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WO2014195730A3 - Auto-antigen biomarkers for lupus - Google Patents

Auto-antigen biomarkers for lupus Download PDF

Info

Publication number
WO2014195730A3
WO2014195730A3 PCT/GB2014/051760 GB2014051760W WO2014195730A3 WO 2014195730 A3 WO2014195730 A3 WO 2014195730A3 GB 2014051760 W GB2014051760 W GB 2014051760W WO 2014195730 A3 WO2014195730 A3 WO 2014195730A3
Authority
WO
WIPO (PCT)
Prior art keywords
auto
lupus
antibodies
biomarkers
antigen biomarkers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2014/051760
Other languages
French (fr)
Other versions
WO2014195730A2 (en
Inventor
Timothy VYSE
Michael Bernard Mcandrew
Colin Henry Wheeler
Jens-Oliver Koopmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kings College London
Sense Proteomic Ltd
Original Assignee
Kings College London
Sense Proteomic Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kings College London, Sense Proteomic Ltd filed Critical Kings College London
Publication of WO2014195730A2 publication Critical patent/WO2014195730A2/en
Publication of WO2014195730A3 publication Critical patent/WO2014195730A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104—Lupus erythematosus [SLE]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The presence of certain auto-antibodies indicates that a subject has lupus. The auto-antibodies recognise antigens listed in Table 1 herein. These auto-antibodies and/or the antigens themselves can be used as biomarkers for assessing lupus in a subject.
PCT/GB2014/051760 2013-06-07 2014-06-06 Auto-antigen biomarkers for lupus Ceased WO2014195730A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1310216.5 2013-06-07
GB201310216A GB201310216D0 (en) 2013-06-07 2013-06-07 SLE(IV): Auto-antigen biomarkers for lupus

Publications (2)

Publication Number Publication Date
WO2014195730A2 WO2014195730A2 (en) 2014-12-11
WO2014195730A3 true WO2014195730A3 (en) 2015-03-12

Family

ID=48875961

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2014/051760 Ceased WO2014195730A2 (en) 2013-06-07 2014-06-06 Auto-antigen biomarkers for lupus

Country Status (2)

Country Link
GB (1) GB201310216D0 (en)
WO (1) WO2014195730A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10928398B2 (en) * 2008-12-17 2021-02-23 Cornell University Method for double staining colocalized nuclear-markers in histological lymphoid or bone marrow tissue sample
EP3090064B1 (en) 2013-12-31 2019-11-13 Yeda Research and Development Co. Ltd. Diagnosis of systemic lupus erythematosus using oligonucleotides antigens
WO2016139659A1 (en) * 2015-03-01 2016-09-09 Immunarray Ltd. Diagnosis of systemic lupus erythematosus using protein, peptide and oligonucleotide antigens
US20180231565A1 (en) * 2015-08-09 2018-08-16 Immunarray Ltd Methods for determining the risk of a systemic lupus erythematosus (sle) patient to develop neuropsychiatric syndromes
CN107290539B (en) * 2017-06-07 2019-06-07 哈尔滨医科大学 For detecting peptide composition and its application of Serum of Patients With Autoimmune Diseases blood serum designated object
CN109142730B (en) * 2018-06-14 2021-04-23 郑州大学第一附属医院 A kind of lung cancer marker anti-PSIP1 autoantibody and its application
US20210349094A1 (en) * 2020-05-11 2021-11-11 Musc Foundation For Research Development Detection of autoreactive fecal immunoglobulin a (iga) for diagnosis of lupus

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010023837A1 (en) * 2008-08-27 2010-03-04 Oncotherapy Science, Inc. Breast cancer related gene rqcd1
US20100273671A1 (en) * 2007-03-01 2010-10-28 Universite Catholique De Louvain Method for the determination and the classification of rheumatic conditions
WO2012049664A2 (en) * 2010-10-15 2012-04-19 Sense Proteomic Limited Auto-antigen biomarkers for lupus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100273671A1 (en) * 2007-03-01 2010-10-28 Universite Catholique De Louvain Method for the determination and the classification of rheumatic conditions
WO2010023837A1 (en) * 2008-08-27 2010-03-04 Oncotherapy Science, Inc. Breast cancer related gene rqcd1
WO2012049664A2 (en) * 2010-10-15 2012-04-19 Sense Proteomic Limited Auto-antigen biomarkers for lupus

Also Published As

Publication number Publication date
GB201310216D0 (en) 2013-07-24
WO2014195730A2 (en) 2014-12-11

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