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WO2015141280A1 - Fil-guide - Google Patents

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Publication number
WO2015141280A1
WO2015141280A1 PCT/JP2015/052053 JP2015052053W WO2015141280A1 WO 2015141280 A1 WO2015141280 A1 WO 2015141280A1 JP 2015052053 W JP2015052053 W JP 2015052053W WO 2015141280 A1 WO2015141280 A1 WO 2015141280A1
Authority
WO
WIPO (PCT)
Prior art keywords
guide wire
contrast
outer diameter
wire according
section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2015/052053
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English (en)
Japanese (ja)
Inventor
陽助 鍋島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Publication of WO2015141280A1 publication Critical patent/WO2015141280A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09083—Basic structures of guide wires having a coil around a core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09058—Basic structures of guide wires
    • A61M2025/09083—Basic structures of guide wires having a coil around a core
    • A61M2025/09091—Basic structures of guide wires having a coil around a core where a sheath surrounds the coil at the distal part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09133—Guide wires having specific material compositions or coatings; Materials with specific mechanical behaviours, e.g. stiffness, strength to transmit torque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09166—Guide wires having radio-opaque features

Definitions

  • the present invention relates to a guide wire.
  • Guidewires can be used to treat difficult-to-surgical sites, such as PTCA (Percutaneous Transluminal Coronary Angioplasty), or for treatment that is minimally invasive to the human body, Used to guide catheters used for examinations such as angiography.
  • PTCA Percutaneous Transluminal Coronary Angioplasty
  • a guide wire used for PTCA surgery is inserted to the vicinity of the target vascular stenosis portion together with the balloon catheter with the tip of the guide wire protruding from the tip of the balloon catheter. Guide to near.
  • a guide wire is usually used by a doctor by bending a distal end portion of a guide wire into a desired shape in order to select a blood vessel branch (see, for example, Patent Document 1 and Patent Document 2).
  • the guide wire described in Patent Document 1 has a wire main body as a core material, and the tip end portion of the wire main body is composed only of a material having a relatively high elastic modulus, and thus can be reshaped. .
  • tip part which is this reshape part can be bent into a desired shape, and the shape can be maintained. As a result, the operability during the operation of inserting the guide wire into the living body is improved.
  • the guide wire described in Patent Document 1 can be reshaped within a range of, for example, about 200 mm from the tip where there is a reshaped portion, and within that range, it becomes easy to form a shape evenly at any location. Yes.
  • the guide wire described in Patent Document 1 does not have such a configuration, that is, a portion that can be preferentially reshaped in the middle of the longitudinal direction, and is difficult to use.
  • the guide wire described in Patent Document 1 is a pre-shaped portion that can be pre-shaped. Therefore, the confirmation is impossible.
  • An object of the present invention is, for example, in the case of being used for diagnosis or treatment in a peripheral region, a guide in which the middle in the longitudinal direction of the wire can be reshaped preferentially over other portions, and the reshaped portion can be surely confirmed. To provide a wire.
  • a guide wire including a wire body having a front end tapered portion with an outer diameter gradually decreasing toward the front at a front end,
  • the wire main body is provided continuously behind the front end taper portion, and is provided continuously outside the constant outer diameter constant portion along the longitudinal direction and behind the constant outer diameter portion.
  • a rear end taper portion whose outer diameter gradually increases toward the rear,
  • the functional part is provided around the boundary part between the outer diameter constant part and the rear end taper part so that the reshapable part can be reshaped, and is wound around an outer peripheral part of the reshapable part.
  • each of the contrast section and the auxiliary contrast section is configured by a single continuous linear body.
  • the functional portion can be reshaped preferentially over other portions in the longitudinal direction of the guide wire, and is a portion that can be reliably confirmed, for example, under X-ray contrast. .
  • a guide wire When a guide wire is used for diagnosis or treatment in a peripheral region, for example, if the shape is reshaped before insertion, the reshaped state is reliably maintained. Then, the guide wire can be inserted into the living body in the reshaped state. Thereby, a guide wire can be reliably advanced to the direction which wants to advance in the living body. In addition, during this insertion operation, the reshaped functional part can be reliably confirmed under X-ray contrast. Thereby, the operator can grasp
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention.
