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WO2015015021A1 - Composition antiallergénique et désinfectante - Google Patents

Composition antiallergénique et désinfectante Download PDF

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Publication number
WO2015015021A1
WO2015015021A1 PCT/ES2014/000129 ES2014000129W WO2015015021A1 WO 2015015021 A1 WO2015015021 A1 WO 2015015021A1 ES 2014000129 W ES2014000129 W ES 2014000129W WO 2015015021 A1 WO2015015021 A1 WO 2015015021A1
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WO
WIPO (PCT)
Prior art keywords
composition
disinfectant
antialergenic
allergens
approximately
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2014/000129
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English (en)
Spanish (es)
Inventor
Ignacio FERNÁNDEZ MARTORELL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Superquimica SA
Original Assignee
Superquimica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Superquimica SA filed Critical Superquimica SA
Publication of WO2015015021A1 publication Critical patent/WO2015015021A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C11D1/62—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
    • C11D3/3776—Heterocyclic compounds, e.g. lactam
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention develops a composition for domestic use, disinfectant and anti-allergen, which can be used on both hard and soft surfaces, fabrics, carpets, etc., with which improved results are obtained both in its disinfectant efficacy and in the combat of most common household allergens.
  • An allergen is an environmental substance capable of generating an allergic reaction in some individuals.
  • the most common allergens correspond to peptide sequences derived from pollen, desquamation of animals, and dust mites, etc.
  • the allergic response occurs with the generation by the immune system of specific antibodies against the allergen causing a rapid and exacerbated response to future exposures to the allergen.
  • the reduction of the allergic response is usually achieved by limiting exposure to the allergen.
  • One way to reduce this exposure is to interfere with the interaction between the allergenic molecules and their specific antibodies by attacking / preventing affinity / recognition between them.
  • the degree of this interference is measured by a decrease in antigen-antibody recognition in an ELISA assay.
  • many microorganisms coexist with us, as is the case with mites that feed mainly on human and animal skin.
  • the most common dust mites are Dermatophagoides farinae, Dermatophagoid.es pteronssinus and Euroglyphus maynei. They measure approximately 0.3 mm and live approximately four and a half months, of which about 25 days are used in the stages of egg, larva or nymph. They are sexed animals in which an adult female can lay 20 to 50 eggs and make one or two layouts in her life. Each day these mites produce about 20 stools.
  • these mites have suction cups that allow them to hang from textile fibers, so they can not only populate surfaces and corners of the domestic environment, but also inhabit carpets, curtains, etc., and preferably pillows and mattresses , being favored by body heat and humidity.
  • US2002 / 0150540 is an allergen neutralizing composition containing ions of aluminum and at least 60% of this aluminum ion is provided by a salt of an anion from the group of sulfates, chloride, nitrite, potassium sulfate or others.
  • An anti-allergenic efficacy of at least 60% is claimed according to an ELISA test performed.
  • the invention provides, for example, the addition of reinforcement disinfectants, including the group of quaternary ammoniums, the inclusion of film-forming polymers, humectants, etc.
  • US2009 / 0175958 develops a liquid hypohalous acid composition for allergen deactivation and disinfection.
  • the invention contemplates among many other optional ingredients the inclusion as a quaternary ammonium booster disinfectant. It uses hypochlorite in its essential formulation, which is an oxidizing agent. Its disinfectant power has the counterpart that attacks the tissues.
  • US2011 / 0232683 develops methods and composition for eliminating allergens, said composition consisting of a surfactant, a protein denaturant and dense phase carbon dioxide, with a pressure of 400 to 1070 pounds per square inch. It contemplates the use of quaternary ammoniums as an aid in the inactivation of allergenic proteins.
  • US6428801 develops a method and a composition for controlling mites and their allergens, in which the composition is mainly formed by alcohol as a disinfectant, water, benzyl benzoate as acaricide and a film-forming polymer, together with propellant to be dispensed as aerosol.
  • This document contemplates the possibility of using one or more antimicrobial reinforcing agents and among them a quaternary ammonium.
