu set based on the instructed exposure condition. Radiation is emitted from the source 30 to the imaging surface 20.
  • the radiation source 30 emits cone beam radiation (for example, a conical X-ray beam).
  • the radiation image generation unit 41 has a function of generating a radiation image of the subject based on the radiation transmitted through the subject.
  • the radiation image generation unit 41 includes a radiation detector 42 and an image processing unit 45.
  • the radiation detector 42 receives image radiation carrying image information, records the image information, and outputs the recorded image information.
  • a specific example of the radiation detector 42 is an FPD (Flat Panel Detector) that arranges a radiation sensitive layer, converts radiation into digital data, and outputs the digital data.
  • the radiation sensitive layer can be disposed substantially parallel to the imaging surface 20.
  • the radiation detector 42 receives image radiation that has passed through the breast N and obtains image information indicating a radiographic image. Then, the image processing unit 45 performs necessary processes such as gain correction, offset correction, and defective pixel correction on the image information obtained by the radiation detector 42 to generate a radiation image.
  • the position where the image processing unit 45 is provided is not limited to the present embodiment.
  • the image processing unit 45 may be provided in the radiation detector 42. Further, the image processing unit 45 may be provided in the image processing apparatus 50 as described later.
  • the region-of-interest detection unit 47 has a function of detecting a region of interest from the radiographic image generated by the image processing unit 45.
  • the site of interest refers to a site of interest when a user such as a doctor observes a radiographic image, and includes, for example, a site of mutation due to a lesion or the like.
  • Specific examples of the mutation site include a mutation site suspected of calcification and a mutation site suspected of being a tumor.
  • Information for detecting the region of interest is stored in the memory 43B of the control unit 46 or the like.
  • the image processing unit 45 and the region-of-interest detection unit 47 are provided in the control unit 46 as a part of the control unit 46 in order to perform high-speed processing without going through the network 49.
  • the image processing unit 45 and the region of interest detection unit 47 may have a hardware configuration different from that of the control unit 46.
  • the image processing unit 45 and the region-of-interest detection unit 47 may be provided on the image processing device 50 side.
  • information for detecting a mutation site by the site-of-interest detection unit 47 may be stored in the ROM 54 of the image processing device 50 or the like.
  • the image processing unit 45 and the region-of-interest detection unit 47 may have a hardware configuration or a software configuration that is executed by the CPU 43A executing a program. In that case, it may be software executed on the same computer as the computer on which software for controlling the entire radiographic imaging apparatus 10 is executed, or software executed on another computer.
  • the instruction input unit 84 has a function of setting various operation information including shooting conditions, various operation instructions, and the like. It should be noted that the function of the engineer moving the compression plate 26 up and down while sandwiching the patient's breast N before tilting, or tilting the support 29 (ie, the radiation irradiating unit 24) in order to perform CC imaging, MLO imaging, etc.
  • An operation panel 44 is also provided.
  • the operation panel 44 is provided as a plurality of switches on the imaging table 22 of the radiographic imaging apparatus 10. Note that the operation panel 44 may be provided as a touch panel.
  • the imaging conditions set by the instruction input unit 84 include information on radiographic imaging such as tube voltage, tube current, exposure conditions including irradiation time, and posture information.
  • the posture information specified by the instruction input unit 84 includes information indicating an imaging position (including an incident angle and an incident angle range) when imaging is performed with radiation incident on the breast N at a plurality of incident angles. It is.
  • the instruction input unit 84 functions as a display unit of the disclosed technology.
  • the present invention is not limited to this.
  • the operation panel 44 may function as a display unit.
  • various operation information such as exposure conditions and posture information, various operation instructions, and the like may be set by the operator through the instruction input unit 84, or other control devices (for example, RIS: Radiology Information System). Or may be stored in advance in a storage unit in the control unit 46.
  • RIS Radiology Information System
  • the control unit 46 emits radiation from the radiation irradiation unit 24 according to the imaging menu set based on the set various information (breast N ) To capture a radiographic image.
  • the control unit 46 adjusts the posture of the holding unit 28 so that the imaging surface 20 faces upward, and the radiation irradiation unit 24 moves upward with respect to the imaging surface 20.
  • the attitude of the support portion 29 is adjusted to the position.
  • the control unit 46 rotates the support unit 29 to move the radiation irradiation unit 24 in an arc shape from the angle ⁇ to the angle ⁇ based on the imaging conditions, and causes the radiation irradiation unit 24 to move. Radiation is emitted from the radiation source 30 provided. As a result, n radiation images having different radiation incident angles are obtained.
  • the communication I / F unit 48 is a communication interface having a function for transmitting and receiving a captured radiographic image and various information via the network 49 between the radiographic image capturing apparatus 10 and the image processing apparatus 50. .
  • the image processing apparatus 50 has a function of generating a tomographic image reconstructed from the radiographic image acquired from the radiographic image capturing apparatus 10 (tomographic image generating unit 68).
  • the image processing apparatus 50 has a function (not shown) for performing image processing for a doctor or the like to observe a tomographic image, a projection image described below, or the like on the display device 80.
  • a person who observes a captured radiographic image or generated tomographic image, or observes or diagnoses a region of interest or the like, such as a doctor is referred to as a “user”.
  • the radiation image obtained by the radiation detector 42 detecting radiation by tomosynthesis imaging in the radiation image capturing apparatus 10 is referred to as a “projection image”.
  • the image processing apparatus 50 includes a CPU 52, ROM 54, RAM 56, HDD 58, communication I / F unit 60, image display instruction unit 62, instruction reception unit 64, tomographic image generation unit 68, and storage unit 74. These are connected to each other by a bus 75 such as a control bus or a data bus.
  • the CPU 52 has a function of controlling the entire image processing apparatus 50 and the like. Specifically, the CPU 52 performs control by executing various programs 55 stored in the ROM 54. In the image processing apparatus 50 of the present embodiment, the case where the program 55 is stored in advance is shown. However, the present invention is not limited to this, and the program 55 is stored in a recording medium such as a CD-ROM or a removable disk. Alternatively, it may be installed in the ROM 54 or the like from a recording medium. The program 55 may be installed in the ROM 54 or the like from an external device via a communication line such as the Internet.
  • the RAM 56 has a function of securing a work area when the CPU 52 executes the program 55.
  • the HDD 58 has a function of storing and holding various data.
  • the tomographic image generation unit 68 is described as being included in the image processing apparatus 50 as a part of the image processing apparatus 50, but the present invention is not limited to this.
  • the tomographic image generation unit 68 may have a hardware configuration different from that of the image processing apparatus 50.
  • the communication I / F unit 60 is a communication interface having a function for transmitting and receiving a radiographic image and various information captured between the image processing apparatus 50 and the radiographic image capturing apparatus 10 via the network 49. is there.
