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WO2015009257A1 - Procédé d'obtention d'un biomatériau empêchant l'accumulation bactérienne - Google Patents

Procédé d'obtention d'un biomatériau empêchant l'accumulation bactérienne Download PDF

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Publication number
WO2015009257A1
WO2015009257A1 PCT/TR2014/000254 TR2014000254W WO2015009257A1 WO 2015009257 A1 WO2015009257 A1 WO 2015009257A1 TR 2014000254 W TR2014000254 W TR 2014000254W WO 2015009257 A1 WO2015009257 A1 WO 2015009257A1
Authority
WO
WIPO (PCT)
Prior art keywords
biomaterial
fouling
plasma
precursor
bacteria anti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2014/000254
Other languages
English (en)
Inventor
Ebru AKDOGAN
Levent MERGEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DELTAMED YASAM BILIMLERI VE PLAZMA TEKNOLOJILERI AR-GE SANAYI VE TICARET AS
Original Assignee
DELTAMED YASAM BILIMLERI VE PLAZMA TEKNOLOJILERI AR-GE SANAYI VE TICARET AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DELTAMED YASAM BILIMLERI VE PLAZMA TEKNOLOJILERI AR-GE SANAYI VE TICARET AS filed Critical DELTAMED YASAM BILIMLERI VE PLAZMA TEKNOLOJILERI AR-GE SANAYI VE TICARET AS
Publication of WO2015009257A1 publication Critical patent/WO2015009257A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D1/00—Processes for applying liquids or other fluent materials
    • B05D1/62—Plasma-deposition of organic layers
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
    • C23C16/44—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating
    • C23C16/453—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating passing the reaction gases through burners or torches, e.g. atmospheric pressure CVD
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
    • H01J37/32—Gas-filled discharge tubes
    • H01J37/32431—Constructional details of the reactor
    • H01J37/32798—Further details of plasma apparatus not provided for in groups H01J37/3244 - H01J37/32788; special provisions for cleaning or maintenance of the apparatus
    • H01J37/32816—Pressure
    • H01J37/32825—Working under atmospheric pressure or higher
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/26—Plasma torches
    • H05H1/32—Plasma torches using an arc
    • H05H1/42—Plasma torches using an arc with provisions for introducing materials into the plasma, e.g. powder or liquid

Definitions

  • This invention relates to biomaterials that are modified using atmospheric pressure plasma system, leading to bacteria anti-fouling properties which in turn reduce the risk of infection after implantation.
  • Biomaterial is a general name given to all materials, natural or synthetic, that are used in medical devices and materials and that are used to repair or replace any organ, tissue or functional parts for a defined period. Biomaterials can be produced from a wide range of materials including metals, alloys, ceramics, synthetic polymers, natural polymers, biological materials and composites.
  • biomaterial related infection occurs when bacterial adhesion occurs first.
  • biomaterial related infections can be reduced by preventing or reducing bacterial adhesion to a biomaterial surface.
  • Antibiotic containing biomaterials usually prevents bacterial infection by killing bacteria close to the surface.
  • the main drawbacks of this method are the limited the amount of antibiotic to be impregnated depending upon the biomaterial's bulk structure and the risk of antibiotic resistance.
  • Silver is also used to prevent bacterial infections.
  • silver when silver is used as the antimicrobial agent in-vivo, its activity decreases due to the affinity of silver ions to proteins and chloride.
  • silver accumulates in hypothalamus and choroid plexus which can damage the central nervous system.
  • the main drawbacks of implants containing antibiotics and peptides are that the shelf life of such materials are limited, they are not feasible to be sterilized with all sterilization methods, the need to store and transport in cold chain, the loose of activity in case the cold chain is broken, and their high costs. Plus the amount of reduction in protein and bacterial fouling for these materials is usually no more than 80%.
  • JP2010005428 the coating of implants and similar devices used in medical applications with a biocompatible thin film is mentioned.
  • Another aim of the invention is to achieve a method for obtaining a biomaterial with homogeneous coatings on materials surfaces.
  • Another aim of the invention is to achieve a method for obtaining a biomaterial using plasma polymerisation systems.
  • Another aim of the invention is to achieve a method for obtaining a biomaterial that is relatively cheap.
  • Another aim of the invention is to achieve a method for obtaining a biomaterial that has no cytotoxicity to mammalian cells.
  • Another aim of the invention is to achieve a method for obtaining a biomaterial that is biocompatible.
  • Another aim of the invention is to achieve a method for obtaining a biomaterial using atmospheric pressure plasma systems.
  • Plasma polymerisation process used to achieve above mentioned goals is shown in figures. These figures are:
  • FIG. 1 Schematic representation of plasma polymerisation system.
  • Figure-2 Flow chart for obtaining a biomaterial with above mentioned specifications.
  • the plasma polymerisation system (1) used for obtaining a biomaterial with pre- mentioned properties works at atmospheric pressure and in its simplest form consists of;
  • a potential zone (7) where a potential difference is produced - A plasma restriction zone (8) that contains the plasma inside the probe (2) and that prevents the plasma to extinguish after discharge,
  • At least one precursor injection channel (9) that feeds the precursor used to modify the material surface (A),
  • At least one power supply (1) that supplies the energy required to the system (1).
  • the method for developed obtaining a bacteria anti-fouling biomaterial (100) using a plasma polymerisation system consists of the following steps:
  • the material to be modified is placed at the plasma polymerisation system (101).
  • the plasma forming gas is fed to the system through the plasma gas feeding channel (3), (102).
  • the plasma gas feeding channel (3) 102
  • at least one of nitrogen, oxygen, air, helium, argon, hydrogen or C0 2 gases is used as the plasma forming gas.
  • Plasma gas can be fed to the system (102) with a flow rate of 1-100 L/min at 1-10 bar pressure.
  • a doping gas can be fed to the" system (103) through the doping gas feeding channel (4).
  • the doping gas can be at least one of oxygen, hydrogen, nitrogen, CF 4 , CH 4 or C0 2 gases.
  • Doping gas can be fed to the system with a flow rate of 0-100 L/min at 0,01-10 bar and the percentage of doping gas inside plasma gas is %0,001-%51.
  • a precursor is also fed to the system through the precursor injection channel (7) with the help of a carrier gas and a peristaltic pump (104).
  • the carrier gas is the same as the plasma forming gas.
  • the flow rate of the carrier gas is between 0,01-100 L/min.
  • the feeding rate of the precursor to the system is between 0,01-100 mL/min.
  • At least one of the following chemicals can be used as precursor: posphate containing organophosphates with the general formula of OP(OR)(OR')(OR"), phosphite containing organophosphites with the general formula of P(OR) 3 , ethers and polyethers with the general formula of R-O-R', carboxylic acids with the general formula of R-COOH, organosilicones and organo fluorines .
  • organophosphates diethyl allyl phosphate, dibutyl phosphate and diethyl phosphite are preferred as the precursor.
  • ethers and polyether polyethylene glycol is preferred as the precursor.
  • carboxylic acids acrylic acid, acrylates and methacrylates, and especially hydroxyethyl methacrylate and methyl methacrylate are preferred as the precursor.
  • organosilicones hexamethyldisilane and hexamethyldisilazane are preferred as the precursor.
  • organofluorines hexafluoroisopropanol is preferred as the precursor.
  • plasma is ignited in the electrode (5) by supplying the required power from the power supply (10), (105).
  • the working frequency of the power supply (10) is between 1-100 kHz.
  • Material (A) is modified by moving the probe (2) that contains the electrode (5) on its surface at a distance of 0,1-50 mm and at a speed of 0-500 mm/sec (106).
  • the surface to be modified is moved under the non-moving probe at a speed of 1-1000 mm/sec.
  • the moving-coating cycle is repeated 1 to 100 times until a coating at a desirable thickness or property is obtained.
  • both the probe and the material are fixed and plasma is generated on the surface for 0,1 to 1000 minutes.
  • the power fed to the system (1) is between 0,1-100 kVA.
  • the plasma modification is applied to biomaterials that are being used either in- vitro or in- vivo.
  • the biomaterials to be used in- vivo are; cochlear implants, silicone implants, cerebrospinal fluid shunts, catheters, stents, joint implants, orthopaedic implants, intraocular lenses, contact lenses, bio-degradable membranes, capsules, drug delivery systems.
  • the biomaterials to be used in- vitro are; the materials that are not implanted into the living body but that contacts tissues or body parts for a pre-determined time such as in-vitro diagnostic kits and catheters.

