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WO2015020367A1 - Système de diagnostic et dispositif de diagnostic utilisant une réponse basée sur la transpiration humaine - Google Patents

Système de diagnostic et dispositif de diagnostic utilisant une réponse basée sur la transpiration humaine Download PDF

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Publication number
WO2015020367A1
WO2015020367A1 PCT/KR2014/007148 KR2014007148W WO2015020367A1 WO 2015020367 A1 WO2015020367 A1 WO 2015020367A1 KR 2014007148 W KR2014007148 W KR 2014007148W WO 2015020367 A1 WO2015020367 A1 WO 2015020367A1
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Prior art keywords
light
examinee
perspiration
human body
sweating
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PCT/KR2014/007148
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English (en)
Korean (ko)
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최용학
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Individual
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Individual
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Priority claimed from KR20130092301A external-priority patent/KR101479415B1/ko
Priority claimed from KR1020140042334A external-priority patent/KR20150117071A/ko
Application filed by Individual filed Critical Individual
Publication of WO2015020367A1 publication Critical patent/WO2015020367A1/fr
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4035—Evaluating the autonomic nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0064—Body surface scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4261—Evaluating exocrine secretion production
    • A61B5/4266—Evaluating exocrine secretion production sweat secretion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4824—Touch or pain perception evaluation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication

Definitions

  • the present invention relates to a diagnosis system and a diagnostic apparatus using a human sweating, more specifically, sweat secreted by a sweating through light irradiation on the skin of a subject without using a coloring reagent chemically reacting to the subject's sweat. Diagnosis of autonomic nervous system, diagnosis of lesions and pain areas of subjects through qualitative and quantitative analysis of system and system for diagnosing sweat perspiration of test subjects by qualitative and quantitative analysis.
  • the present invention relates to a diagnostic apparatus using a human perspiration reaction which can be used without a separate coloring reagent in diagnosing peripheral neuropathy and autonomic neuropathy.
  • the equipment for detecting such abnormalities is a QSART (Quantitative Sudomotor Axon Reflex Test), a skin tissue test using a confocal microscope, and a measuring device to measure nerves. Method, TST, and the like.
  • TST Inconvenient to measure only some nerves or to inject a large amount of drug to the subject for examination.
  • infrared thermography DITI
  • DITI infrared thermography
  • EMG EMG
  • EMG is widely used because of high reproducibility, but only thick coarse nerves can be examined, and the test is inconvenient, expensive, and often unstable in diagnosing autonomic nervous system.
  • the TST method for recognizing the whole body sweat pattern of the entire nerve state in a short time has been widely used.
  • the existing TST method simply installs the device manually in some spaces in the hospital, and it is difficult to popularize because there is a high cost and other inconveniences because it is not systemized.
  • the existing TST device has many advantages, but because it only inspects and diagnoses with a sweating pattern, there are a number of limitations in detecting the amount of sweating for each part other than the pattern and the change of sweating with time. .
  • autonomic dysfunction may be seen in various diseases, and in certain diseases, the autonomic nervous system is selectively invaded to show symptoms, and the anatomical and physiological structures of the autonomic nervous system are very complicated and diverse, and the symptoms may change. Diagnostically difficult to access.
  • the autonomic nervous system can be divided into the sympathetic nervous system and the parasympathetic nervous system, and there are subdivided test methods according to their characteristics, and the autonomic nervous system test can identify damaged components and further determine the treatment method according to the degree of damage and the damaged location. have.
  • Classical heat control test is applied by applying starch powder all over the patient's skin and raising body temperature through warm tea or stove, and then checking the distribution, form and quantity of infinity by the color change of starch. to be.
  • the Gutman Kinizarin Perspiration Test was performed by applying an indicator mixture of kinizarin mixed indicator (Quinizarin 2-6-disulphonic acid, sodium carbonate, and rice starch) to the entire patient's skin. It is a method of measuring the distribution, shape, and quantity of infinity by changing the temperature from red-gray to blue-gray by raising the body temperature using a cabinet.
  • indicator mixture of kinizarin mixed indicator Quinizarin 2-6-disulphonic acid, sodium carbonate, and rice starch
  • the Mayo Clinic presented a heat-controlled sweat test that complements the Gutman Kinizarin sweat test, in which the alizarin red S (Alizarin is proportional to the weight of the skin exposed to the supine position immediately when the patient is not dressed).
  • red S Alizarin is proportional to the weight of the skin exposed to the supine position immediately when the patient is not dressed.
  • red S sodium carbonate and cornstarch mixed indicators are applied to the entire skin and enter the cabinet where the temperature and humidity are maintained to increase the body temperature, and the rate of sweating by heat control on the front surface of the body ( TST%), the distribution, shape, and quantity of infinity.
  • the sweat test by heat control using the medical chamber (TST-100) induces sweating by keeping the user's skin temperature at a constant temperature through a chamber that controls the temperature and humidity after applying reagents to the patient's body. It is a method of acquiring, storing, and inquiring a patient's sweating state in digital form through a camera.
