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WO2015033667A1 - Fil-guide - Google Patents

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Publication number
WO2015033667A1
WO2015033667A1 PCT/JP2014/068339 JP2014068339W WO2015033667A1 WO 2015033667 A1 WO2015033667 A1 WO 2015033667A1 JP 2014068339 W JP2014068339 W JP 2014068339W WO 2015033667 A1 WO2015033667 A1 WO 2015033667A1
Authority
WO
WIPO (PCT)
Prior art keywords
guide wire
lumen
light
end side
wire
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/068339
Other languages
English (en)
Japanese (ja)
Inventor
泰直 大谷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to JP2015535364A priority Critical patent/JP6400586B2/ja
Publication of WO2015033667A1 publication Critical patent/WO2015033667A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M2025/09175—Guide wires having specific characteristics at the distal tip

Definitions

  • the present invention relates to a guide wire used in the medical field.
  • catheter device that is inserted into a body lumen such as a blood vessel and used to acquire various diagnostic images for diagnosing the inside of the lumen.
  • an ultrasonic wave that oscillates from inside the lumen, receives the ultrasonic wave reflected by the inner wall of the lumen at a predetermined detection unit, and generates a tomographic image based on the reception result
  • image diagnostic apparatuses optical image diagnostic apparatuses that irradiate optical signals instead of ultrasonic waves, receive reflected light reflected on the inner wall of the lumen, and generate tomographic images based on the light reception results.
  • each catheter device When each of the above catheter devices is used, by using a guide wire generally used in the medical field, a predetermined portion of each catheter device (for example, a target portion of a biological lumen to be diagnosed) (for example, , Oscillation unit, light emitting unit, detection unit, etc.) can be smoothly reached.
  • a predetermined portion of each catheter device for example, a target portion of a biological lumen to be diagnosed
  • Oscillation unit for example, Oscillation unit, light emitting unit, detection unit, etc.
  • a conventional guide wire is configured to have a metal core
  • when used in a catheter device that acquires an image by an optical technique light is blocked by the guide wire and is displayed on the image.
  • the so-called “back shadow” is generated by the guide wire. Since the blood vessel wall in the portion where the back shadow occurs is not displayed on the image, it is difficult to visually diagnose the blood vessel wall in the portion where the back shadow occurs.
  • a part of the guide wire is made of a resin material or glass material having light transmittance, and the occurrence of back shadow is prevented by transmitting light through the portion.
  • a guide wire that enables the above has been proposed (see Patent Document 1).
  • Guidewires used in the medical field are provided with a tip flexibility so that the guidewire can move following a complicated meandering and branched path like a living body lumen.
  • tip flexibility is added by forming a tapered portion with a gradually decreasing outer diameter toward the tip side on a metal thin core material.
  • resin materials and glass materials are more likely to be damaged or worn during processing than metal materials, the desired taper shape is processed with high precision for thin materials made of resin materials and glass materials. It is not easy. For this reason, it has been difficult to impart tip flexibility to a guide wire using a resin material or a glass material, and it has been difficult to realize such a guide wire.
  • an object of the present invention is to provide a guide wire having light-transmitting properties and tip flexibility that enables smooth movement in a living body lumen.
  • the present invention can be achieved by the guide wire described in any of (1) to (4) below.
  • a medical guide wire having an elongated wire main body, wherein the wire main body is at least partially on the distal end side in the axial direction and intersects the axial direction of the wire main body. It has a light transmissive part having a light transmissive property capable of transmitting the irradiated light, the light transmissive part is made of a resin material or a glass material, and has a cross-sectional area of a cross section in the direction perpendicular to the axis.
  • a guide wire having a lumen that is increased from the proximal side to the distal side.
  • the light transmission part includes a long member in which a lumen whose diameter continuously increases gradually from the proximal end side to the distal end side is formed.
  • each of the light transmission parts includes a plurality of hollow members each having an inner cavity formed with a different diameter and connected to each other in the axial direction. Wire.
