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WO2015071667A2 - Dispositif d'insufflation de poudre pleurale - Google Patents

Dispositif d'insufflation de poudre pleurale Download PDF

Info

Publication number
WO2015071667A2
WO2015071667A2 PCT/GB2014/053365 GB2014053365W WO2015071667A2 WO 2015071667 A2 WO2015071667 A2 WO 2015071667A2 GB 2014053365 W GB2014053365 W GB 2014053365W WO 2015071667 A2 WO2015071667 A2 WO 2015071667A2
Authority
WO
WIPO (PCT)
Prior art keywords
container
interface
gas
powder
curve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2014/053365
Other languages
English (en)
Other versions
WO2015071667A3 (fr
Inventor
Edwin Richard ROE
Richard Martin VAREY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rocket Medical PLC
Original Assignee
Rocket Medical PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rocket Medical PLC filed Critical Rocket Medical PLC
Publication of WO2015071667A2 publication Critical patent/WO2015071667A2/fr
Publication of WO2015071667A3 publication Critical patent/WO2015071667A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/101—Pleural cavity

Definitions

  • the invention is a device for the insufflation of powder into the lungs
  • the device is a medical device for the insufflation of powder into the lungs of human subjects during pleural procedures
  • Background and prior art insufflation also known as talc poudrage
  • talc poudrage is a widely used method of instilling talc into the pleural space, it is usually performed during thoracoscopy under local anaesthesia or after video assisted thoracic surgery (VATS).
  • the current methods and equipment for talc poudrage are clumsy to use, often requiring multiple kits; as such, they can yield poor results.
  • Clinicians are currently using equipment supplied by the thoracoscopy suite equipment manufacturers, Karl Stortz or Richard Wolf, or equipment supplied by the talc supplier Novatech.
  • the Stortz and Wolf versions of such equipment might comprise an insufflation device with an elongate end for introducing to the site requiring poudrage, with a tube running from the device to apparatus for fitting to a container (and, in use, the container itself), followed by a further tube terminating in a puffer bulb, which provides air for puffing talc through the apparatus into a patient's lungs.
  • the Novatech apparatus dispenses with any sort of dedicated dispensing device at ail, using a plurality of interconnected tubes, for attaching to a puffer bulb and a powder source,
  • the invention comprises a hand-held powder insufflation device comprising an actuator for providing a succession of bursts of gas, an interface for attaching a powder container to said device; said powder containe
  • said interface comprises a gas entry aperture through which said bursts of gas enter said powder container and a gas exit aperture through which a mixture of gas and powder exits; said interface being configured to hold said body with Its opening located downwards.
  • a further advantage is that it allows the practitioner to relatively precisely dose a bottle to patient.
  • This device is singularly handheld and singularly hand-operated. It provides an advantage therefore over the prior art which comprises a plurality of tubes and sections and requires both hands or even two people to perform insufflation.
  • the powder container comprises a neck and wherein the aperture of the container is situated at the end of the neck distal the container, wherein the interface comprises attachmen means comprising a raised retaining portion which partially surrounds the neck of the container.
  • This feature is particularly advantageous, in that during the undertaking of the quick, real time task of lung insufflation it can be necessary to use more than one container of powder (the powder is dispensed in relatively small bottles) and as such the ability to quickly and easily change bottles carries a marked advantage over the prior art where powder may be located within the device Itself making it thus very difficult to access let alone re ⁇ fill; or wherein the device utilises the known containers but seeks to lock them in or onto the device firmly such that changing between bottles is a difficult multi-step process which effectively dispenses with the advantages of the device as a handheld device so that the device may have to be put. down and several actions be taken relative to it in order to make the change of the bottles.
  • the partial surrounding is a simple means of providing a light touch-fit connection - via slight friction or a click-in, click-out fit into the partial surround - thereby facilitating a straightforward way of allowing the quick removal of a first container bottle and Its replacement with a second.
  • the raised retaining portion lightly grips the container. More preferably, the container further comprises a lip surrounding the opening, and projecting from the neck, and wherein the raised retaining portion further comprises a channel portion and a bracket portion, wherein the bracket portion is so sized and shaped as to match the profile of the neck of an inserted container and wherein the channel portion is so sized and shaped to accept a portion of the lip of the container, such that, in use, the container is held in a grip along two notional axes.
  • bracket and channel allows for a continuous connection about, the neck of the bottle, and further utilises the lip such that the connection is made in multiple axes, thus ensuring a firm fit.
  • the attachment comprises a continuously curved portion.
  • the continuously curved portion provides a further means of ensuring continuous contact with the circular neck of the style of container.
  • the curve has a span of 181-210 degrees.
  • the slightly more than half- or semi-circular curve provides a fit that uses the minimum of additional material and ensures that the fit is particularly light, such that the powder container can be changed quickly by simply removing the container from contact with the device.
  • the curved portion is of a resiliency deforrnabie plastics material and wherein the curved portion must be deformed in order to locate or remove the container in use and wherein the touch fit comprises a light grip of the container by the curved portion.
  • the deforrnabie plastics material in tandem with the curved portion, provides a simple and effective means of lightly holding a container in place such that it is readily removable and replaceable.