  • thermoregulatory sweat tester TST
  • the coloring reagent 15
  • the sweating reaction Examine the sweating reaction by photographing the deformation pattern according to the chemical reaction of the camera (20).
  • the test subject in the case of the TST using the color developing reagent, the test subject must apply a coloring reagent to the entire subject's skin, and thus the test subject can feel a great sense of rejection. There is a problem.
  • the sweat is secreted according to the perspiration test of the subject during the sweat test, there is a problem that an error occurs in the test by reacting even the coloring reagent of the area where the actual sweat did not occur.
  • the color of the reagent changes, since the change in sweating state is not known thereafter, there is a disadvantage that it is impossible to examine the results of the sweating change over time.
  • a pattern obtained by applying a coloring reagent and sweating is obtained based on (a) the sweating image, and based on the sweating pattern, the condition of the examinee, such as “peripheral neuropathy.
  • (B) Diagnosis of the pattern in which case there is a risk that the coloring reagent in response to sweating may flow or bleed, and diagnosis is made using only a rough pattern in the overall image.
  • additional post-treatment is cumbersome, such as cleaning the coloring reagent on the skin and cleaning the inside of the diagnostic apparatus after sweating.
  • the conventional TST method diagnoses only on the basis of a fixed camera pattern image, the amount of sweating on the side surface or the inclined surface of the body has a problem that it is difficult to accurately capture.
  • the present invention is to solve the problems of the prior art as described above, it is an object of the present invention to provide an sweat diagnosis device that can determine the abnormality of the autonomic nervous system according to the sweating response of the subject through light irradiation to the subject. .
  • test subject feels a great sense of rejection as the reagent is applied to the entire skin of the test subject, and also to solve the problem that the test subject's skin becomes dirty due to the reagent after the test.
  • the perspiration reaction is examined as a deformation pattern according to the chemical reaction of the reagent. Even the reagents in the non-reacted areas are reacted to solve the problem that an error occurs in the test.
  • it is intended to improve the change of sweating over time, for example, a lot of sweating occurs and then decreases and then again to make it possible to examine the results of the sweating changes.
  • the object of the present invention is to measure the sweating reaction caused by the sympathetic nerve reaction under the appropriate stimulus called fever in a comfortable state of the subject, and through the qualitative and quantitative analysis to diagnose the autonomic nervous system, the lesion and pain area of the subject.
  • Diagnosis and functional neurofibers and autonomic neurological disorders to diagnose peripheral neuropathy and autonomic dysplasia to provide a diagnostic device using a human perspiration reaction that can be used without a separate reaction coloring reagent.
  • a diagnostic system using a human sweating response is a system for examining a sweating response of a test subject by heat control, including: temperature control means for inducing a sweating response by raising a body temperature of the testee; Light irradiation means for irradiating light to the skin of the examinee; Light measuring means for collecting the reflected light from the skin of the examinee; And it may include a human diagnostic means for measuring the perspiration response of the subject based on the change in the amount of light or the intensity distribution of the reflected light collected by the light measuring means.
  • the light irradiation means includes a light source unit for generating visible light and irradiating the skin of the examinee
  • the light measuring means includes an optical sensor, a camera, or an optical sensor and a camera for detecting visible light reflected from the skin of the examinee. It includes a light-receiving unit including, can measure the perspiration response of the examinee based on the amount of light to the reflected light of the visible light.
  • the light irradiation means includes a light source unit for generating infrared light and irradiating the skin of the examinee
  • the light measuring means includes an infrared light sensor, an infrared camera, or an infrared ray for detecting infrared light reflected from the skin of the examinee. It includes a light receiving unit including an optical sensor and an infrared camera, it is possible to measure the sweat perspiration of the subject based on the amount of light to the reflected light of the infrared light.
  • the light irradiation means includes a light source unit for generating ultraviolet light and irradiating the skin of the examinee
  • the light measuring means includes an ultraviolet light sensor, an ultraviolet camera, or an ultraviolet ray for sensing the ultraviolet light reflected from the skin of the examinee.
  • It includes a light receiving unit including a light sensor and an ultraviolet camera, it is possible to measure the sweat perspiration of the examinee based on the amount of light to the reflected light or interference light of the infrared light.
  • the light irradiation means and the light measuring means may be integrally formed in one housing.
  • the light irradiation means comprises a plurality of light source units, each light source unit irradiates light to different skin portions of the examinee, and the light measuring means corresponds to the plurality of light source units. It may include a plurality of light receiving portion for collecting the reflected light from the skin.
  • the apparatus further includes a transfer means for transferring the light irradiation means and the light measuring means in a horizontal direction or a vertical direction corresponding to the human body of the examinee, wherein the light irradiation means includes the whole or the skin of the examinee through the transfer means.
  • the light is irradiated while moving a portion, and the light measuring means may collect the reflected light from the skin of the examinee while moving in response to the movement of the light irradiating means.
  • the apparatus further includes rotating means for rotating the light irradiating means and the light measuring means about the human body of the examinee, wherein the light irradiating means rotates around the human body of the examinee to provide light to all or part of the skin of the examinee.
