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WO2015053361A1 - Dispositif d'assistance d'inhalation pour poudre orale - Google Patents

Dispositif d'assistance d'inhalation pour poudre orale Download PDF

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Publication number
WO2015053361A1
WO2015053361A1 PCT/JP2014/077055 JP2014077055W WO2015053361A1 WO 2015053361 A1 WO2015053361 A1 WO 2015053361A1 JP 2014077055 W JP2014077055 W JP 2014077055W WO 2015053361 A1 WO2015053361 A1 WO 2015053361A1
Authority
WO
WIPO (PCT)
Prior art keywords
inhalation
mouthpiece
storage chamber
air
assisting device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/077055
Other languages
English (en)
Japanese (ja)
Inventor
将充 原
政彦 岡田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REACH HIGHER Inc
Original Assignee
REACH HIGHER Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by REACH HIGHER Inc filed Critical REACH HIGHER Inc
Priority to JP2015541633A priority Critical patent/JP5990866B2/ja
Publication of WO2015053361A1 publication Critical patent/WO2015053361A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
    • A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the present invention relates to an inhalation assisting device for ensuring that a powder inhalant can be ingested by being attached to an inhalation port of a container containing an oral powder such as a powder drug or a powder supplement.
  • Inhalers are used to take powdered drugs and powder supplements (hereinafter collectively referred to as “oral powder”) by oral inhalation.
  • oral powder when oral powder stored in a storage chamber in a container is inhaled from the suction port, air is introduced into the storage chamber from an outside air inlet provided in the container, and the oral powder is rolled up by this air. The mechanism moves into the oral cavity through the suction port (see Patent Document 1).
  • Non-Patent Document 1 When ingesting oral powder with an inhaler, the success or failure depends largely on the skill of the user compared to ingestion by infusion or internal use.
  • the inventor of the present application investigated the actual inhalation of powdered anti-influenza drugs (see Non-Patent Document 1) and clarified that the following problems exist. (1) A single suction may leave the powder in the container, and a plurality of suctions may be required before the specified amount is sucked. (2) About 10% of people under the age of 9 failed to inhale, and most of the causes were accidentally inhaled.
  • Patent Document 1 has the following problems.
  • the oral powder after a single inhalation, the oral powder actually remains in the container, but it is difficult to visually confirm it, so it is misrecognized that the inhalation was successful, and the intake amount
  • the intake amount there is a possibility that sufficient effects cannot be obtained because the amount is less than the prescribed amount.
  • an object of the present invention is to provide an inhalation assisting device capable of effectively ingesting an oral powder in a container by being attached to an inhalation port of the container in which the oral powder is stored.
  • the inhalation aid of the present invention introduces an intake port, a storage chamber for storing oral powder in a container, an air flow passage connecting the suction port and the storage chamber, and outside air into the storage chamber.
  • the outside air inlet is attached to an inhaler having at least one mounting portion to be attached to the suction port at one end portion, a mouthpiece at the other end portion, and the inside of the inhaler only for inhalation.
  • the opening diameter of the mouthpiece is different from the opening diameter of the mounting portion.
  • it is provided with a collar portion extending radially outward from the outer peripheral surface.
  • the mouthpiece has a filter for preventing accidental ingestion of foreign matter.
  • the oral powder in the storage chamber is formed by the air introduced into the storage chamber from the outside air inlet. It is rolled up, moves in the air flow passage with air, passes through the one-way valve, and reaches from the mouthpiece to the oral cavity.
  • the opening cross-sectional area of the mouthpiece is larger than the opening cross-sectional area of the storage chamber, when the flow rate of air in the mouthpiece and the flow rate of air in the storage chamber are compared by the venturi effect, The flow velocity of the air in the storage chamber is larger (faster).
  • the flow velocity of the air in a storage chamber can be increased. That is, since the effect of increasing the suction force can be obtained, the amount of the oral powder remaining in the container after a single suction can be greatly reduced, and the oral powder can be effectively ingested.
  • the present invention includes a one-way valve that allows the passage of air only during inhalation, so air has been inadvertently blown. In this case, the one-way valve functions to prevent a situation where air flows backward into the air flow passage and the storage chamber.
  • the function of the one-way valve prevents air from moving through the mouthpiece, so that the malfunction cannot be performed (operation is blocked). And, after repeating trial and error several times, only when normal operation (inhalation operation) is performed, the function of the one-way valve allows air and oral powder to move through the mouthpiece, so that they can be inhaled. Infants can understand sensuously what actions (inhalation) are necessary for inhalation.
  • the opening diameter of the mouthpiece different from the opening diameter of the mounting portion, it is possible to prevent the user from accidentally mounting the mouthpiece on the suction port.
  • a buttocks when the user (especially an infant) tries to put the inhalation aid into the mouth, the buttocks get caught in the lips. Can be prevented.
  • a filter even if the one-way valve is removed from the fixed position, it can be caught by the filter and thus prevent accidental ingestion.
  • FIG. 1 Perspective view showing appearance of inhalation aid Diagram showing the internal structure of the inhalation aid Front view of inhalation aid
  • the inhalation assisting device 10 is a hollow member that is schematically composed of a mounting portion 20, a mouthpiece 30, and a one-way valve 40.
  • the mounting portion 20 is a hollow member having an elliptical cross section provided at one end of the inhalation assisting device 10.
