[go: up one dir, main page]

WO2014190331A2 - Biocapteurs utilisant la spectroscopie raman nanophotonique - Google Patents

Biocapteurs utilisant la spectroscopie raman nanophotonique Download PDF

Info

Publication number
WO2014190331A2
WO2014190331A2 PCT/US2014/039457 US2014039457W WO2014190331A2 WO 2014190331 A2 WO2014190331 A2 WO 2014190331A2 US 2014039457 W US2014039457 W US 2014039457W WO 2014190331 A2 WO2014190331 A2 WO 2014190331A2
Authority
WO
WIPO (PCT)
Prior art keywords
waveguide
raman
light
optical
coupled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/039457
Other languages
English (en)
Other versions
WO2014190331A3 (fr
Inventor
Michal Lipson
Christopher PHARE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell University
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Publication of WO2014190331A2 publication Critical patent/WO2014190331A2/fr
Publication of WO2014190331A3 publication Critical patent/WO2014190331A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0256—Compact construction
    • G01J3/0259—Monolithic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band

Definitions

  • the base unit includes a waveguide optically coupled to the coherent light source to carry the emitted light beam to an interface with the sensing unit and collect Raman scattered light travelling in the opposite direction from the interface, an optical filter coupled to the waveguide to filter the collected Raman scattered light, and an optical detector coupled to the optical filter to detect a Raman spectrum of the collected Raman scattered light.
  • the sensing unit includes a slot waveguide resonator optically coupled to the waveguide at the interface and to enhance the Raman scattered light generated based on the presence of the substance in the fluid,
  • the waveguide structure includes a slot waveguide configured to enhance the Raman scattering interaction by focusing the probe light strongly inside and in close proximity of the slot region of the slot waveguide.
  • Techniques, systems, and devices are disclosed for optically detecting or sensing one or more biological, chemical, biochemical or other substances to obtain Raman scattering signals from such one or more substances.
  • the specific examples provided use a Iluid as a sample that contains the one or more substances to be detected.
  • the disclosed technology can be implemented in various configurations including a biosensor system for optically detecting a fluid that is configured to include a base unit to direct probe light to the target sample and to detect signal light from the target sample and a sensing unit that holds the target sample and to provide the optical interaction between the probe light and the target sample.
  • the waveguide is optically coupled to receive the emitted light beam from the light source to carr the emitted light beam to an interface with the sensing unit to collect Raman scattered light travelling in the opposite direction from the interface.
  • the optical filter is coupled to the waveguide to receive and filter the collected Raman scattered light
  • the optical detector is coupled to the optical filter to detect a Raman spectrum of the collected Raman scattered light.
  • the waveguide resonator may be a slot waveguide resonator to increase an optical field of the emitted light beam interacting with the fluid to enhance the Raman scattered light.
  • Such and other structures can be designed to provide a sensitive micro-Raman spectrometer based on high confinement nanometer-scale photonic structures, e.g., which enhances the sensitivity while maintaining a compact size.
  • Raman spectroscopy is a molecular spectroscopy technique that is sensitive to analyte composition. Molecules have individual Raman fingerprints, so their composition and concentration can be measured even in complex mixtures, without separate chemical markers. The Raman signature of glucose, and any other molecule of interest, is unique and can easily be isolated from the environment. The Raman spectroscopy based detection technique is extremely promising for the detection of analytes in general in a "dirty" medium (e.g., such as body fluids) without the need for pre-filtering.
  • a "dirty" medium e.g., such as body fluids
  • the disclosed chip-scale sensing system/platform can be fully portable (e.g., size of fully packaged device can be configured to be ⁇ 3 cm x 3 cm) and can include both a fixed analysis unit (e.g., containing a fixed chip, electronics and display) and one or more disposable sensing "chips" or “strips" receiving biological fluid samples, including but not limited to blood, saliva, and urine.
  • a fixed analysis unit e.g., containing a fixed chip, electronics and display
  • disposable sensing "chips" or “strips” receiving biological fluid samples, including but not limited to blood, saliva, and urine.
  • FIG. 3A shows a scanning electron microscopy (8EM) image of an exemplary silicon slotted micro-ring resonator 302 used in the exemplary chip-scale sensing systems and techniques.
  • the inset image of FIG. 3 A shows a zoom-in view of a section of the exemplary- slot waveguide 302, wherein the low-index slot region is clearly shown through the middle of the waveguide.
  • FIG. 3A also shows a straight waveguide 304 in close proximity to slotted ring resonator 302, in which red arrows show direction of light propagation.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des procédés, des systèmes et des dispositifs permettant de mettre en œuvre un micro-spectromètre Raman ultra-sensible basé sur des structures photoniques de l'ordre du nanomètre de confinement élevé, qui peut améliorer la sensibilité tout en conservant une taille extrêmement compacte. Selon un aspect, la présente invention concerne un système portatif ultra-sensible à l'échelle d'une puce permettant une détection et une identification sur des échantillons liquides et gazeux basées sur la spectroscopie Raman. Le système à l'échelle d'une puce décrit peut être particulièrement utile pour la biodétection, notamment la détection et la surveillance du glucose (par ex., la détermination des concentrations de glucose dans des fluides corporels complexes comme le sang, l'urine ou la salive). Par exemple, selon des modes de réalisation permettant la surveillance du glucose, la technologie décrite peut avoir un impact en ce que non seulement elle permet d'éviter la « piqûre au doigt » type requise pour les prélèvements sanguins mais en ce qu'elle fournit également un dispositif facile à utiliser que les diabétiques et les autres personnes qui ont besoin d'une surveillance du glucose (et au final d'autres types de surveillance) peuvent utiliser.
PCT/US2014/039457 2013-05-23 2014-05-23 Biocapteurs utilisant la spectroscopie raman nanophotonique Ceased WO2014190331A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361826978P 2013-05-23 2013-05-23
US61/826,978 2013-05-23