  • the light measuring means may collect the reflected light from the skin of the examinee while rotating in response to the movement of the light irradiation means.
  • the light irradiation means irradiates light to the top, bottom, and side surfaces of the human body of the examinee
  • the light measuring means corresponds to the top, bottom, and side surfaces of the human body of the examinee in response to light irradiation of the light irradiation means.
  • the human body inspection means may measure the three-dimensional sweating state of the human body of the subject.
  • the apparatus further comprises a human body support means for supporting the examinee in a state of lying down on the space, wherein the human body support means includes a transparent material bed, a mesh-shaped mesh bed or a plurality of rods that allow light to pass through at a predetermined interval in parallel. It may include a parallel bar bed spaced apart.
  • the human body support means may be formed of transparent glass or transparent plastic.
  • an antiperspirant diagnostic device that can determine whether the autonomic nervous system abnormality according to the perspiration response of the subject through light irradiation to the subject.
  • the diagnostic apparatus using the human body perspiration reaction it is possible to quickly and accurately diagnose the subject in a comfortable state, such as the daily environment, the display through the diagnosis and character model dummy through the analysis of the characteristics of sweating
  • the lesion, pain area, and pain level of the examinee can be known, so that it is possible to simultaneously pursue convenience and efficiency of the test.
  • TST Thermoregulatory Sweat Tester
  • FIG. 2 is a block diagram of a first embodiment of a diagnostic system using a human body antiperspirant reaction according to an aspect of the present invention
  • Figure 3 shows the principle of measuring the sweating response using light irradiation in the diagnostic system using the human sweating response according to an aspect of the present invention
  • Figure 4 shows an embodiment of a human body support means in a diagnostic system using a human body sweat response according to an aspect of the present invention
  • FIG. 5 is a block diagram of a second embodiment of a diagnostic system using a human body antiperspirant reaction according to an aspect of the present invention.
  • FIG. 6 illustrates an embodiment of a light irradiation means and a light measuring means in a diagnostic system using a human body sweat response according to an aspect of the present invention
  • FIG. 7 is a block diagram of a third embodiment of a diagnostic system using a human sweating response according to an aspect of the present invention.
  • FIG. 8 is a block diagram of a fourth embodiment and a fifth embodiment of a diagnostic system using a human body antiperspirant reaction according to an aspect of the present invention.
  • FIG. 9 is a view for explaining the structure of a diagnostic apparatus using a human body sweat response according to another aspect of the present invention.
  • FIG. 10 is a view for explaining the connection between the components of the diagnostic apparatus using the human body perspiration reaction according to another aspect of the present invention.
  • FIG. 11 is a view for explaining the function of the control unit of the diagnostic device using the human body sweat response according to another aspect of the present invention.
  • FIG. 12 is a flowchart illustrating an operation process of a diagnostic apparatus using a human body sweat response according to another aspect of the present invention.
  • FIG. 13 is a view illustrating an optical system and a driving device such as a camera of a diagnostic device using a human body antiperspirant reaction according to another aspect of the present invention.
  • FIG. 14 is a view for explaining an example displayed on the display unit of the diagnostic device using the body perspiration reaction according to another aspect of the present invention.
  • 15 is a diagram illustrating an example of a sweating image and pattern diagnosis of a conventional TST method.
  • Diagnosis system using the human perspiration reaction a system for examining the perspiration response of the subject by heat control, temperature control means for inducing a perspiration reaction by raising the body temperature of the subject; Light irradiation means for irradiating light to the skin of the examinee; Light measuring means for collecting the reflected light from the skin of the examinee; And it may include a human diagnostic means for measuring the perspiration response of the subject based on the change in the amount of light or the intensity distribution of the reflected light collected by the light measuring means.
  • a method for inspecting the sweating response of the subject according to the reflected light by performing light irradiation on the subject without using a color reagent.
  • Figure 2 shows a block diagram of a first embodiment of a diagnostic system using a human perspiration reaction according to the present invention.
  • perspiration reaction means 200 perspiration reaction means 200, temperature control means 300, human body monitoring means 400, human body support means 500, human diagnostic means (not shown), etc. It may be configured to include.
  • the main characteristic sweat perspiration test means 200 of the present invention may include a light irradiation means 210 and a light measuring means 230, the light irradiation means 210 to the skin of the examinee 10
  • the light 211 is irradiated
  • the light measuring means 230 collects the reflected light 231 which is irradiated onto the skin of the examinee 10 and reflected from the skin.
  • the human diagnosis means (not shown) may measure the sweating response of the examinee 10 based on the collected reflected light 231.
  • the human diagnostic means may include a device such as a PC for analyzing the sweat glands of the examinee 10 according to the characteristics of the reflected light collected by the reflected light 231.
  • the perspiration response is measured by using the difference between the light reflection characteristics of the sweat and non- sweaty skin and the light reflection characteristics of the sweat in the sweaty skin, that is, the irradiated skin is not irradiated and reflected.
  • the difference in light quantity, light intensity, etc. is generated due to the characteristics of interference, refraction, scattering, absorption, reflection, etc. Will be examined.