  • the light emitted from a predetermined medical device to acquire a diagnostic image is transmitted through the light transmitting portion included in the guide wire, and the biological lumen side, the medical device side, Therefore, the back shadow is not reflected on the diagnostic image in the procedure using the guide wire. For this reason, it is possible to suitably diagnose a disease state or the like of a living body lumen based on the acquired examination image.
  • the light transmission part has a lumen in which the cross-sectional area of the cross section in the direction perpendicular to the axis of the guide wire is increased from the proximal end side to the distal end side. Flexibility is provided. Therefore, it is possible to provide a guide wire that has light transparency and can realize smooth movement in a living body lumen.
  • the light transmitting portion can be formed by the long member configured so that the diameter of the lumen gradually increases from the proximal end side to the distal end side.
  • a guide wire configured to continuously increase flexibility can be provided.
  • the light transmission part can be provided in the guide wire by a simple operation of connecting a plurality of hollow members each having a lumen formed with a different diameter.
  • the manufacturing work of the guide wire having the flexibility and the tip flexibility can be simplified.
  • the antireflection material is provided on the outer surface of the light transmission part and the inner surface of the lumen, the light emitted from the predetermined medical device is reflected by the light transmission part. This can be prevented, and a clearer diagnostic image can be obtained when the guide wire is used.
  • FIG. 2A is an enlarged cross-sectional view of a broken line portion 2A shown in FIG. 1 and FIG. 2B is an arrow 2B shown in FIG. 2A.
  • FIG. It is a figure which simplifies and shows the whole structure of the catheter apparatus used in order to image a diagnostic image. It is a figure which simplifies and shows the whole structure of the external drive device used in order to image a diagnostic image. It is a figure for demonstrating the effect
  • FIG. 7A is an enlarged cross-sectional view of a broken-line portion 7A shown in FIG. 1 and FIG. 7B is an arrow 7B shown in FIG. 7A.
  • FIG. 7 is an enlarged sectional view taken along line -7B.
  • FIGS. 1 and 2 are diagrams showing a configuration of each part of the guide wire according to the first embodiment
  • FIGS. 3 to 5 are diagrams for explaining an example of use of the guide wire according to the embodiment.
  • the guide wire 10 is a medical guide wire having a long wire main body portion 11, and the wire main body portion 11 is at least one on the distal end side in the axial direction.
  • the light transmitting portion 20 is provided with a light transmitting property capable of transmitting light irradiated in a direction intersecting the axial direction of the wire main body portion 11.
  • the light transmitting portion 20 is made of a resin material, and has a lumen 21 that changes so that the cross-sectional area of the cross section in the direction perpendicular to the axis increases from the proximal end side to the distal end side.
  • the left-right direction in FIG. 1, that is, the guide wire stretching direction is referred to as “axial direction”
  • the left side is referred to as “tip side”
  • the right side is referred to as “base end side”.
  • the distal end side of the wire main body portion means a predetermined region on the distal end side of the wire main body portion 11, and an area including the most distal end portion 13 of the wire main body portion 11 or the most distal end portion of the wire main body portion 11. It means any region that does not include 13.
  • the guide wire 10 is inserted into a living organ such as a living body lumen, and a medical instrument that allows a predetermined medical device to be introduced and guided to each part in the living body via the guide wire 10. It is.
  • predetermined information data
  • prescribed information data
  • optical signal F optical signal F
  • prescribed light optical signal F
  • OCT optical coherence tomographic image diagnostic apparatus
  • a catheter apparatus 100 such as an image diagnostic apparatus (OFDI) may be mentioned (see FIG. 3).
  • the biological organ that is the target of use of the guide wire 10 is not particularly limited as long as the above-described medical device can be introduced, and examples thereof include blood vessels, digestive tracts, bile ducts, urethra, digestive organs, and the like. .
  • the wire main body portion 11 provided in the guide wire 10 has a long shape in which the entire shape is extended in the axial direction. Flexibility is provided so that it can deform
  • the outer surface of the wire main body 11 is formed smoothly from the distal end side to the proximal end side. For this reason, the outer diameter of the wire main-body part 11 is formed uniformly from the front end side to the base end side.
