[go: up one dir, main page]

WO2014117205A1 - Procédé et système de mesure clinique de la santé pulmonaire - Google Patents

Procédé et système de mesure clinique de la santé pulmonaire Download PDF

Info

Publication number
WO2014117205A1
WO2014117205A1 PCT/AU2014/000042 AU2014000042W WO2014117205A1 WO 2014117205 A1 WO2014117205 A1 WO 2014117205A1 AU 2014000042 W AU2014000042 W AU 2014000042W WO 2014117205 A1 WO2014117205 A1 WO 2014117205A1
Authority
WO
WIPO (PCT)
Prior art keywords
lung
subject
resistance
imaging
functional measurement
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2014/000042
Other languages
English (en)
Inventor
Andreas Fouras
Stephen Dubsky
Jordan THURGOOD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
Original Assignee
Monash University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013900320A external-priority patent/AU2013900320A0/en
Application filed by Monash University filed Critical Monash University
Publication of WO2014117205A1 publication Critical patent/WO2014117205A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A61B5/085—Measuring impedance of respiratory organs or lung elasticity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7246—Details of waveform analysis using correlation, e.g. template matching or determination of similarity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics
    • A61M2230/46—Resistance or compliance of the lungs

Definitions

  • the present invention relates to the field of clinical measurement of the lung for diagnostic or research applications.
  • the invention relates to dynamic lung health measurement in a human or animal.
  • the present invention is suitable for use in lung function testing for assessing lung function and lung condition.
  • Lung diseases adversely affect airflow during breathing and alter normal lung motion. Specifically, lung diseases change the elasto-mechanical and aero-resistive properties of the lung which in turn alters the airflow in and out of the lung. For example, interstitial fibrosis increases distal airway stiffness, asthma increases airway resistance and emphysema reduces lung tissue recoil thereby increasing its compliance. Although these diseases differ markedly in both cause and consequence, the mechanical properties of diseased regions are invariably impaired and this must also alter motion of these regions.
  • a commonly used clinical measure of lung health is spirometry, which assesses global pulmonary function by measuring the amount (volume) and/or speed (flow) of air that can be inhaled and exhaled.
  • Spirometry is an important tool used for generating pneumo-tachographs and calculating the expiratory time-constant which is the product of lung compliance (elasticity) and resistance. Both are helpful in assessing conditions such as asthma, pulmonary fibrosis, cystic fibrosis and chronic obstructive pulmonary disease.
  • Forced Oscillation Technique is a very popular and successful global lung function test. FOT works by applying an oscillation to the airway opening and then simultaneously measuring the pressure and flow at the airway opening. FOT determines the impedance of the lungs with very limited regional information. This technique is popular for determining the state and function of lung tissue non-invasively by measuring the lungs' reaction to a series of input oscillations. Oscillations are generally in the order of 4-48Hz and as a result any technique to measure the lung response across such a broad range will obviously require very high temporal resolution. For example, US patent 5,318,038 (Jackson et al) describes an infant respiratory impedance measuring apparatus and method that use FOT.
  • Standard imaging techniques such as X-ray Computer Tomography (CT) and Magnetic Resonance Imaging (MRI) imaging during breath-holds provide little or no information on lung motion and cannot detect disease that cause subtle changes in lung structure or function. These approaches are particularly limited by the need to image the lung while it is stationary to minimise blurring.
  • CT X-ray Computer Tomography
  • MRI Magnetic Resonance Imaging
  • MRI and CT have poor temporal resolution preventing them from being used to image the lungs during a dynamic lung test.
  • both MRI and CT are often used to compare the state of the lung at two different time intervals, usually minutes apart. Interpolation is required to deduce lung motion between two steady state conditions within a breath and such methods assume that the motion follows a linear or defined path. This has obvious drawbacks and limits the ability of the techniques to be used for dynamic lung function testing.
  • Clinical gated 4D-CT has also been used for measurement of lung function, including expansion using traditional absorption based imaging at the expense of significant levels of radiation dose.
  • the phase matching is performed to an accuracy of 7.1 % of the breath cycle or 400ms. This results in poor temporal resolution for investigation for the dynamic patterns of motion and expansion within the lung, particularly for small animal studies.
  • Vibration Response Imaging is a technology developed for investigating regional lung function and for diagnosis of conditions.
  • US patent application 2007/0244401 relates to a method and system for assessing an interventional pulmonology procedure including VRI imaging. Images indicative of airflow in at least a portion of the respiratory tract are generated from signals indicative of pressure waves at transducers applied to the skin of a subject. Specifically, the signals are measured before and after the interventional pulmonology procedure and used to generate images for comparison. This technique however, suffers from very poor spatial resolution and is based on measurements taken through the chest wall resulting in poor dynamic range of measurements.