  • any one of visible light, infrared light, and ultraviolet light may be selectively used as irradiated light to the examinee, and for this, the light irradiating means 210 generates visible light and irradiates the skin of the examinee 10 to the light.
  • An infrared light source unit generating infrared light to irradiate the skin of the test subject 10 or an ultraviolet light source unit generating ultraviolet light and irradiating the skin of the test subject 10, and the light measuring means 230
  • the type of light of the light irradiation means 210 may include a light sensor or camera for visible light, or an IR light sensor or IR camera for infrared light, or a light receiving unit having a UV light sensor or UV camera for ultraviolet light. have.
  • the amount of reflected light or the intensity of light may vary slightly depending on the type of light. As shown in FIG. 3A, the reflected light is collected at a uniform amount of light or light intensity A2.
  • the amount of light or the intensity of the reflected light is changed and collected due to characteristics such as interference of light, refraction, absorption, and reflection on sweat, for example, in FIG.
  • the reflected light reflected by the sweat is more light or intensity (A3) than the reflected light to the non-sweated skin. Can be collected.
  • the reflected light is not secreted due to the characteristic that the infrared light is absorbed by the sweat. It can be collected with less light or light intensity A4 than reflected light to the skin.
  • the ultraviolet light when the ultraviolet light is irradiated to the skin of a subject whose sweat is secreted at a predetermined light intensity or light intensity (A1) in FIG. 3 (d), the ultraviolet light is reflected by sweat in contrast to the skin where the sweat is not secreted. It is more likely to occur and can be collected with more light or intensity (A5) than reflected light for non-sweatened skin, and interference can occur, resulting in more irregular light or light than reflected light for non-sweated skin. Can be collected at an intensity A5.
  • the measurement of the sweating response of the subject by using the point that the optical properties of the sweat and the light properties for the non-secreted skin is different.
  • the light irradiation means 210 irradiates the examinee 10 with at least two different types of light among visible light, infrared light, and ultraviolet light, and the light measuring means 230 emits two or more different kinds of reflected light reflected.
  • the results may be combined to measure the perspiration response.
  • the temperature control means 300 raises the body temperature of the subject 10 to induce a sweating reaction.
  • the temperature adjusting means 300 is provided with a heating wire to increase the temperature in the space where the subject 10 is located.
  • the body temperature of (10) can be raised.
  • the human body monitoring means 400 may optionally include various sensors such as a body temperature sensor, a heart rate monitor, a blood pressure monitor, and the like to be sensed by the human body detecting means 400.
  • the physical state information of 10 may be used as basic information for controlling the degree of increase in body temperature of the examinee 10 in the temperature control means 300, or further, based on the past test record for the specific examinee 10 It may be provided as information for checking the physical condition of the) or temperature control.
  • the human body support means 500 supports the examinee 10 in a lying state on the space, where the human body support means 500 may be formed of various kinds of stable materials capable of supporting the examinee 10, It is more preferable that it is formed of a material which can transmit light.
  • the examinee 10 is lightly lying down toward the front to examine the sweating reaction by only irradiating the upper surface of the examinee 10, and then examines the examinee (although it is possible to perform the perspiration test on the entire subject 10 as a two-time inspection process by examining only the rear surface of the light 10 to examine the perspiration reaction, it is more preferable to look through the following examples.
  • the human body support means 500 is made of a material that can transmit light. It is preferably formed.
  • the human body support means 500 may be formed of a material such as transparent glass or plastic, and furthermore, may be formed in a structure in which light irradiation to the skin of the examinee 10 is not hindered.
  • An embodiment of a human body supporting means in a diagnostic system using the human body antiperspirant reaction according to the present invention is shown.
  • FIG. 4A illustrates a case where the human body support means is a transparent material bed 500a through which light is transmitted, and a bed is formed of glass, transparent plastic, or the like.
  • the bed 500b is formed of a mesh 510b in the form of a mesh on the frame 550b so as not to disturb the light irradiation as much as possible is shown.
  • a plurality of rods 510c are spaced apart at a predetermined interval in parallel to form a bed 500c on the frame 550c so that light irradiation to the skin of the examinee is not disturbed as much as possible. Illustrated.
  • the mesh 510b shown in FIG. 4B and the rod 510c shown in FIG. 4C may be formed of transparent glass or plastic. It may be.
  • FIG. 5 uses the antiperspirant reaction according to the present invention.
  • a schematic diagram of a second embodiment of a diagnostic system is shown.
  • the upper and lower surfaces of the examinee 10 may be irradiated at once to inspect the sweating response to the entire human body of the examinee 10.
  • a human body support means (500b) to support the image is applied to the mesh bed of the mesh type shown in Figure 4 (b).
  • perspiration test means 200b1 and 200b2 are disposed on the upper surface of the examinee 10 to check the sweating response to the upper surface of the examinee 10, and sweat perspiration test means 200c1 and below the lower surface of the examinee 10, respectively. 200c2) was placed.
  • the light irradiation unit 210 and the light measuring unit 230 of the sweating test means 200 are separately configured, but the sweating reaction in the second embodiment of FIG. 5.