  • the sensitivity of allergic populations may vary and a person may be affected by relatively low concentrations of allergens.
  • the allergic sensitivity of, for example, a child can be triggered with allergen concentrations of only 50 ng / g (allergen / dust). 2 g / g are enough to reach the level of sensitivity in an adult, 10 g / g can activate asthma symptoms. Therefore, insufficient neutralization of surface allergens may represent the uselessness of the product for this purpose. To get an idea of this problem linked to the effectiveness of the product, it is enough to consider that if there are 10,000 mites per gram of dust in a heavily infested room and they produce 20 bowel movements daily, in just 5 days you get a number of allergens per gram of dust.
  • a population of mites is hardly 100% exterminated.
  • the surviving population can recover and even increase their population levels in several biological cycles, each of about 4 months, so that the production of allergens can be important again in a relatively short period, and the bodies of the bodies must also be added. Eliminated mites that also incorporate allergens.
  • an anti-allergenic composition can contribute to the improvement of the allergic response in sensitive populations by decreasing the level of allergens in the environment. Consequently, not only is an effective product convenient after its application, but it is essential that it maintain a residual allergenic effect on the treated surface, and this without affecting its touch, color or smell.
  • the present invention has as its main object a composition with better anti-allergen effects than the prior art, for example in terms of the time to achieve the desired effect, after 15 min after its application.
  • Another objective of the present invention is a composition that in addition to its allergenic effect includes biocidal properties and contributes to the disinfection of surfaces and materials where it is applied.
  • the aforementioned product has odor qualities that do not hinder its application in the domestic environment. Also that by its very nature does not discolor or tarnish fabrics or fibers so that it can be applied on both woven and nonwoven textile material.
  • the present invention develops an allergenic composition, of the type used to combat allergens derived from mites, of the type of house mites or dust such as D. farinae, D. minoceras or D. Euroglyphurs whose defecations produce allergenic material, also of the allergens of pollen grains and those produced by the saliva and secretions of domestic animals such as cats, that is to say of the main allergens present in our homes, in which in an aqueous solution a cationic surfactant has been combined within the group of the quaternary ammoniums and a film-forming polymer, which not only adds their respective qualities but also allows them to be enhanced with their combined effect.
  • Didecyl Dimethyl Ammonium Chloride is used as cationic surfactant.
  • Vinyl Caprolactam (Copolymer Dimethylaminoethyl Methacrylate) is used as a film-forming polymer. It is a film-forming polymer. Large quantities of Caprolactam are manufactured in the world, which is the basis for the manufacture of Nylon. Vinyl Caprolactam is, for its part, widely used in hair conditioners, gels, etc., for its ease in film formation and its water-soluble nature.
  • the surfactant nature of Quat allows an excellent aqueous combination of the compound that can be used in aerosols, sprays, etc.
  • alcohol since alcohol is not available as the main solvent, the product does not classify as flammable. Compared with chlorine-releasing products to produce abundant oxidation, this allows its use in tissues without them becoming discolored or aging due to their oxidizing action.
  • the composition of the invention is effective both at the disinfectant level, presenting bactericidal and fungicidal efficacy according to criteria defined in the European disinfection standards, as an anti-allergen, denaturing the allergenic proteins to decrease the specific recognition between antigen-antibody. It is also a composition with a long-lasting effect on both hard and soft surfaces. These criteria have been evaluated experimentally by recognized methods.
  • the anti-allergenic efficacy has been contrasted with the test ELISA, obtaining values not less than 90% decrease in specific antigen / antibody recognition, or its usefulness as a disinfectant against bacteria and fungi, verified by complying with European disinfection regulations, such as UNE-EN 13697.