  • EIT Electrical Impedance Tomography
  • US patent application 2011/0054341 (Jeong et al) teaches the use of a spirometer apparatus worn in association with a band around the patient's chest.
  • the band includes a variable resistor with a conductive yarn, the length (and concomitantly the resistance) of which changes according to the change in circumference of the patient's chest during breathing.
  • this apparatus is only capable of measuring resistance globally across the whole lung and provides no regional information. This method is also affected by changes in lung structure, such as the deformation of the lung due to the action of the diaphragm.
  • US patent 5,720,709 (Schnall) teaches the use of an apparatus for measuring airway resistance by short-time occlusion of inhalation.
  • a pneumotachograph is mounted in a narrow airway and connected to recording instrumentation.
  • An elastic balloon is positioned in the inlet channel and manually inflated and deflated with liquid using a syringe. This alternately hinders or allows air to flow through the airway.
  • the information recorded is limited to the airway measured and because it is manually controlled, issues arise in relation to the accuracy, reliability, repeatability and meaning of the measurements.
  • An object of the present invention is to provide improved technology for assessing lung function and diagnosing lung conditions.
  • Another object of the present invention is to provide an improved method for dynamic lung function testing.
  • Another object of the present invention is to provide improved technology for assessing lung function and lung condition in a localised manner.
  • Another object of the present invention is to provide a method and apparatus for measuring regional respiratory impedance using a flow restriction, or resistance to respiration.
  • a further object of the present invention is to alleviate at least one disadvantage associated with the related art. [0025] It is an object of the embodiments described herein to overcome or alleviate at least one of the above noted drawbacks of related art systems or to at least provide a useful alternative to related art systems.
  • a method for investigating a subject lung comprising the steps of (i) applying resistance to respiration of the lung, (ii) carrying out a functional measurement of the lung and (iii) correlating the resistance applied with the functional measurement to obtain information regarding lung function.
  • the functional measurement may, for example, be carried out multiple times in response to changes in resistance. Specifically, at least steps (i) and (ii) may be repeated with the application of different resistance. At least one of the repetitions is preferably zero external resistance. Typically the outcome of the method is a record of volume flow versus resistance, thus providing a measure of lung compliance.
  • the method may include a step of varying another parameter that affects respiration.
  • the inhaled air may include an agonist or antagonist, such as beta-2-adrenergic receptor agonists, methylxanthines or leukotriene antagonists which are used to treat asthma and other pulmonary disease states.
  • the method of the present invention may be carried out each time the subject lung is exposed to a different dosage.
  • a method for investigating a subject lung comprising the steps of (i) applying resistance to respiration of the lung, (ii) carrying out a functional measurement of the lung comprising imaging and, (iii) correlating the resistance applied with the functional measurement to obtain information regarding lung function.
  • Steps (i), (ii) and (iii) may be carried out simultaneously, or in sequence.
  • step (ii) may be carried out simultaneously or subsequently to step (i)
  • step (iv) may be carried out simultaneously or subsequently to step (ii).
  • the present invention includes any convenient functional measurement at one or more locations.
  • the functional measurement is performed with a change in expiratory resistance.
  • the functional measurement is performed with a change in changing resistance to inhalation.
  • an external resistance to respiration typically at the airway opening.
  • the variation of lung mechanics can be assessed.
  • the subject may be made to expire through one or more resistors.
  • the resistors can be located at the subject's mouth to control and change expiratory resistance of the subject.
  • the resistor could also be placed in a specific airway of the subject to restrict only a specific airway or region of the lung.
  • the resistor could be located in place by any convenient method such as via a catheter balloon.
  • a commonly used functional measurement of lung health is the expiratory time constant, which is known to be equal to the product of lung compliance (elasticity) and resistance. It is typically clinically measured by spirometry. External resistance increases the time constant for both inspiration and expiration.
  • resistance is applied to the subject lung during inspiration and expiration. In another preferred embodiment, resistance is applied to inspiration only. In another preferred embodiment resistance is applied to expiration only. [0035] In another preferred embodiment, resistance is applied to both the inspiration and expiration phase of the respiratory cycle, but the functional measurement is only carried out on one of the two phases. In another preferred embodiment, resistance is applied to both the inspiration and expiration phase of the respiratory cycle, and the functional measurement is carried out on one or more expirations, and subsequently, one or more inhalations. The functional measurement typically comprises analysis of the time constant.