  • the inspection means (200b1, 200b2, 200c1, 200c2) is formed integrally on the light irradiation means and the light measuring means on one housing, the diagnostic system using the human body sweat response according to the present invention shown in Figure 6
  • the light irradiation means and the light measuring means by applying the form of the light irradiation means 210a and the light measuring means 230a integrally in one housing 240a as a sweat perspiration test means (200a)
  • the light irradiation means and the light measuring means can be arranged in a narrower space, and the light receiving angle of the reflected light of the light measuring means according to the light irradiation of the light irradiation means does not need to be separately made.
  • a plurality of perspiration reaction inspection means for each zone is configured to divide the human body of the examinee 10 into zones and to collect reflected light by irradiating light in each zone for more accurate perspiration reaction inspection ( 200b1, 200b2, 200c1, 200c2) were disposed.
  • the anti-perspirant test means 200b1, 200b2, 200c1, and 200c2 radiate different types of light to the same skin part of the examinee 10 and collect a plurality of reflected light to collect the reflected light. You can also increase the accuracy.
  • the temperature control means (300a) to induce a sweating response to the upper surface of the subject 10 induces an sweating response to the lower surface of the examinee (10)
  • the sweat test on the upper surface of the test subject 10 and the sweat test on the lower surface of the test subject 10 are not performed separately.
  • the reaction test can be performed.
  • FIG. 7 illustrates a third embodiment of a diagnosis system using the antiperspirant reaction according to the present invention. The schematic diagram is shown.
  • a transfer means for transferring the sweating test means 200d and 200e including light irradiation means and light measuring means in a horizontal direction is formed, and the transfer means is a human body of the examinee 10.
  • Perspiration reaction including a transfer motor (not shown) for moving the horizontal transfer rails 250d and 250e and the anti-perspiration reaction means 200d and 200e formed in the horizontal direction in parallel to the horizontal transfer rails 250d and 250e.
  • the inspection means 200d and 200e may irradiate light along the human body of the examinee 10 in the horizontal direction and collect the reflected light correspondingly.
  • the diagnostic system using the human body sweating reaction may examine the sweating reaction in three dimensions by irradiating light on the upper, lower, and side surfaces of the subject's human body.
  • the diagnostic system using the reaction may further include a vertical conveying means as well as a horizontal conveying means shown in the third embodiment of FIG.
  • sweat perspiration test means 200f, 200g including light irradiation means and light measuring means May be provided with a vertical conveying means for conveying in the vertical direction from the side of the subject 10
  • the vertical conveying means is a vertical conveying rail (250f, 250g) formed in a vertical direction with the human body of the subject 10
  • a transfer motor not shown for moving the sweating test means (200f, 200g) on the vertical transfer rails (250f, 250g), the sweating test means (200f, 200g) of the subject 10 in the vertical direction
  • the light may be irradiated along the human body, and the reflected light may be collected correspondingly.
  • the perspiration test means may be able to more accurately test the perspiration test of the subject by maintaining a constant distance from the human body of the subject, the perspiration reaction according to the present invention shown in Figure 8 (b)
  • the antiperspiration reaction means 200h1 and 200h2 including light irradiation means and light measuring means are rotated about the human body of the examinee 10 to irradiate light and reflect light.
  • the sweat transfer test means 200h1 and 200h2 are transported on the circular transfer rail 250h and the transfer rail 250h formed at the same separation distance around the human body of the examinee 10.
  • an antiperspirant diagnostic device that can determine the abnormality of the autonomic nervous system according to the perspiration response of the examinee through light irradiation to the examinee, in particular using a color reagent It is possible to test for sweating reaction through light irradiation of the examinee's skin, which solves the problem that the examinee feels great rejection as the reagent is applied to the whole skin of the examinee and the subject's skin becomes dirty after the test. The problem of becoming unclean can be solved.
  • the diagnosis of the subject can be performed quickly and accurately in a comfortable state such as a daily environment, and the subject's lesion through the display method displayed on the dummy and the dummy by analyzing the characteristics of sweating.
  • the present invention provides a method for pursuing convenience and efficiency at the same time by providing detailed information on pain, pain area, and pain level.
  • FIG. 9 is a view for explaining the structure of the diagnostic device using the human body sweating according to another aspect of the present invention
  • (a) is a front view
  • (b) is a side view
  • Figure 10 is a component of the diagnostic device using the human sweating response It is a figure explaining the connection between.
  • the chamber 40 is a fastening part for fastening the transparent window 42 and the transparent window 42 which are rotatably attached to the ring 41 formed at the top of the chamber 40 so that the examinee can easily enter and exit the chamber 40. 43), and may further include a chamber support (30) for supporting the chamber (40).
  • a chamber capsule or box
  • Such a chamber is composed of a hook portion and a fastening portion is preferably configured to be easily constructed and to ensure the safety of the examinee entrance and exit. Moreover, it is good also as a conventional sliding structure.