  • the product is served in hand spray, it is colorless and has a suitable and pleasant smell, being the product effective in the denaturation of at least 90% of the allergens. It can be applied on any type of surfaces and is especially suitable for objects that are not easy to wash, such as carpets, upholstery, etc. Applied on a surface, both hard and soft, a fabric, displays a rapid effect already 15 minutes after its application. Drying, letting the product stand, is very fast. Remove bad odors by eliminating the bacteria that cause them. Its effects, although they decrease over time, remain active for days, even more than a week, thanks to the product film that invisibly covers the treated surfaces, retaining the allergens and preventing their suspension. Thus, with the composition of the invention all the inventive objectives pursued have been obtained, resulting in a product suitable for high consumption, efficient and at the same time economical. DETAILED EXPLANATION OF THE INVENTION
  • the present invention consists of a disinfectant and anti-allergenic composition, of use for all type of surfaces, both hard and soft, including woven and nonwoven fabrics, including fabrics with threads such as blankets, carpets, etc., of prolonged effect on the surfaces on which it is applied, which does not discolor or tarnish fabrics and carpets, It has no bad smell and can be applied in sprays, aerosols, liquids, etc.
  • composition of the invention consists mainly of an aqueous solution of a cationic biocidal surfactant from the group of quaternary ammoniums and a film-forming polymer.
  • said quaternary ammonium is didecyl dimethyl ammonium chloride.
  • Quaternary ammoniums are a family of antimicrobials considered potent in their disinfectant activity. They are active against most gram positive and gram negative bacteria. They are bactericidal, fungicidal and virucidal. They act in both an acidic and alkaline environment. Quaternary ammoniums are known as benzalkonium chloride or n-alkyl dimethyl benzyl ammonium chloride, in which the alkyl chain may have variations in the composition of the number of carbons. With 12 to 14 carbons a good antibacterial power is already obtained. It is a product of more than 50 years that is still widely used today.
  • the present invention preferably uses linear dialkyl chains without a benzene ring: didecyl dimethyl ammonium chloride or dioctyl dimethyl ammonium chloride or octyl decyl ammonium chloride, each isolated. They have excellent germicidal activity, are low foam and have a high tolerance to protein loads and hard water.
  • the other essential ingredient of the composition of the invention is the Vinyl Caprolactam copolymer (Dimethylaminoethyl Methacrylate Copolymer).
  • Water-soluble film-forming polymer known in the world of cosmetics and widely used in hair conditioners, gels, etc.
  • the surfactant aids in the wetting of the application surface which is thus "wet” with ease entirely by the aqueous formulation of the present invention.
  • the alcohols present in the compound allow, among other functions, to facilitate rapid drying, preventing the sensation of "moisture” or “wetting” after a reasonable period of application of the product.
  • 3- methoxy-3-methyl-l-butanol is used alternatively to the most common alcohols. It is a very stable amphipathic solvent against self-oxidation with applications in the field of cleaners, the development of insecticides, pesticides and air fresheners, among others. Other substances are also added, within the known, in order to obtain certain properties. For example, perfumes provide a refreshing and suitable smell for a product of domestic application.
  • the composition of the invention has excellent anti-allergenic and disinfectant efficacy results quickly, in the first 5 to 15 minutes after its application and retains a good residual effect on the treated surfaces, without discoloration, glue or dust sensation on the surface. same, etc.
  • This result of efficacy can be considered, in view of the prior art known, as surprising and unexpected.
  • the anti-allergenic and / or disinfectant effect of the compound is superior to that of the individual components and it is that an addition relationship is established between the two that contributes to extending its effectiveness.
  • One hypothesis of why this linkage would be that the proportion used between the two components of the invention, being optimal, promotes maximum interaction between the active ingredients and the antigens to inactivate. This maximum interaction is defined by the relationship between the size of the molecules and their ionic charges.
  • the composition of the invention includes said cationic surfactant, Didecyl Dimethyl Ammonium Chloride, in approximately 0.5 to 5% by weight, and more specifically in approximately 0.6 to 1.3% of the total weight.
  • said film-forming polymer, Vinyl Caprolactam is present in the composition in approximately between 0.05 and 0.5% of the total weight, and more specifically between 0.28 and 0.42% of the weight total.
  • the following parameters are established: type of allergen, amount of allergen, type of surface, detection method.