  • the mounting portion 20 is designed so that the cross-sectional shape of the inner surface of the mounting portion 20 and the cross-sectional shape of the outer surface of the suction port 110 are substantially the same in order to be mounted on the suction port 110 of the inhaler 100 shown in FIG. ing.
  • the mouthpiece 30 is a hollow member having an elliptical cross-sectional shape provided at the other end of the inhalation assisting device 10, and the user performs a suction operation with the mouthpiece 30 held in the mouth.
  • the cross-sectional shape of the mouthpiece 30 is larger than the cross-sectional shape of the mounting part 20.
  • the minor axis of the inner surface of the elliptical mounting part 20 is 14 mm and the major axis is 16 mm
  • the elliptical mouse The short diameter of the inner surface of the piece 30 is 16 mm, and the long diameter is 18 mm, which are slightly larger.
  • the opening diameter of the mouthpiece 30 is different from the opening diameter of the mounting portion 20, it is possible to prevent the user from accidentally mounting the mouthpiece 30 to the suction port 110.
  • the mouth cross-sectional area of the mouthpiece 30 is designed to be larger than that of the housing chamber 130 in the inhaler 100.
  • a taper portion 50 is provided that gradually changes the short diameter and the long diameter so as to connect the end of the mounting portion 20 and the end of the mouthpiece 30.
  • the one-way valve 40 is a thin oval member attached to the inner surface of the mounting portion 20. Specifically, as shown in FIG. 2, a part of the periphery of the one-way valve 40 is fixed to the inner surface of the mounting portion 20, and swings in the front-rear direction (air movement direction) with the fixed portion as a fulcrum. It can be moved. Further, a stopper 41 is attached to the inner surface of the mounting portion 20 at a position facing the fixed portion of the one-way valve 40.
  • FIG. 4 shows an example of an internal structure in a state where the inhalation assisting device 10 is attached to the inhaler 100.
  • the inhaler 100 includes an inhalation port 110, an accommodation chamber 130 for accommodating the oral powder P in the container 120, and the inhalation port 110 and the accommodation chamber 130, similarly to a generally known inhaler.
  • At least an air flow passage 140 to be connected and an outside air inlet 150 for introducing outside air into the storage chamber 130 are provided.
  • FIG. 5A when the user performs an inhalation operation, that is, when air moves from the mounting portion 20 side toward the mouthpiece 30 side (the direction of the arrow in the figure is the direction in which the air flows).
  • the one-way valve 40 tilts toward the mouthpiece 30 under the pressure of air.
  • a gap S is formed between the one-way valve 40 and the inner surface of the mounting portion 20, and air and oral powder P reach the oral cavity through the gap S.
  • FIG. 5B when the user accidentally performs the blowing operation, that is, when the air moves from the mouthpiece 30 side toward the mounting portion 20 side, the air pressure is received.
  • the gap S between the one-way valve 40 and the inner surface of the mounting portion 20 is closed, and the backflow of air and oral powder P occurs. And these are prevented from being ejected to the outside from the outside air inlet 150.
  • the opening cross-sectional area A1 of the mouthpiece 30 is designed to be larger than the opening cross-sectional area A2 of the storage chamber 130 (see FIG. 4). Therefore, when the user holds the mouthpiece 30 and sucks it, the air passing through the accommodation chamber 130 is faster than the flow velocity of the air passing through the mouthpiece 30 due to the venturi effect, and the suction force is further increased. can get.
  • the material of the inhalation assisting device is not particularly limited, and examples thereof include plastic resin, silicone resin, metal, rubber, and the like, or a combination thereof as appropriate.
  • the structure of the inhaler is not particularly limited. For example, as shown in FIG.
  • two container chambers 201 and 202 are provided in one container 200, and left and right containers can be accommodated by sliding left and right. It may have a structure for inhaling each oral powder P accommodated in the chambers 201 and 202.
  • the one-way valve 40 may be attached to the inner surface of the mouthpiece 30.
  • the shape of the mounting part 20, the mouthpiece 30, and the one-way valve 40 is not limited to an ellipse, and may be a regular circle or a polygon.
  • the inhalation assisting device 300 is characterized in that it includes a collar portion 301 and a filter 302.
  • the collar portion is a circular member extending radially outward from the outer peripheral surface of the tapered portion.
  • the outer diameter of the buttocks is not particularly limited, but if the user of the inhalation assisting device 300 is an infant, the infant will try to put the inhalation assisting device 300 into the mouth if it is approximately 40 mm or more.
  • the position where the collar portion 301 is provided is not necessarily the Taber portion 50, and may be the outer peripheral surface of the mouthpiece 30 or the mounting portion 20. Moreover, the shape of the collar part 301 does not necessarily need to be circular, and may be elliptical or rectangular.
  • the filter 302 is a member provided at the opening of the mouthpiece 30 and includes a ring portion 302a and a cross-shaped bar 302b that are fitted into the inner peripheral surface of the opening.
  • the filter 302 is provided in order to prevent accidental ingestion of foreign matter, and examples of the foreign matter include the one-way valve 40 and the stopper 41 that have been removed from the fixed portion.
  • the shape of the filter 302 is not limited to a cross shape, but it is necessary to have an eye roughness that does not hinder the flow of air during inhalation.
  • the inhalation assisting device 300 includes both the flange portion 301 and the filter 302.
  • the present invention is not limited to this, and as illustrated in FIG. Only the filter 302 may be provided as shown in FIG.
  • the present invention relates to an inhalation assisting device that can effectively ingest the oral powder in the container by being attached to the suction port of the container in which the oral powder is stored, and has industrial applicability.
  • Inhalation assisting device 20 Mounting portion 30 Mouthpiece 40 One-way valve 41 Stopper 50 Tapered portion 100 Inhaler 110 Suction port 120 Container 130 Storage chamber 140 Air flow passage 150 Outside air inlet 200 Container 201 Storage chamber 202 Storage chamber 300 Inhalation Auxiliary instrument 301 ridge 302 filter 302a ring 302b bar