  • FIG. 2 is a vertical cross-sectional view sequentially illustrating the manufacturing process of the reshapable part of the guide wire shown in FIG.
  • FIG. 3 is a partial longitudinal sectional view showing a second embodiment of the guide wire of the present invention.
  • FIG. 4 is a partial longitudinal sectional view showing a third embodiment of the guide wire of the present invention.
  • FIG. 5 is a schematic view showing a use state of the guide wire shown in FIG.
  • FIG. 6 is a longitudinal sectional view showing the configuration of the reshapable part of the guide wire (fourth embodiment) of the present invention.
  • FIG. 1 is a partial longitudinal sectional view showing a first embodiment of the guide wire of the present invention.
  • FIG. 2 is a vertical cross-sectional view sequentially illustrating the manufacturing process of the reshapable part of the guide wire shown in FIG.
  • the right side in FIGS. 1 and 2 (the same applies to FIGS. 3, 4 and 6) is “rear (rear)” or “base”, and the left is “front (front). ) "Or" tip ".
  • FIG. 1 and FIG. 2 (the same applies to FIG. 3 and FIG. 4), for the sake of clarity, the length direction of the guide wire is shortened and the thickness direction of the guide wire is exaggerated and schematically illustrated. The ratio between the length direction and the thickness direction is very different from the actual one.
  • the guide wire 1 shown in FIG. 1 has flexibility, is inserted from a lower limb, and is used in a blood vessel 200 of the lower limb, that is, a peripheral region.
  • the total length of the guide wire 1 is not particularly limited, but is preferably, for example, 1500 to 3500 mm, and more preferably 1800 to 3000 mm.
  • the guide wire 1 includes a wire body 2, a first covering portion (tubular portion) 3, and a second covering portion 4.
  • the wire body 2 has a long shape, and is arranged in order from the front to the rear, a first constant outer diameter portion (small diameter portion) 21, a first taper portion (front end taper portion) 22, a second outer portion. It has a constant diameter portion (medium diameter portion) 23, a second taper portion (rear end taper portion) 24, and a third outer diameter constant portion (large diameter portion) 25.
  • the first outer diameter constant portion 21 has an outer diameter that is constant along the longitudinal direction of the wire, and its size is the smallest portion in the wire body 2.
  • the first taper portion 22 is a portion whose outer diameter gradually decreases toward the front, and is continuously provided behind the first outer diameter constant portion 21.
  • the taper angle (decrease rate of the outer diameter) of the first taper portion 22 may be constant along the wire longitudinal direction, or there may be a portion that varies along the wire longitudinal direction. For example, a portion where a relatively large taper angle and a relatively small portion are alternately formed a plurality of times may be used.
  • the second constant outer diameter portion 23 is provided continuously behind the first taper portion 22.
  • the second outer diameter constant portion 23 has a constant outer diameter along the wire longitudinal direction, and the size of the second outer diameter constant portion 23 is an intermediate size portion in the wire body 2.
  • the second taper part 24 is provided continuously behind the second constant outer diameter part 23.
  • the second constant outer diameter portion 23 is a portion whose outer diameter gradually increases toward the rear.
  • the taper angle of the second taper portion 24 may be constant along the wire longitudinal direction or may vary along the wire longitudinal direction, like the first taper portion 22.
  • the taper angle of the second taper portion 24 may be the same as or different from the taper angle of the first taper portion 22.
  • the third constant outer diameter portion 25 is provided continuously behind the second taper portion 24.
  • the third outer diameter constant portion 25 has an outer diameter that is constant along the wire longitudinal direction, and the size of the third outer diameter constant portion 25 is the largest in the wire body 2. Note that the base end 251 of the third constant outer diameter portion 25 is preferably rounded.
  • the wire body 2 has the rigidity (bending rigidity, torsional rigidity) gradually decreased toward the front.
  • the guide wire 1 can obtain good flexibility at the front end portion, improve followability to the blood vessel 200, improve safety, and prevent bending and the like.
  • the wire body 2 is a continuous linear body, and the constituent material thereof is not particularly limited, and for example, a superelastic alloy can be used.
