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WO2014114838A3 - Procedimiento para la fabricación de un microencapsulado y compuesto anfifílico reactivo, microencapsulado y composición correspondientes - Google Patents

Procedimiento para la fabricación de un microencapsulado y compuesto anfifílico reactivo, microencapsulado y composición correspondientes Download PDF

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Publication number
WO2014114838A3
WO2014114838A3 PCT/ES2014/070046 ES2014070046W WO2014114838A3 WO 2014114838 A3 WO2014114838 A3 WO 2014114838A3 ES 2014070046 W ES2014070046 W ES 2014070046W WO 2014114838 A3 WO2014114838 A3 WO 2014114838A3
Authority
WO
WIPO (PCT)
Prior art keywords
microencapsulate
amphiphilic compound
polymer
composition
functional groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2014/070046
Other languages
English (en)
French (fr)
Other versions
WO2014114838A2 (es
Inventor
Josep Rocas Sorolla
Pau ROCAS ALONSO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ecopol Tech SL
Original Assignee
Ecopol Tech SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopol Tech SL filed Critical Ecopol Tech SL
Priority to EP14708924.7A priority Critical patent/EP2992953B1/en
Priority to US14/762,876 priority patent/US20150367312A1/en
Priority to ES14708924T priority patent/ES2884161T3/es
Priority to DK14708924.7T priority patent/DK2992953T3/da
Publication of WO2014114838A2 publication Critical patent/WO2014114838A2/es
Publication of WO2014114838A3 publication Critical patent/WO2014114838A3/es
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/14—Derivatives of isocyanic acid containing at least two isocyanate groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Materials Engineering (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polyurethanes Or Polyureas (AREA)

Abstract

Procedimiento para la fabricación de un microencapsulado y compuesto anfifílico reactivo, microencapsulado y composición correspondientes. Procedimiento para la fabricación de un microencapsulado/nanoencapsulado polimérico y anfifílico, altamente funcionalizable y versátil, que comprende 2 etapas: dispersar una primera fase líquida en una segunda fase líquida formando una emulsión, de manera que dicha primera fase quede dispersa en dicha segunda fase, y polimerizar un polímero que forma la pared del microencapsulado. Entre ambas fases se forma una interfase con un compuesto anfifílico reactivo, que es un prepolímero del polímero. El compuesto anfifílico tiene dos o más grupos funcionales principales que reaccionan en la posterior polimerización para la formación del polímero. Estos dos grupos funcionales principales están separados entre sí entre 4 y 12 eslabones. El compuesto anfifílico tiene por lo menos un grupo funcional hidrófilo o hidrófobo en una cadena que es lateral respecto de la cadena que une ambos grupos funcionales principales.
PCT/ES2014/070046 2013-01-25 2014-01-23 Procedimiento para la fabricación de un microencapsulado y compuesto anfifílico reactivo, microencapsulado y composición correspondientes Ceased WO2014114838A2 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP14708924.7A EP2992953B1 (en) 2013-01-25 2014-01-23 Method for producing a microencapsulate, microencapsulate and composition.
US14/762,876 US20150367312A1 (en) 2013-01-25 2014-01-23 Method for producing a microencapsulate and corresponding reactive amphiphilic compound, microencapsulate and composition
ES14708924T ES2884161T3 (es) 2013-01-25 2014-01-23 Procedimiento para la fabricación de un microencapsulado, microencapsulado y composición
DK14708924.7T DK2992953T3 (da) 2013-01-25 2014-01-23 Fremgangsmåde til fremstilling af en mikroindkapsling, mikroindkapsling og sammensætning

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201330086 2013-01-25
ES201330086A ES2480343B1 (es) 2013-01-25 2013-01-25 Procedimiento para la fabricación de un microencapsulado y compuesto anfifílico reactivo, microencapsulado y composición correspondientes

Publications (2)

Publication Number Publication Date
WO2014114838A2 WO2014114838A2 (es) 2014-07-31
WO2014114838A3 true WO2014114838A3 (es) 2015-03-05

Family

ID=50239666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2014/070046 Ceased WO2014114838A2 (es) 2013-01-25 2014-01-23 Procedimiento para la fabricación de un microencapsulado y compuesto anfifílico reactivo, microencapsulado y composición correspondientes

Country Status (5)

