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WO2015050199A3 - 新規化合物、その製造方法及びその用途 - Google Patents

新規化合物、その製造方法及びその用途 Download PDF

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Publication number
WO2015050199A3
WO2015050199A3 PCT/JP2014/076397 JP2014076397W WO2015050199A3 WO 2015050199 A3 WO2015050199 A3 WO 2015050199A3 JP 2014076397 W JP2014076397 W JP 2014076397W WO 2015050199 A3 WO2015050199 A3 WO 2015050199A3
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WIPO (PCT)
Prior art keywords
therefor
production method
novel
novel compound
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/076397
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English (en)
French (fr)
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WO2015050199A2 (ja
Inventor
良雄 林
晶大 梶山
晃弘 田口
謙太郎 福元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KOKUSAN CHEMICAL CO LTD
Tokyo University of Pharmacy and Life Sciences
Original Assignee
KOKUSAN CHEMICAL CO LTD
Tokyo University of Pharmacy and Life Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KOKUSAN CHEMICAL CO LTD, Tokyo University of Pharmacy and Life Sciences filed Critical KOKUSAN CHEMICAL CO LTD
Priority to US15/026,061 priority Critical patent/US20160304459A1/en
Priority to CN201480054769.XA priority patent/CN105593268B/zh
Priority to JP2015540539A priority patent/JP6661073B2/ja
Publication of WO2015050199A2 publication Critical patent/WO2015050199A2/ja
Publication of WO2015050199A3 publication Critical patent/WO2015050199A3/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

【解決課題】　従来とは全く異なる新規ペプチド合成手法の提供、ならびに新規人工機能タンパク質の合成・創出、新規機能ペプチドの合成・創出を可能とする新規化合物、その製造方法を提供すること。 【解決手段】　以下の式（Ｉ）で表される化合物又はその塩。
PCT/JP2014/076397 2013-10-04 2014-10-02 新規化合物、その製造方法及びその用途 Ceased WO2015050199A2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US15/026,061 US20160304459A1 (en) 2013-10-04 2014-10-02 Novel compound, production method therefor, and application therefor
CN201480054769.XA CN105593268B (zh) 2013-10-04 2014-10-02 化合物、其制造方法及其用途
JP2015540539A JP6661073B2 (ja) 2013-10-04 2014-10-02 新規化合物、その製造方法及びその用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013209166 2013-10-04
JP2013-209166 2013-10-04

Publications (2)

Publication Number Publication Date
WO2015050199A2 WO2015050199A2 (ja) 2015-04-09
WO2015050199A3 true WO2015050199A3 (ja) 2015-05-28

Family

ID=52779246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2014/076397 Ceased WO2015050199A2 (ja) 2013-10-04 2014-10-02 新規化合物、その製造方法及びその用途

Country Status (4)

Country Link
US (1) US20160304459A1 (ja)
JP (1) JP6661073B2 (ja)
CN (1) CN105593268B (ja)
WO (1) WO2015050199A2 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112017002597T5 (de) 2016-05-20 2019-04-25 Kokusan Chemical Co.,Ltd. Selektives Disulfidierungsreagenz verwendend eine stickstoffenthaltende Verbindung und ein Verfahren zur Herstellung einer disulfidenthaltenden Verbindung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH111479A (ja) * 1997-06-11 1999-01-06 Nippon Steel Corp アミド結合を有するイソオキサゾール誘導体、並びにこれらを含有するキマーゼ阻害剤及びアンジオテンシンｉｉ産生抑制剤
JP2006517600A (ja) * 2003-01-06 2006-07-27 ネクター セラピューティクス アラバマ，コーポレイション チオール選択的水溶性ポリマー誘導体
JP2009531478A (ja) * 2006-03-30 2009-09-03 バイオ−ケル ソシエタ ア レスポンサビリタ リミタータ 新規な活性化ポリ（エチレングリコール）及び関連ポリマー並びにそれらの適用
JP2012117981A (ja) * 2010-12-02 2012-06-21 Yoshio Hayashi 固相担持型ｓｈ基選択的標識試薬

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2352337T5 (es) * 2003-01-06 2017-08-11 Nektar Therapeutics Derivados tiol-selectivos de un polimero soluble en agua

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH111479A (ja) * 1997-06-11 1999-01-06 Nippon Steel Corp アミド結合を有するイソオキサゾール誘導体、並びにこれらを含有するキマーゼ阻害剤及びアンジオテンシンｉｉ産生抑制剤
JP2006517600A (ja) * 2003-01-06 2006-07-27 ネクター セラピューティクス アラバマ，コーポレイション チオール選択的水溶性ポリマー誘導体
JP2009531478A (ja) * 2006-03-30 2009-09-03 バイオ−ケル ソシエタ ア レスポンサビリタ リミタータ 新規な活性化ポリ（エチレングリコール）及び関連ポリマー並びにそれらの適用
JP2012117981A (ja) * 2010-12-02 2012-06-21 Yoshio Hayashi 固相担持型ｓｈ基選択的標識試薬

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KENTAROU FUKUMOTO ET AL.: "Development of a solid-supported biotinylation reagent for efficient biotin labeling of SH groups on small molecules", TETRAHEDRON LETTERS, vol. 53, no. 5, 1 February 2012 (2012-02-01), pages 535 - 538 *

Also Published As

Publication number Publication date
JP6661073B2 (ja) 2020-03-11
CN105593268B (zh) 2018-04-17
CN105593268A (zh) 2016-05-18
US20160304459A1 (en) 2016-10-20
JPWO2015050199A1 (ja) 2017-03-09
WO2015050199A2 (ja) 2015-04-09

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