  • the allergens selected are Bet v that of Betula verrucosa (pollen), Der p 1 (dust mite allergen) and Fel D 1 (cat saliva allergen).
  • biotechnology companies such as Biomay, MyBioSource.com and Thermo Fischer Scientific for the determination and quantification of these allergens.
  • the anti-allergenic effect is measured by the ability of the formulation to generate changes in the structure of the allergen that causes the specific recognition between the antigen and the antibody to be broken.
  • the ELISA test Enzyme linked Immune sorbent Assays - Enzyme-linked immunosorbent assay
  • the dust mite allergen Natural Der p 1 was obtained from Indoor Biotechnologies (Warminster, United Kingdom). Der p 1 is a thiol protease present in the feces of house mites in Europe ⁇ Dermatophagoides pteronyssinus). Der p 1 is one of the most important allergens originating in dust mites that causes an allergic reaction in humans and links with specific antibodies in 80% of patients with dust allergy.
  • the cat saliva allergen, natural Fel d 1 was obtained from Indoor Biotechnologies. This allergen is produced abundantly in the cat's saliva and in its sebaceous glands, being the main allergen in cats.
  • Bet allergen obtained from Biomay (Vienna, Austria). It is the main allergen of birch pollen. It is present in the white birch pollen (Betula verrucosa) which is one of the most widespread in Europe. Sensitivity to Bet v la is the main cause of type I allergies at the beginning of spring, characterized by bronchial asthma, allergic rhinitis and conjunctivitis.
  • the ability of specific antibodies to detect Fel D 1 in the presence or absence of the solution of the invention is evaluated by the protocol described above.
  • the amount of nonspecific signal of the composition in the absence of the allergenic protein is determined.
  • the concentration of Fel D 1 specifically recognized in each sample was corrected after eliminating the nonspecific signal obtained from the composition of the invention.
  • This procedure was also used to measure the result of the action of the composition of the invention before Der pl and Bet v la.
  • a liquid-liquid method is used to determine the recognition of allergens by specific antibodies.
  • PBS are the initials for Phosphate Buffer Saline or phosphate buffered saline which is an aqueous isotonic solution containing sodium phosphate, potassium phosphate, sodium chloride and potassium chloride. The following incubations were performed:
  • Fel DI and Der p 1 39 ⁇ of formulate or PBS each were added to 261 ⁇ of PBS with 25 ng of Fel D 1 and Der pl, respectively.
  • Bet v la 75 ⁇ of formula or PBS which were added to 500 ⁇ of PBS with 500 ng of Bet vi a.
  • the allergen was determined first by coating ELISA plates for 15 hours at 4 ° C with m ⁇ of 50mM of a carbonate-bicarbonate buffer (PH 9.6) containing specific captured antibodies (in dilution 1: 1000) - Three washes were performed with PBS - 0.1% Tween-20 (PBS-T). The wells were blocked with PBS-2.5% BSA for 90 minutes at room temperature. ⁇ of each incubation sample was loaded into each well and remained at 1 h at room temperature. Each sample was analyzed in triplicate. Control samples without allergenic protein were included for verification.
  • the plates were washed three times with PBS-T and incubated for 1 hour at room temperature with 100 ⁇ of PBS T 1% BSA including biotinylated antibodies against the study allergen in a 1: 1000 dilution.
  • the plates were washed three times with PBS-T.
  • 100 ⁇ of 1% BSA-containing PBS-T containing avidin-HRP in a 1: 1000 dilution was loaded into each well and incubation was allowed for 30 minutes at room temperature.
  • Interference efficiency (%) 100 - [(Average amount of allergen recognized in the replica / average amount of allergen recognized in the control replica with
  • the 2nd objective it is intended to determine whether the exposure of the allergens to the solution of the invention when they are on textile surfaces interferes with the recognition of the allergen by specific antibodies.
  • Cotton I (100% cotton)
  • Cotton II (100% cotton - thinner than Cotton I)
  • Cotton-Polyester III (70% cotton, 30% polyester).