  • the guide wire 10 includes a resin-made long member 30 having light permeability and a predetermined tip 40 attached to the long member 30.
  • the wire body 11 is constituted by a long member 30.
  • the guide wire 10 has a configuration in which the guide wire 10 as a whole has optical transparency.
  • a portion where the lumen 21 is formed in the wire main body portion 11 is referred to as a light transmitting portion 20.
  • the overall length of the wire body 11 can be appropriately designed according to the intended use and purpose, and is not particularly limited.
  • the wire body 11 can be formed to have a length of 1000 mm to 3500 mm.
  • the outer diameter of the wire main body 11 is not particularly limited similarly to the length dimension, but can be formed to be 0.2 mm to 0.5 mm, for example.
  • the lumen 21 provided in the wire main body 11 is formed with a predetermined length from the most distal end portion 13 to the proximal end side of the wire main body 11 as shown in FIGS.
  • the lumen 21 is formed in a shape in which the diameter (inner diameter) continuously increases from the proximal end side to the distal end side. Since the thickness of the wire main body portion 11 becomes thinner toward the distal end side with respect to an arbitrary portion where the lumen 21 is formed in the wire main body portion 11, the flexibility of the wire main body portion 11 is increased. For this reason, the guide wire 10 is provided with a tip flexibility that gradually increases toward the tip side without processing a tapered shape on the outer surface like a conventional metal guide wire. .
  • the position and length of the lumen 21 formed in the wire main body 11 are not particularly limited as long as the distal end flexibility of the guide wire 10 can be ensured. 13 to a length of 10 mm to 500 mm. Further, the diameter of the lumen 21 is not particularly limited as long as the flexibility of the distal end can be ensured and the breakage or the like is not caused in relation to the outer diameter of the guide wire 10, for example, The diameter of the most distal portion 13 where the diameter of the lumen 21 is maximum can be 0.19 mm to 0.49 mm, and the diameter of the minimum portion can be 0 mm to 0.35 mm.
  • the cross-sectional shape of the lumen 21 is formed in a circular shape, but this cross-sectional shape can be changed as long as the guide wire 10 can be provided with a tip flexibility.
  • the cross-sectional shape is a rectangle, a rhombus, an ellipse or the like, the distal end of the guide wire 10 may be formed if the distal-side cross-sectional area is larger than the proximal-side cross-sectional area. Flexibility can be provided. For this reason, the cross-sectional shape of the lumen 21 is not limited to a circle.
  • the cross-sectional shape of the wire main body 11 is circular, it is preferable to form the cross-sectional shape of the lumen 21 in a circular shape in accordance with this shape. This is because such a configuration makes it possible to provide uniform tip flexibility at each portion in the circumferential direction of the wire main body portion 11.
  • Examples of the resin material (resin material having optical transparency) constituting the wire main body 11 included in the guide wire 10 include PEEK (polyether ether ketone), polyolefin such as polyethylene, polyvinyl chloride, polystyrene, polyamide (example) : Nylon 6, nylon 46, nylon 66, nylon 610, nylon 612, nylon 11, nylon 12, nylon 6-12, nylon 6-66), polyimide, polycarbonate (PC), acrylic resin, other fluororesins, styrene , Polyolefins, polyvinyl chlorides, polyurethanes, and other thermoplastic elastomers, epoxy resins, phenol resins, silicone resins, polyurethanes, etc., or copolymers, blends, polymer alloys, etc. mainly comprising these This is It can be used singly or in combination of two or more of al.
  • PEEK polyether ether ketone
  • polyolefin such as polyethylene, polyvinyl chloride,
  • the long member 30 constituting the wire main body 11 is formed in a long shape so that any of the materials exemplified above is provided with a predetermined lumen 21. Is used. Although it does not specifically limit as a manufacturing method of the elongate member 30, For example, the injection molding method using a predetermined metal mold
  • the wire body 11 is made of a member that has transparency and can be visually recognized from a part of the outer peripheral surface to the opposite side through the central axis.
  • “transparent” includes colorless and transparent as well as colored (colored) transparency.