  • Superelastic alloys include any shape of stress-strain curve due to tension, including those that can measure the transformation point of Ms, Mf, As, Af, etc., and those that cannot be measured. However, everything that returns to its original shape by removing stress is included.
  • Ms is a temperature at which martensitic transformation starts
  • Mf is a temperature at which martensitic transformation ends
  • “As” is a temperature at which reverse transformation starts
  • “Af” is the temperature at which the reverse transformation ends.
  • the preferred composition of the superelastic alloy is a Ni—Ti alloy such as a Ni—Ti alloy of 49 to 52 atomic% Ni, a Cu—Zn alloy of 38.5 to 41.5 wt% Zn, 1 to 10 wt% X Cu—Zn—X alloy (X is at least one of Be, Si, Sn, Al, and Ga), Ni-Al alloy of 36 to 38 atomic% Al, and the like. Of these, a Ni-Ti alloy is particularly preferable.
  • Such a superelastic alloy is relatively flexible, has a resilience, and is difficult to bend, so that the guide wire 1 has sufficient flexibility and resilience to bending as a whole, and is curved in a complicated manner. -The followability with respect to the bending blood vessel 200 is improved, and more excellent operability is obtained. In addition, even if the guide wire 1 is repeatedly bent and bent, the guide wire 1 is not bent due to its resilience, so that it is possible to prevent the operability from being deteriorated due to the guide wire 1 being bent during use. be able to.
  • the first covering portion 3 is a resin coating layer that has a cylindrical shape and is in close contact with the front end portion (tip) from the first outer diameter constant portion 21 to the second tapered portion 24 and covers the front end portion. is there.
  • coated part 3 can be formed for various objectives, as an example, it can be provided in order to improve the safety
  • the first covering portion 3 is preferably made of a material (soft resin material) rich in flexibility.
  • the flexible material examples include polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyester (PET, PBT, etc.), polyamide, polyimide, polyurethane, polystyrene, silicone resin, polyurethane elastomer, polyester elastomer, polyamide elastomer, and the like.
  • Various rubber materials such as thermoplastic elastomers, latex rubbers, and silicone rubbers, or composite materials in which two or more of these are combined.
  • the first covering portion 3 is made of a thermoplastic elastomer or various rubber materials, the flexibility of the front end portion of the guide wire 1 is further improved.
  • the wall 201 and the like can be more reliably prevented from being damaged, and the safety is extremely high.
  • coated part 3 are roundish.
  • particles (fillers) made of an X-ray opaque material are dispersed in the first covering portion 3.
  • X-ray contrast property is obtained for the guide wire 1, and the guide wire 1 can be inserted into the living body while confirming the position of the tip under fluoroscopy.
  • the material constituting the particles is not particularly limited as long as it is an X-ray opaque material.
  • a noble metal such as gold, platinum, tungsten, or an alloy containing these (for example, a platinum-iridium alloy) can be used.
  • hydrophilic layer 7 coated with a hydrophilic material is provided on the outer surface of the first covering portion 3.
  • hydrophilic materials include cellulose-based polymer materials, polyethylene oxide-based polymer materials, and maleic anhydride-based polymer materials (for example, maleic anhydride copolymers such as methyl vinyl ether-maleic anhydride copolymer).
  • Acrylamide polymer substances for example, polyacrylamide, block copolymer of polyglycidyl methacrylate-dimethylacrylamide (PGMA-DMAA)), water-soluble nylon, polyvinyl alcohol, polyvinylpyrrolidone and the like.
  • the second covering portion 4 has a spiral portion 5 and a base layer 6.
  • coated part 4 has the front-end
  • the spiral portion 5 is provided by being wound in a loosely spiral shape on the outer peripheral side of the base layer 6 (wire body 2).
  • the spiral portion 5 is preferably made of a material that can reduce friction. Thereby, the frictional resistance with the blood vessel wall 201 in the 2nd coating
  • materials that can reduce such friction include polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyesters (PET, PBT, etc.), polyamides, polyimides, polyurethanes, polystyrenes, polycarbonates, silicone resins, fluorine resins ( PTFE, ETFE, PFA, etc.) or a composite material thereof. Of these, fluorine-based resins (or composite materials containing them) are preferred.