  • Pieces of the specified fabrics were added (5 cm x 5 cm) in 50 ml falcon tubes with adhesive cap.
  • An aliquot of allergen was placed in the tissue (20 ⁇ of PBS with 500ng of Bet via, 10 ⁇ of PBS with lOOng of natural Der Pl or 20 ⁇ of PBS with 35ng of natural Fel D 1. Allergens were allowed to fix the piece for 15 min. For each replica two sprays were fired at about 10 cm away allowing them to dry for 15 min.
  • the pieces of fabric were removed from the tubes and incubated in 2ml of PBS to elute the allergens from the tissue for 20 min.
  • Incubations in rotary tubes were performed at room temperature, then 100 ⁇ were used to determine allergenic reactivity via a specific ELISA sandwich kit (Indoor Technologies, EL-BV1 for Bet vi a, EL-DP1 for Der P 1 and EL-FDl for Feld DI). Allergen determination was performed by a first coating of ELISA plates for 15 hours at 4 ° C with 100 ⁇ of 50mM carbonate-bicarbonate buffer (PH 9.6) with specific antibodies in a 1: 1000 dilution. He performed three washes with PBS-0.1% Tween-20 (PSB-T). The boxes were blocked with PBS-2.5% BSA for 90 min at room temperature. 100 ⁇ of each incubation replica was loaded in each box and kept lh at room temperature.
  • a specific ELISA sandwich kit Indoor Technologies, EL-BV1 for Bet vi a, EL-DP1 for Der P 1 and EL-FDl for Feld DI. Allergen determination was performed by a first coating of ELISA plates for 15
  • Replica 1 1.77 0.64 1.55 13.98 16.07 7.17 0.69 0.00 1.26
  • Replica 2 2.00 1.66 1.63 13.42 18.04 10.23 0 , 00 0.00 0.00
  • Replica 3 1.94 2.06 1.70 13.33 15.92 13.31 0.00 0.02 0.45 Average 1.90 1.45 1.63 13.58 16.68 10.24 0.23 0.01 0.57
  • Interference efficiency (%) 100 - [(Amount of allergen in a replica / amount of allergen in the control replica with PBS) * 100]
  • Replica 1 84.89 91.81 82.15 39.98 35.06 14.16 99.08 100.00 92.63
  • Replica 2 83.02 77.87 80.53 33.12 23.75 -33.62 100.00 100.00 100.00
  • Replica 3 79.36 74.60 76.87 26.08 21.85 -79.31 100.00 99.97 97.65 Average 82.42 81.43 79.85 32 , 73 26.89 -32.92 99.69 99.99 97.76
  • composition of the invention is an agent with no less than 90% efficacy in neutralizing the most common household allergens: dust mite allergens, of cats and pollen.
  • composition of the invention applied to Fabrics depend on their nature, the type of fabric. In general, its effectiveness is around 90% on average, being a variable data depending on the type of surface, although in polyester fabrics its effect has not been clearly determined.
  • the preferred composition of the invention has been contrasted in its biocidal efficacy with the criteria established in the European standards for the evaluation of disinfectant products.
  • the product complies with the UNE EN 13697 standard used to evaluate the bactericidal and fungicidal efficacy of disinfectants. It also complies with the UNE EN 14476 standard for the evaluation of the virucidal efficacy of disinfectants.
  • virucidal efficacy is reported at 5 min of application.
  • the composition of the invention is effective in more than 99.99% at 5 min of application against the Influenza A (H1N1) virus.
  • the main solvent of the formulation of the invention is water, since it is an aqueous solution.
  • the proportion by weight of osmotized water over the total is approximately between 85 and 93%.
  • solvents used are within the group of low molecular weight alcohols, with low carbon numbers.
  • the invention includes in the formulation of its preferred embodiment, ethanol and isopropanol. These elements also facilitate rapid drying of the composition of the invention. Its proportions as a group, by weight of the total, are approximately between 1 and 10% of total.
