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WO2014122638A3 - Thalidomide et analogues de thalidomide pour la stimulation chez des êtres humains/animaux d'un facteur de cellule souche pour augmenter le potentiel régénératif dans des conditions de vieillissement - Google Patents

Thalidomide et analogues de thalidomide pour la stimulation chez des êtres humains/animaux d'un facteur de cellule souche pour augmenter le potentiel régénératif dans des conditions de vieillissement Download PDF

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Publication number
WO2014122638A3
WO2014122638A3 PCT/IE2014/000001 IE2014000001W WO2014122638A3 WO 2014122638 A3 WO2014122638 A3 WO 2014122638A3 IE 2014000001 W IE2014000001 W IE 2014000001W WO 2014122638 A3 WO2014122638 A3 WO 2014122638A3
Authority
WO
WIPO (PCT)
Prior art keywords
thalidomide
stem cell
cell factor
analogues
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IE2014/000001
Other languages
English (en)
Other versions
WO2014122638A2 (fr
Inventor
Thomas Patrick PRENDERGAST
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2014122638A2 publication Critical patent/WO2014122638A2/fr
Publication of WO2014122638A3 publication Critical patent/WO2014122638A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne l'administration de thalidomide et/ou d'analogues de thalidomide à un patient pour améliorer ou maintenir les taux endogènes du facteur de cellule souche chez un patient pour prévenir et/ou traiter des états médicaux associés à des taux décroissants de facteur de cellule souche endogènes également connu en tant que facteur de croissance de mastocytes ou ligand de kit.
PCT/IE2014/000001 2013-02-08 2014-02-10 Thalidomide et analogues de thalidomide pour la stimulation chez des êtres humains/animaux d'un facteur de cellule souche pour augmenter le potentiel régénératif dans des conditions de vieillissement Ceased WO2014122638A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IE20130078A IE20130078A1 (en) 2013-02-08 2013-02-08 Methods for using thalidomide and thalidomide analogues to maintain or increase muscle mass in treating sarcopenia
IE2013/0078 2013-02-10

Publications (2)

Publication Number Publication Date
WO2014122638A2 WO2014122638A2 (fr) 2014-08-14
WO2014122638A3 true WO2014122638A3 (fr) 2015-01-08

Family

ID=50693713

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IE2014/000001 Ceased WO2014122638A2 (fr) 2013-02-08 2014-02-10 Thalidomide et analogues de thalidomide pour la stimulation chez des êtres humains/animaux d'un facteur de cellule souche pour augmenter le potentiel régénératif dans des conditions de vieillissement

Country Status (2)

Country Link
IE (1) IE20130078A1 (fr)
WO (1) WO2014122638A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021143816A1 (fr) * 2020-01-16 2021-07-22 江苏恒瑞医药股份有限公司 Dérivé imide fusionné, son procédé de préparation et son utilisation médicale
GB202012152D0 (en) * 2020-08-05 2020-09-16 Vicore Pharma Ab New compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008144720A2 (fr) * 2007-05-21 2008-11-27 University Of Washington Compositions et procédés pour le traitement de troubles respiratoires

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008144720A2 (fr) * 2007-05-21 2008-11-27 University Of Washington Compositions et procédés pour le traitement de troubles respiratoires

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LASKE C ET AL: "Stem cell factor plasma levels are decreased in alzheimer's disease patients with fast cognitive decline after one-year follow-up period: The pythia-study", JOURNAL OF ALZHEIMER'S DISEASE 2011 IOS PRESS NLD, vol. 26, no. 1, 2011, pages 39 - 45, XP008169653, ISSN: 1387-2877 *
M R HORTON ET AL: "Revisiting thalidomide: fighting with caution against idiopathic pulmonary fibrosis", DRUGS OF TODAY, vol. 48, no. 10, 1 October 2012 (2012-10-01), ES, pages 661 - 671, XP055151234, ISSN: 1699-3993, DOI: 10.1358/dot.2012.48.10.1855760 *
PING HE ET AL: "Long-Term Treatment of Thalidomide Ameliorates Amyloid-Like Pathology through Inhibition of [beta]-Secretase in a Mouse Model of Alzheimer's Disease", PLOS ONE, vol. 8, no. 2, 6 February 2013 (2013-02-06), pages e55091, XP055120531, DOI: 10.1371/journal.pone.0055091 *
Q. YE: "Thalidomide reduces IL-18, IL-8 and TNF- release from alveolar macrophages in interstitial lung disease", EUROPEAN RESPIRATORY JOURNAL, vol. 28, no. 4, 1 October 2006 (2006-10-01), pages 824 - 831, XP055120547, ISSN: 0903-1936, DOI: 10.1183/09031936.06.00131505 *

Also Published As

Publication number Publication date
WO2014122638A2 (fr) 2014-08-14
IE20130078A1 (en) 2014-08-13

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