Country Link
US (1) US20150367312A1 (es)
EP (1) EP2992953B1 (es)
DK (1) DK2992953T3 (es)
ES (2) ES2480343B1 (es)
WO (1) WO2014114838A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109925553A (zh) * 2017-12-18 2019-06-25 光宝电子(广州)有限公司 血液透析器及其制造方法
CN109107499B (zh) * 2018-07-30 2021-02-02 浙江工业大学 一种用于疏水染料缓释的聚合物微胶囊的制备方法
CN109397803A (zh) * 2018-09-10 2019-03-01 天津大学 新型透气除臭抗菌垫
CN113040139B (zh) * 2021-03-29 2022-06-24 中国农业科学院植物保护研究所 一种噻呋酰胺纳米囊及其制备方法
CN113198399B (zh) * 2021-05-20 2022-09-06 吉林建筑大学 一种相变微胶囊及其制备方法和应用、复合ab涂料
WO2022253483A1 (en) * 2021-06-03 2022-12-08 Ecopol Tech S.L. Nanotechnological platform based on polyurethane/polyurea chemistry to furnish water-oil-water multi walled and functionalizable nanocapsules and their preparation process

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875074A (en) * 1972-03-06 1975-04-01 Champion Int Corp Formation of microcapsules by interfacial cross-linking of emulsifier, and microcapsules produced thereby
GB2135469A (en) * 1983-02-14 1984-08-30 Konishiroku Photo Ind Microcapsule type toner
WO2001019509A1 (en) * 1999-09-10 2001-03-22 Zeneca Limited Variable release microcapsules
US20020040065A1 (en) * 2000-06-05 2002-04-04 Scher Herbert Benson Novel emulsions
US20040197357A1 (en) * 2001-06-11 2004-10-07 Heming Alexander Mark Use of reactive polymeric surfactants in the formation of emulsions
US20070166697A1 (en) * 2005-12-30 2007-07-19 Applera Corporation Synthesis and use of cross-linked hydrophilic hollow spheres for encapsulating hydrophilic cargo
US20070270508A1 (en) * 2006-03-30 2007-11-22 Liu Leo Z Reactive monomeric surfactants
WO2008021800A2 (en) * 2006-08-15 2008-02-21 Syngenta Participations Ag Method for preventing crystallization
CN102198386A (zh) * 2010-03-24 2011-09-28 青岛科技大学 聚氨酯纳米胶囊相变材料的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4130743A1 (de) * 1991-09-16 1993-03-18 Bayer Ag Mikrokapseln aus isocyanaten mit polyethylenoxidhaltigen gruppen
US6262152B1 (en) 1998-10-06 2001-07-17 E. I. Du Pont De Nemours And Company Particles dispersed w/polymer dispersant having liquid soluble and cross-linkable insoluble segments
WO2011084106A1 (en) * 2010-01-06 2011-07-14 Agency For Science, Technology And Research Novel amphiphiles
ES2361311B1 (es) * 2011-04-14 2012-02-21 Ecopol Tech, S.L. Procedimiento para la fabricación de un microencapsulado de un principio activo hidrófobo y microencapsulado y composiciones correspondientes.

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875074A (en) * 1972-03-06 1975-04-01 Champion Int Corp Formation of microcapsules by interfacial cross-linking of emulsifier, and microcapsules produced thereby
GB2135469A (en) * 1983-02-14 1984-08-30 Konishiroku Photo Ind Microcapsule type toner
WO2001019509A1 (en) * 1999-09-10 2001-03-22 Zeneca Limited Variable release microcapsules
US20020040065A1 (en) * 2000-06-05 2002-04-04 Scher Herbert Benson Novel emulsions
US20040197357A1 (en) * 2001-06-11 2004-10-07 Heming Alexander Mark Use of reactive polymeric surfactants in the formation of emulsions
US20070166697A1 (en) * 2005-12-30 2007-07-19 Applera Corporation Synthesis and use of cross-linked hydrophilic hollow spheres for encapsulating hydrophilic cargo
US20070270508A1 (en) * 2006-03-30 2007-11-22 Liu Leo Z Reactive monomeric surfactants
WO2008021800A2 (en) * 2006-08-15 2008-02-21 Syngenta Participations Ag Method for preventing crystallization
CN102198386A (zh) * 2010-03-24 2011-09-28 青岛科技大学 聚氨酯纳米胶囊相变材料的制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 201257, 29 September 2011 Derwent World Patents Index; AN 2011-N72619, XP002726860 *
LIN J J ET AL: "Phase inversion of self-aggregating Mannich amines with poly(oxyethylene) segments", JOURNAL OF COLLOID AND INTERFACE SCIENCE, ACADEMIC PRESS, NEW YORK, NY, US, vol. 258, no. 1, 1 February 2003 (2003-02-01), pages 155 - 162, XP027136630, ISSN: 0021-9797, [retrieved on 20030201] *

Also Published As

Publication number Publication date
ES2480343A1 (es) 2014-07-25
ES2480343B1 (es) 2015-05-20
WO2014114838A2 (es) 2014-07-31
EP2992953B1 (en) 2021-05-26
US20150367312A1 (en) 2015-12-24
ES2884161T3 (es) 2021-12-10
EP2992953A2 (en) 2016-03-09
DK2992953T3 (da) 2021-07-26

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