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un dispositif d'assistance d'inhalation qui est installé sur l'ouverture d'inhalation d'un récipient dans lequel une poudre orale est stockée de manière à permettre une ingestion efficace de la poudre orale dans le récipient. Ce dispositif d'assistance d'inhalation (10) est fixé à un inhalateur (100) qui comprend au moins : une ouverture d'inhalation (110) ; une chambre de stockage (130) pour stocker une poudre orale (P) dans un récipient (120) ; un passage de flux d'air (140) qui raccorde l'ouverture d'inhalation et la chambre de stockage ; et une entrée d'air extérieur (150) pour guider l'air extérieur dans la chambre de stockage. Ce dispositif d'assistance d'inhalation est caractérisé en ce qu'il est un élément creux dans lequel une extrémité de celui-ci est pourvue d'une partie de montage (20) qui est installée sur l'ouverture d'inhalation, l'autre extrémité de celui-ci étant pourvue d'une embouchure (30), et une valve antiretour (40) qui permet uniquement le passage d'air pendant l'inhalation est également disposée à l'intérieur dudit élément creux, l'aire de section transversale ouverte (A1) de l'embouchure étant plus grande que l'aire de section transversale ouverte (A2) de la chambre de stockage. Le dispositif d'assistance d'inhalation produit ainsi un effet Venturi, conduisant à un débit d'air plus élevé (plus rapide) à l'intérieur de la chambre de stockage et une aspiration augmentée.
PCT/JP2014/077055 2013-10-11 2014-10-09 Dispositif d'assistance d'inhalation pour poudre orale Ceased WO2015053361A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2015541633A JP5990866B2 (ja) 2013-10-11 2014-10-09 経口粉末の吸入補助器具