  • the chamber may include a camera, lighting, an optical system, a driving unit, and the like, and the diagnoser visually checks the state of the diagnosis apparatus by configuring the entire chamber as a transparent window or a translucent window as well as the transparent window 42. You can make it possible.
  • the chamber may be made of a whole heat insulating structure.
  • the chamber 40 may further include a human body supporting means 500, which may support the examinee in a state in which the examinee is in a lying state.
  • Temperature control means 300 may be the same as that used in the diagnostic system using the human body perspiration reaction according to an aspect of the present invention, is provided in the chamber 40 to increase the body temperature of the subject to induce a perspiration response will be.
  • the temperature control means 300 may be composed of a plurality of heat generating means, typically a hot air generating device such as a coil-type heater, hot water pipes of the concept of hot water boiler, infrared, near infrared or far-infrared light emitting device and PTC in addition to the above-described heating wire Etc.
  • the antiperspirant test means 200 is provided in the chamber 40 to measure the exothermic and perspiration reactions of the subject to detect the exothermic and perspiration conditions in two or three dimensions.
  • the human body monitoring means 400 includes the chamber 40. It is provided inside to detect the physical condition of the subject in real time. These configurations can be used as the same as those used in the diagnostic system using the human body sweat response according to an aspect of the present invention described above.
  • the perspiration test means 200 is connected to the driving device to detect the heating state as well as the heat state of the examinee in two dimensions and three dimensions can be adjusted in position and angle.
  • the value (data) detected by the sweat perspiration test means 200 is transmitted to the software 700 to analyze the data to diagnose the lesion, pain area and pain degree of the subject.
  • the chamber internal state sensor 600 is a component provided in the chamber 40 to measure the state of the inside of the chamber.
  • the wind direction sensor 600a senses and outputs the air volume and the wind speed in the chamber to the controller 900; It may include a humidity sensor (600b) for sensing the humidity in the chamber and outputs to the control unit 900 and a temperature sensor (600c) for sensing the temperature in the chamber and outputs to the control unit 900, and the other inside the chamber If there is an object may be further provided with a sensor for detecting it.
  • the temperature sensor 600a may measure the center temperature and the surface (skin) temperature of the examinee and the temperature inside the chamber.
  • a temperature sensor is installed in each chamber of the human body and a chamber temperature sensor capable of measuring the temperature inside the chamber (Fig. 10, Ta) and the central temperature of the human body (Fig. 10, Tc) and the skin temperature for each part (Fig. 10, It may include a human body temperature sensor that can measure Ts).
  • the human body temperature sensor is attached to the forehead, armpits, mouth and ears to detect the central temperature of the human body (Fig. 10, Tc) and attached to the leg, torso and face, respectively, the skin temperature of each part (Fig. 10, Ts) It may be made of a skin temperature sensor to detect.
  • the central temperature sensor and the skin temperature sensor may be electronic thermometers or infrared thermometers, and the center temperature and surface temperature of the human body may be measured by contact or noncontact with the forehead, armpits, mouth, ears, legs and torso.
  • the humidity sensor 600b detects humidity in the chamber
  • the wind direction sensor 600c detects air volume and wind speed of the wind in the chamber.
  • infrared cameras, temperature distribution cameras, etc. monitor the air condition of the chamber and the condition of the examinee, and can control the optimal internal chamber conditions.
  • it has a plurality of cameras and illumination, optical system and a driving unit for moving the position / angle of the camera to enable two-dimensional and three-dimensional measurement of the sweating state, it is possible to secure the data to determine the sweating state.
  • the values measured by these sensors are transmitted to the software 700 and control the air in the diagnostic device such as temperature, humidity and wind through each control unit.
  • the chamber internal condition adjusting unit 610 is a component for adjusting the state of the inside of the chamber measured by the chamber internal condition sensor unit 600, and the humidity control unit 610b for controlling the humidity in the chamber and the air volume of the wind in the chamber. It may include a wind controller 610a for adjusting the wind speed and the temperature controller 610c for controlling the temperature in the chamber, and controls to adjust the state of the inside of the chamber measured by the sensor for sensing other necessary conditions It may be further provided.
  • the temperature control unit 600a may use the same or similar device as the above-described temperature control unit 300.
  • the humidity controller 600b may use various types of humidity controllers, for example, a filter-type air purifying humidifier, an ultrasonic humidifier, a heated humidifier, a dehumidifier, and the like using a capillary phenomenon.
  • the wind control unit 600c may use an air conditioner for controlling the air volume and the wind speed in the chamber.
  • the software 700 is a component for diagnosing the lesion, pain area, and pain degree of the examinee by analyzing data measured from the sweating test means 200. That is, the software 700 that can be stored in the computer performs a function of storing and analyzing information received from the chamber in real time in a computer through an interface such as RS-232C and USB, and controlling a camera mounted in the chamber. By taking a picture of the subject at a predetermined time interval and storing it in the database, the sweat pattern of the subject can be analyzed through image processing.
  • the software obtains the sweating state of the 3D surface shape and corrects it with the expression of sweating degree for the 2D area and expresses it as the sweating state value per unit area, constructs a database of sweating state, and stores the data stored therein.
