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WO2014196940A2 - Agent de scellement antimicrobien au bore - Google Patents

Agent de scellement antimicrobien au bore Download PDF

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Publication number
WO2014196940A2
WO2014196940A2 PCT/TR2014/000145 TR2014000145W WO2014196940A2 WO 2014196940 A2 WO2014196940 A2 WO 2014196940A2 TR 2014000145 W TR2014000145 W TR 2014000145W WO 2014196940 A2 WO2014196940 A2 WO 2014196940A2
Authority
WO
WIPO (PCT)
Prior art keywords
joint sealant
spp
borate
sealant material
material according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2014/000145
Other languages
English (en)
Other versions
WO2014196940A3 (fr
Inventor
Fikrettin Sahin
Selami DEMIRCI
Zeynep USTAOGLU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeditepe Universitesi
Original Assignee
Yeditepe Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeditepe Universitesi filed Critical Yeditepe Universitesi
Priority to EP14739271.6A priority Critical patent/EP3003043A2/fr
Publication of WO2014196940A2 publication Critical patent/WO2014196940A2/fr
Publication of WO2014196940A3 publication Critical patent/WO2014196940A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/14—Boron; Compounds thereof

Definitions

  • the present invention relates to an antimicrobial joint sealant obtained by adding boron derivatives therein.
  • Microorganisms such as molds, yeasts and bacteria can live on all known surfaces. These organisms, which are primary and opportunistic pathogens, lead to clinical diseases dangerous to humans.
  • Surface adsorption characteristic of the microorganisms is the main aspect that supports microbial life on surfaces. Microorganisms which adsorb to the surface proliferate by using the moisture in the air together with the inorganic and organic nutrients on the surfaces. Microorganisms, whose quantity has risen above a certain level, even if they are not primary pathogens, may be dangerous for individuals especially in hospital environments in which there are patients with suppressed or weak immune systems. Contaminated surfaces transfer their microbial loads to humans via inhalation, touching or nutrition. Especially contamination of the surfaces in hospitals increases hospital -acquired infection risks and affects mortality rate and hospitalization time (Sawrtz, 1994).
  • Bacteria and fungi can be shown as the most important reason for environmental diseases, epidemics, acute and chronic allergic risks not only in hospital environment but also in all of the other living spaces. It is observed that particularly molds and yeasts are isolated from all surfaces mainly toilet, bathroom and kitchen surfaces in previous studies. Hamada and Abe (2010) have reported in their study that they have isolated the fungal species such as Ramicloridium strelitzi e, Cyphellophora laciniata, Phoma fimeti, and Exophiala spp. from the bathroom surfaces even under different conditions. Proliferation of these microorganisms above a certain number increases the risk of infection and acute and chronic allergies. Many studies have shown that being exposed to fungus such as Alternaria spp.
  • Joint sealant powder made into a grout by mixing with an adequate amount of water, is used for filling in the spaces between the tiles applied on the wall or floor. Due to the cement it contains, the joint sealant grout dries and holds on to the area on which it is applied and ensures that no space remains between the tiles. Although the surface of the tile is water, oil and dust repellent, since the joint sealant between the tiles does not have this characteristic, all of the wastes accumulate on the surface of the joint sealant. These areas satiated with organic wastes and water become an extremely convenient area for microbial growth. Microorganisms settling on material surfaces, in addition to leading to infections, cause materials to wear out and deteriorate.
  • Microorganisms proliferate by using organic and inorganic components on materials in addition to the humidity in the air. During reproduction, they damage the structure of materials in different ways and make them dysfunctional. Thousands of health-threatening microorganisms varying according to temperature and humidity rate have been isolated from all of the surfaces and objects inside the house (Reponen et al., 2001). Microorganisms, which can proliferate at any place where they can access humidity and nutrients, cause abrasion on surfaces with the damaging end products they produce both due to using the organic and inorganic nutrients on the surface that they are growing and as a result of their metabolic activities. Thus, this type of surface abrasions may cause significant financial losses. It was determined that microbial abrasion is higher particularly at regions with high humidity rate.
  • boric acid has antibacterial activity on enteric bacteria.
  • Antimicrobial agents containing boron were applied on gram negative bacteria (Escherichia coli and Proteus mirabilis) and they were found to be effective.
  • boric esters have broad spectrum antibacterial activity. They have discovered in their study that boric esters inhibit DNA methyl transferase in gram negative and positive bacteria.
  • Reynold et al. (2007) showed that lipophilic 2,4-diamino-6-methylpyrimidine antifolate compound comprising two different borons has moderate antibacterial activity against the bacteria Mycobacterium avium and Lactobacillus case. In addition to these, it is shown that some boron derivatives have antifungal activities.
  • Qin et al. (2007) showed that potassium tetraborate has an inhibitory effect on micelle growth of Penicillium expansium.