  • the spiral part 5 is a part wound spirally, the contact area with the blood vessel wall 201 can be suppressed as much as possible. Thereby, combined with the friction reducing material, the frictional resistance is further reduced, which is preferable.
  • the underlayer 6 has a function as an adhesive layer that bonds the wire body 2 and the spiral portion 5.
  • the underlayer 6 is preferably made of a material containing, for example, a curable resin such as a thermosetting resin and a fluorine-based resin. Fluorine-based resins usually have low adhesion to other materials. However, the inclusion of fluorine-based resin in the underlayer 6 improves the adhesion between the underlayer 6 and the spiral portion 5, and the underlayer By including the curable resin in 6, the adhesive force between the base layer 6 and the spiral portion 5 can be maintained at a sufficient level. Thereby, the 2nd coating
  • thermosetting resin used as a constituent material of the base layer 6 an epoxy resin, a phenol resin, polyester (unsaturated polyester), a polyimide, a silicone resin, a polyurethane, etc. are mentioned, for example, One of these or Two or more kinds can be used in combination.
  • the content of the fluororesin in the underlayer 6 is preferably about 20 to 80% by weight, and more preferably about 30 to 70% by weight with respect to the entire underlayer 6.
  • the content of the fluororesin in the underlayer 6 may be constant at each part in the underlayer 6, but the spiral part 5 side (on the wire body 2 side (inner peripheral side) side ( It is preferable that the part on the outer peripheral side is higher. Thereby, both the adhesive force between the underlying layer 6 and the spiral portion 5 and the adhesive force between the underlying layer 6 and the wire body 2 can be improved.
  • the guide wire 1 is inserted from the lower limb and used in the peripheral region (lower limb blood vessel 200).
  • the guide wire 1 can be easily reshaped preferentially in the middle of its longitudinal direction over other portions, and the position of the reshaped portion in the blood vessel 200 is preferred. It is preferable to be able to confirm.
  • the guide wire 1 of the present invention has such a configuration. This will be described below.
  • “reshapable” means that a part of the guide wire 1 can be bent into a desired shape and the shape can be maintained.
  • the guide wire 1 is provided with a reshape portion 26.
  • the reshape part 26 can be reshaped more easily than before and after.
  • the reshapable portion 26 is a portion of the wire body 2 before and after the boundary portion 27 between the second outer diameter constant portion 23 and the second taper portion 24, that is, the second outer diameter constant portion 23. This is a portion including the base end portion and the entire second tapered portion 24.
  • the position of the reshapable portion 26 is, for example, in the present embodiment, on the condition that it is a portion including the proximal end portion of the second constant outer diameter portion 23 and the entire second tapered portion 24.
  • the distance L1 from the tip 211 of the main body 2 is preferably 40 mm or more, and more preferably 50 to 100 mm.
  • the length L2 of the reshape part 26 is preferably, for example, 10 to 80 mm, and more preferably 20 to 40 mm.
  • a base material 2 ' which is a wire body 2 made of a Ni-Ti alloy, is prepared. Then, as shown in FIG. 2 (b), a heat treatment is performed on a portion 26 'to be the reshaped portion 26 in the base material 2'. As a result, the physical properties of the portion 26 ′ are changed, that is, the superelasticity is reduced or eliminated, and the reshape portion 26 can be provided as shown in FIG.
  • the portion 26 ' may be subjected to cold working in addition to heat treatment.
  • a part of the spiral part 5 is wound around the outer peripheral part of the reshapable part 26, that is, the part is a contrast part 51 having a contrast property.
  • a method for supporting the contrast for example, a method of dispersing a filler made of a radiopaque material in the spiral portion 5 (contrast portion 51) as in the first covering portion 3 can be given. It is done.
  • the first outer diameter constant portion 21 to the second tapered portion 24 are covered with the first covering portion 3.
  • the filler of the contrast part 51 and the filler of the first covering part 3 are combined, so that the contrast is the highest.