  • the location of sweating, the amount of sweating, and the distribution of sweating are displayed on the dummy of the 3D or 3D human body, and the data of the subject's heat generation temperature, time, input heating temperature, etc. are secured for a plurality of times to identify the subject's heat generation and sweating characteristics.
  • the sweating and fever characteristics which have been identified will enable a personalized measurement for each subject on the basis of retesting later.
  • comparative data according to the degree of healing of the examinee can be obtained.
  • the display 800 is a component that displays the results diagnosed by the software 700 in two or three dimensions using a human body model.
  • control unit 900 is an antiperspirant test means 200, a human body monitoring means 400, the chamber interior It is a component that controls the state control unit 610, software 700 and the display unit 800, and can further control wired and wireless communication means (not shown) that can transmit and receive data between these components Of course.
  • the diagnostic apparatus using the human body perspiration reaction further includes a database unit having the past perspiration response data of the examinee, the control unit 900 using the data if the past perspiration response data is present
  • the temperature adjusting means 300 may be controlled to minimize the measurement time.
  • control unit 900 divides the entire heating area of the examinee into a plurality of small area modules, measures a temperature distribution by mounting a plurality of sensors and cameras at the bottom of each module, and then prevents the local skin surface temperature from rising above a set value. It can be controlled to enable safe diagnosis.
  • FIG. 12 is a flowchart illustrating the operation of the diagnosis apparatus using the human body sweat response according to another aspect of the present invention.
  • the switch when the switch is turned on with the start, it asks whether the examination is to be started, and if the examination is started, the information of the examinee is input.
  • the information of the examinee may be any information that can identify the examinee, such as the resident registration number of the examinee or the control number of the examinee provided when the inspection is requested.
  • the control unit will check the past sweating data.
  • the temperature, humidity and wind in the chamber are adjusted accordingly, and the body temperature of the subject is raised by using a temperature control means to induce a perspiration reaction.
  • the controller may have an advantage of rapidly heating the first sweating characteristic of the examinee and rapidly controlling temperature, humidity, and wind in the chamber.
  • the condition of the chamber is set in advance, and the detection signals of the wind direction sensor, humidity sensor, and temperature sensor are provided and compared with the preset wind, humidity, and temperature data.
  • the control unit increases the human skin temperature and the center temperature to a predetermined temperature so as to increase the body temperature of the subject through the temperature control means to induce a sweating response.
  • the controller collects the skin temperature (FIG. 10, Ts) and the center temperature (FIG. 10, Tc) data of the examinee output from the skin temperature sensor and the central temperature sensor, and periodically reports the temperature data to a computer.
  • the computer collects data on the internal environment, such as the internal temperature of the chamber (FIG. 10, Ta) transmitted from the controller in real time, the skin temperature and the center temperature of the patient, and stores the data in a database, and controls the camera at a set time interval.
  • the upper and lower body sweat patterns are transmitted from the camera and stored in the database.
  • the computer receives the center temperature data transmitted from the control unit to determine whether the center temperature has risen to the set temperature, and when the temperature reaches a preset temperature, for example, 38 to 38.4 ° C., the computer sends a check end command to the control unit.
  • the image of the collected test subject is image-processed and the pattern is quantified and stored in a database.
  • control unit may stop the operation of the temperature control unit, the temperature control unit, the humidity control unit, the wind control unit and other sensors and the camera according to the end of the examination of the computer.
  • FIG. 13 illustrates an optical system such as a camera of a diagnostic apparatus using a perspiration reaction according to another aspect of the present invention, and a driving device to project a moire lattice onto an examinee to detect the change through interference or comparison with a reference lattice pattern.
  • This is an example of an optical system for measuring the degree of sweating in three dimensions, it shows a measuring camera having a drive unit for controlling the position and angle of a portion of the camera for accurate measurement.
  • Diagnosis device using the human perspiration reaction basically secures the data of the sweating state through a plurality of measuring cameras, using a three-dimensional image and a two-dimensional image parallel to the skin surface as the base image of the database.
  • the image of the sweat pattern obtained by applying the coloring reagent it is possible to obtain an image of a surface parallel to the surface of the skin through the drive control of the position and angle of the multiple cameras in the case of the side surface or the inclined surface.
  • the three-dimensional image is obtained by controlling the positions and angles of the plurality of cameras.
  • the three-dimensional image using stereo vision, the three-dimensional measurement image of sweating state through the moiré interference pattern or the interference pattern at the sweat position, and applying the reagent and measuring the sweating pattern It is possible to secure a variety of images suitable for diagnosis, such as stereoscopic images that obtain images or optical three-dimensional height data.
  • the 3D image can be extracted based on the obtained image, and the sweating state of the 2D surface area with respect to the 3D surface shape can be extracted and softwareized.
  • FIG. 14 is a view for explaining an example displayed on a display unit of a diagnostic apparatus using a human sweating response according to another aspect of the present invention.
  • the software 700 obtains perspiration characteristic values, such as perspiration position, perspiration amount, and perspiration distribution, for a three-dimensional surface shape, and then corrects them with an average perspiration characteristic value for a two-dimensional exposed surface area, followed by perspiration position, perspiration amount.