  • the image display instruction unit 62 has a function of instructing the display 82 of the display device 80 to display a radiation image.
  • the case where the image display instruction unit 62 is provided in the image processing apparatus 50 will be described. However, part or all of the functions of the image display instruction unit 62 are incorporated in the control unit 46. May be.
  • the display device 80 has a function of displaying captured radiographic images, and includes a display 82 and an instruction input unit 84 on which radiographic images are displayed.
  • the instruction input unit 84 may be, for example, a touch panel, a keyboard, a mouse, or the like.
  • the instruction input unit 84 allows the user to input an instruction related to the display of the radiation image, the above-described imaging conditions, and the like.
  • the user can instruct the start of shooting from the instruction input unit 84.
  • the display 82 and the instruction input unit 84 are touch panels, the display 82 and the instruction input unit 84 can be shared.
  • the instruction receiving unit 64 has a function of receiving an instruction from the user input by the instruction input unit 84 of the display device 80.
  • the tomographic image generation unit 68 has a function of reconstructing a plurality of projection images and generating a tomographic image parallel to the imaging surface 20 at a predetermined slice interval.
  • “parallel” is used, but it also includes substantially parallel which is a design error.
  • the breast N is pressed and fixed by the compression plate 26 in a state where the breast N is in contact with the imaging surface 20 of the imaging table 22.
  • the radiation incident angle with respect to the normal direction of the detection surface of the radiation detector 42 that is parallel to the imaging surface 20, and the tomographic image of the breast N is equal.
  • the tomographic image generator 68 moves the radiation irradiator 24 (radiation source 30) to the positions P1, P2, P3,..., Pn, and at a predetermined slice interval from a plurality of projection images photographed at each position. A tomographic image is generated. Note that the position at which the region of interest is projected on the projection image differs depending on the incident angle of radiation with respect to the imaging surface 20. Therefore, the tomographic image generation unit 68 acquires imaging conditions when a projection image is captured from the radiation image capturing apparatus 10. The tomographic image generation unit 68 calculates the amount of movement of the region of interest between the plurality of projection images based on the incident angle of the radiation included in the imaging conditions, and based on a known reconstruction method such as a shift addition method. Reconstruct a tomographic image.
  • a conventionally known CT (Computed Tomography) reconstruction method can be used in addition to the shift addition method.
  • CT reconstruction method a typical method, FBP method (Filtered Back Projection method) can be used.
  • the FBP method is a reconstruction method in which tomographic parallel plane tomographic scanning is regarded as part of cone beam CT scanning and the filter back projection method is extended.
  • JP2011-125698A an iterative reconstruction method described in JP2011-125698A can also be used.
  • this iterative reconstruction method is also a reconstruction method for CT, it can also be applied to reconstruction when tomosynthesis imaging is performed, as in the FBP method.
  • the tomographic image generation unit 68 can be realized by hardware, for example, hardware such as a general electronic circuit, ASIC (Application Specific Integrated Circuit), or FPGA (Field Programmable Gate Array).
  • ASIC Application Specific Integrated Circuit
  • FPGA Field Programmable Gate Array
  • the tomographic image generation unit 68 can generate tomographic images having different resolutions from the projection image obtained by one tomosynthesis imaging.
  • the upper limit of the resolution of the tomographic image generated by the tomographic image generation unit 68 is determined by the size (width) of the incident angle range when the projection image is captured.
  • the resolution is the resolution in the normal direction (depth direction) of the tomography, and refers to the resolution in the normal direction of the detection surface of the radiation detector 42.
  • the incident angle range is larger (wider)
  • the upper limit of the resolution of the tomographic image becomes higher and the resolution can be increased.
  • the region of interest can be projected to more different positions on the projection image, so that the resolution can be increased.
  • the tomographic image with high resolution is included in the thickness according to the required height.
  • Image information that is, necessary image information is obtained. Therefore, the reconstructed tomographic image is an image with a sharp appearance.
  • the reconstructed tomographic image becomes an image that looks dull, as in the case of superimposing high-resolution tomographic images.
  • the tomographic image generation unit 68 can reduce the resolution of the tomographic image by generating a tomographic image using only a part of the captured projection images. For example, the resolution of the tomographic image can be lowered as compared with the case where all the projection images are used.
  • the storage unit 74 has a function of storing a projection image captured by the radiation image capturing apparatus 10, image information representing each of the tomographic images generated by the tomographic image generation unit 68, and the like.
  • a specific example of the storage unit 74 is a mass storage device such as a hard disk.
  • the storage unit 74 also stores imaging conditions (such as an incident angle of radiation) in which a radiographic image is captured by the radiographic image capturing apparatus 10.
  • FIG. 5 is a diagram illustrating a first configuration example of the radiation detector 42.
  • the radiation detector 42 receives radiation that has passed through the subject and outputs image information indicating a radiation image of the subject. As shown in FIG. 5, the radiation detector 42 accumulates in a scintillator (not shown) that emits light upon receiving radiation, a sensor unit S that generates light by receiving light generated by the scintillator, and the sensor unit S. A plurality of pixels 21 including switching elements Tr for reading out the generated charges are provided. Specific examples of the switching element Tr include a thin film transistor. Hereinafter, the switching element Tr is referred to as “transistor Tr”.
  • the radiation detector 42 further includes a charge amplifier, an A / D (analog / digital) converter, a readout control IC (Integrated Circuit), etc., all of which are not shown.
  • the radiation detector 42 according to the present embodiment is an indirect conversion type radiation detector that generates charges by irradiating the sensor unit S with light converted according to radiation by the scintillator, but is not limited thereto. .
  • a plurality of charge generation layers for example, a layer whose main component is Se
  • a plurality of switching elements that read out the charges accumulated in the charge generation layer Pixel 21.
  • the plurality of pixels 21 are arranged in one direction (control wiring direction corresponding to the horizontal direction in FIG. 5, hereinafter referred to as “row direction”) and the cross direction with respect to the row direction (signal wiring direction corresponding to the vertical direction in FIG. 5). In a matrix).
  • the arrangement of the pixels 21 is shown in a simplified manner. For example, 1024 ⁇ 1024 pixels 21 are arranged in the row direction and the column direction.
  • the radiation detector 42 is provided with a plurality of control wirings G (G1 to G4 in FIG. 5) and a plurality of signal wirings D (D1 to D4 in FIG. 5) intersecting each other. .
  • the control wiring G is for controlling on / off of the transistor Tr.
  • the signal wiring D is provided for each column of the pixels 21 in order to read out the electric charge accumulated in the sensor unit S.
  • the charge of each pixel 21 flowing from the signal wiring D becomes digital data (that is, an example of image information indicating a radiation image) through a charge amplifier, an A / D converter, etc. (not shown), and enters the image processing unit 45. Is output.
