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WO2015032251A1 - Appareil de surveillance par imagerie de la microcirculation et procédé associé - Google Patents

Appareil de surveillance par imagerie de la microcirculation et procédé associé Download PDF

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Publication number
WO2015032251A1
WO2015032251A1 PCT/CN2014/083639 CN2014083639W WO2015032251A1 WO 2015032251 A1 WO2015032251 A1 WO 2015032251A1 CN 2014083639 W CN2014083639 W CN 2014083639W WO 2015032251 A1 WO2015032251 A1 WO 2015032251A1
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WIPO (PCT)
Prior art keywords
imaging
light
microcirculation
incident
polarized light
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PCT/CN2014/083639
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English (en)
Chinese (zh)
Inventor
刘满林
张莉均
滕升
亚历克斯⋅布兰多
罗晓川
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GUANGZHOU MEDSOFT SYSTEM Ltd
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GUANGZHOU MEDSOFT SYSTEM Ltd
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Publication of WO2015032251A1 publication Critical patent/WO2015032251A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy

Definitions

  • the present invention relates to the field of bio-optical imaging technology, and in particular, to a micro-circulation imaging monitoring apparatus and method. Background technique
  • microcirculation refers to the blood circulation between the arterioles and venules. It is the final link that transports oxygen and nutrients to the tissue cells and transports carbon dioxide co 2 and metabolites. It is also the most important link. .
  • the perfusion of microcirculation is very important for cell metabolism. Microcirculatory perfusion disorders will cause severe metabolic disorders, which will cause the failure of various tissues and organs and lead to death. Real-time monitoring of microcirculation conditions, especially how to quickly and easily monitor microcirculatory conditions in critically ill patients, such as early detection of shock (microcirculatory failure) signs, is critical to improving the survival rate of critically ill patients.
  • microcirculation is the main means of microcirculation observation and research.
  • the living microscope requires the injection of a fluorescent dye, it cannot be used clinically.
  • Another method of observing microcirculation is based on laser Doppler microcirculation imaging techniques. This technique uses the frequency shift effect produced by the interaction of laser and red blood cells to achieve microvessel blood flow velocity measurement.
  • Laser Doppler microcirculation imaging has been used to monitor microcirculation in the skin and muscle of patients with sepsis.
  • the limitation of laser Doppler microcirculation imaging technology is that it only measures the average value of all blood vessels in a specific volume of tissue, so it can not reflect the difference of blood flow velocity of different microvessels, that is, the blood flow velocity of each microvessel. The difference between the microcirculation and the microcirculation is an important parameter for judging the state of the microcirculation.
  • microcirculation imaging device based on orthogonal polarization imaging method to achieve non-invasive and real-time monitoring of microcirculation to a certain extent.
  • the current microcirculation imaging devices based on orthogonal polarization imaging still have their limitations, mainly in:
  • the normal light is used to project polarized light onto the skin surface, so that the transmitted depth of polarized light or the observed microvessels The depth is limited and usually only penetrates within 1 mm of the skin, while the microcirculation is deeper below the surface of the skin.
  • the microcirculation imaging device has a fixed field of view and numerical aperture, so that the device has a fixed field of view and image resolution, so even if the electronic amplification process is used, the region of interest cannot be Make a more detailed observation. For example, if a microcirculation anomaly area is found in an image, there is no way to observe the area in more detail, and no more detailed information can be obtained. Summary of the invention
  • the technical problem to be solved by the present invention is to provide a microcirculation imaging monitoring device and method, which can adjust the transmission depth of polarized light in human tissue, and can view the field of view and resolution of the acquired microcirculation according to actual needs.
  • the rate is adjusted in real time to achieve a more detailed view of the specific area of the microcirculation imaging.