  • the degree of X-ray contrast property with respect to the reshapable portion 26 is increased, and the position of the reshapable portion 26 can be reliably confirmed under fluoroscopy.
  • the reshaping portion 26 and the contrast portion 51 are provided with the functional portion 10 that can be reshaped and has high contrast properties. That is, in the guide wire 1, the functional unit 10 can be reshaped preferentially over other parts in the longitudinal direction of the wire, and is reliably confirmed under X-ray contrast (under X-ray projection). .
  • the guide wire 1 configured as described above When the guide wire 1 configured as described above is used by being inserted into the blood vessel 200 from the lower limb, if the reshaping is performed by the functional unit 10 prior to the insertion, the reshaped state is reliably maintained. Then, the guide wire 1 can be inserted into the blood vessel 200 in the reshaped state. Thereby, the guide wire 1 can be surely advanced in the direction in which it is desired to advance in the blood vessel 200, that is, the guide wire 1 can be prevented from entering other than the target site in the blood vessel 200. Further, during this insertion operation, the reshaped functional unit 10 can be reliably confirmed under X-ray contrast. Thereby, the operator can grasp
  • the functional unit 10 is covered with the first covering portion 3, it is reliably protected by the first covering portion 3 even during the insertion operation. Thereby, for example, the separation of the contrast unit 51 is surely prevented, and thus the contrast in the function unit 10 can be maintained.
  • the superelasticity is maintained in the front part of the function part 10 of the guide wire 1, it can follow the shape of the blood vessel 200. Thereby, it is possible to prevent an excessive force from the guide wire 1 from being applied to the blood vessel wall 201, and the safety is high.
  • the spiral part 5 has a plurality of auxiliary contrast parts 52 arranged at intervals behind the contrast part 51.
  • Each auxiliary contrast unit 52 has contrast, and the degree thereof may be the same as or different from the degree of contrast of the contrast unit 51.
  • a method of supporting contrast a method of dispersing a filler made of a radiopaque material in the spiral portion 5 as in the contrast portion 51 can be cited.
  • the contrast section 51 and the auxiliary contrast section 52 can exhibit a function as a scale, that is, a length measurement for measuring the length.
  • a function as a scale that is, a length measurement for measuring the length.
  • the auxiliary contrasted part located at the forefront is arranged by placing it in front of the lesioned part 202 (peripheral side) with the contrasted part 51 as a reference. 52 (hereinafter referred to as “auxiliary contrast unit 52 a”) is disposed behind (on the hand side) of the lesioned part 202. If the distance between the contrast unit 51 and the auxiliary contrast unit 52a is known in advance, the length L3 of the lesioned part 202 can be known.
  • the length L3 of the lesioned part 202 generally tends to be 100 mm or more. For this reason, grasping the length L3 of the lesioned part 202 is very effective in terms of the technique.
  • the guide wire 1 is further advanced by 50 to 150 mm after the tip of the guide wire 1 passes through the lesioned part 202.
  • the range in which the imaging unit 51 and the auxiliary imaging unit 52 are arranged is in the range of more than 50 mm and within 400 mm from the tip of the guide wire 1.
  • the contrast unit 51 and the auxiliary contrast unit 52 are constituted by a single linear body. Thereby, the contrast part 51 and the auxiliary contrast part 52 can be visually recognized from any of the circumferential directions of the guide wire 1.
  • the portions other than the contrast portion 51 and the auxiliary contrast portion 52 of the spiral portion 5 are low contrast portions 53 having a contrast property lower (or not) than these contrast portions.
  • the low contrast unit 53 is omitted, for example, a step is generated between the contrast unit 51 and the auxiliary contrast unit 52a.
  • the low contrast unit 53 is provided, such a step can be eliminated. it can. Thereby, the guide wire 1 can be smoothly inserted into the blood vessel 200.
  • FIG. 3 is a partial longitudinal sectional view showing a second embodiment of the guide wire of the present invention.
  • This embodiment is the same as the first embodiment except that the shape of the first covering portion and the configuration of the second covering portion are different.
  • the first covering portion 3 covers the entire wire body 2 together with the second covering portion 4.