  • a control signal flows through each control wiring G and M by a read control IC (not shown).
  • the sensor unit S of each pixel 21 is provided with a semiconductor layer and a bias electrode that applies a bias voltage to the semiconductor layer.
  • the bias electrode of each pixel is connected to the common wiring 90.
  • a bias voltage is applied from a power source 92 through the common wiring 90.
  • Control signal for switching (ON / OFF) each transistor Tr flows through the control wiring G.
  • each transistor Tr is switched (ON / OFF).
  • an electrical signal corresponding to the amount of charge accumulated in each pixel 21 flows through the transistor Tr in accordance with the switching state (on / off state) of the transistor Tr in each pixel 21.
  • FIG. 6 is a diagram illustrating a second configuration example of the radiation detector 42.
  • the radiation detector 42 shown in FIG. 6 has a pixel area except that a plurality of pixels 21 having a hexagonal shape are arranged in a two-dimensional honeycomb shape adjacent to each other to form a substantially rectangular area as a whole. This is the same as the configuration of the radiation detector 42 shown in FIG.
  • Each pixel 21 receives the light converted by the scintillator, generates a charge, a charge storage capacitor 5 that stores the charge generated by the sensor unit 98, and reads the charge stored in the charge storage capacitor 5.
  • Thin film transistor hereinafter referred to as “transistor”).
  • the arrangement of the pixels 21 in a honeycomb shape means that the first pixel rows and the second pixel rows are alternately arranged in a direction intersecting the column direction (vertical direction in FIG. 6), and the first Pixels 21 in two pixel rows are arranged corresponding to adjacent pixels in the first pixel row, and are shifted in the row direction by 1 ⁇ 2 of the arrangement pitch of the pixels 21 in the first pixel row. Is to be placed.
  • the first pixel row a plurality of pixels 21 having a hexagonal pixel area and the same size are arranged in the row direction (horizontal direction in FIG. 6).
  • the second pixel row a plurality of pixels 21 having the same size as the pixels 21 in the first pixel row and having a hexagonal pixel region are arranged in the row direction.
  • the radiation detector 42 includes first control wirings G1 to G4 arranged corresponding to each pixel row.
  • the first control wirings G1 to G4 are collectively referred to as “control wiring G”.
  • a gate electrode of the transistor 4 provided in each pixel 21 is connected to the control wiring G, and on / off of the transistor 4 is controlled according to a signal flowing through the control wiring G.
  • the radiation detector 42 includes a plurality of signal wirings D1 to D3 that are generated in the sensor unit 98 in each pixel 21 and read out the charges accumulated in the charge storage capacitor 5, a common ground (common ground) wiring 31, A plurality.
  • the signal wirings D1 to D3 are collectively referred to as “signal wiring D”.
  • the charge of each pixel 21 flowing from the signal wiring D becomes digital data (that is, an example of image information indicating a radiation image) through a charge amplifier, an A / D converter, etc. (not shown), and enters the image processing unit 45. Is output.
  • a charge signal corresponding to each pixel 21 flows in each of the signal wirings D1 to D3 for each pixel row. Thereby, the image information which shows a radiographic image with the radiation irradiated to the radiation detector 42 can be obtained.
  • control unit 46 captures a two-dimensional image before tomosynthesis imaging.
  • control unit 46 analyzes and detects the presence / absence of the region of interest from the obtained radiographic image by the region-of-interest detection unit 47.
  • the control unit 46 determines imaging conditions for tomosynthesis imaging including the incident angle range based on the analysis result.
  • the control unit 46 performs tomosynthesis imaging under the determined imaging conditions, so that tomosynthesis imaging can be performed under appropriate imaging conditions.
  • the region-of-interest detection unit 47 of the control unit 46 converts a radiographic image obtained by capturing a two-dimensional image before tomosynthesis imaging to CAD (Computer Aided).
  • CAD Computer Aided
  • the region of interest is detected by performing analysis using an analysis technique such as Diagnosis.
  • the control unit 46 determines imaging conditions for tomosynthesis imaging according to the presence / absence of a region of interest.
  • region of interest detection unit 47 For the detection of the region of interest in the control unit 46 (region of interest detection unit 47), for example, a technique described in JP 2011-120747 A is employed.
  • a technique using iris filter processing or the like as described in the above publication Japanese Patent Laid-Open No. 10-97624
  • a technique using a morphology filter see also Japanese Patent Laid-Open No. 8-294479
  • the techniques and techniques used for detecting the region of interest are not limited to these.
  • the control unit 46 when the region of interest is not detected by the control unit 46 (region of interest detection unit 47), the control unit 46 performs tomosynthesis imaging under the first condition in which the incident angle range is set to the small incident angle range. I do.
  • the control unit 46 when the region of interest is detected, the control unit 46 performs control to perform tomosynthesis imaging under the second condition in which the incident angle range is set to the large incident angle range.
  • tomosynthesis imaging performed under the first condition is referred to as “first tomosynthesis imaging”
  • tomosynthesis imaging performed under the second condition is referred to as “second tomosynthesis imaging”. When doing so, it is called “tomosynthesis photography”.
  • the region-of-interest detection unit 47 of the control unit 46 is described as detecting the region of interest. However, for example, when the processing capability of the region-of-interest detection unit 47 of the control unit 46 is low, an image is displayed.
  • the processing device 50 may be provided with the function of the region-of-interest detection unit 47.
  • the exposure condition determination method may be as follows, for example. That is, the control unit 46 analyzes the density of the two-dimensional image captured prior to tomosynthesis imaging. Then, a single irradiation dose in tomosynthesis imaging may be determined as an irradiation dose in which the shade of the projection image obtained by tomosynthesis imaging falls within a predetermined range.
  • FIG. 7 is a flowchart showing an example of a process flow (radiation image capturing method) performed by the control unit 46 in the radiation image capturing system 6 according to the present embodiment.
  • the control unit 46 of the radiographic image capturing apparatus 10 moves the compression plate 26 toward the imaging surface 20 and compresses the breast N in step S100.
  • the control unit 46 performs first imaging for acquiring a two-dimensional image (radiation image) of the breast N prior to tomosynthesis imaging described later.
  • the first imaging is performed with the radiation irradiation unit 24 at a predetermined incident angle with respect to the breast N.
  • the radiation determined according to the thickness of the breast N detected by the radiographic imaging device 10 in a state where the radiation irradiation unit 24 is in a vertical position (the center position in FIG. 2) with respect to the imaging table 22.
  • the breast N is imaged by the amount.
  • the dose of radiation that reaches the radiation detector 42 decreases.
  • the correspondence between the predetermined incident angle and the thickness of the breast N and the radiation dose to be irradiated is stored in the memory 43B in the control unit 46 in advance.