  • an embodiment of the present invention provides a microcirculation imaging monitoring apparatus, including: a light source system, a beam splitter, a light guide tube, a mirror, an optical imaging probe, an analyzer, and a zoom optical system; a polarizing light for providing a polarization direction parallel to an incident plane of the skin surface; the beam splitter being disposed in a forward direction of the polarized light for introducing the polarized light into the light guide tube;
  • the light guide tube includes an illumination channel, and the illumination light channel is configured to transmit the polarized light guided by the beam splitter to the mirror;
  • the mirror is disposed at an end of the illumination channel for adjusting an incident angle ⁇ of the polarized light projected onto an incident plane of the skin surface, wherein 0 ⁇ 90° ;
  • the light guide tube further includes an imaging channel, the optical imaging probe is disposed at an end of the imaging channel; the optical imaging probe is configured to collect light that is returned to the skin surface after being scattered by human tissue, and the light is passed through the The imaging channel is transmitted to the analyzer;
  • the polarization direction of the analyzer is perpendicular to the incident plane of the skin surface, and is used for filtering the light collected by the optical imaging probe to obtain a first image of human tissue, and transmitting the filtered light to the Zoom optical system
  • the zoom optical system is configured to adjust an imaging magnification and a numerical aperture in real time, to the first
  • the field of view and image resolution of the image are adjusted to obtain a second image of the body tissue and the second image is acquired.
  • the zoom optical system is composed of three sets of optical lenses: a fixed group, a zoom group, and a compensation group;
  • the zoom group is configured to continuously change the focal length of the zoom optical system by manually or automatically adjusting its position; and continuously change the entrance pupil of the zoom optical system by manually or automatically adjusting the aperture stop size of the zoom group
  • the zoom optical system realizes real-time adjustment of the imaging magnification and the numerical aperture according to the continuous change of the focal length and the entrance pupil diameter to change the field of view and image resolution of the zoom optical system ;
  • the compensation group is used for interlocking with the zoom group to compensate for the image image distance to maintain a clear field of view.
  • the light source system includes a light source, a condensing mirror, and a polarizer; the light source is configured to provide incident light of a wavelength ⁇ , wherein ⁇ >0;
  • the condensing mirror is disposed in a forward direction of the incident light for collimating the incident light into parallel light;
  • the polarizer is disposed in a forward direction of the parallel light emitted by the condensing mirror for converting the parallel light into polarized light having a polarization direction parallel to an incident plane of the skin surface.
  • the incident light ray has a wavelength ⁇ of 550 nm.
  • the invention still further provides a microcirculation imaging monitoring method, comprising:
  • the microcirculation imaging monitoring device activates the light source to emit incident light of wavelength ⁇ , and after collimating the incident light into parallel light, converts the parallel light into polarized light whose polarization direction is parallel to the incident plane of the skin surface, wherein ⁇ >0 ;
  • the microcirculation imaging monitoring device projects the polarized light at an incident angle ⁇ onto an incident plane of the skin surface, wherein 0 ⁇ 90°;
  • the microcirculation imaging monitoring device collects light that is returned to the skin surface after being scattered by human tissue, and Filtering the light to obtain a first image of the human tissue;
  • the microcirculation imaging monitoring device adjusts the field of view and image resolution of the first imaging by adjusting an imaging magnification and a numerical aperture in real time to obtain a second imaging of the human tissue, and the second imaging Imaging is performed.
  • the acquiring the second imaging is performed by performing image capturing and/or video recording on the second imaging.
  • the microcirculation imaging monitoring device further comprises performing photoelectric conversion and image processing on the second imaging to perform analysis and measurement on the human body tissue to obtain human microcirculation information.
  • the invention also provides a microcirculation imaging monitoring method, which has the following beneficial effects: Using the microcirculation imaging monitoring device described above, controlling the incident angle of the polarized light projected onto the incident plane of the skin surface, and transmitting the incident polarized light to the human body The depth of the tissue can be adjusted, and the maximum transmission depth can be obtained when the incident angle is the Brewster angle, and the human body with different depth levels, field of view and resolution can be collected by the zoom optical system in the microcirculation imaging device. Imaging of the tissue. DRAWINGS
  • FIG. 1 is a structural block diagram of an embodiment of a microcirculation imaging monitoring apparatus provided by the present invention
  • FIG. 2 is a schematic structural view of the microcirculation imaging monitoring apparatus provided in FIG.