  • the device comprises a piston bearing portion and a valve bearing portion and wherein the piston bearing portion comprises a piston and a barrel, wherein the barrel comprises an inner bore and wherein the piston forms a touching fit with the inner bore of the barrel, the device being so configured that movement of the piston forces air along the conduit and through the gas entry aperture and the gas exit aperture.
  • the piston bearing portion comprises a piston and a barrel
  • the barrel comprises an inner bore
  • the piston forms a touching fit with the inner bore of the barrel
  • This plunger-based version is simple to create and requires relatively little energy to manufacture.
  • the device further comprises a handle such that when the handle is squeezed, the piston is forced down the barrel, forcing the air through the conduit.
  • the squeezable handle and collocated handle portions advantageously provide a means of one-handed dispensing of the powder.
  • the handle comprises a first portion attached to the barrel and a second portion attached to the piston and wherein, in use, air is pushed through the device by bringing the first portion and the second portion together - thereby moving the piston down the barrel
  • the palm and fingers configuration provides a particularly preferred movement, because the squeezing of the fingers into the palm is a natural movement which can be done with a degree of control and also quickly.
  • the device is so sized and shaped to fit into the user's hand, is use, with the first portion being contacted, in use, by the user ' s fingers end the second portion being contacted, in use, by the user's palm, and wherein the device is operated by bringing the palm and fingers together.
  • the first and second portions are biased apart by a spring.
  • the biasing spring allows for the movement of the two handle portions back into the first position allowing for a quick series of puffs of powder to be dispensed.
  • the relative movement of the first and second portions is governed by a plurality of elongate guides.
  • the guide portions advantageously ensure that the two handle portions are correctly collocated at ail times. More preferably, the guides comprise a plurality of laterally collocated fringes, said fringes being in a laterally sliding collection with one another.
  • channels allows for the continuously correct collocation of the two handle portions to be achieved
  • the second portion comprises a first end, proximal the plunger, and a second end, distal the plunger and wherein the second portion widens towards the distal end,
  • the flared second portion comprises a sympathetic shape that fits and follows the line of the palm of the hand, thus providing a second portion which is easie to hold.
  • the interface is detachable from the rest of the device.
  • the detachable interface advantageously allows for the cleaning of the interface but also for the handheld device to be used with other interfaces and for other tasks.
  • the invention also comprises a device, substantially as described herein, with reference to and as illustrated by any appropriate combination of the text and/or drawings.
  • the invention comprises a valve comprising an interface for attaching a powder container to said device principal conduit, a conduit In communication with said interface an air inlet in fluid communication with the principal conduit wherein the interface comprises a gas entry aperture and a gas exit aperture; said interface being configured to hold the body of a powder container with its opening located downwards, and wherein the Interface comprises a connection for connecting the ccoonnttaaiinneerr ttoo tthhee ddeevviiccee,, ssaaiidd ccoonnnneeccttiioonn ccoommpprriissiinngg aa ccuurrvvee wwiitthh aa ssppaann ooff "" 118811 --221100 ddeeggrreeeess,, wwhheerreeiinn tthhee ccuu vvee iis
  • TThhee vvaallvvee aaddvvaannttaaggeeoouussllyy ccoommpprriis seess tthhee ssaammee aaddvvaannttaaggeess aaffffoorrddeedd bbyy ttoo tthhee ffeeaattuurreess wwhheenn mmeennttiioonneedd iinn tthhee ccoonntteexxttt ooff tthhee ddeevviiccee aabboovvee..
  • TThhee iinnvveennttiioonn aallssoo ccoommpprriis seess aa vvaallvvee,, ssuubbssttaannttiiaallllyy aass ddeessccrriibbeedd hheerreeiinn,, wwiitthh rreeffeerreennccee ttoo aannyy aapppprroopprriiaattee ccoommbbiinnaattiioonn ooff tthhee tteexxttt aanndd//oorr ddrraawwiinnggss..
  • Figure 1 is a diagrammatic perspective view of the invention
  • Figure 2 a further diagrammatic perspective view of the invention.
  • Figure 3 is an exploded diagrammatic perspective view of the invention.
  • FIG 1 there is shown a single handheld lung insufflation device indicated generally at 2.
  • the device 2 comprises a piston bearing portion 4 and a barrel bearing portion 6.
  • Each of the piston bearing portion 4 and the barrel bearing portion 6 comprise a handle; a first handle section 8 and a second handle section 10 respectively.
  • piston 12, which resides inside cylindrical piston housing 14 is shown.
  • Piston 12 comprises shaft 16 and head 18 with head 18 comprising at least a resiliently deformable surface of natural or synthetic rubber or the like, being so sized and shaped that it forms a moveable seal inside and against the inner bore 20 of barrel 22 of barrel bearing portion 6.
  • the various portions are constructed so that the present a single piece to the user and can be held operated by one hand of one person in a pistol-like fashion.
  • first handle portion 8 comprises a proximal end 24 adjacent piston bearing portion 4 and a second, distal end 26.
  • the first handle portion 8 is narrower at proximal end 24 than distal end 26; the first handle portion 8 flares towards distal portion 26.
  • the first handle portion S has a back edge 28 which is rounded,
  • the first handle portion 8 further comprises a bevelled corner 30.
  • the edge 30 and comer 32 are examples of features of the device 2 which make it tactile and easier to handle - It does not present sharp edges to the user, at least not related to the portions which the user must touch.
  • the second handle portion 10 presents a straight member 32.
  • the member 32 has incu 34 which like member 32 is elongate, running along the length of the member 32,
  • the second handle portion 10 joins with barrel bearing portion 6 via a tone reinforcement portion 36 which runs around the outer sectional perimeter of the barrei bearing portion 6 and is of a single piece with said barrei bearing portion 6.