  • the image processing unit 45 performs necessary processing such as gain correction, offset correction, and defective pixel correction on the image information of the breast N obtained from the radiation detector 42 to generate a radiation image of the breast N.
  • a RAW format Raw (image format) is applied as the format of the radiation image generated here. Based on the first imaging result, imaging conditions for tomosynthesis imaging to be performed later are determined.
  • the region-of-interest detection unit 47 of the control unit 46 analyzes the radiation image generated by the image processing unit 45 as described above, and detects the region of interest.
  • the region-of-interest detection unit 47 of the control unit 46 determines whether or not there is a region of interest (is detected). If a region of interest is detected, the process proceeds to step S108. On the other hand, if the region of interest is not detected, the process proceeds to step S110.
  • step S108 the control unit 46 sets a large incident angle range as an imaging condition for tomosynthesis imaging. That is, the control unit 46 performs control for setting the incident angle range in acquiring the projection image of the breast N to the large incident angle range.
  • the control unit 46 sets the tomosynthesis imaging conditions, the process proceeds to step S112.
  • step S110 the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging. Specifically, the control unit 46 performs control so that the incident angle range in acquiring a projection image of the breast N is a small incident angle range. By capturing an incident angle range when performing tomosynthesis imaging within a small incident angle range, imaging time is shortened compared to when capturing within a large incident angle range. Therefore, when the region of interest is not detected, it is possible to perform imaging while reducing the burden on the subject W due to the compression of the breast N. After the control unit 46 sets the tomosynthesis imaging conditions, the process proceeds to step S112.
  • the radiographic imaging apparatus 10 performs tomosynthesis imaging according to the set imaging conditions for tomosynthesis imaging. That is, the radiographic image capturing apparatus 10 starts tomosynthesis imaging by moving the support unit 29 to the maximum angle of the set incident angle range, for example, by performing imaging while moving the support unit 29 one by one. A plurality of projection images corresponding to the incident angle range is taken. The radiographic image capturing at each position will be described in detail.
  • the image processing unit 45 performs necessary processing such as gain correction, offset correction, and defective pixel correction on the image information obtained by the radiation detector 42. A radiographic image (projected image) such as a RAW format is generated.
  • the process proceeds to step S114.
  • step S114 the control unit 46 releases the fixation of the breast N by the compression plate 26.
  • the fixation of the breast N is released, for example, by moving the compression plate 26 away from the imaging surface 20.
  • control unit 46 outputs the captured radiation image to the image processing apparatus 50.
  • the tomographic image generation unit 68 of the image processing apparatus 50 performs the above-described image processing such as the FBP method based on the projection image output by the control unit 46, and generates a tomographic image.
  • the tomographic image generation unit 68 of the present embodiment generates a low-resolution tomographic image when the region of interest is not detected and the first tomosynthesis imaging is performed.
  • the tomographic image generation unit 68 generates a high-resolution tomographic image (having higher resolution than the tomographic image obtained by the first tomosynthesis imaging) when the region of interest is detected and the second tomosynthesis imaging is performed. .
  • the slice thickness of the tomographic image generated by the tomographic image generation unit 68 is not particularly limited, and an initial value stored in the storage unit 74, the RAM 56, or the like may be used, or the user may use the instruction input unit 84 or the like. The value indicated by may be used.
  • the image display instruction unit 62 displays the generated tomographic image on the display 82 of the display device 80, and then the present process is terminated.
  • FIG. 8A and 8B show specific examples of tomographic images displayed on the display 82.
  • FIG. FIG. 8A shows a specific example of a high-resolution tomographic image obtained by the second tomosynthesis imaging.
  • FIG. 8A shows a tomographic image including a region of interest image, the tomographic image does not include a region of interest depending on the position (height) of the tomography.
  • FIG. 8B shows a specific example of a low-resolution tomographic image obtained by the first tomosynthesis imaging.
  • the display method of the tomographic image by the image display instruction unit 62 is not particularly limited, and may be sequentially displayed on the display 82 in the height (depth) direction, or when the region of interest is detected, You may display the tomographic image containing a site
  • the radiographic image capturing apparatus 10 can perform two-dimensional image capturing, detection of a region of interest, setting of an imaging condition according to the detection result, and tomosynthesis imaging with only one compression of the breast N. Intelligent device.
  • a region of interest is detected by the region-of-interest detection unit 47 from a radiographic image captured before tomosynthesis imaging (that is, a two-dimensional image of the breast N obtained by the first imaging), and the detection result Based on the above, the photographing conditions are determined and tomosynthesis photographing is performed. If the region of interest is not detected, the first tomosynthesis imaging is performed with the radiation incident angle range set to the small incident angle range. Further, the tomographic image generation unit 68 of the image processing device 50 generates a low-resolution tomographic image from the captured projection image, and the image display instruction unit 62 displays the tomographic image on the display device 80. Since the radiation image capturing apparatus 10 has a small (narrow) incident angle range, the time required for capturing can be shortened, and the burden on the subject W can be reduced.
  • the second tomosynthesis imaging is performed with the radiation incident angle range set to the large incident angle range. Furthermore, the tomographic image generation unit 68 of the image processing apparatus 50 generates a high-resolution tomographic image from the captured projection image, and causes the display device 80 to display the tomographic image by the image display instruction unit 62. Since the radiographic imaging apparatus 10 displays a high-resolution tomographic image, the user can obtain an accurate radiographic image for observing a region of interest.
  • the configuration of the radiographic image capturing system 6 is the same as that of the radiographic image capturing system 6 (see FIGS. 1 to 6) of the first embodiment, the description thereof is omitted.
  • FIG. 9 is a flowchart showing an example of a process flow (radiation image capturing method) performed in the radiation image capturing system 6 according to the present embodiment.
  • the control unit 46 compresses the breast N with the compression plate 26 in step S100.
  • the control unit 46 images the breast N with a dose according to the thickness of the breast N, and acquires a two-dimensional image.
  • the region-of-interest detection unit 47 of the control unit 46 analyzes the radiation image generated by the image processing unit 45 and detects the region of interest.
  • the region-of-interest detection unit 47 of the control unit 46 determines whether or not there is a region of interest (is detected). When the region of interest is detected, the process proceeds to step S108, and the control unit 46 sets a large incident angle range as an imaging condition for tomosynthesis imaging.
  • step S110 the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging.
  • step S110 the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging.
  • the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging.
  • the process proceeds to step S112.
  • step S112 the radiographic imaging device 10 performs tomosynthesis imaging according to the set imaging conditions.
  • the control unit 46 releases the fixation of the breast N in the next step S114.
  • next step S ⁇ b> 116 the control unit 46 outputs the captured radiation image to the image processing apparatus 50.
