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WO2015066189A3 - Modification of nuclear actin by mical-2 regulates srf signaling - Google Patents

Modification of nuclear actin by mical-2 regulates srf signaling Download PDF

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Publication number
WO2015066189A3
WO2015066189A3 PCT/US2014/062915 US2014062915W WO2015066189A3 WO 2015066189 A3 WO2015066189 A3 WO 2015066189A3 US 2014062915 W US2014062915 W US 2014062915W WO 2015066189 A3 WO2015066189 A3 WO 2015066189A3
Authority
WO
WIPO (PCT)
Prior art keywords
mical
regulates
modification
srf
signaling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/062915
Other languages
French (fr)
Other versions
WO2015066189A2 (en
Inventor
Mark Lundquist
Samie R. Jaffrey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell University
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Publication of WO2015066189A2 publication Critical patent/WO2015066189A2/en
Publication of WO2015066189A3 publication Critical patent/WO2015066189A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Provided are methods for identification of agents that interfere with MICAL-2 induced activation of SRF/MRTF pathway. The method comprises evaluating the activity of the candidate agents on the various points in the pathway.
PCT/US2014/062915 2013-10-29 2014-10-29 Modification of nuclear actin by mical-2 regulates srf signaling Ceased WO2015066189A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361897008P 2013-10-29 2013-10-29
US61/897,008 2013-10-29

Publications (2)

Publication Number Publication Date
WO2015066189A2 WO2015066189A2 (en) 2015-05-07
WO2015066189A3 true WO2015066189A3 (en) 2015-11-12

Family

ID=53005370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/062915 Ceased WO2015066189A2 (en) 2013-10-29 2014-10-29 Modification of nuclear actin by mical-2 regulates srf signaling

Country Status (1)

Country Link
WO (1) WO2015066189A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3733837A4 (en) * 2017-12-28 2021-10-06 Kaneka Corporation MEANS TO PROMOTE THE CELL AGGREGATION
CN110331156B (en) * 2019-05-30 2021-10-12 深圳大学 anti-Mical 2 polyclonal antibody and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060160991A1 (en) * 2002-09-30 2006-07-20 Oncotherapy Science, Inc. Genes and polypeptides relating to prostate cancers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060160991A1 (en) * 2002-09-30 2006-07-20 Oncotherapy Science, Inc. Genes and polypeptides relating to prostate cancers

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HUNG ET AL.: "Direct redox regulation of F-actin assembly and disassembly by Mical.", SCIENCE, vol. 334, no. 6063, 2011, pages 1710 - 3, XP055235364 *
LUNDQUIST ET AL.: "Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.", CELL, vol. 156, no. 3, pages 563 - 76, XP028828121 *
LUNDQUIST., MICAL-2 REGULATES NUCLEAR ACTIN. PH.D. THESIS., 2012, pages ii *
MATSUKI-FUKUSHIMA ET AL.: "The actin-specific reagent jasplakinolide induces apoptosis in primary rat parotid acinar cells.", ARCH ORAL BIOL., vol. 57, no. 5, 2012, pages 567 - 76, XP055235362 *

Also Published As

Publication number Publication date
WO2015066189A2 (en) 2015-05-07

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