  • Resistance Typically, a resistor is used for imparting resistance.
  • the resistor may be any convenient device for modifying the flow of inhaled or exhaled air.
  • the resistor may simply comprise a piece of tubing. However, it is important that the characteristics of the tubing are known and can be accounted for.
  • the resistor may form part of a device that imparts variable resistance at the mouth and measures the time constant at the airway opening.
  • the resistor may comprise, for example a pneumotach type flow device or an impeller flow measurement device with an additive resistance or restriction through which the air must flow.
  • the resistor comprises a valve, such as an iris valve.
  • the resistor may impart a constant level of resistance.
  • the resistor may impart variable resistance.
  • multiple resistors, each of different resistance may be attached to a manifold so that the resistance can be changed.
  • the lung imaging may be any convenient two dimensional or three dimensional lung imaging means including X-ray velocimetry, CTXV, Xe-CT (contrast), hyperpolarised He-MRI scanning (optimally with IM 2 wash-outs), EIT, or the imaging method described in WO 20 1/032210.
  • the lung imaging could provide, for example, multiple independent regions of the lung (ie as many as 2,000 to 1 ,000,000) allowing a functional measurement to be made at each of the 2,000 to 1 ,000,000 localities imaged, instead of being averaged over the entire lung.
  • the lung imaging method described in WO 201 1/032210 would be particularly preferred X-ray technique for the method of the present invention because it would provide a lower radiation dose to the subject as compared with other methods.
  • the preferred non-X-radiation technique is He-MRI scanning however it provides general function information instead of the regional information provides by the technique of WO 201 1/032210
  • any suitable coordinate system could be used for the imaging and data could be converted from one coordinate system to another.
  • Cartesian, cylindrical or polar coordinates could be used, or local coordinates that are oriented to the relevant anatomical features of the lung.
  • the term 'region' or 'regional' is used in the sense of functional information pertaining to an area or locale (such as, for example, a part of the lung, such as a lobe) and may be used in contradistinction to functional information derived from a combination or average of data from multiple regions (such as, for example the entire lung).
  • region or regional may also be based on geometrical or any arbitrary markers and not based on anatomical markers, for example a region may for example be a slice or a block based on image co-ordinates or any co-ordinate system.
  • the present invention may be used to present functional information that is commonly used in scientific and clinical practice but has not hitherto been available regionally, in a manner that is useful and relevant to medical practitioners and clinicians.
  • the present invention permits the extraction and manipulation of data to allow presentation of functional information in a format that is easy to compare and interpret. In particular, it can be made easy to interpret for medical and clinical practitioners, who have become accustomed over time to certain metrics and methods of presentation. In particular it can be used for presentation of regional functional information.
  • this invention is well suited for use in methods of imaging respiratory time constants. Such methods commonly include wash-in and wash-out of gases during CT and MRI imaging. This provides regional information on respiratory time constants within the lungs. For instance this invention may be used in making multiple measurements of respiratory time constants throughout a subject lung for each of several different resistances imposed at the subject's mouth or at a specific location within the lungs. In this manner one or more time constants can be obtained for one or more locations in a subject lung.
  • this invention may also be used for 2D imaging methods such fluoroscopy, or even a 2D variant of a CTXV system.
  • a 2D imaging system is ideally suited to applications where fast imaging is required and patient cooperation is limited, such as in the paediatric environment.
  • a 2D system will provide information of regional lung function, at extremely low radiation dose, and is thus acceptable for use in paediatrics.
  • This technique can also be used in a CTXV scanner as a screening test prior to the full CTXV scan or even during a CTXV scan.
  • Correlation of the functional measurement with the imaging may be carried out, for example, by making a first functional measurement of expiration then changing the expiratory resistance (eg by adding an extra resistor at the subject's mouth during expiration) and making a second functional measurement.
  • the measurements can be expressed as pairs of simultaneous equations and solved for both the compliance and the resistance of the lung at every location imaged.
  • results of correlating the functional measurement with the imaging can be presented in any convenient format including text, graphics or a combination of text and graphics.
  • the method of the present invention may further include the use of a lung model.
  • the one or more images recorded may be applied to a multidimensional lung model so that a multidimensional image field of the subject lung can be reconstructed.
  • the extra information provided by the images adds extra degrees of freedom (parameters) to the model.
  • the resistance and compliance two parameters of the expiratory time constant C