  • step S120 the tomographic image generation unit 68 of the image processing apparatus 50 determines whether tomosynthesis imaging of the left and right breasts N of the same subject W is performed. When only tomosynthesis imaging of one of the breasts N is performed, the process returns to step S100, and the processing of steps S100 to S116 is repeated in order to perform tomosynthesis imaging of the other breast N that has not been imaged. On the other hand, if tomosynthesis imaging is performed on both the left and right breasts N, the process proceeds to step S122.
  • step S122 the tomographic image generation unit 68 of the image processing apparatus 50 determines whether a region of interest has been detected. If no region of interest is detected in both the left and right breasts N by the process in step S104, the process proceeds to step S124.
  • step S124 the tomographic image generation unit 68 performs image processing such as the FBP method described above based on the projection image output from the control unit 46, and generates a tomographic image.
  • the tomographic image generation unit 68 generates a low-resolution tomographic image for both the left and right breasts N because the first tomosynthesis imaging was performed without detecting the region of interest.
  • the image display instruction unit 62 displays the generated tomographic images of the left and right breasts N on the display 82 of the display device 80.
  • FIG. 10 shows a specific example of a low-resolution tomographic image displayed on the display 82 when the region of interest is not detected for both the left and right breasts N.
  • the tomographic image display method may be the same as in step S120 of the first embodiment.
  • the image display instruction unit 62 causes the instruction input unit 84 of the display device 80 to display the button 99 which is an example of a predetermined mark of the disclosed technology.
  • the button 99 is substantially displayed on the display 82 together with the tomographic image.
  • the button 99 displayed on the display 82 together with the tomographic image indicates whether or not the resolution of the displayed tomographic image can be switched, and the resolution of the displayed tomographic image is high. It has a function of displaying two types of information indicating which of the low resolutions. When the button 99 is in an active state, it means that the resolution of the displayed tomographic image can be switched. Further, when the button 99 is in an inactive state, it means that the resolution of the displayed tomographic image cannot be switched. When the button 99 is in an inactive state, the radiographic imaging system 6 does not react particularly even when the user operates the button 99. In the present embodiment, the color of the button 99 indicates whether the resolution of the displayed tomographic image is high resolution or low resolution.
  • the thickness of the line of the button 99 indicates whether the button 99 is in an active state or an inactive state.
  • a thick button 99 line represents an active state
  • a thin button 99 line represents an inactive state.
  • the method of displaying two types of information using the button 99 is not limited to the present embodiment, and the button 99 may be displayed by appropriately combining the size of the button 99, blinking, and color shading.
  • the color of the button 99 may indicate the resolution
  • the color shading may indicate the active or inactive state.
  • two types of information are displayed by one button 99, but the buttons to be displayed may be different for each information.
  • buttons 99 for the left and right breasts N displayed on the instruction input unit 84 in this step S128 both indicate an inactive state and low resolution.
  • the image display instruction unit 62 determines whether or not to end this process.
  • both the left and right breasts N when a region of interest is not detected, both are low-resolution tomographic images, and thus the tomographic images are not switched. Therefore, when this process is not terminated, the process enters a standby state and continues to display the tomographic image and the button 99.
  • the present process is terminated.
  • step S122 if a region of interest is detected in both the left and right breasts N in step S122, the process proceeds to step S132.
  • step S132 the tomographic image generation unit 68 performs image processing such as the FBP method described above based on the projection image output from the control unit 46, and generates a tomographic image.
  • the tomographic image generation unit 68 generates a high-resolution tomographic image for both the left and right breasts N because the region of interest has been detected and the second tomosynthesis imaging has been performed.
  • the image display instruction unit 62 displays the generated tomographic images of the left and right breasts N on the display 82 of the display device 80.
  • FIG. 11 shows a specific example of a high-resolution tomographic image displayed on the display 82 when a region of interest is detected for both the left and right breasts N.
  • the tomographic image display method may be the same as in step S126.
  • the image display instruction unit 62 causes the button 99 to be displayed on the instruction input unit 84 of the display device 80.
  • a button 99 for each of the left and right breasts N displayed on the instruction input unit 84 represents an inactive state and high resolution.
  • the image display instruction unit 62 determines whether or not to end this process.
  • the region of interest is detected in both the left and right breasts N, since both are high-resolution tomographic images, the tomographic images are not switched. Therefore, when this process is not terminated, the process enters a standby state and continues to display the tomographic image and the button 99.
  • the present process is terminated.
  • step S122 if a region of interest is detected in either one of the left and right breasts N in step S122, the process proceeds to step S140.
  • step S140 the tomographic image generation unit 68 performs the above-described image processing such as the FBP method based on the projection image output from the control unit 46 to generate a tomographic image. Since the first tomosynthesis imaging has been performed for the breast N from which the region of interest has not been detected, the tomographic image generation unit 68 generates only a low-resolution tomographic image. On the other hand, since the second tomosynthesis imaging was performed on the breast N from which the region of interest was detected, the tomographic image generation unit 68 generates both a high-resolution tomographic image and a low-resolution tomographic image. . In the case of generating a low-resolution tomographic image, a projection image in a small incident angle range may be selected from the projection image obtained by the second tomosynthesis imaging, and the tomographic image may be generated by the selected projection image.
  • a projection image in a small incident angle range may be selected from the projection image obtained by the second tomosynthesis imaging, and the to
  • the image display instruction unit 62 displays the generated low-resolution tomographic images of the left and right breasts N on the display 82 of the display device 80.
  • FIG. 12 shows a specific example of a tomographic image displayed on the display 82 when a region of interest is detected on one side (specifically, the right breast N).
  • FIG. 12A shows a case where a low-resolution tomographic image is displayed on both the left and right breast N images.
  • the tomographic image display method may be the same as in step S126.
  • the image display instruction unit 62 displays the button 99 on the instruction input unit 84 of the display device 80.
  • a button 99 for the left breast N displayed on the instruction input unit 84 represents an inactive state and low resolution.
  • a button 99 for the right breast N indicates an active state and low resolution. Since the button 99 for the right breast N represents the active state, the user can recognize that the resolution of the tomographic image can be switched. Therefore, when it is desired to perform switching, the user issues a switching instruction using the button 99.
  • the instruction input unit 84 is a touch panel and is shared with the display 82. Therefore, the user instructs the button 99 itself (screen of the display 82) (touch operation). However, it is not limited to this.
  • the button 99 only the two types of information described above may be performed on the button 99, and the user may perform a switching instruction from an instruction input unit 84 such as a keyboard provided separately from the display 82.
  • an instruction input unit 84 such as a keyboard provided separately from the display 82.
  • the user gives a switching instruction.
  • step S146 the instruction receiving unit 64 determines whether the instruction input unit 84 has received a switching instruction. If there is no switching instruction, the process proceeds to step S154. On the other hand, if there is a switching instruction, the process proceeds to step S148.