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013-213891 2013-10-11
JP2013213891 2013-10-11

Publications (1)

Publication Number Publication Date
WO2015053361A1 true WO2015053361A1 (fr) 2015-04-16

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PCT/JP2014/077055 Ceased WO2015053361A1 (fr) 2013-10-11 2014-10-09 Dispositif d'assistance d'inhalation pour poudre orale

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JP (1) JP5990866B2 (fr)
WO (1) WO2015053361A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2767698C1 (ru) * 2018-12-06 2022-03-18 Филип Моррис Продактс С.А. Мундштук с внутренней и внешней трубчатыми секциями

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08317978A (ja) * 1995-05-26 1996-12-03 Unisia Jecs Corp 吸入式投薬器
JP2001517979A (ja) * 1997-03-14 2001-10-09 アストラ・アクチエボラーグ 吸入装置
JP2002512092A (ja) * 1998-04-20 2002-04-23 インフェイムド リミティド 改良投薬装置および改良投薬方法
JP2007536962A (ja) * 2004-05-13 2007-12-20 ノバルティス アクチエンゲゼルシャフト 吸入器
US20080196716A1 (en) * 2007-02-16 2008-08-21 Wachter Allan M Mouthpiece and Flow Rate Controller for Intrapulmonary Delivery Devices
JP2012010724A (ja) * 2010-06-29 2012-01-19 Shinko Chemical Co Ltd 粉末製剤用の吸入器
WO2012078804A1 (fr) * 2010-12-07 2012-06-14 Respira Therapeutics, Inc. Inhalateur de poudre sèche

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6345617B1 (en) * 1997-09-26 2002-02-12 1263152 Ontario Inc. Aerosol medication delivery apparatus and system
WO2008042951A2 (fr) * 2006-10-03 2008-04-10 Manta Product Development Dispositifs d'inhalation et procédés associés
EP2077882A2 (fr) * 2006-10-25 2009-07-15 Nektar Therapeutics Appareil de dispersion de poudre, procédé de fabrication et d'utilisation de l'appareil et composant pouvant être utilisé sur l'appareil et d'autres dispositifs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08317978A (ja) * 1995-05-26 1996-12-03 Unisia Jecs Corp 吸入式投薬器
JP2001517979A (ja) * 1997-03-14 2001-10-09 アストラ・アクチエボラーグ 吸入装置
JP2002512092A (ja) * 1998-04-20 2002-04-23 インフェイムド リミティド 改良投薬装置および改良投薬方法
JP2007536962A (ja) * 2004-05-13 2007-12-20 ノバルティス アクチエンゲゼルシャフト 吸入器
US20080196716A1 (en) * 2007-02-16 2008-08-21 Wachter Allan M Mouthpiece and Flow Rate Controller for Intrapulmonary Delivery Devices
JP2012010724A (ja) * 2010-06-29 2012-01-19 Shinko Chemical Co Ltd 粉末製剤用の吸入器
WO2012078804A1 (fr) * 2010-12-07 2012-06-14 Respira Therapeutics, Inc. Inhalateur de poudre sèche

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2767698C1 (ru) * 2018-12-06 2022-03-18 Филип Моррис Продактс С.А. Мундштук с внутренней и внешней трубчатыми секциями
US12232535B2 (en) 2018-12-06 2025-02-25 Philip Morris Products S.A. Mouthpiece with inner and outer tubular sections

Also Published As

Publication number Publication date
JPWO2015053361A1 (ja) 2017-03-09
JP5990866B2 (ja) 2016-09-14

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