  • Figure 3 is a schematic diagram of the propagation of polarized light in two isotropic media
  • FIG. 4 is a schematic flow chart of an embodiment of a microcirculation imaging monitoring method provided by the present invention. detailed description
  • the microcirculation imaging monitoring device includes: a light source system 101, a beam splitter 102, a light guide tube 103, a mirror 104, an optical imaging probe 105, an analyzer 106, and a zoom optical system.
  • the basic working principle of the monitoring device is: the light source system 101 emits polarized light having a polarization direction parallel to the incident surface of the skin to the spectroscope 102; after the spectroscope 102 receives the incident polarized light, the incident polarized light passes through the light guide 103 to reach Mirror 104; through the mirror 104, the incident angle of the incident polarized light on the skin surface can be adjusted to change the depth of the polarized light incident on the skin to obtain optical imaging images of different depth levels; the optical imaging probe 105 is used for acquisition The polarized light scattered back from the surface of the skin passes the collected polarized light through the light guide tube 103 and passes through the beam splitter 102 to reach the analyzer 106.
  • the polarization direction of the analyzer 106 is perpendicular to the horizontal surface of the skin surface. Therefore, the polarized light collected by the optical imaging probe 105 can be filtered, and the obtained primary imaging can be projected to the zoom.
  • Optical system 107 for processing is processed by the zoom optical system 107 to light, to obtain a desired imaging microcirculation of human skin.
  • FIG. 2 it is a schematic structural view of the microcirculation imaging monitoring apparatus provided in Fig. 1.
  • the light source system is configured to provide polarized light having a polarization direction parallel to an incident plane of the skin surface.
  • the light source system includes a light source 201, a condensing mirror 202, and a polarizer 203.
  • the light source 201 is for providing incident light of a wavelength ⁇ , where ⁇ > 0.
  • the "light” emitted by the light source 201 may be pulsable light, including but not limited to: pulsed orphaned light or lamp, mercury orphan, or lamp, 13 ⁇ 4 plain light or lamp, tungsten orphan, or laser, laser, Laser diode or Light-Emitting Diode (LED).
  • "Light" can also be classified as coherent light or incoherent light, and thus the light source 201 can be a coherent light source or an incoherent light source.
  • the wavelength ⁇ of the incident light provided by the light source 201 is determined by the absorption spectrum of hemoglobin and deoxyhemoglobin in the microcirculation. In the absorption spectra of hemoglobin and deoxyhemoglobin, 420 nm (nanometer), 550 nm and 800 nm are isoabsorbance peaks of hemoglobin and deoxyhemoglobin.
  • the incident light ray provided by the light source 201 in this embodiment has a wavelength ⁇ of 550 nm. But not limited to 550nm.
  • the condensing mirror 202 is disposed in a forward direction of the incident ray for collimating the incident ray into parallel light.
  • the concentrating mirror 202 acts to converge and collimate the incident light, collimating the incident light into parallel light, thereby causing the incident light from the light source 201 to be coupled into the light guide 205 with higher efficiency.
  • the polarizer 203 is disposed in a forward direction of the parallel light emitted by the condensing mirror 202 for converting the parallel light into polarized light having a polarization direction parallel to an incident plane of the skin surface.
  • the polarizer 203 functions to polarize the incident light into polarized light, and the incident polarized light has a vibration direction parallel to the horizontal surface of the incident skin.
  • the beam splitter 204 is disposed in a forward direction of the polarized light for introducing the polarized light into the light guide tube 205. Specifically, the polarized light emitted from the polarizer 203 is incident into the beam splitter 204.
  • the beam splitter 204 is a mirror with an intermediate aperture. Therefore, there is no reflection or occlusion of the light in the middle of the beam splitter 204, and the light can be freely propagated in the hole in the middle of the beam splitter 204.
  • the beam splitter 204 can also be realized by, but not limited to, a polarization beam splitting prism, a beam splitting prism, a beam splitting film, or the like.
  • the light pipe 205 includes an illumination channel for transmitting polarized light guided by the beam splitter 204 to the mirror.