  • step S148 the image display instruction unit 62 displays a high-resolution tomographic image of the right breast N on the display 82 of the display device 80.
  • FIG. 12B shows a case where the image of the left breast N is a low-resolution tomographic image and the image of the right breast N is a high-resolution tomographic image.
  • the image display instruction unit 62 displays the button 99 on the instruction input unit 84 of the display device 80.
  • a button 99 for the right breast N displayed on the instruction input unit 84 represents an active state and high resolution. Since the button 99 for the right breast N represents the active state, the user can recognize that the resolution of the tomographic image can be switched as described above. Therefore, when it is desired to perform switching, the user issues a switching instruction using the button 99. For example, in order to compare the left and right breasts N, when the image quality of both tomographic images is desired, a switching instruction is issued by the user.
  • step S152 the instruction receiving unit 64 determines whether or not the instruction input unit 84 has issued a switching instruction. If there is no switching instruction, the process proceeds to step S154. On the other hand, if there is a switching instruction, the process returns to step S142 and the above processing is repeated.
  • step S154 the image display instruction unit 62 determines whether or not to end this process. If this process is not terminated, the process returns to step S152, enters a standby state, and continues to display the tomographic image and the button 99. On the other hand, when the user gives an instruction for termination using the instruction input unit 84, the present process is terminated.
  • the site-of-interest detection unit 47 determines the site of interest from the radiographic image (two-dimensional image), similarly to the radiographic image capture apparatus 10 according to the first embodiment. If the region of interest is detected and the region of interest is not detected, the radiation incident angle range is set as the small incident angle range. When a region of interest is detected, the radiation incident angle range is set as a large incident angle range, and tomosynthesis imaging is performed.
  • the radiographic image capturing apparatus 10 of the present embodiment can obtain an accurate radiographic image while reducing the burden on the subject W, similarly to the radiographic image capturing apparatus 10 of the first exemplary embodiment. .
  • a region of interest is detected in both the left and right breasts N
  • a high-resolution tomographic image is generated and displayed for both the left and right breasts N
  • a low-resolution tomographic image is generated and displayed for both the left and right breasts N.
  • a region of interest is detected in one of the left and right breasts N
  • a low-resolution and high-resolution tomographic image of one breast N in which the region of interest is detected is generated, and the other region in which the region of interest is not detected is generated.
  • a low-resolution tomographic image of the breast N is generated, and low-resolution tomographic images of the left and right breasts N are displayed.
  • the user may want to compare tomographic images of the left and right breasts N. If the resolution of the tomographic image is different, the image quality and the appearance of the image may be different.
  • the left and right breasts N are displayed with the same resolution, so that the left and right breasts N can be easily compared.
  • the radiographic imaging system 6 of the present embodiment whether or not the display can be switched to a tomographic image having a different resolution and whether the displayed tomographic image is a high resolution or a low resolution.
  • the representing button 99 is displayed on the display 82 of the display device 80 together with the tomographic image.
  • a high-resolution tomographic image is also generated, and it is determined whether or not the display can be switched to a tomographic image having a different resolution.
  • a button 99 is displayed.
  • the user may want to observe the region of interest using a high-resolution tomographic image.
  • the display is switched to a high-resolution tomographic image in accordance with an instruction input from the user in response to the button 99, so that a tomographic image suitable for observation of a region of interest is displayed. It can be performed.
  • the configuration of the radiographic image capturing system 6 is the same as that of the radiographic image capturing system 6 (see FIGS. 1 to 6) of the first embodiment, the description thereof is omitted.
  • FIG. 13 is a flowchart showing an example of a process flow (radiation image capturing method) performed in the radiation image capturing system 6 according to the present embodiment.
  • the control unit 46 compresses the breast N with the compression plate 26 in step S100.
  • the control unit 46 images the breast N with a dose according to the thickness of the breast N, and acquires a two-dimensional image.
  • the region-of-interest detection unit 47 analyzes the radiation image generated by the image processing unit 45 and detects the region of interest.
  • the region-of-interest detection unit 47 determines whether or not there is a region of interest (is detected). When the region of interest is detected, the process proceeds to step S108, and the control unit 46 sets a large incident angle range as an imaging condition for tomosynthesis imaging.
  • step S110 the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging.
  • step S110 the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging.
  • the control unit 46 sets a small incident angle range as an imaging condition for tomosynthesis imaging.
  • the process proceeds to step S112.
  • step S112 the radiographic imaging device 10 performs tomosynthesis imaging according to the set imaging conditions.
  • the control unit 46 releases the fixation of the breast N in the next step S114.
  • next step S ⁇ b> 116 the control unit 46 outputs the captured radiation image to the image processing apparatus 50.
  • step S116 the process proceeds to step S120, where it is determined whether tomosynthesis imaging of the left and right breasts N of the same subject W is performed, and both the left and right breasts N are tomosynthesis. If a picture is taken, the process proceeds to step S122.
  • step S122 the tomographic image generation unit 68 determines whether a region of interest has been detected.
  • step S104 When the region of interest is not detected in both the left and right breasts N by the processing in step S104, the same processing as in steps S124 to S130 (see FIG. 9) of the second embodiment is performed.
  • step S124 the tomographic image generation unit 68 performs image processing such as the above-described FBP method based on the projection image to generate a tomographic image.
  • the tomographic image generation unit 68 generates a low-resolution tomographic image for both the left and right breasts N.
  • the image display instruction unit 62 displays the generated tomographic images of the left and right breasts N on the display 82 (see FIG. 10).
  • the image display instruction unit 62 causes the instruction input unit 84 to display a button 99 indicating an inactive state and low resolution.
  • the image display instruction unit 62 determines whether or not to end the present process. If the present process is not ended, the display of the tomographic image and the button 99 is continued. On the other hand, when the user gives an instruction for termination using the instruction input unit 84, the present process is terminated.
  • step S122 when a region of interest is detected in either one of the left and right breasts N in step S122, the same processing as in steps S140 to S154 (see FIG. 9) of the second embodiment is performed.
  • step S140 the tomographic image generation unit 68 performs image processing such as the above-described FBP method based on the projection image to generate a tomographic image. Note that for the breast N in which the region of interest has not been detected, the tomographic image generation unit 68 generates only a low-resolution tomographic image. On the other hand, for the breast N from which the region of interest has been detected, the tomographic image generation unit 68 generates both a high-resolution tomographic image and a low-resolution tomographic image.
  • the image display instruction unit 62 displays the generated low-resolution tomographic images of the left and right breasts N on the display 82 (see FIG. 12).
  • the image display instruction unit 62 displays the button 99 on the instruction input unit 84.