  • the first handle portion 8 and second handle portion 10 are sOdeabiy attached to one another via a plurality of interlocking shelves 38 with the shelves 38 projecting from second handle portion 10 comprising a plurality of flanges or fringes projecting from a centrally disposed plate 42.
  • the shelves 38 of the first handle portion 8 are disposed as projections 44 within the cavity of cavity 46 of first handle portion 8. Projections 44 and shelves 38 mate to form a sliding fit between first and second handle portions 8, 10.
  • the movement between first and second handle portions 8, 10 is between a an extended position wherein the first handle portion 8 and the second handle portion 10 are extended apart from each other to a second position, wherein they are brought together thereby forcing the piston 12 along the inner bore 20 of the barrel 22.
  • the respective handle portions 8, 10 can be moved from the first position to the second position and vice versa.
  • a biasing spring 48 biases the first handle portion 8 and the second handle portion 10 apart.
  • the movement can be characterised as a linear, reciprocating movement.
  • the barrei 22 has a tapered end 50 and tapers to meet flo assembly 52, Flow assembly 52 comprises an inlet 54 and an outlet 56 the latter of which may be attached to rubber tubing such as a catheter. Between inlet 54 and outlet 56 there is gas entry aperture 58 and gas exit aperture 60.
  • gas entry aperture 58, gas exit aperture 60 and outlet 56 form a flow path - however, it is necessary for a container (not shown) to be placed over gas entry aperture 58 and gas exit aperture 60 in order for the flow path to he completed, in the present embodiment, the gas used is air drawn from the atmosphere through inlet 54.
  • Other propellent gases may be utilised.
  • the gas entry aperture 58 and the gas exit aperture 60 are surrounded by O ring 62 and pari surrounded by interface 64.
  • interface 64 serves to retain a container, in an in use upside down position i.e. with aperture and where applicable neck and lip of container held within interface 64 and sealed to the flow path by O ring 62.
  • interface 64 is mounted on discoid base 66 and comprises a curve 68.
  • Curve 68 comprises an 181° span, although a range of 181° to 210° is useful for the purposes of gripping or clamping a container such that the container is readily removable and replaceable.
  • Curve 68 is made of deformable material such as plastics material.
  • the curve 68 comprises a bracket 70 and a channel 72 with the bracket 70 providing a uniform rim and the channel 72 likewise providing a uniform channel around the span of said curve 68,
  • a container with a neck and a lip, i.e. standard talc dispensing bottle configuration will be held in place along two axes; in other words it will be gripped from the side by the curve 68 and will be held in place
  • inlet 54 comprises a one-way valve 74 and that the valve assembly 52 further comprises a narrowing portion 76 for concentrating the airflow in use, in use, when the device 2 is in a first position and the first and second handle portions 8, 10 are apart, gas is drawn through inlet 52 and into the barrel 22, The user who holds the device 2 with the first handle portion 8 in the palm of his or her hand and the second handle portion 10 held by his fingers, squeezes first and second handle portions 8,10 together, thereby pushing piston 12 along barrel 22 and forcing air through narrow portion 76. The air then flows through gas entry aperture 58 and swirls around the container and exits through gas exit aperture 60 and subsequently through outlet 56.
  • the biasing spring 48 serves to move the first handle portion 8 and second handle portion 10 back into the first position, when the grip of the user is relaxed. As the piston 12 is pulled back along the barrel 22.. air is drawn from air inlet. 52 As such, it is possible to dispense a series of puffs or bursts of powder entrained air into pleural cavity, in some embodiments the biasing spring 48 need not take the form of a metal or alloy spring and may be made of plastics and can be of a configuration other than the coil design presented here.
  • the device 2 is here shown made of plastics materials but other combinations of metals, aiioys and natural fibres are envisaged.
  • Other forms of gas actuation such as a puffer bulb or a compressed gas canister, may be utilised in orde provide the entrapment gas.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un dispositif d'insufflation de poudre portatif comprenant un actionneur permettant de fournir une succession d'explosions de gaz, une interface permettant de fixer un contenant de poudre audit dispositif; ledit contenant de poudre comportant un corps et une ouverture; et une conduite permettant de communiquer lesdites explosions de gaz à ladite interface, ladite interface comprenant une ouverture d'entrée de gaz à travers laquelle lesdites explosions de gaz entrent dans ledit contenant de poudre et une ouverture de sortie de gaz à travers laquelle un mélange de gaz et de poudre sort; ladite interface étant conçue pour contenir ledit corps avec son ouverture située vers le bas. L'invention comprend également une soupape présentant une interface permettant de fixer un contenant de poudre à la conduite principale dudit dispositif; une conduite en communication avec ladite interface et une admission d'air en communication fluidique avec la conduite principale, l'interface comprenant une ouverture d'entrée de gaz et une ouverture de sortie de gaz; ladite interface étant conçue pour contenir le corps d'un contenant de poudre avec son ouverture située vers le bas et l'interface comprenant un raccordement permettant de raccorder le contenant au dispositif, ledit raccordement présentant une courbe d'une envergure de 181-210 degrés, la courbe étant composée d'une matière plastique élastiquement déformable et, lors de l'utilisation, le contenant étant placé dans l'envergure de la courbe, ce qui amène la courbe à se déformer, de sorte que le contenant soit saisi par la courbe.
PCT/GB2014/053365 2013-11-18 2014-11-13 Dispositif d'insufflation de poudre pleurale Ceased WO2015071667A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1320290.8A GB2520324B (en) 2013-11-18 2013-11-18 Pleural powder insufflation device
GB1320290.8 2013-11-18