  • the base layer 6 is omitted from the second covering portion 4. Since the contrast part 51 and the auxiliary contrast part 52 of the second covering part 4 are pressed against the wire main body 2 by the first covering part 3, the underlying layer 6 responsible for adhesion between these contrast parts and the wire main body 2. Can be omitted.
  • the low contrast portion 53 is omitted from the spiral portion 5.
  • the low contrast portion 53 is omitted, for example, a step is generated between the contrast portion 51 and the auxiliary contrast portion 52a.
  • the first covering portion 3 can eliminate the step.
  • assistant contrast part 52 may be distribute
  • FIG. 4 is a partial longitudinal sectional view showing a third embodiment of the guide wire of the present invention.
  • FIG. 5 is a schematic view showing a use state of the guide wire shown in FIG.
  • the third embodiment of the guide wire of the present invention will be described with reference to these drawings. However, the difference from the above-described embodiment will be mainly described, and the description of the same matters will be omitted.
  • the present embodiment is the same as the first embodiment except that the configuration of the wire body is different.
  • the wire body 2 includes a constricted portion 28 and a fourth outer diameter constant portion 29 that are arranged in order from the third outer diameter constant portion 25 to the rear. Have.
  • the constricted portion 28 has an outer diameter that continuously decreases, and includes a small tapered portion 281 and a small tapered portion 282.
  • the small taper portion 281 is a portion that is provided continuously behind the third constant outer diameter portion 25 and has an outer diameter that gradually decreases toward the rear.
  • the small taper portion 282 is a portion that is provided continuously behind the small taper portion 821 and has an outer diameter that gradually increases rearward. Due to the constricted portion 28, the wire body 2 has a rigidity changing portion that is different in bending rigidity (stiffness) with respect to the front and rear of the portion in the middle of the longitudinal direction, that is, reduced.
  • the guide wire 1 can be easily bent and deformed at the constricted portion 28. Accordingly, as shown in FIG.
  • the guide wire 1 can be engaged with the curved portion of the blood vessel 200 in the vicinity of the bent constricted portion 28, and is thus stably placed in the blood vessel 200. In this state, for example, measurement of the lesioned part 202 can be performed accurately.
  • the constricted portion 28 is disposed rearward of the third outer diameter constant portion 25, and as a result, the constricted portion 28 is disposed rearward of the functional portion 10. Since the constricted portion 28 is positioned behind the functional portion 10, the guide wire 1 is stabilized by the constricted portion 28 being bent as a bent portion, and the blood vessel 200 is selected (reshaped) on the distal end side of the constricted portion 28. It can have a contrast marker function (contrast).
  • the distance L4 from the tip 211 of the wire body 2 to the boundary 283 between the small taper portion 281 and the small taper portion 282 is not particularly limited, and is preferably 100 to 400 mm, for example, 200 to 300 mm. It is more preferable that
  • the taper angle of the small taper portions 281 and 282 may be constant along the wire longitudinal direction, or there may be a portion that varies along the wire longitudinal direction. Further, the taper angle of the small taper portion 281 and the taper angle of the small taper portion 282 may be the same or different.
  • the constricted portion 28 is provided with an auxiliary contrast portion 52 so as to overlap. Thereby, the position of the constricted part 28 bent and deformed in the blood vessel 200 can be confirmed under X-ray contrast.
  • the fourth constant outer diameter portion 29 is provided continuously behind the constricted portion 28.
  • the fourth constant outer diameter portion 29 has a constant outer diameter along the wire longitudinal direction, and has the same size as the third constant outer diameter portion 25.
  • the base end 291 of the fourth constant outer diameter portion 29 is preferably rounded.
  • FIG. 6 is a longitudinal sectional view showing the configuration of the reshapable part of the guide wire (fourth embodiment) of the present invention.
  • This embodiment is the same as the first embodiment except that the configuration of the reshapable part is different.
  • the wire body 2 is made of stainless steel in the portion that becomes the reshape portion 26.
  • the reshape part 26 can be reshaped reliably.
  • butt resistance welding can be used to connect the Ni—Ti alloy and the stainless steel.
  • each part which comprises a guide wire is a thing of arbitrary structures which can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.
