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WO2015060206A1 - Méthode de détection de kératoconjonctivite atopique - Google Patents

Méthode de détection de kératoconjonctivite atopique Download PDF

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Publication number
WO2015060206A1
WO2015060206A1 PCT/JP2014/077635 JP2014077635W WO2015060206A1 WO 2015060206 A1 WO2015060206 A1 WO 2015060206A1 JP 2014077635 W JP2014077635 W JP 2014077635W WO 2015060206 A1 WO2015060206 A1 WO 2015060206A1
Authority
WO
WIPO (PCT)
Prior art keywords
periostin
tears
atopic keratoconjunctivitis
concentration
protein concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/077635
Other languages
English (en)
Japanese (ja)
Inventor
出原　賢治
和彦 有馬
鈴木　章一
昭一郎 太田
斎藤　博久
松本　健治
直子 岡田
浩 藤島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TSURUMI UNIVERSITY
Saga University NUC
Original Assignee
TSURUMI UNIVERSITY
Saga University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TSURUMI UNIVERSITY, Saga University NUC filed Critical TSURUMI UNIVERSITY
Publication of WO2015060206A1 publication Critical patent/WO2015060206A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/162—Conjunctival disorders, e.g. conjunctivitis

Definitions

  • an object of the present invention is to provide a method for detecting atopic keratoconjunctivitis more easily and accurately.
  • the analysis value of periostin protein in tear fluid that is, the protein concentration of periostin is used as an index and associated with atopic keratoconjunctivitis.
  • the periostin protein concentration in the tear fluid is equal to or higher than the predetermined protein concentration, or when the tear fluid shows a high value for a subject who has not developed atopic keratoconjunctivitis, the tear fluid is atopic keratoconjunctivitis. May be treated as a strong ground for being derived from a subject suspected of developing the disease.
  • Examples of statistical processing include analysis using Receiver-Operating-Characteristics (ROC) curves.
  • ROC Receiver-Operating-Characteristics
  • Normal sample (also referred to as “control sample”) is tear fluid collected from a subject who is determined not to develop atopic keratoconjunctivitis.
  • Subjects who are judged not to develop atopic keratoconjunctivitis include healthy individuals and diseases other than atopic keratoconjunctivitis (eg, other allergic conjunctivitis, preferably spring catarrh or seasonal allergic conjunctivitis) It may be a person who develops.
  • the normal sample is tear fluid collected from a healthy person.
  • the following technique is adopted as a technique for providing a standard for determining that it is suspected that atopic keratoconjunctivitis has been developed.
  • the periostin protein concentration in the tear fluid to be measured is measured, and the average value of the periostin protein concentration measured for each subject group is obtained.
  • periostin protein in tears increases with the severity of atopic keratoconjunctivitis, so the analysis of periostin protein in tears can be used to measure the severity of atopic keratoconjunctivitis. It has also been shown to be useful.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne une méthode de détection de kératoconjonctiité atopique, ladite méthode consistant à mesurer la concentration de protéine périostine dans un liquide lacrymal prélevé chez un sujet. Ainsi, l'invention concerne une méthode de détection de kératoconjonctivite atopique, qui peut être mise en oeuvre de manière plus simple et précise.
PCT/JP2014/077635 2013-10-21 2014-10-17 Méthode de détection de kératoconjonctivite atopique Ceased WO2015060206A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013218612A JP6381013B2 (ja) 2013-10-21 2013-10-21 アトピー性角結膜炎の検出方法
JP2013-218612 2013-10-21

Publications (1)

Publication Number Publication Date
WO2015060206A1 true WO2015060206A1 (fr) 2015-04-30

Family

ID=52992803

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/077635 Ceased WO2015060206A1 (fr) 2013-10-21 2014-10-17 Méthode de détection de kératoconjonctivite atopique

Country Status (2)

Country Link
JP (1) JP6381013B2 (fr)
WO (1) WO2015060206A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007534935A (ja) * 2004-02-09 2007-11-29 ラピッド パトゲン スクリーニング インコーポレイテッド ヒトの体液中のターゲットを高速に診断する方法
JP2012058048A (ja) * 2010-09-08 2012-03-22 Shino Test Corp ペリオスチン測定の正確性の改善方法
WO2013065671A1 (fr) * 2011-10-31 2013-05-10 国立大学法人佐賀大学 Procédé de détection d'une sinusite chronique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007534935A (ja) * 2004-02-09 2007-11-29 ラピッド パトゲン スクリーニング インコーポレイテッド ヒトの体液中のターゲットを高速に診断する方法
JP2012058048A (ja) * 2010-09-08 2012-03-22 Shino Test Corp ペリオスチン測定の正確性の改善方法
WO2013065671A1 (fr) * 2011-10-31 2013-05-10 国立大学法人佐賀大学 Procédé de détection d'une sinusite chronique

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AALDERS-DEENSTRA V ET AL.: "Measurement of total IgE antibody levels in lacrimal fluid of patients suffering from atopic and non-atopic eye disorders.", EVIDENCE FOR LOCAL IGE PRODUCTION IN ATOPIC EYE DISORDERS?, BR J OPHTHALMOL., vol. 69, no. 5, May 1985 (1985-05-01), pages 380 - 384 *
KANJI HORI ET AL.: "Gan Hyomen ni Okeru Periostin Bunshi no Hatsugen", JAPAN CORNEA SOCIETY SOKAI KERATOPLASTY SOCIETY OF JAPAN PROGRAM SHOROKUSHU, vol. 36 TH-28, 2012, pages 32 *
MITSURU NAKAZAWA: "Gankai nimo Wakaru Seiri Kassei Busshitsu to Gan Shikkan no Kihon 33 Rinsho-hen: Kakushu Gan Shikkan to Seiri Kassei Busshitsu tono Kakawari Atopic Dermatitis no Kagi o Nigiru Periostin", GANKA, vol. 66, no. 9, 2012, pages 1300 - 1302 *

Also Published As

Publication number Publication date
JP6381013B2 (ja) 2018-08-29
JP2015081796A (ja) 2015-04-27

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