  • perspiration characteristic values such as perspiration distribution on the display unit 800 in which a dummy of two-dimensional or three-dimensional human models is represented. That is, the sweating characteristic may be expressed on the display unit by using a point, color, and / or shape such as the position, quantity, and distribution (pattern) on the 2D or 3D human body model.
  • the sweating characteristic may further comprise a sweating time.
  • the dummy dummy represented in the display unit may be rotated and enlarged or clicked or touched by a click or touch for each part of the display unit or provide detailed sweating information of the corresponding part. That is, when a user clicks or touches a specific position of the dummy dummy represented in the display unit, the image of the specific position can be rotated or enlarged and detailed sweating information of the corresponding position can be displayed.
  • the present invention is composed of a heating means, a sensor, a measuring instrument, an analysis computer, etc., it is possible to systemize, remote communication through communication, etc., it is possible to constitute a relatively inexpensive and convenient device have.
  • systemic techniques for detecting fever and sweating conditions such as sweating amount, sweating time, initial sweating characteristics and temporal change characteristics of sweating, and changes according to temperature and humidity can be used to simplify lesions, pain areas, and pain levels of subjects.
  • the present invention can proceed the test for the sweating reaction by irradiating the skin of the examinee without using a coloring reagent, solve the problem that the subject feels a great sense of rejection by applying the reagent to the entire skin of the subject and after the test Diagnosis system using the human perspiration reaction to solve the problem that the subject's body becomes dirty with reagents, and can quickly and accurately diagnose the subject in a comfortable condition such as a daily environment, and diagnosis through the characterization of sweating and the human body
  • the display method displayed on the dummy can identify the subject's lesion, pain area, and pain level, which can be usefully used in industries such as diagnostic devices using human perspiration, which can simultaneously pursue convenience and efficiency.

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Abstract

L'invention concerne un système de diagnostic utilisant une réponse basée sur la transpiration humaine, qui permet d'améliorer un test relatif à une réponse basée sur la transpiration humaine par exposition de la peau d'une personne testée à la lumière sans utiliser d'agent de développement de couleur, ce qui permet de résoudre le problème selon lequel la personne testée ressent une résistance à l'application du réactif sur la totalité de la peau, et selon lequel le corps de la personne testée est sali et taché par le réactif. L'invention concerne également un dispositif de diagnostic utilisant une réponse basée sur la transpiration humaine, qui permet de diagnostiquer rapidement et précisément une personne testée à l'état détendu, tel que dans un environnement quotidien, et reconnait des lésions, des zones de douleur et les degrés de douleur de la personne testée par l'intermédiaire d'un diagnostic par analyse des caractéristiques de la transpiration et par l'intermédiaire d'un mode d'affichage dans lequel l'affichage est réalisé sur un mannequin de corps humain, ce qui permet d'améliorer à la fois la commodité et l'efficacité du test.
PCT/KR2014/007148 2013-08-04 2014-08-01 Système de diagnostic et dispositif de diagnostic utilisant une réponse basée sur la transpiration humaine Ceased WO2015020367A1 (fr)

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KR20130092301A KR101479415B1 (ko) 2013-08-04 2013-08-04 피부 발한 반응을 이용한 신경 진단시스템
KR10-2013-0092301 2013-08-04
KR1020140042334A KR20150117071A (ko) 2014-04-09 2014-04-09 인체 발한 반응을 이용한 진단 시스템
KR10-2014-0042334 2014-04-09

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US11123011B1 (en) 2020-03-23 2021-09-21 Nix, Inc. Wearable systems, devices, and methods for measurement and analysis of body fluids

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KR100588306B1 (ko) * 2005-04-08 2006-06-09 (주) 엑스메드론 열조절에 의한 발한 검사기
KR20090020347A (ko) * 2007-08-23 2009-02-26 (주)메쉬 적외선 체열 검출 및 분석 방법
KR101088970B1 (ko) * 2003-02-26 2011-12-01 마시오 마크 아우렐리오 마틴스 애브리우 생물학적 파라미터 측정 장치 및 방법
JP2013132363A (ja) * 2011-12-26 2013-07-08 Toshiba Corp 医用画像診断装置及び診療支援方法

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Publication number Priority date Publication date Assignee Title
KR101088970B1 (ko) * 2003-02-26 2011-12-01 마시오 마크 아우렐리오 마틴스 애브리우 생물학적 파라미터 측정 장치 및 방법
KR100588306B1 (ko) * 2005-04-08 2006-06-09 (주) 엑스메드론 열조절에 의한 발한 검사기
KR20090020347A (ko) * 2007-08-23 2009-02-26 (주)메쉬 적외선 체열 검출 및 분석 방법
JP2013132363A (ja) * 2011-12-26 2013-07-08 Toshiba Corp 医用画像診断装置及び診療支援方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123011B1 (en) 2020-03-23 2021-09-21 Nix, Inc. Wearable systems, devices, and methods for measurement and analysis of body fluids

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