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne un biomatériau et un procédé permettant d'obtenir un biomatériau qui empêche l'accumulation bactérienne, qui est biocompatible et qui réduit le risque d'infection (107). Le procédé comprend les étapes consistant à placer le matériau à modifier dans le système (1), (101), à introduire un gaz plasma dans le système (1), (102), à introduire un gaz dopant dans le système (1), (103), à introduire un précurseur dans le système (1), (104), à activer le plasma (105), à modifier la surface du matériau (A), (106), à obtenir un matériau à surface modifiée (A) avec le précurseur (107).
PCT/TR2014/000254 2013-07-15 2014-07-14 Procédé d'obtention d'un biomatériau empêchant l'accumulation bactérienne Ceased WO2015009257A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201308528 2013-07-15
TR2013/08528 2013-07-15

Publications (1)

Publication Number Publication Date
WO2015009257A1 true WO2015009257A1 (fr) 2015-01-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2014/000254 Ceased WO2015009257A1 (fr) 2013-07-15 2014-07-14 Procédé d'obtention d'un biomatériau empêchant l'accumulation bactérienne

Country Status (1)

Country Link
WO (1) WO2015009257A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017085482A1 (fr) * 2015-11-20 2017-05-26 Semblant Limited Dispositifs médicaux revêtus
US11871745B2 (en) 2021-03-08 2024-01-16 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites
US12054594B2 (en) 2021-03-08 2024-08-06 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites
US12134672B2 (en) 2021-02-03 2024-11-05 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151253A1 (fr) * 2008-07-31 2010-02-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Couche de biocompatibilité et objets revêtus
WO2012010299A1 (fr) * 2010-07-21 2012-01-26 Dow Corning France Traitement au plasma de substrats
EP2591743A1 (fr) * 2011-11-09 2013-05-15 Colorado State University Research Foundation Revêtement conducteur non collant pour applications biomédicales

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151253A1 (fr) * 2008-07-31 2010-02-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Couche de biocompatibilité et objets revêtus
WO2012010299A1 (fr) * 2010-07-21 2012-01-26 Dow Corning France Traitement au plasma de substrats
EP2591743A1 (fr) * 2011-11-09 2013-05-15 Colorado State University Research Foundation Revêtement conducteur non collant pour applications biomédicales

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017085482A1 (fr) * 2015-11-20 2017-05-26 Semblant Limited Dispositifs médicaux revêtus
CN108472412A (zh) * 2015-11-20 2018-08-31 赛姆布兰特有限公司 覆有涂层的医疗器械
US12134672B2 (en) 2021-02-03 2024-11-05 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites
US11871745B2 (en) 2021-03-08 2024-01-16 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites
US12054594B2 (en) 2021-03-08 2024-08-06 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites

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