  • the International patent document no. WO2006084161 discloses antimicrobial granules for use in various surface coating and grouting materials.
  • the boron added compositions in the state of the art are antibacterial whereas a study on antimicrobial (antibacterial + antifungal + anticandidal) joint sealant is not encountered.
  • An objective of the present invention is to provide an antimicrobial joint sealant containing boron derivatives.
  • Another objective of the present invention is to provide a joint sealant material which provides protection against microbial decomposition, corrosion and decay on the products and surfaces obtained by using antimicrobial joint sealant.
  • a further objective of the present invention is to provide a long lasting joint sealant which prevents the yellowing and discoloration resulting from microbial growth.
  • Table 1 shows the results of the modified disc diffusion test conducted with joint sealant materials containing/not containing Zinc Borate (1/10 w/w).
  • Table 2 shows the results of the modified disc diffusion test conducted with joint sealant materials containing/not containing Sodium Borate (1/10 w/w).
  • Table 3 shows the results of the modified disc diffusion test conducted with joint sealant materials containing/not containing Potassium Borate (1/10 w/w).
  • the boron derivatives used in the experimental studies were sodium borate ((Na 2 O)(B 2 O 3 )5.10H 2 O), zinc borate (2Zn0.3B 2 0 3 .3.5H 2 0) and potassium borate ( ⁇ 2 ⁇ 4 ⁇ 7.4 ⁇ 2 0).
  • Modified disc diffusion test was employed in the antimicrobial activity tests.
  • At least one of sodium borate ((Na 2 O)(B 2 O 3 ) 5 .10H 2 O), zinc borate (2Zn0.3B 2 0 3 .3.5H 2 0) or potassium borate (K 2 B 4 0 7 .4H 2 0) boron derivatives in mineral form was mixed with a commercially available joint sealant at a ratio of 0,5- 20% (w/w). The homogenous mixtures were subjected to antimicrobial activity tests.
  • boric acid alkaline or alkaline earth metal borates
  • lithium borates such as lithium tetra borate, lithium metaborate, lithium pentaborate
  • sodium borates such as sodium metaborate, sodium hexaborate, sodium tetraborate, sodium octaborate
  • potassium borates such as potassium tetraborate, potassium metaborate, potassium hexaborate, potassium octaborate
  • calcium borates such as calcium diborate, calcium metaborate, calcium tetraborate, tricalcium tetraborate, pentacalcium tetraborate, calcium hexaborate
  • magnesium borates such as magnesium metaborate, magnesium diborate, trimagnesium tetraborate, pentamagnesium tetraborate) or all hydrate forms thereof, ammonium borates (ammonium metaborate,
  • Standard NCCLS disc diffusion method (Lalitha and Vellore, 2005) with modifications was used to determine the antimicrobial activity of zinc borate and sodium borate on each microorganism tested.
  • the lOOul solution containing 10 8 cfu/ml bacteria, 10 6 cfu/ml yeast and 10 4 spor/ml mold was prepared with new cultures and was inoculated on Nutrient Agar (NA), Sabouraud Dextrose Agar (SDA) and Potato Dextrose Agar (PDA), respectively. 20 ⁇ 1 of sterile water was dropped on the empty discs and it was separately immersed into the joint sealant compositions comprising pulverized zinc borate, sodium borate and potassium borates at a concentration of 0.5-10% (w/w).
  • the discs coded with the boron containing joint sealant materials were placed on inoculated petri dishes. Empty discs with 20ul drop of sterile water were used as negative control. Ofloxacin (10 ⁇ g/disc) and nystatin (30 ⁇ g/disc) were used as positive control groups for bacteria and fungi, respectively.
  • the joint sealant material containing sodium, potassium and zinc borate, applied at specific ratios, was determined to be effective against all tested microorganisms by the modified disc diffusion method, and the results are given in Table 1, 2, and 3.
  • a shows that the applied Sodium-Borate ratio is weight/weight
  • b + mark shows that joint sealant formulation produced inhibition zone.
  • - mark shows that joint sealant formulation did not produce inhibition zone.
  • a shows that the applied Potassium-Borate ratio is weight/weight
  • b + mark shows that joint sealant formulation produced inhibition zone.
  • - mark shows that joint sealant formulation did not produce inhibition zone.
  • Antimicrobial activity of the homogenous mixture (boron- joint sealant) containing/non-containing boron derivatives on microorganisms were determined by the modified disc diffusion test. It was found that the mixture prepared at a ratio of 1/10 (w/w) by all three boron derivatives exhibited antimicrobial effect. It was determined that the joint sealant mixture obtained with sodium, zinc and potassium borates were antibacterial (for bacteria), anticandidal (for yeasts) and antifungal (for fungi).
  • Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Botrytis spp., Aspergillus spp., Penicillium spp., Fusarium spp., Alternaria spp., Penicillium spp., and Candida spp. could be controlled by means of the boron derivatives added to the joint sealant materials.
  • the surfaces of all kinds of raw materials and semi finished products produced from the joint sealant material of the present invention provide protection against microbial contamination and degradation, corrosion and decay.
  • the present invention can be applied to cement, concrete, gypsum, liquid or powder paint, prefabrication materials gunite, glue, adhesive, polish or plaster instead of the joint sealant.
  • Antibacterial Agents Effects on Growth and Morphology of Bacteria Under Various Culture Conditions". Antimicrobial Agents and Chemotherapy, 17, 549, 1980.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Inorganic Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Sealing Material Composition (AREA)

