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WO2015037016A3 - An improved process for the preparation of ticagrelor and intermediates thereof - Google Patents

An improved process for the preparation of ticagrelor and intermediates thereof Download PDF

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Publication number
WO2015037016A3
WO2015037016A3 PCT/IN2014/000587 IN2014000587W WO2015037016A3 WO 2015037016 A3 WO2015037016 A3 WO 2015037016A3 IN 2014000587 W IN2014000587 W IN 2014000587W WO 2015037016 A3 WO2015037016 A3 WO 2015037016A3
Authority
WO
WIPO (PCT)
Prior art keywords
ticagrelor
preparation
improved process
intermediates
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2014/000587
Other languages
French (fr)
Other versions
WO2015037016A2 (en
Inventor
Ravindra Babu Bollu
Subha Nair Velayudhan
Prasanta Kumar DALASINGH
Venkata Sunil Kumar Indukuri
Seeta Rama Anjaneyulu GORANTLA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laurus Labs Pvt Ltd
Original Assignee
Laurus Labs Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Pvt Ltd filed Critical Laurus Labs Pvt Ltd
Publication of WO2015037016A2 publication Critical patent/WO2015037016A2/en
Publication of WO2015037016A3 publication Critical patent/WO2015037016A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Ceramic Products (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of ticagrelor, which involves ecofriendly reaction solvent and bases. The present invention also relates to a process for preparation of ticagrelor in crystalline Form or an amorphous form.
PCT/IN2014/000587 2013-09-10 2014-09-10 An improved process for the preparation of ticagrelor and intermediates thereof Ceased WO2015037016A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4023/CHE/2013 2013-09-10
IN4023CH2013 IN2013CH04023A (en) 2013-09-10 2014-09-10

Publications (2)

Publication Number Publication Date
WO2015037016A2 WO2015037016A2 (en) 2015-03-19
WO2015037016A3 true WO2015037016A3 (en) 2015-06-04

Family

ID=52666472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000587 Ceased WO2015037016A2 (en) 2013-09-10 2014-09-10 An improved process for the preparation of ticagrelor and intermediates thereof

Country Status (2)

Country Link
IN (1) IN2013CH04023A (en)
WO (1) WO2015037016A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
CN106243108A (en) * 2015-06-03 2016-12-21 四川海思科制药有限公司 A kind of highly purified ticagrelor and preparation method thereof
KR101787449B1 (en) 2016-07-29 2017-10-18 주식회사 종근당 Novel salts of Ticagrelor and Preparation Method thereof
CN106478636B (en) * 2016-08-30 2019-02-15 山东罗欣药业集团恒欣药业有限公司 Ticagrelor crystal form and preparation method
WO2020021110A1 (en) 2018-07-27 2020-01-30 Krka, D.D., Novo Mesto Pharmaceutical composition of ticagrelor
CN110437237A (en) * 2019-09-06 2019-11-12 上海汇伦生命科技有限公司 A kind of preparation method of the single crystallization of 1,2- diol compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092262A1 (en) * 2000-06-02 2001-12-06 Astrazeneca Ab New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound
WO2010030224A1 (en) * 2008-09-09 2010-03-18 Astrazeneca Ab A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates
WO2012138981A2 (en) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. New intermediates and processes for preparing ticagrelor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092262A1 (en) * 2000-06-02 2001-12-06 Astrazeneca Ab New crystalline and amorphous form of a triazolo(4,5-d)pyrimidine compound
WO2010030224A1 (en) * 2008-09-09 2010-03-18 Astrazeneca Ab A process for preparing [1s- [1-alpha, 2-alpha, 3-beta (1s*, 2r*) 5-beta] ] -3- [7- [2- (3, 4-dif luorophenyl) -cyclopropylamino] - 5- (propylthio) -3h-1, 2, 3-triazolo [4, 5-d] pyrimidin-3-yl] -5- (2- hydroxyethoxy) cyclopentane-1, 2-diol and to its intermediates
WO2012138981A2 (en) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. New intermediates and processes for preparing ticagrelor

Also Published As

Publication number Publication date
IN2013CH04023A (en) 2015-08-07
WO2015037016A2 (en) 2015-03-19

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