  • the mirror 206 is disposed at an end of the illumination channel for adjusting an incident angle ⁇ of the polarized light projected onto an incident plane of the skin surface, wherein 0 ⁇ 90°.
  • the reflection angle of the mirror 206 can be flexibly adjusted, and the incident angle ⁇ of the polarized light projected to the horizontal surface of the skin surface can be adjusted within a range of 0° to 90° according to actual needs.
  • the polarized light is incident on the second medium having the refractive index n2 at the incident angle in the first medium having the refractive index nl, and the angle of refraction of the polarized light in the second medium is ⁇ 2 .
  • the microcirculation image of different depths in the human tissue can be obtained by adjusting the incident angle of the incident polarized light.
  • the transmittance (transmittance) ⁇ of light propagating in two isotropic media is in accordance with the following relationship:
  • the first dielectric is an incident medium, such as air
  • the second dielectric is human tissue. Therefore, in the formula (1), 1 ⁇ ⁇ a refractive index of the incident medium, the refractive index [eta] 2 is a human tissue, the incident angle 9 i is the angle of polarized light transmittance from the air to the human skin surface, the polarization angle of refraction 92 The angle of refraction that light transmits into human tissue.
  • the mirror 6 adjusts the incident angle of the polarized light projected onto the skin surface in an angle range of 0° to 90°, wherein when the incident light is incident perpendicularly, that is, the corpse 0, the transmittance ⁇ is 2 ni. / (n 2 + 3 ⁇ 4 ) ;
  • the transmittance ⁇ can reach the theoretical maximum: 1. Therefore, the transmittance of the polarized light in the second medium will also vary with the change of the incident angle ,, so that the light scattered by the human body tissue having different depth levels can be collected by the optical imaging probe 207, and the zoom optical system is obtained.
  • microcirculation images of different depths in human tissues were obtained.
  • n 2 is The refractive index of human tissue.
  • the reflected light and the refracted light are generally partially polarized, and the reflected light is only when the incident angle ⁇ is a certain angle. Linearly polarized light whose direction of vibration is perpendicular to the incident surface.
  • This particular angle is called the Brewster's angle or the yaw angle 9 b .
  • the polarized light is shot at Brewster's angle 9 b A, the reflected light and the refracted light are perpendicular to each other, and there is a relationship:
  • the incident plane of polarized light is not a strict horizontal plane. Therefore, when implemented, microcirculation imaging is used for monitoring.
  • the light pipe 205 also includes an imaging channel, and the optical imaging probe 207 is disposed at an end of the imaging channel.
  • the light pipe 205 has a tubular structure of inner and outer layers, the middle portion is an imaging channel, and the outer portion is an illumination channel.
  • the top view of the light pipe 205 is a ring shape, wherein the inner ring portion is the image forming channel, and the outer ring portion is the illumination channel.
  • the optical imaging probe 207 is configured to collect light that is returned to the skin surface after being scattered by body tissue, and transmits the light to the analyzer 208 via the imaging channel.
  • the beam splitter 204 is implemented by a mirror with an intermediate aperture
  • the light collected by the optical imaging probe 207 passes through the imaging channel and passes through a hole in the middle of the beam splitter 204.
  • the analyzer 208 is reached.
  • the polarization direction of the analyzer 208 is perpendicular to the incident plane of the skin surface, and is used for filtering the light collected by the optical imaging probe 207 to obtain a first imaging of human tissue and transmitting the filtered light.
  • the zoom optical system 209 is configured to adjust a field of view and an image resolution of the first imaging by adjusting an imaging magnification and a numerical aperture in real time to obtain a second imaging of the human tissue, and The second imaging is performed.
  • the zoom optical system 209 is composed of a fixed group, a zoom group, and a compensation group.
  • the zoom group is used to continuously change the focal length of the zoom optical system 209 by manually or automatically adjusting its position; and continuously change the zoom optical system by manually or automatically adjusting the aperture stop size of the zoom group
  • the entrance pupil diameter of 209; the zoom optical system 209 is based on the focal length
  • a continuous change with the diameter of the entrance pupil achieves real-time adjustment of the imaging magnification and the numerical aperture to change the field of view and image resolution of the zoom optical system 209.