  • the product according to the composition of the present invention is applied, according to the known technique, preferably by means of a sprayer thus facilitating humidification and at the same time drying. It is sprayed at approximately 30 cm from the surfaces, fabrics, etc., until slightly moistened. Then just let them dry freely or ventilating the room. In case of resistant fabrics, the application can be repeated several times to ensure the result.
  • microparticles that is, the fact that the preferential shipment of the product by sprayer uses microparticles or micro-drops of water for its application, favors an effect of impregnation of the dust and of the related allergens that increase its joint weight, making it difficult Its easy air suspension.
  • the aggregative effect of the drops favored by the surfactant used in the composition, increases this fixation by linking some dust particles with nearby ones.
  • the use of the product of the invention is mainly the domestic environment, not only the appearance of the product, colorless and aqueous, should inspire confidence in the user, but this confidence is also influenced by the smell.
  • a foul-smelling product will hardly be applicable in our homes and mainly in our bedrooms, affecting pillows, mattresses and carpets.
  • the invention includes perfumes to improve the fragrance of the compound, so that it has a pleasant smell and increases the feeling of freshness and cleanliness after application.
  • Perfumes within those known in the art, are included in a proportion of approximately 0.1 to 1% of the total weight.
  • the product was subjected to odor tests before 15 experts.
  • a "kitchen type” reference smell was used as a control.
  • Petri dishes 2g of base perfume and ⁇ of bad smell replica were placed. Each Replica of smell or scented product was introduced in a plastic bag that was left at rest to balance for a period greater than 16h.
  • composition of the invention may incorporate other substances that, without being relevant in relation to the disinfectant or anti-allergenic efficacy, fulfill specific purposes within the technique known as pH regulators, corrosion inhibitors, stabilizers, dyes, bitters to avoid ingestion, propellant for presentations that require it, etc.
  • the invention in accordance with the foregoing, fulfills all the initially planned objectives, being configured as a highly effective disinfectant and anti-allergenic product, designed for domestic use in a spray, the results of which application are of rapid effect on the application surfaces, maintaining a long lasting residual effect on said treated surfaces. Applicable both on hard surfaces such as furniture, tables, etc., on soft surfaces such as pillows, sheets, fabrics, etc., and even on surfaces and objects that are difficult to machine wash and / or that incorporate threads, such as curtains, upholstery, carpets , etc.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne une composition désinfectante et antiallergénique, utilisée pour tout type de surfaces vitrées, tant dures que molles, y compris des tissus tissé et non-tissé, y compris des tissus et des objets à fils tels que des couvertures, des tapis, etc., formée principalement d'une solution aqueuse d'un tensioactif cationique biocide, dans le groupe des ammoniums quaternaires, et un polymère formateur de pellicule, qui comprend principalement du chlorure de didécyldiméthylammonium, le copolymère caprolactame de vinyle (méthacrylate diméthylaminoéthyl copolymère) et de l'eau avec d'autres solvants et parfums; la composition est efficace à environ non moins de 90% dans la neutralisation des allergènes domestiques les plus courants, comme les bactéricides et les fongicides.
PCT/ES2014/000129 2013-08-01 2014-07-29 Composition antiallergénique et désinfectante Ceased WO2015015021A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201300714A ES2530590B1 (es) 2013-08-01 2013-08-01 Composición antialergénica y desinfectante
ESP201300714 2013-08-01

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WO2015015021A1 true WO2015015021A1 (fr) 2015-02-05

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6559116B1 (en) * 1999-09-27 2003-05-06 The Procter & Gamble Company Antimicrobial compositions for hard surfaces
ES2280558T3 (es) * 2001-11-02 2007-09-16 Reckitt Benckiser Inc. Composiciones limpiadoras y desinfectantes de superficies duras.
US20100273697A1 (en) * 2007-11-06 2010-10-28 Rhodia Operations Copolymer for processing or modifying surfaces
CH702966A2 (de) * 2010-04-08 2011-10-14 Joker Ag Reinigungsmasse zum Entfernen von Feststoffpartikeln.

Patent Citations (4)

* Cited by examiner, † Cited by third party
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