Publications (2)

Publication Number Publication Date
WO2015071667A2 true WO2015071667A2 (fr) 2015-05-21
WO2015071667A3 WO2015071667A3 (fr) 2015-09-17

Family

ID=49883751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2014/053365 Ceased WO2015071667A2 (fr) 2013-11-18 2014-11-13 Dispositif d'insufflation de poudre pleurale

Country Status (2)

Country Link
GB (1) GB2520324B (fr)
WO (1) WO2015071667A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017191125A3 (fr) * 2016-05-04 2017-12-28 Alfred Von Schuckmann Dispositif de délivrance d'une substance pouvant être évacuée par l'air

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102877143B1 (ko) * 2023-03-03 2025-10-27 주식회사 넥스트바이오메디컬 의약용 분말 분사용 디스펜서 장치

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Publication number Priority date Publication date Assignee Title
US2185927A (en) * 1937-02-16 1940-01-02 Herman A Shelanski Insufflator
EP0106578B1 (fr) * 1982-10-08 1988-06-08 FISONS plc Pistolet d'injection à dose réglable
JP2809976B2 (ja) * 1993-10-04 1998-10-15 株式会社カイゲン 散粉器及び散粉器に接続する散粉用ノズル
DE29806361U1 (de) * 1998-04-07 1998-09-03 Pauldrach, Georg, 30827 Garbsen Gerät zur Talkumpleurodese
US6453956B2 (en) * 1999-11-05 2002-09-24 Medtronic Minimed, Inc. Needle safe transfer guard
SG172177A1 (en) * 2008-12-15 2011-07-28 Profibrix Bv Powder delivery device
KR20140011299A (ko) * 2010-08-22 2014-01-28 세인트 존스 메디칼 리서치 인스티튜트 인코포레이티드 액체 컨테이너에 부착하도록 구성된 바늘 안전 덮개
GB201021881D0 (en) * 2010-12-23 2011-02-02 Profibrix Bv Powder delivery device
JP5672449B2 (ja) * 2011-01-14 2015-02-18 ニプロ株式会社 粉体噴射装置
DK2731573T3 (da) * 2011-07-13 2020-01-02 Pharmaxis Ltd Forbedringer af indgivelsesanordninger

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017191125A3 (fr) * 2016-05-04 2017-12-28 Alfred Von Schuckmann Dispositif de délivrance d'une substance pouvant être évacuée par l'air

Also Published As

Publication number Publication date
GB2520324B (en) 2015-10-07
WO2015071667A3 (fr) 2015-09-17
GB201320290D0 (en) 2014-01-01
GB2520324A (en) 2015-05-20

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