  • Carrying out measurements with and then without resistance allows the resistance and compliance terms to be separated.
  • the resultant output may be averaged across the whole lung.
  • one or more detectors for recording images created by energy from the one or more energy sources passing through a sample; wherein in use, the subject is located intermediate the energy sources and detectors and at least one image is recorded at each of a single, or a plurality of energy projection angles simultaneously with the application of expiratory resistance to the subject.
  • any convenient range of projection angles may be used from 1° to 360°. However, typically the range of projection angles does not reach the extremes of this range. For example, projection angles spaced over as little as 30° or as much as 180° are likely to be suitable.
  • the different energy projection angles may be achieved by moving the subject relative to the energy sources and detectors, or by moving the energy sources and detectors relative to the subject, or a combination thereof.
  • the apparatus for use with the method of the present invention may include a number of other components including, for example, (i) systems for modulating and aligning the source, the target and/or the detector, (ii) systems for image capture, processing and analysis, and (iii) a convenient user interface [0055]
  • systems for modulating and aligning the source, the target and/or the detector including, for example, (i) systems for modulating and aligning the source, the target and/or the detector, (ii) systems for image capture, processing and analysis, and (iii) a convenient user interface
  • Other aspects and preferred forms are disclosed in the specification and/or defined in the appended claims, forming a part of the description of the invention.
  • embodiments of the present invention stem from the realization that improved information relating to lung health can be obtained by changing expiratory resistance of the lung in concert with the use of an imaging technique. More specifically the present invention stems from the realisation that direct in vivo measurement of lung tissue motion (with concomitant accurate measurement of volume and flow, with improved spatial resolution) coupled with a change in resistance, can be used to obtain values for both compliance and resistance of the lung. In particular, the measurements can be obtained for individual regions or locations instead of being averaged out over the entire lung.
  • Figure 1 illustrates a plot of expiratory time constants calculated using 2D X-ray PIV data for seven rabbit pups with data averaged over each lung, which is equivalent to carrying out measurements at the mouth as per traditional spirometry of the prior art.
  • Figure 2 includes plots showing the variation of measured lung time constant with lung height for a preterm rabbit pup under four levels of expiratory resistance with corresponding maps showing regional time constants calculated using X-ray PIV imaging.
  • the lung is a complex and non-homogeneous system. Exhaling through the resistor causes varying changes through out different regions of the lung.
  • the present invention is based on the placing of an external resistor adjacent the lung, varying the degree of resistance and monitoring the effect on the lung. Imaging is a particularly effective means for monitoring the effect. This may be done for example, by carrying out a normal scan, then subsequent scans after each change in resistance.
  • FIG. 1 illustrates a plot of expiratory time constants calculated using 2D X- ray PIV data for the seven pups but with data averaged over each lung.
  • the pups are indicated as follows: Pup 1 0; Pup 2 ⁇ , Pup 3 A ; Pup 4 x; Pup 5 *; Pup 7 ⁇ ; and Pup 8 +.
  • the data obtained is equivalent to carrying out measurements at the mouth as per traditional spirometry of the prior art. Different degrees of airway resistance were applied by having the pups breath through tubes of different lengths.
  • Figure 2 includes graphs showing the variation of measured lung expiratory time constant (x-axis) with lung height (y-axis) for (i) low, (ii) moderately low, (iii) normal and (iii) high additional airway resistance. Each graph is adjacent a corresponding map showing regional time constant calculated via X-ray PIV imaging methodologies.
  • Figure 2 illustrates how, as resistance is increased there is decreasing homogeneity of the lung, with air taking longer to expire from the top of the lungs (apex) than the bottom (base). This relationship allows us to solve for the resistance and compliance of the lung on a regional basis. A minimum of only two resistance measurements are actually required.
  • the expiratory time constant has been measured at the same time as carrying out imaging sequences.
  • the expiratory time constant is the time taken to expel 63% of lung volume. In rabbit lungs this has shown a shift in behaviour which can be used to measure resistance ( * ) and compliance (c) - two parameters of the expiratory time constant (C).
  • the value C is relatively constant across the lung. Potentially, C could be measured across the lung from the aforementioned method, especially if the properties of resistance across the lung are known.
  • a spatial model for r and c can be calculated throughout the lung.
  • r may vary from one part of the lung to another and trending can be used. Accordingly, it is not necessary to make large numbers of scans in multiple regions because predictive or trending tools can be used.
  • This application is intended to cover any variations uses or adaptations of the invention following in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains and as may be applied to the essential features hereinbefore set forth.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