Abstract

La présente invention concerne l'obtention d'un agent de scellement par addition de bore à ses composés. Les surfaces de toutes sortes de matières premières et de produits semi-finis formés à partir du matériau de l'agent de scellement de la présente invention sont protégées contre la contamination et la dégradation microbienne, la corrosion et la pourriture. Dans l'invention, il est déterminé que Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Botrytis spp., Aspergillus spp., Penicillium spp., Fusarium spp., Alternaria spp., Penicillium spp., and Candida spp. peuvent être contrôlés en ajoutant à l'agent de scellement du borate de sodium ((Na2O)(B2O3)5.10H2O), du borate de zinc (2ZnO.3B2O3.3.5H2O) et du borate de potassium (K2B4O7.4H2O) en tant que dérivés du bore.
PCT/TR2014/000145 2013-06-03 2014-06-03 Agent de scellement antimicrobien au bore Ceased WO2014196940A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14739271.6A EP3003043A2 (fr) 2013-06-03 2014-06-03 Agent de scellement antimicrobien au bore

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2013/06616 2013-06-03
TR201306616 2013-06-03

Publications (2)

Publication Number Publication Date
WO2014196940A2 true WO2014196940A2 (fr) 2014-12-11
WO2014196940A3 WO2014196940A3 (fr) 2015-02-26

Family

ID=51179129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2014/000145 Ceased WO2014196940A2 (fr) 2013-06-03 2014-06-03 Agent de scellement antimicrobien au bore

Country Status (2)

Country Link
EP (1) EP3003043A2 (fr)
WO (1) WO2014196940A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021029836A1 (fr) 2019-08-09 2021-02-18 Safaş Saf Plasti̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Mousse de polyuréthane souple modifiée au bore pour l'hygiène et son procédé de production

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9223636D0 (en) * 1992-11-11 1992-12-23 Vispak Ltd Sealants
JP3339772B2 (ja) * 1995-11-30 2002-10-28 住友ベークライト株式会社 エポキシ樹脂組成物
JP2001278863A (ja) * 2000-01-26 2001-10-10 Yoshitomi Fine Chemicals Ltd ピリチオン含有組成物の変色防止または改善方法および変色が防止された組成物
US8715540B2 (en) * 2002-01-16 2014-05-06 MG3 Technologies Inc. Aqueous and dry duel-action flame and smoke retardant and microbe inhibiting compositions, and related methods
US8067321B2 (en) * 2008-05-21 2011-11-29 Icl Performance Products, Lp Sodium-potassium hexametaphosphate and potassium metaphosphate with a low insolubles content
US20100003345A1 (en) * 2008-07-02 2010-01-07 Kamlesh Gaglani Synergistic antimicrobial mixtures
US8772334B2 (en) * 2008-07-02 2014-07-08 Kamlesh Gaglani Synergistic antimicrobial mixtures
CN104204340A (zh) * 2011-11-16 2014-12-10 巴克托根生物科技产品工业和贸易公司 抗微生物纺织品

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021029836A1 (fr) 2019-08-09 2021-02-18 Safaş Saf Plasti̇k Sanayi̇ Ve Ti̇caret Anoni̇m Şi̇rketi̇ Mousse de polyuréthane souple modifiée au bore pour l'hygiène et son procédé de production

Also Published As

Publication number Publication date
EP3003043A2 (fr) 2016-04-13
WO2014196940A3 (fr) 2015-02-26

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