  • the compensation group is used for interlocking with the zoom group to compensate for the image image distance to keep the image clear.
  • the resolution capability (i.e., image resolution) ⁇ of the image of the zoom optical system 209 is related to its numerical aperture ⁇ :
  • the image resolution ⁇ of the zoom optical system 209 is determined by its numerical aperture ; and the numerical aperture ⁇ of the zoom optical system 209 is determined by its input diameter D and focal length /:
  • n is the refractive index between the object to be observed and the lens; The angle between the light from the point on the optical axis to the edge of the pupil and the optical axis; D is the diameter of the entrance pupil of the lens; f is the focal length of the lens.
  • the component size of the imaging receiver y' is usually fixed, so the field of view of the microcirculation imaging monitoring device can be changed by adjusting the imaging magnification ⁇ of the zoom optical system 209.
  • the focal length and the imaging magnification of the zoom optical system 209 can be continuously changed within a threshold range by manually or automatically adjusting the positions of the zoom group and the compensation group, thereby implementing the pair of microcirculation imaging monitoring devices provided by the present invention.
  • Real-time adjustment of the field of view and resolution In particular, when searching for a target, a smaller imaging magnification and a larger field of view can be used to facilitate quick search of the target; when the target is found, it is possible to switch to a larger imaging magnification, and the target can be carefully observed.
  • the specific working process is as follows: the polarized light emitted by the light source system parallel to the incident plane of the skin surface,
  • the light mirror 204 introduces the parallel polarized light emitted by the light source system into the illumination channel of the light guide tube 205 and reaches the mirror 206; the user adjusts the position of the mirror 206 to adjust the incident angle of the polarized light transmitted to the incident plane of the skin surface, thereby Light reflected from the surface of the skin is collected by optical imaging probe 207.
  • the light comprises polarized light that retains its initial polarization state only after being reflected through the surface of the skin or only into the shallow layer of the skin and is scattered once or several times, and also includes depolarization after multiple scattering in deep human tissue. polarized light.
  • the optical imaging probe 207 collects the light; the light passes through the imaging tube of the light pipe 205 to the analyzer 208; since the polarization direction of the analyzer 208 is strictly perpendicular to the polarization direction of the polarized light emitted by the light source system, The polarized light of the original polarization state cannot pass through the analyzer 208, that is, after being filtered by the analyzer 208, unpolarized light which is depolarized after being scattered for a plurality of times in deep human tissue is obtained.
  • the micro-circulating image of the deep layer of the human body tissue can be obtained by imaging the unpolarized light by the zoom optical system 209.
  • the field of view and resolution of the microcirculation image can be adjusted in real time by the user using the zoom optical system 209 according to actual needs.
  • the microcirculation imaging monitoring apparatus provided in this embodiment further includes an imaging receiver 210.
  • the imaging receiver 210 is a charge coupled device image sensor, or a complementary metal oxide semiconductor image sensor.
  • the imaging receiver 210 is configured to receive the second imaging and photoelectrically convert the second imaging to obtain a digital image signal.
  • the charge coupled device image sensor is also referred to as a CCD (Charge Coupled Device) image sensor.
  • the CCD is a semiconductor device that converts optical images into digital signals and is divided into two types of Liner CCDs and Area CCDs according to their pixel arrangement.
  • an area array CCD is preferably employed as the acquisition and conversion of the microcirculation optical signal.
  • CMOS Complementary Metal-Oxide-Semiconductor
  • CMOS mainly uses two elements, silicon and germanium, to form a semiconductor with N (negatively charged) and P (positively charged) poles. The current generated by these two complementary effects can be processed and interpreted by the chip. Into an image. Therefore, CMOS can be processed after processing For the image sensor.
  • imaging in the zoom optical system 209 is preferably received using an area array CMOS image sensor.
  • the microcirculation imaging monitoring device further includes a data processor (neither shown in FIG. 1 nor FIG. 2).