  • the wire main body part 11 can also be comprised with the glass material provided with a light transmittance, for example.
  • the glass material include quartz glass, alkali-free glass, soda glass, crystalline glass, potassium glass, and borosilicate glass.
  • the wire main body portion 11 has light permeability with respect to predetermined light emitted from the catheter device 100 described later. As a result, it is possible to suitably prevent the back shadow from being formed on the diagnostic image when the diagnostic image is acquired using the guide wire 10.
  • the type of light that can be transmitted by the light transmitting unit 20 is, for example, near infrared light when used in the catheter device 100 or the like described later.
  • the type of light that can be transmitted (wavelength of light) is changed according to the relationship with various medical devices and the like used together with the guide wire 10, and thus is limited to only near infrared light. There is nothing.
  • the wire main body 11 is made of a resin material having a light transmitting property, and thus the entire guide wire 10 has a light transmitting property.
  • the part 20 should just be provided in at least one part of the front end side of the wire main-body part 11.
  • a light transmitting portion 20 is formed using a resin material or glass material having light transmission properties at a part of the front end side or at a plurality of locations on the front end side, and other portions are not provided with light transmission properties. It is also possible to configure with materials or other materials.
  • Such materials include various metal materials such as stainless steel, Ni—Ti alloys, Ni—Al alloys, Cu—Zn alloys, and other superelastic alloys used in the conventional guidewire 10.
  • metal materials such as stainless steel, Ni—Ti alloys, Ni—Al alloys, Cu—Zn alloys, and other superelastic alloys used in the conventional guidewire 10.
  • a resin material having a relatively high rigidity can be used.
  • the tip 40 provided at the most distal portion 13 of the wire main body 11 serves as a buffer member that prevents the living organs and the like from being damaged by the tip of the guide wire 10 when the guide wire 10 is introduced into the living body. It has a function.
  • a tip having X-ray contrast properties can be used. By using the tip tip 40 having an X-ray contrast property, it becomes possible to confirm the position of the tip of the guide wire 10 during the procedure using the guide wire 10, so that the procedure can be performed more quickly and smoothly. Can proceed. It is also possible to connect a contrast coil to the tip chip 40.
  • a known material having X-ray contrast properties such as Pt, Pt alloy, W, W alloy, Ag, and Ag alloy can be used.
  • the outer shape of the tip 40 can be formed, for example, in a shape in which the tip is curved with a predetermined curvature as shown in the figure, as long as it is formed so as to reduce invasiveness to a living organ. It is possible to change. Further, the method for attaching the guide wire 10 to the tip can be appropriately selected from known methods such as adhesion, fusion, welding, and fitting according to the material of the wire main body 11 and the like.
  • an antireflection material 25 for preventing light reflection can be provided on the outer surface 24 of the light transmitting portion 20 and the inner surface 23 of the lumen 21. As shown in FIG.
  • the light transmitting portion 20 In the portion where the lumen 21 is formed in the light transmitting portion 20, light is refracted at the interface between the resin material or glass material constituting the light transmitting portion 20 and the lumen 21 adjacent to the light transmitting portion 20, and light is emitted. May be reflected.
  • the reflected light becomes noise and it is difficult to acquire a clear diagnostic image. Therefore, by providing the antireflection material 25 on the outer surface 24 of the light transmitting portion 20 and the inner surface 23 of the lumen 21 of the light transmitting portion 20, the light is reflected when the predetermined light passes through the guide wire 10. Is prevented.
  • the outer surface 24 of the light transmission part 20 is an outer surface of the position where the light transmission part 20 was formed in the wire main body part 11 in this embodiment.
  • the antireflection material 25 provided on the inner surface 23 of the lumen 21 is provided along the axial direction in the entire lumen 21.
  • the range (length in the axial direction) of the outer surface 24 on which the antireflection material 25 is provided is not particularly limited as long as it is formed at least along the position where the inner cavity 21 is formed.
  • the antireflection material 25 is not particularly limited as long as it can prevent light reflection and does not impair the light transmittance of the light transmitting portion 20.