L'invention concerne un procédé d'évaluation d'un poumon d'un sujet. Le procédé consiste à : (i) appliquer une résistance à la respiration du poumon, (ii) effectuer une mesure fonctionnelle du poumon et (iii) mettre en corrélation la résistance appliquée à la mesure fonctionnelle pour obtenir des informations concernant la fonction pulmonaire.
PCT/AU2014/000042 2013-02-01 2014-01-24 Procédé et système de mesure clinique de la santé pulmonaire Ceased WO2014117205A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2013900320 2013-02-01
AU2013900320A AU2013900320A0 (en) 2013-02-01 Method and System for Clinical Measurement of Lung Health

Publications (1)

Publication Number Publication Date
WO2014117205A1 true WO2014117205A1 (fr) 2014-08-07

Family

ID=51261303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2014/000042 Ceased WO2014117205A1 (fr) 2013-02-01 2014-01-24 Procédé et système de mesure clinique de la santé pulmonaire

Country Status (1)

Country Link
WO (1) WO2014117205A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021505258A (ja) * 2017-12-08 2021-02-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 振動暗視野撮像

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6631716B1 (en) * 1998-07-17 2003-10-14 The Board Of Trustees Of The Leland Stanford Junior University Dynamic respiratory control
WO2011032210A1 (fr) * 2009-09-16 2011-03-24 Monash University Vélocimétrie d'images de particules pour imagerie de projection aux rayons x

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6631716B1 (en) * 1998-07-17 2003-10-14 The Board Of Trustees Of The Leland Stanford Junior University Dynamic respiratory control
WO2011032210A1 (fr) * 2009-09-16 2011-03-24 Monash University Vélocimétrie d'images de particules pour imagerie de projection aux rayons x

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KACZKA, D ET AL.: "Analysis of Regional Mechanics in Canine Lung Injury Using Forced Oscillations and 3D Image Registration", ANNALS OF BIOMEDICAL ENGINEERING, vol. 39, no. 3, 2011, pages 1112 - 1124 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021505258A (ja) * 2017-12-08 2021-02-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 振動暗視野撮像

Similar Documents

Publication Publication Date Title
US11317815B2 (en) Sensor device for electrical impedance tomography imaging, electrical impedance tomography imaging instrument and electrical impedance tomography method
AU2017248470B2 (en) Heart imaging method
CN110087540B (zh) 用于肺功能测试的方法和设备
US10952634B2 (en) Electrical impedance tomography system
EP2194863B1 (fr) Procédé et dispositif de mesure d'absorption/de perfusion d'oxygène dans une région
JP6321548B2 (ja) 被験者の個人的胸部パラメータの導出
US20030055331A1 (en) Methods of endobronchial diagnosis using imaging
WO2005089651A1 (fr) Procede de commande de recueil de donnees d’image et dispositif de recueil de donnees d’image
JP2006512961A (ja) コンピュータ断層撮影のための呼吸モニタ
DK2925227T3 (en) ANALYSIS OF RESPIRATORY DATA
Fuld et al. Systems for lung volume standardization during static and dynamic MDCT-based quantitative assessment of pulmonary structure and function
US20160354269A1 (en) Method and system for imaging
EP3057509B1 (fr) Système de contrôle de flux sanguin et méthodes d'imagerie in vivo ainsi qu'applications autres
WO2019118462A1 (fr) Systèmes, procédés et supports lisibles par ordinateur pour estimer un mouvement de la cavité thoracique pendant la respiration
CN105050502B (zh) 用于根据图像数据确定呼吸体积信号的装置和方法
CN110623668A (zh) 一种用于肺顺应性定量评价的快速磁共振成像方法
CN114144116A (zh) 一种获得x射线图像的方法
WO2014117205A1 (fr) Procédé et système de mesure clinique de la santé pulmonaire
Liu et al. Universal Modeling Method of Electrical Impedance Response During Respiration
Izawa et al. A Method of Vital Capacity Measurement Using Three-Dimensional Depth Sensor
Frerichs et al. Electrical impedance tomography in acute respiratory distress syndrome
Putensen et al. Electrical impedance tomography for monitoring of regional ventilation in critically III patients
Dasgupta et al. A Review of Instrumentation for Lung Volume Estimation for Diagnosis of Pulmonary Disorders
Cinel et al. Dynamic lung imaging techniques in mechanically ventilated patients

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14746355

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14746355

Country of ref document: EP

Kind code of ref document: A1