WO2015144977A8 - Trpa1 modulators - Google Patents
Trpa1 modulators Download PDFInfo
- Publication number
- WO2015144977A8 WO2015144977A8 PCT/FI2015/000013 FI2015000013W WO2015144977A8 WO 2015144977 A8 WO2015144977 A8 WO 2015144977A8 FI 2015000013 W FI2015000013 W FI 2015000013W WO 2015144977 A8 WO2015144977 A8 WO 2015144977A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- trpa1
- trpa1 modulators
- modulators
- compounds
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds of formula I, wherein X, R1 and R2 are as defined in the claims, exhibit TRPA1 activity and useful as TRPA1 modulators.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20140093 | 2014-03-28 | ||
| FI20140093 | 2014-03-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2015144977A1 WO2015144977A1 (en) | 2015-10-01 |
| WO2015144977A8 true WO2015144977A8 (en) | 2015-10-29 |
Family
ID=53005580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FI2015/000013 Ceased WO2015144977A1 (en) | 2014-03-28 | 2015-03-27 | Trpa1 modulators |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR099881A1 (en) |
| TW (1) | TW201620877A (en) |
| WO (1) | WO2015144977A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013326429B2 (en) * | 2012-10-01 | 2017-10-26 | Orion Corporation | N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists |
| FR3114235A1 (en) | 2020-09-18 | 2022-03-25 | Université Grenoble Alpes | INHIBITION OF ASTROCYTIC TRPA1 CHANNEL AS A NEW NEUROPROTECTIVE THERAPEUTIC TARGET IN THE PRODROMAL PHASES OF ALZHEIMER'S DISEASE |
| IT202100015098A1 (en) | 2021-06-09 | 2022-12-09 | Flonext S R L | TRPA1 CHANNEL ANTAGONIST COMPOUND FOR USE IN DEGENERATIVE DISEASES OF THE RETINA |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009137340A1 (en) * | 2008-05-05 | 2009-11-12 | Allergan, Inc. | Alpha2b and alpha2c agonists |
| AU2013326429B2 (en) * | 2012-10-01 | 2017-10-26 | Orion Corporation | N-prop-2-ynyl carboxamide derivatives and their use as TRPA1 antagonists |
-
2015
- 2015-03-26 TW TW104109731A patent/TW201620877A/en unknown
- 2015-03-27 AR ARP150100931A patent/AR099881A1/en unknown
- 2015-03-27 WO PCT/FI2015/000013 patent/WO2015144977A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AR099881A1 (en) | 2016-08-24 |
| TW201620877A (en) | 2016-06-16 |
| WO2015144977A1 (en) | 2015-10-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 15718505 Country of ref document: EP Kind code of ref document: A1 |
|
| NENP | Non-entry into the national phase in: | ||
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 15718505 Country of ref document: EP Kind code of ref document: A1 |