  • the guide wire of the present invention may be a combination of any two or more configurations (features) of the above embodiments.
  • the functional unit is provided at one location behind the first taper portion, but is not limited thereto, and may be provided at, for example, two or more locations.
  • the first covering portion is a resin coating layer in each of the embodiments described above, but is not limited thereto, and may be a coil, for example.
  • the winding state of the spiral portion is loosely wound in each of the embodiments described above, but is not limited thereto, and may be densely wound.
  • auxiliary contrast portions formed is plural in each of the embodiments described above, but is not limited thereto, and may be one.
  • the spiral portion is made of a resin material in each of the embodiments described above, but is not limited thereto, and may be made of a metal material.
  • a material having a contrast property among metal materials for example, a noble metal such as gold, platinum, tungsten, or an alloy containing these (for example, a platinum-iridium alloy) or the like is used for the contrast portion or the auxiliary contrast portion. preferable.
  • the guide wire of the present invention is a guide wire including a wire body having a front end taper portion whose outer diameter is gradually reduced toward the front at the front end portion, and at least at one position behind the front end taper portion, A functional part that can be reshaped more easily than before and after and has high contrast properties is provided. Therefore, for example, when used for diagnosis or treatment in a peripheral region, the middle of the wire longitudinal direction can be reshaped preferentially over other portions, and the reshaped portion can be confirmed with certainty. Therefore, the guide wire of the present invention has industrial applicability.

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  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un fil-guide pourvu d'un corps de fil, sur l'extrémité antérieure duquel se trouve une section conique d'extrémité antérieure dans laquelle le diamètre externe diminue progressivement vers l'avant. Au moins un site du fil-guide derrière la section conique d'extrémité antérieure est pourvu d'une section fonctionnelle qui est plus facilement refaçonnable et présente des propriétés d'imagerie de contraste supérieures à celles des sections situées avant et après ledit site. Le corps de fil comprend également une section de diamètre externe constant, qui est placée de façon contiguë à l'extrémité postérieure de la section conique d'extrémité antérieure et dans laquelle le diamètre externe est constant le long de la direction longitudinale, et une section conique d'extrémité postérieure, qui est placée de façon contiguë à l'extrémité postérieure de la section de diamètre externe constant et dans laquelle le diamètre externe augmente progressivement vers l'arrière. La section fonctionnelle est conçue à partir d'une section de refaçonnage dans laquelle les zones en avant et en arrière de la limite entre la section de diamètre externe constant et la section conique d'extrémité antérieure sont aptes à être reformées, et une partie d'imagerie de contraste, qui est prévue en étant enroulée sur la circonférence externe de la section de refaçonnage et présente des propriétés d'imagerie de contraste.
PCT/JP2015/052053 2014-03-19 2015-01-26 Fil-guide Ceased WO2015141280A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014-057287 2014-03-19
JP2014057287 2014-03-19

Publications (1)

Publication Number Publication Date
WO2015141280A1 true WO2015141280A1 (fr) 2015-09-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2015/052053 Ceased WO2015141280A1 (fr) 2014-03-19 2015-01-26 Fil-guide

Country Status (1)

Country Link
WO (1) WO2015141280A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08112356A (ja) * 1994-10-17 1996-05-07 Nippon Life Line Kk ガイドワイヤー
JP2008161589A (ja) * 2006-12-28 2008-07-17 Terumo Corp ガイドワイヤ
JP2012090949A (ja) * 2010-09-27 2012-05-17 Terumo Corp 内視鏡用ガイドワイヤ
JP2013176560A (ja) * 2012-02-28 2013-09-09 Covidien Lp 脈管内ガイドワイヤ

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08112356A (ja) * 1994-10-17 1996-05-07 Nippon Life Line Kk ガイドワイヤー
JP2008161589A (ja) * 2006-12-28 2008-07-17 Terumo Corp ガイドワイヤ
JP2012090949A (ja) * 2010-09-27 2012-05-17 Terumo Corp 内視鏡用ガイドワイヤ
JP2013176560A (ja) * 2012-02-28 2013-09-09 Covidien Lp 脈管内ガイドワイヤ

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