  • the well-known thing comprised by the coating material and film form provided with a function can be used.
  • well-known methods, such as vacuum evaporation and sputtering, are employable as an application
  • the antireflection material 25 for example, an inorganic compound such as MgF2 or SiO2, or a solution system using a fluororesin can be used.
  • the antireflection material 25 may contain various coating agents that exhibit functions such as water / oil repellency, antifouling properties, fingerprint wiping properties, and slipperiness.
  • the thickness dimensions of the antireflection material 25 provided on the outer surface 24 of the light transmitting portion 20 and the inner surface 23 of the lumen 2 are not particularly limited as long as the flexibility of the distal end of the guide wire 10 and the light transmittance of each portion are not impaired.
  • the thickness dimension at each portion can be formed to 0.01 mm to 0.49 mm, for example. .
  • the catheter device 100 includes a long catheter main body 110 that can be inserted into a living body lumen, and an operation unit 120 that is arranged on the user's hand side.
  • the catheter apparatus 100 is configured as an optical coherence tomography diagnostic apparatus (OCT) or an optical coherence tomography diagnostic apparatus (OFDI) using wavelength sweep.
  • OCT optical coherence tomography diagnostic apparatus
  • OFDI optical coherence tomography diagnostic apparatus
  • Near-infrared rays emitted from a prism 131 included in the imaging unit 130 described later are emitted to a living tissue (for example, an inner wall surface of a living body lumen) through a window 115 provided in the catheter main body 110.
  • a tomographic image (diagnosis image) of the biological lumen is drawn based on the interference light.
  • the catheter main body 110 has a guide wire insertion portion 111 extending to the distal end side thereof.
  • the guide wire insertion portion 111 is disposed so that the central axis thereof is eccentric with respect to the central axis of the catheter body. That is, the catheter device 100 is configured as a so-called “rapid exchange type (short monorail type)” in which the guide wire 10 can be inserted and removed from the side of the catheter main body 110.
  • a working lumen 113 extending in the longitudinal direction is formed in the catheter main body 110.
  • An imaging means 130 (described later) is inserted into the working lumen 113 so as to be movable back and forth in the axial direction.
  • an X-ray contrast marker 114 is provided at the distal end of the catheter main body 110 so that the position of the distal end can be confirmed during use.
  • the X-ray contrast marker 114 is formed by spirally winding an element wire made of a radiopaque metallic material such as platinum.
  • the tube wall at the distal end portion of the catheter main body 110 is configured as a window portion 115 that can transmit the optical signal F.
  • This window part 115 can be comprised by the resin material or glass material provided with the light transmittance mentioned above, for example.
  • An X-ray contrast marker may be provided around the window 115 so that the position of the window 115 can be confirmed when the catheter device 100 is used.
  • the imaging means 130 includes an imaging core 133 configured by a prism 131 that transmits and receives an optical signal F to and from an inner wall surface of a living body lumen, and a housing 132 that houses the prism 131 therein, and the imaging core 133 is on the distal side. And a drive shaft 135 disposed at the same position.
  • a right-angle prism 131 can be used as the prism 131.
  • the prism 131 is fixed to the tip of the drive shaft 135.
  • the fixing method is not particularly limited, and for example, it can be bonded by an adhesive or soldering.
  • the drive shaft 135 has a function of transmitting the rotational force generated in the operation unit 120 to the imaging core 133.
  • the imaging shaft 133 is rotated about the axis by the driving shaft 135 transmitting the rotational power. Thereby, a diagnostic image in the circumferential direction (360 ° direction) of the living body lumen can be acquired.
  • An optical fiber 136 connected to the imaging core 133 is disposed in the drive shaft 135.
  • the operation unit 120 is connected to the hub 121 arranged on the proximal end side, the unit connector 126 connected to the hub 121 via the inner pipe 123, and the unit connector 126 via the outer pipe 125.
  • the relay connector 127 is connected to connect the catheter body 110 and the operation unit 120.
  • the drive shaft 135 and the inner pipe 123 are held by the hub 121.