  • a button 99 for the left breast N displayed on the instruction input unit 84 represents an inactive state and low resolution.
  • a button 99 for the right breast N indicates an active state and low resolution.
  • the instruction receiving unit 64 determines whether or not there is a switching instruction. If there is no switching instruction, the process proceeds to step S154. On the other hand, if there is a switching instruction, the process proceeds to step S148.
  • step S ⁇ b> 148 the image display instruction unit 62 displays a high-resolution tomographic image of the right breast N on the display 82 of the display device 80.
  • the image display instruction unit 62 causes the instruction input unit 84 to display the button 99.
  • a button 99 for the right breast N displayed on the instruction input unit 84 represents an active state and high resolution.
  • the user instructs switching using the button 99.
  • the instruction receiving unit 64 determines whether or not there is a switching instruction. If there is no switching instruction, the process proceeds to step S154. On the other hand, if there is a switching instruction, the process returns to step S142 and the above processing is repeated. In step S154, it is determined whether or not to end this process. If this process is not terminated, the process returns to step S152, and the display of the tomographic image and button 99 is continued.
  • step S122 if a region of interest is detected in both the left and right breasts N in step S122, the process proceeds to step S200 in the present embodiment.
  • the tomographic image generation unit 68 performs image processing such as the FBP method described above based on the projection image output by the control unit 46, and generates a tomographic image. Since the region of interest is detected for both the left and right breasts N and the second tomosynthesis imaging is performed, the tomographic image generation unit 68 performs the high-resolution tomographic image and the low-resolution tomographic image for both the left and right breasts N. And generate both. In the case of generating a low-resolution tomographic image, a projection image in a small incident angle range may be selected from the projection image obtained by the second tomosynthesis imaging, and the tomographic image may be generated by the selected projection image.
  • the image display instruction unit 62 displays the generated low-resolution tomographic images of the left and right breasts N on the display 82 of the display device 80.
  • FIG. 14 shows a specific example of a tomographic image displayed on the display 82 when a region of interest is detected in the left and right breasts N.
  • FIG. 14A shows a case where a low-resolution tomographic image is displayed on both the left and right breast N images.
  • the tomographic image display method may be the same as in step S126.
  • the image display instruction unit 62 displays the button 99 on the instruction input unit 84 of the display device 80.
  • the buttons 99 for the left and right breasts N displayed on the instruction input unit 84 both indicate an active state and low resolution. Since the button 99 represents the active state, the user can recognize that the resolution of the tomographic image can be switched. Therefore, when switching is desired, the user issues a switching instruction using the button 99.
  • step S206 the instruction receiving unit 64 determines whether or not the instruction input unit 84 has issued a switching instruction. If there is no switching instruction, the process proceeds to step S214. On the other hand, if there is a switching instruction, the process proceeds to step S208.
  • step S208 the image display instruction unit 62 displays a high-resolution tomographic image of the left and right breasts N on the display 82 of the display device 80.
  • FIG. 14 (2) shows a case where a high-resolution tomographic image is displayed on both the left and right breast N images.
  • the image display instruction unit 62 displays the button 99 on the instruction input unit 84 of the display device 80.
  • a button 99 for the left and right breasts N displayed on the instruction input unit 84 represents an active state and high resolution. Since the button 99 represents the active state, the user can recognize that the resolution of the tomographic image can be switched as described above. Therefore, when switching is desired, the user issues a switching instruction using the button 99.
  • step S212 the instruction receiving unit 64 determines whether the instruction input unit 84 has issued a switching instruction. If there is no switching instruction, the process proceeds to step S214. On the other hand, if there is a switching instruction, the process returns to step S202 and the above process is repeated.
  • step S214 the image display instruction unit 62 determines whether or not to end this process. If the process is not terminated, the process returns to step S212, enters a standby state, and continues to display the tomographic image and the button 99. On the other hand, when the user gives an instruction for termination using the instruction input unit 84, the present process is terminated.
  • the resolution of the tomographic image is simultaneously switched for both the left and right breasts N, but this is not limiting, and only one of the designated ones may be switched.
  • FIG. 14 shows a case where a tomographic image including a region-of-interest image is displayed for both the left and right breasts N, but is not limited thereto.
  • a tomographic image including a region-of-interest image is displayed for both the left and right breasts N, but is not limited thereto.
  • one of them may be a tomographic image including the image of the region of interest, and the other may be a tomographic image at the same position as the position of one depth direction. .
  • the site-of-interest detection unit 47 determines the site of interest from the radiographic image (two-dimensional image), similarly to the radiographic image capture apparatus 10 according to the first embodiment. If the region of interest is detected and the region of interest is not detected, the radiation incident angle range is set as the small incident angle range. When a region of interest is detected, the radiation incident angle range is set as a large incident angle range, and tomosynthesis imaging is performed.
  • an accurate radiographic image can be obtained while reducing the burden on the subject W, as in the radiographic imaging device 10 of the first exemplary embodiment. .
  • both the left and right breasts N when a region of interest is detected in both the left and right breasts N, both the left and right breasts N generate low-resolution and high-resolution tomographic images, A low-resolution tomographic image of the breast N is displayed. If no region of interest is detected in both the left and right breasts N, a low-resolution tomographic image is generated and displayed for both the left and right breasts N.
  • a region of interest is detected in one of the left and right breasts N
  • a low-resolution and high-resolution tomographic image of one breast N in which the region of interest is detected is generated, and the other region in which the region of interest is not detected is generated.
  • a low-resolution tomographic image of the breast N is generated, and low-resolution tomographic images of the left and right breasts N are displayed.
  • the radiographic imaging system 6 of the present embodiment first displays a low-resolution tomographic image of the left and right breasts N. Therefore, like the radiographic image capturing system 6 of the second embodiment, the radiographic image capturing system 6 of the present exemplary embodiment can easily compare the left and right breasts N.
  • an active state button 99 indicating that the display can be switched to a tomographic image having a different resolution is displayed.
  • an inactive button 99 indicating that the display cannot be switched to a tomographic image having a different resolution is displayed. Therefore, the user can recognize whether the region of interest has been detected based on whether the button 99 is in the active state or the inactive state. For example, even when a tomographic image having a height that does not include the region of interest is displayed on the display 82, it can be easily recognized whether or not the region of interest has been detected for the breast N.
  • the radiographic image capturing system 6 is different from the first exemplary embodiment in that a recommended display for recommending whether to perform the first tomosynthesis image capturing or the second tomosynthesis image capturing is performed for the user. Different.
  • the configuration of the radiographic image capturing system 6 is the same as that of the radiographic image capturing system 6 (see FIGS. 1 to 6) of the first embodiment, the description thereof is omitted.
  • FIG. 15 is a flowchart illustrating an example of a processing flow (radiation image capturing method) performed in the radiation image capturing system 6 according to the present embodiment.
