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WO2015142001A3 - 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물 - Google Patents

강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물 Download PDF

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WO2015142001A3
WO2015142001A3 PCT/KR2015/002498 KR2015002498W WO2015142001A3 WO 2015142001 A3 WO2015142001 A3 WO 2015142001A3 KR 2015002498 W KR2015002498 W KR 2015002498W WO 2015142001 A3 WO2015142001 A3 WO 2015142001A3
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compound
preventing
pharmaceutical composition
heart failure
treating heart
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PCT/KR2015/002498
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English (en)
French (fr)
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WO2015142001A2 (ko
Inventor
정상헌
우선희
김상겸
므니캄마노즈
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Industry and Academy Cooperation In Chungnam National University
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Industry and Academy Cooperation In Chungnam National University
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Priority claimed from KR1020140193610A external-priority patent/KR101922542B1/ko
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Publication of WO2015142001A2 publication Critical patent/WO2015142001A2/ko
Publication of WO2015142001A3 publication Critical patent/WO2015142001A3/ko
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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Abstract

본 발명은 강심 활성을 지니는 화합물 및 이를 함유하는 약학적 조성물을 개시하며, 본 발명에 따른 화합물을 포함하는 조성물은 심부전의 예방 및 치료에 유용하다.
PCT/KR2015/002498 2014-03-21 2015-03-16 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물 Ceased WO2015142001A2 (ko)

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KR20140033453 2014-03-21
KR10-2014-0033453 2014-03-21
KR10-2014-0193610 2014-12-30
KR1020140193610A KR101922542B1 (ko) 2014-03-21 2014-12-30 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물

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WO2015142001A3 true WO2015142001A3 (ko) 2015-12-03

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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2941423B1 (en) 2013-01-07 2021-06-09 University of Southern California Deoxyuridine triphosphatase inhibitors
WO2017006270A1 (en) 2015-07-08 2017-01-12 University Of Southern California Deoxyuridine triphosphatase inhibitors
DK3319939T3 (da) 2015-07-08 2025-02-24 Cv6 Therapeutics Ni Ltd Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer
US10570100B2 (en) 2015-07-08 2020-02-25 University Of Southern California Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage
US10544105B2 (en) 2015-07-08 2020-01-28 Cv6 Therapeutics (Ni) Limited Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage
KR101827794B1 (ko) * 2016-03-07 2018-02-09 충남대학교산학협력단 1,3-이치환유레아 유도체 화합물, 이의 광학이성질체, 또는 이의 약학적으로 허용 가능한 염, 및 이를 유효성분으로 포함하는 심혈관 질환의 예방 또는 치료용 약학 조성물
WO2018098204A1 (en) * 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited 6-membered uracil isosteres
WO2018098206A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
WO2018098207A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Hydantoin containing deoxyuridine triphosphatase inhibitors
US10829457B2 (en) 2016-11-23 2020-11-10 Cv6 Therapeutics (Ni) Limited Nitrogen ring linked deoxyuridine triphosphatase inhibitors
WO2018098209A1 (en) 2016-11-23 2018-05-31 Cv6 Therapeutics (Ni) Limited Amino sulfonyl compounds
WO2018128720A1 (en) 2017-01-05 2018-07-12 Cv6 Therapeutics (Ni) Limited Uracil containing compounds
CA3075669A1 (en) 2017-09-13 2019-03-21 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof
CN109824601B (zh) * 2017-11-23 2020-10-02 中国科学院大连化学物理研究所 一种铱催化2-羟基嘧啶化合物的不对称氢化合成手性环状脲的方法
CN109824600B (zh) * 2017-11-23 2020-10-02 中国科学院大连化学物理研究所 一种钯催化2-羟基嘧啶化合物的不对称氢化合成手性环状脲的方法
EP3740481B9 (en) 2018-01-19 2024-10-23 Cytokinetics, Inc. Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors
JP7734917B2 (ja) * 2019-01-28 2025-09-08 ミトコンドリア エモーション， インク． トランス－４－ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法
JP7473565B2 (ja) * 2019-01-28 2024-04-23 ミトコンドリア エモーション， インク． マイトフュージン活性化物質及びその使用方法
CN110003176B (zh) * 2019-05-28 2021-12-21 沈阳药科大学 含有酰胺的苯并咪唑类化合物及其应用
CN110003177B (zh) * 2019-05-28 2021-11-19 沈阳药科大学 含有脲基的苯并咪唑类化合物及应用
CN114901652A (zh) * 2019-09-17 2022-08-12 比亚尔R&D投资股份公司 用于治疗医学病症的经取代的饱和和不饱和n-杂环甲酰胺及相关化合物
CN119751454A (zh) * 2025-01-22 2025-04-04 石河子大学 一种β-咔啉桥连脲类衍生物及其制备方法、应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027108A2 (en) * 1996-12-16 1998-06-25 Fujisawa Pharmaceutical Co., Ltd. New amide compounds and their use as nitric oxide synthase inhibitors
WO2004064730A2 (en) * 2003-01-14 2004-08-05 Cytokinetics, Inc. Compounds, compositions and methods
WO2006009726A2 (en) * 2004-06-17 2006-01-26 Cytokinetics, Inc. Substituted urea derivatives for treating cardiac diseases
US20120122842A1 (en) * 2010-11-15 2012-05-17 Abbott Laboratories Nampt and rock inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998027108A2 (en) * 1996-12-16 1998-06-25 Fujisawa Pharmaceutical Co., Ltd. New amide compounds and their use as nitric oxide synthase inhibitors
WO2004064730A2 (en) * 2003-01-14 2004-08-05 Cytokinetics, Inc. Compounds, compositions and methods
WO2006009726A2 (en) * 2004-06-17 2006-01-26 Cytokinetics, Inc. Substituted urea derivatives for treating cardiac diseases
US20120122842A1 (en) * 2010-11-15 2012-05-17 Abbott Laboratories Nampt and rock inhibitors

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