  • the drive shaft 135 is moved in the axial direction in the operation unit 120 and the working lumen 113 of the catheter body 110 in conjunction with this operation. It moves forward and backward (arrows a and b in FIG. 5 indicate the forward and backward movement of the drive shaft 135).
  • connection connector 128 connected to the base end portion of the drive shaft 135 is disposed on the base end side of the hub 121.
  • the connection connector 128 is configured to include, for example, an optical fiber connector (not shown).
  • the connection connector 128 is configured to be connectable and detachable to the scanner device 210 for rotating the drive shaft 135 at a high speed.
  • FIG. 4 shows an overall configuration diagram of the external drive device 200 used when a predetermined diagnostic image is acquired using the catheter device 100.
  • the external drive device 200 includes a scanner device 210 incorporating an external drive source such as a motor, a scanner device 210, an axial movement device 220 that moves the scanner device 210 back and forth in the axial direction by a motor or the like, and the scanner device 210. And a control unit 230 that controls the axial movement device 220 and a display unit 240 that displays an image obtained by the imaging core 133.
  • the axial direction moving device 220 is provided with a scanner gripping portion 221 for gripping and fixing the scanner device 210 and a catheter support portion 222 that supports the catheter main body portion 110 so that it does not shift during movement.
  • a connecting connector 128 provided on the proximal end side of the hub 121 can be connected to the scanner device 210.
  • the scanner device 210 transmits and receives a signal from the imaging core 133 and transmits a driving force for rotating the driving shaft 135.
  • Scanning (scanning) in the catheter device 100 is transmitted and received by the imaging core 133 by transmitting the rotational motion of the motor in the scanner device 210 to the drive shaft 135 and rotating the housing 132 fixed to the tip of the drive shaft 135. This is performed by scanning an image in a substantially radial direction.
  • the image obtained here is a tomographic image (cross-sectional image) of a living body lumen. Further, by pulling the entire catheter device 100 toward the hand side and moving the imaging core 133 in the axial direction, a tomographic image in the circumferential direction of the biological lumen at an arbitrary position in the axial direction of the biological lumen can be acquired. .
  • the imaging result obtained by the imaging core 133 is transmitted to the external driving device 200, and then a predetermined process is performed in the control unit 230 and displayed as an image on the display unit 240.
  • the guide wire 10 is inserted into the living body lumen in advance of the catheter device 100.
  • the catheter body 110 is moved into the living body lumen along the guide wire 10.
  • the scanner device 210 moves the drive shaft 135 of the catheter device 100 around the axis and moves it in the proximal direction (the arrow in FIG. 5). b). Thereby, a tomographic image of the living body lumen can be acquired.
  • the window portion 115 of the catheter body 110 is configured to have light transmittance
  • the optical signal F emitted from the prism 131 disposed on the drive shaft 135 is transmitted through the window portion 115.
  • the optical signal F that has passed through the window 115 is applied to the guide wire 10 in a direction that intersects the axial direction of the guide wire 10.
  • the direction intersecting with the axial direction means at least one of all directions passing through the central axis of the guide wire 10.
  • the optical signal F passes through the light transmitting portion 20 of the guide wire 10 and reaches the inner wall surface of the living body lumen. Thereafter, the light is reflected by the inner wall surface of the living body lumen and becomes reflected light. The reflected light is again transmitted through the light transmitting portion 20 of the guide wire 10 and the window portion 115 of the catheter main body 110 and received by the prism 131 disposed on the drive shaft 135. As described above, since the optical path of the optical signal F applied to the guide wire 10 can be prevented from being blocked by the guide wire 10, it is possible to prevent the occurrence of back shadow.
  • the optical signal F emitted from the catheter device 100 in order to acquire a diagnostic image passes through the light transmission unit 20 included in the guide wire 10 and is living. Since it moves back and forth between the lumen side and the catheter device 100 side, back shadow does not appear on the diagnostic image in the procedure using the guide wire 10. For this reason, it is possible to suitably diagnose a disease state or the like of a living body lumen based on the acquired examination image.