  • the data processor is connected to the imaging receiver 210, and configured to receive the second imaged digital image signal obtained by the imaging receiver 210, and perform image processing on the digital image signal to The human tissue is analyzed and measured to obtain microcirculation information of the human body.
  • a series of images are captured by the zoom optical system 209 for multiple depth levels in the same field of view.
  • the imaging receiver 210 After receiving and photoelectrically converting the series of images, the imaging receiver 210 transmits the obtained digital image signals to the data processor. deal with.
  • the microcirculation imaging monitoring device provided by the invention uses orthogonal polarization imaging technology to make the polarization direction of the polarizer of the light source perpendicular to the polarization direction of the analyzer, and is incident on the skin surface through the mirror pair at the end of the light pipe.
  • the incident angle of the plane is adjusted in real time to achieve flexible adjustment of the incident angle of the polarized light
  • the analyzer is used to filter the light scattered by the optical imaging probe collected by the human body tissue, and the human body is filtered by the zoom optical system.
  • the tissue microcirculation is used for imaging. During the imaging process, the field of view and numerical aperture of the zoom optical system can be adjusted in real time according to actual needs to obtain an area image of the desired resolution.
  • the present invention also provides a microcirculation imaging monitoring method.
  • FIG. 4 there is shown a flow diagram of one embodiment of a microcirculation imaging monitoring method provided by the present invention.
  • the microcirculation imaging monitoring device in the above embodiment is used to monitor the microcirculation imaging, and the specific monitoring process includes:
  • the microcirculation imaging monitoring device activates the light source to emit incident light of wavelength ⁇ , and after collimating the incident light into parallel light, converts the parallel light into polarized light whose polarization direction is parallel to the incident plane of the skin surface, wherein ⁇ >0; the microcirculation imaging monitoring device converts the polarized light at an incident angle The plane of incidence that hits the surface of the skin, where 0 ⁇ 90°.
  • the method provided by the present invention can obtain the maximum transmission depth.
  • the refractive index of the human body tissue is different, and the skin surface is rough and has certain concavities and convexities.
  • the incident plane of the polarized light is not a strict horizontal plane.
  • the microcirculation imaging monitoring device collects light that is returned to the surface of the skin after being scattered by human tissue, and filters the light to obtain a first image of the human tissue; the microcirculation imaging monitoring device adjusts the imaging magnification in real time. And a numerical aperture, the field of view and image resolution of the first imaging are adjusted to obtain a second imaging of the body tissue, and the second imaging is acquired.
  • Step S301 The starting light source emits incident light having a wavelength of ⁇ .
  • Step S302 After collimating the incident light into parallel light, converting the parallel light into polarized light whose polarization direction is parallel to the incident plane of the skin surface.
  • Step S303 Projecting the polarized light at an incident angle ⁇ to an incident plane of the skin surface.
  • the incident angle of the incident light is adjusted between 0° and 90° to obtain static and dynamic microcirculation images of a plurality of different depths of human tissue.
  • the incident angle ⁇ is the Brewster's angle e b
  • the transmittance and the transmission depth of the incident polarized light transmitted to the human body at this time are the largest.
  • Step S304 Collecting light that has been scattered back to the skin surface after being scattered by the human tissue, and filtering the light to obtain a first image of the human tissue.
  • the image is collected by the microcirculation imaging monitoring device of the above embodiment, after the light collected by the optical imaging probe 207 passes through the analyzer 208, an imaging surface appears in the forward direction of the light, and the microcirculation imaging monitoring device calls the zoom optical.
  • System 209 acquires and photoelectrically converts these rays to obtain a first image of human tissue.
  • Step S305 Adjusting the field of view and the image resolution of the first imaging by adjusting the imaging magnification and the numerical aperture in real time to obtain a second imaging of the human tissue, and collecting the second imaging.
  • the collecting manner of the second imaging includes: performing the second imaging Image taking and / or video recording.
  • the working principle of adjusting the field of view and image resolution of the first imaging provided by the microcirculation imaging monitoring method provided in the embodiment, and the zooming in the microcirculation imaging monitoring device (shown in FIG. 1) provided by the present invention The working principle of the optical system 209 is the same, and will not be described here.