  • steps S107 to S111 are provided instead of steps S108 and S110 (see FIG. 7) of the process of the first embodiment.
  • the control unit 46 compresses the breast N with the compression plate 26 in step S100.
  • the control unit 46 images the breast N with a dose according to the thickness of the breast N, and acquires a two-dimensional image.
  • the region-of-interest detection unit 47 analyzes the radiation image generated by the image processing unit 45 and detects the region of interest.
  • the region-of-interest detection unit 47 determines whether or not there is a region of interest (is detected).
  • step S107 when a region of interest is detected in step 106, the process proceeds to step S107, and the image display instruction unit 62 of the image processing device 50 performs tomosynthesis imaging in a large incident angle range as imaging conditions.
  • a display that recommends tomosynthesis imaging (hereinafter referred to as “recommended display”) is displayed on the display 82 of the display device 80.
  • FIG. 16A and FIG. 16B show specific examples of recommendation display when the second tomosynthesis imaging is recommended.
  • FIG. 16A is a specific example of the recommended display performed when the instruction input unit 84 is a touch panel or the like.
  • the detection of the region of interest and the recommended type of tomosynthesis imaging (second) are displayed, and a selection button of “Yes” or “No” is displayed.
  • the user refers to the recommendation display and selects one by the instruction input unit 84. Specifically, either “Yes” or “No” on the display 82 (screen) is operated.
  • FIG. 16B is a specific example of the recommended display performed when the instruction input unit 84 is a keyboard or the like.
  • the detection of the region of interest and the recommended type of tomosynthesis imaging (first or second) are displayed, and a display prompting the user to input “1” or “2” is performed for selection.
  • the user refers to the recommendation display and operates one of the instructions using the instruction input unit 84. Specifically, either “1” or “2” such as a keyboard or a numeric keypad is operated.
  • step S109 the image display instruction unit 62 of the image processing apparatus 50 performs tomosynthesis imaging in a small incident angle range as imaging conditions. Is displayed on the display 82 of the display device 80.
  • the recommended display in this case may indicate that the region of interest has not been detected and the recommended type of tomosynthesis imaging (first). For example, in the recommendation display shown in FIG. 16 above, “the part of interest was detected” is changed to “the part of interest was not detected”, and the type of tomosynthesis imaging to be recommended (recommended) is the first. Change to
  • the recommended display is not limited to the specific example shown in FIG. Any type of tomosynthesis imaging (first or second) to be recommended may be displayed to prompt the user to select which tomosynthesis imaging to perform.
  • the control unit 46 sets shooting conditions for tomosynthesis shooting.
  • the small incident angle range is set as the imaging condition
  • the large incident angle range is set as the imaging condition.
  • step S112 the control unit 46 performs tomosynthesis imaging according to the set imaging conditions.
  • the control unit 46 releases the fixation of the breast N in the next step S114.
  • next step S ⁇ b> 116 the control unit 46 outputs the captured radiation image to the image processing apparatus 50.
  • the tomographic image generation unit 68 of the image processing apparatus 50 performs the above-described image processing such as the FBP method based on the projection image to generate a tomographic image.
  • the image display instruction unit 62 displays the generated tomographic image on the display 82 of the display device 80, and then the present process is terminated.
  • the recommended display executed by the image display instruction unit 62 in the present embodiment is not limited to the first embodiment, and may be performed in combination with the second and third embodiments.
  • the present invention is not limited to this, and the recommendation display may be performed on the operation panel 44 of the radiographic image capturing device 10. In that case, the operation panel 44 functions as a display unit of the disclosed technology.
  • the present invention is not limited to this, and the recommended display may be performed only in either case.
  • the site-of-interest detection unit 47 determines the site of interest from the radiographic image (two-dimensional image), similarly to the radiographic image capture apparatus 10 according to the first embodiment. If the region of interest is detected and the region of interest is not detected, the radiation incident angle range is set as the small incident angle range. When a region of interest is detected, the radiation incident angle range is set as a large incident angle range, and tomosynthesis imaging is performed.
  • the radiographic image capturing apparatus 10 of the present embodiment can obtain an accurate radiographic image while reducing the burden on the subject, similarly to the radiographic image capturing apparatus 10 of the first exemplary embodiment.
  • a recommended display that recommends either the first tomosynthesis imaging (small incident angle range) or the second tomosynthesis imaging (large incident angle range) is performed. If the region of interest is not detected, the first tomosynthesis imaging is recommended. If the region of interest is detected, the second tomosynthesis imaging is recommended.
  • the user can select execution of appropriate tomosynthesis imaging according to the presence / absence of the region of interest.
  • the present invention is not limited to this, and three or more types may be used.
  • the region-of-interest detection unit 47 detects the size of the region of interest and the type of lesion (calcification, tumor, etc.) estimated from the size of the region of interest, and the incident angle range according to the detected size and type May be different.
  • the program for executing each step of the process performed by the radiographic imaging system 6 described in each of the above embodiments may be a program 55.
  • each process performed in each of the radiographic image capturing apparatus 10 and the image processing apparatus 50 may be distributed and stored in the memory 43B or the ROM 54 in each apparatus.
  • the radiation in each of the above embodiments is not particularly limited, and X-rays, ⁇ -rays, and the like can be applied.
  • the configurations and operations of the radiation image capturing system 6, the radiation image capturing apparatus 10, and the radiation detector 42 described in the above embodiments are merely examples, and the situation is within the scope of the present invention. Needless to say, it can be changed accordingly.

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Abstract

La présente invention concerne un dispositif de photographie d'image radiologique, caractérisé en ce qu'un site d'intérêt est détecté par une unité de détection de site d'intérêt à partir d'une image radiologique qui est photographiée avant photographie de tomosynthèse, et, sur la base du résultat de la détection, les conditions de photographie sont déterminées et la photographie de tomosynthèse est effectuée. Si le site d'intérêt n'est pas détecté, une plage d'angles incidents de rayonnement est définie comme étant une petite plage d'angles incidents, et une première photographie de tomosynthèse est effectuée. De plus, une unité de génération d'image tomographique d'un dispositif de traitement d'image génère une image tomographique basse résolution à partir d'images de projection photographiées, et une unité d'instruction d'affichage d'image amène un dispositif d'affichage à afficher l'image tomographique.
PCT/JP2015/058975 2014-03-28 2015-03-24 Système de photographie d'image radiologique, procédé de photographie d'image radiologique et photographie d'image radiologique Ceased WO2015147008A1 (fr)

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JP2022131968A (ja) * 2021-02-26 2022-09-07 富士フイルム株式会社 画像処理装置、撮影制御装置、放射線画像撮影システム、画像処理方法、及び画像処理プログラム
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