  • the light transmitting portion 20 is formed with a lumen 21 in which the cross-sectional area of the guide wire 10 in the direction perpendicular to the axis is changed from the proximal end side to the distal end side. 10 is provided with tip flexibility. Therefore, it is possible to provide the guide wire 10 that has optical transparency and can realize smooth movement in the living body lumen.
  • the light transmitting portion 20 is formed by the long member 30 configured so that the diameter of the lumen 21 gradually increases from the proximal end side to the distal end side, the flexibility continuously increases toward the distal end side.
  • a guidewire 10 configured to do so can be provided.
  • the antireflection material 25 is provided on the outer surface 24 of the light transmission part 20 and the inner surface 23 of the lumen 21, the optical signal F emitted from the catheter device 100 is prevented from being reflected by the light transmission part 20.
  • the guide wire 10 is used, a clearer diagnostic image can be acquired.
  • FIG. 6 is a cross-sectional view showing the overall configuration of the guide wire according to the present embodiment.
  • the light transmitting portion 20 capable of transmitting predetermined light has a long length in which a lumen 21 whose diameter continuously increases from the proximal end side to the distal end side is formed. It was comprised by the member 30.
  • the guide wire 50 according to the present embodiment light is emitted by a plurality of hollow members 70, 80, 90 having inner cavities 71, 81, 91 having mutually different diameters and mutually connected in the axial direction.
  • a transmission unit 60 is configured.
  • a light transmission part 60 composed of a plurality of hollow members 70, 80, 90 is provided on the distal end side of the wire main body 51 provided in the guide wire 50.
  • the first to third hollow members 70, 80, 90 in which the lumens 71, 81, 91 having predetermined diameters are formed are used.
  • the length of each of the hollow members 70, 80, 90 can be changed according to the total length of the guide wire 50, but can be formed to be 10 mm to 300 mm, for example.
  • the diameters of the lumens 71, 81, 91 are not particularly limited, but the diameter of the lumen 71 of the first hollow member 70 is 0.2 mm to 0.5 mm, and the lumen 81 of the second hollow member 80.
  • the third hollow member 90 can be formed with a diameter of 0.1 mm to 0.3 mm, and the diameter of the lumen 91 of the third hollow member 90 can be set to 0 mm to 0.2 mm.
  • the third hollow member 90, the second hollow member 80, and the first hollow member 70 are arranged side by side in the axial direction in order from the proximal end side of the guide wire 50, whereby the flexibility of the guide wire 50 is increased. Can be gradually increased from the proximal end side to the distal end side.
  • the resin material or glass material having light transmittance described in the first embodiment described above can be used as the material constituting each of the hollow members 70, 80, 90.
  • the hollow members 70, 80, 90 made of these resin resin materials and glass materials are arranged in the axial direction and connected by a known method such as fusion, adhesion, or welding. it can.
  • the light transmitting portion 60 is formed by the connected hollow members 70, 80, 90, and the lumen 61 of the light transmitting portion 60 is formed by the lumens 71, 81, 91 arranged so as to extend in the axial direction. It is formed.
  • the number of hollow members used for the guide wire 50 is not limited to three as shown in the figure. For example, two hollow members having different lumen diameters or four different lumen diameters are used. It is also possible to use the above hollow members. It is also possible to use a different resin material or glass material for each hollow member.
  • a solid long member comprising first to third hollow members 70, 80, 90 and a metal wire arranged on the proximal end side of the third hollow member 90.
  • 62 constitutes a wire main body 51.
  • the 3rd hollow member 90 and the elongate member 62 can be connected by well-known methods, such as melt
  • the antireflection material 25 can be provided on the inner surface 23 of the inner cavity 61 of the light transmitting portion 60 and the outer surface 24 of the light transmitting portion 60.
  • the point that the tip tip 40 can be attached to the tip, the cross-sectional shape of the lumens 71, 81, 91 of each hollow member 70, 80, 90 is not limited to a circle, etc. It is the same.
  • the guide wire 50 described in the present embodiment is configured to have optical transparency and tip flexibility like the guide wire 10 according to the first embodiment, the guide wire 50 is used together with a predetermined medical device. Therefore, there is no risk of causing back shadow on the examination image, and smooth movement in the living body lumen can be realized.