  • the user can adjust the focal length and magnification of the device in real time, thereby changing the field of view and the magnification of the observation, and achieving the purpose of detailed observation and collection of the image of the region of interest.
  • you can use smaller magnification and larger field of view to find the target quickly.
  • you find the target switch to a larger magnification to achieve a detailed observation of the target.
  • the embodiment further includes:
  • Step S306 The microcirculation imaging monitoring device performs photoelectric conversion and image processing on the second imaging to perform analysis and measurement on the human body tissue to obtain human microcirculation information.
  • the user uses the microcirculation imaging monitoring device to adjust the internal zoom optical system 209 to take a series of images and/or video recordings at multiple depth levels in the same field of view, and use the related image processing technology to acquire the captured image and/or Or video for analysis and processing.
  • the invention also provides a microcirculation imaging monitoring method, which utilizes the microcirculation imaging monitoring device described above to control the incident angle of the polarized light projected onto the incident plane of the skin surface, and the depth of the incident polarized light transmitted to the human tissue can be adjusted.

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Abstract

La présente invention concerne un appareil de surveillance par imagerie de la microcirculation, comprenant : un système source de lumière (101), un spectroscope (102), un tube de guidage de la lumière (103), un miroir réfléchissant (104), une sonde d'imagerie optique (105), un analyseur (106) et un système de zoom optique (107). Le système source de lumière (101) fournit de la lumière polarisée ayant une direction de polarisation parallèle au plan d'incidence de la surface de la peau ; la lumière polarisée atteint le miroir réfléchissant (104) après transmission par le spectroscope (102) et le tube de guidage de lumière (103) ; le miroir réfléchissant (104) ajuste l'angle d'incidence de la lumière polarisée lorsqu'elle est projetée sur le plan d'incidence de la surface de la peau ; la sonde d'imagerie optique (105) collecte la lumière retournant à la surface de la peau après la diffusion à travers le tissu humain et la transmet à l'analyseur (106) ; l'analyseur (106) transfère la lumière au système de zoom optique (107) après la filtration de la lumière pour acquisition par imagerie du tissu humain. L'appareil de surveillance par imagerie de la microcirculation permet que la profondeur de pénétration de la lumière polarisée dans le tissu humain soit ajustable, et le champ de vision et la résolution de l'appareil peuvent être ajustés en temps réel, pour obtenir des observations plus détaillées sur des zones spécifiques pour l'imagerie de la microcirculation. La présente invention concerne en outre un procédé de surveillance par imagerie de la microcirculation.
PCT/CN2014/083639 2013-09-04 2014-08-04 Appareil de surveillance par imagerie de la microcirculation et procédé associé Ceased WO2015032251A1 (fr)

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CN201310395736.9 2013-09-04
CN201310395736.9A CN103445764B (zh) 2013-09-04 2013-09-04 微循环成像监测装置与方法

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107961445A (zh) * 2017-12-20 2018-04-27 深圳乐普智能医疗器械有限公司 经皮黄疸仪
EP3403575A4 (fr) * 2016-01-12 2019-03-13 Feng, Xinghuai Moniteur de micro-circulation susceptible de réaliser un positionnement rapide et répété, système et procédé de surveillance
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CN107961445A (zh) * 2017-12-20 2018-04-27 深圳乐普智能医疗器械有限公司 经皮黄疸仪
CN107961445B (zh) * 2017-12-20 2024-01-26 深圳乐普智能医疗器械有限公司 经皮黄疸仪
CN116847783A (zh) * 2020-12-18 2023-10-03 约翰霍普金斯大学 用于非侵入性血液分析的紧凑型毛细管显微镜
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RU235168U1 (ru) * 2025-04-17 2025-06-23 Федеральное государственное бюджетное учреждение науки Научно-технологический центр уникального приборостроения Российской академии наук (НТЦ УП РАН) Устройство для неинвазивного анализа параметров микроциркуляции произвольных участков кожного покрова

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