  • the use procedure etc. when using the guide wire 50 for OCT and OFDI are the same as the case where the guide wire 10 which concerns on 1st Embodiment is used, the description is abbreviate
  • the light transmission portion 60 can be provided in the guide wire 50 by a simple operation of connecting the plurality of hollow members 70, 80, 90 each having the lumens 71, 81, 91 formed with different diameters,
  • the manufacturing operation of the guide wire 50 having light transmittance and tip flexibility can be simplified.
  • the entire guide wire 50 is bent since each of the connecting portions where the hollow members 70, 80, 90 are connected to each other is a starting point of bending. It is possible to further improve the followability to a steep branch or a meandering path existing in a lumen or the like.
  • the guide wire according to the present invention has been described through the embodiments.
  • the guide wire according to the present invention is not limited to the configuration described in the embodiments, and various types can be made based on the description of the claims. It is possible to modify.
  • the long member described in the first embodiment and the hollow member described in the second embodiment to provide the light transmission part in the guide wire.
  • a plurality of hollow members in which a part of the wire main body portion is constituted by a long member, and lumens having a diameter larger than the diameter of the lumen of the long member are formed on the distal end side of the long member.
  • a plurality of hollow members each having a diameter smaller than the diameter of the lumen of the long member is connected to the proximal end side of the long member to constitute the light transmitting portion. be able to.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endoscopes (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention vise à fournir un fil-guide ayant une perméabilité à la lumière et ayant une flexibilité de l'extrémité distale qui permet que le fil-guide se déplace en douceur à l'intérieur d'une lumière d'un organisme vivant. Un fil-guide (10) a un long corps de fil (11) et une section perméable à la lumière (20) qui est fournie au moins en partie du côté de l'extrémité distale axiale du corps de fil (11) et à travers laquelle passe la lumière émise dans la direction coupant la direction axiale du corps de fil (11). La section perméable à la lumière (20) est dotée d'une cavité (21) qui est configurée pour que sa zone transversale mesurée perpendiculairement à l'axe change pour augmenter du côté extrémité proximale en direction du côté extrémité distale.
PCT/JP2014/068339 2013-09-03 2014-07-09 Fil-guide Ceased WO2015033667A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2015535364A JP6400586B2 (ja) 2013-09-03 2014-07-09 ガイドワイヤ

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013182397 2013-09-03
JP2013-182397 2013-09-03

Publications (1)

Publication Number Publication Date
WO2015033667A1 true WO2015033667A1 (fr) 2015-03-12

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ID=52628155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/068339 Ceased WO2015033667A1 (fr) 2013-09-03 2014-07-09 Fil-guide

Country Status (2)

Country Link
JP (1) JP6400586B2 (fr)
WO (1) WO2015033667A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5465732A (en) * 1992-03-31 1995-11-14 Boston Scientific Corporation Fluoroscopically viewable multifilar calibrated guidewire and method of measuring occlusions with calibrated guidewires
WO1998042268A1 (fr) * 1997-03-27 1998-10-01 Cordis Corporation Fil de guidage a ame en verre compatible avec la resonance magnetique
WO2012176091A1 (fr) * 2011-06-23 2012-12-27 Koninklijke Philips Electronics N.V. Fils-guides à fibres composites

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5465732A (en) * 1992-03-31 1995-11-14 Boston Scientific Corporation Fluoroscopically viewable multifilar calibrated guidewire and method of measuring occlusions with calibrated guidewires
WO1998042268A1 (fr) * 1997-03-27 1998-10-01 Cordis Corporation Fil de guidage a ame en verre compatible avec la resonance magnetique
WO2012176091A1 (fr) * 2011-06-23 2012-12-27 Koninklijke Philips Electronics N.V. Fils-guides à fibres composites

Also Published As

Publication number Publication date
JP6400586B2 (ja) 2018-10-03
JPWO2015033667A1 (ja) 2017-03-02

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