Publications (2)

Publication Number Publication Date
WO2014190331A2 true WO2014190331A2 (fr) 2014-11-27
WO2014190331A3 WO2014190331A3 (fr) 2015-03-12

Family

ID=51934370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/039457 Ceased WO2014190331A2 (fr) 2013-05-23 2014-05-23 Biocapteurs utilisant la spectroscopie raman nanophotonique

Country Status (1)

Country Link
WO (1) WO2014190331A2 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108225555A (zh) * 2016-12-15 2018-06-29 中国科学院苏州纳米技术与纳米仿生研究所 探测芯片与太赫兹波导的集成组件
WO2020006337A1 (fr) * 2018-06-28 2020-01-02 Massachusetts Institute Of Technology Systèmes et procédés pour spectroscopie raman
IT201800009753A1 (it) * 2018-10-24 2020-04-24 Specto Srl Dispositivo e metodo per l'analisi spettroscopica di luce diffusa
US10718668B2 (en) 2017-08-08 2020-07-21 Massachusetts Institute Of Technology Miniaturized Fourier-transform Raman spectrometer systems and methods
GB2580652A (en) * 2019-01-21 2020-07-29 Res & Innovation Uk Infrared spectrometer
WO2020219454A1 (fr) * 2019-04-25 2020-10-29 The Penn State Research Foundation Hybrides de graphène pour la détection biologique et chimique
CN112683879A (zh) * 2020-12-22 2021-04-20 山东大学 聚合物基多元表面增强拉曼检测基底及其制备方法与癌症诊断应用
US10983003B2 (en) 2019-02-11 2021-04-20 Massachusetts Institute Of Technology High-performance on-chip spectrometers and spectrum analyzers
CN113238065A (zh) * 2021-04-19 2021-08-10 吴志洪 一种污水中微量毒品的全自动检测装置及检测方法
CN113418902A (zh) * 2021-03-23 2021-09-21 重庆大学 片上拉曼检测系统
US12153045B2 (en) 2020-05-19 2024-11-26 The Texas A&M University System Mid-infrared integrated photonics for biological sensing
WO2025136394A1 (fr) * 2023-12-21 2025-06-26 Google Llc Spectroscopie raman stimulée différentielle avec une source de lumière d'étalonnage pour détecter un signal sans arrière-plan

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US7659977B2 (en) * 2006-04-21 2010-02-09 Intel Corporation Apparatus and method for imaging with surface enhanced coherent anti-stokes raman scattering (SECARS)
US7512298B2 (en) * 2006-12-01 2009-03-31 3M Innovative Properties Company Optical sensing methods
US7595882B1 (en) * 2008-04-14 2009-09-29 Geneal Electric Company Hollow-core waveguide-based raman systems and methods
EP2523027B1 (fr) * 2011-05-13 2025-07-02 IMEC vzw Dispositif SERS avec un résonateur plasmonique intégré à un guide d'onde intégré

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108225555A (zh) * 2016-12-15 2018-06-29 中国科学院苏州纳米技术与纳米仿生研究所 探测芯片与太赫兹波导的集成组件
US10718668B2 (en) 2017-08-08 2020-07-21 Massachusetts Institute Of Technology Miniaturized Fourier-transform Raman spectrometer systems and methods
US11313725B2 (en) 2017-08-08 2022-04-26 Massachusetts Institute Of Technology Miniaturized Fourier-transform Raman spectrometer systems and methods
US11041759B2 (en) 2018-06-28 2021-06-22 Massachusetts Institute Of Technology Systems and methods for Raman spectroscopy
WO2020006337A1 (fr) * 2018-06-28 2020-01-02 Massachusetts Institute Of Technology Systèmes et procédés pour spectroscopie raman
US11885684B2 (en) 2018-06-28 2024-01-30 Massachusetts Institute Of Technology Systems and methods for Raman spectroscopy
IT201800009753A1 (it) * 2018-10-24 2020-04-24 Specto Srl Dispositivo e metodo per l'analisi spettroscopica di luce diffusa
WO2020084466A1 (fr) * 2018-10-24 2020-04-30 Specto S.R.L. Dispositif et procédé d'analyse spectroscopique d'une lumière diffusée de brillouin
US11846545B2 (en) 2018-10-24 2023-12-19 Specto S.R.L. Device and method for the spectroscopic analysis of Brillouin scattered light
GB2580652A (en) * 2019-01-21 2020-07-29 Res & Innovation Uk Infrared spectrometer
EP3914858A1 (fr) * 2019-01-21 2021-12-01 United Kingdom Research and Innovation Spectromètre infrarouge
US12078536B2 (en) 2019-01-21 2024-09-03 United Kingdom Research And Innovation Infrared spectrometer
US10983003B2 (en) 2019-02-11 2021-04-20 Massachusetts Institute Of Technology High-performance on-chip spectrometers and spectrum analyzers
US11885677B2 (en) 2019-02-11 2024-01-30 Massachusetts Institute Of Technology High-performance on-chip spectrometers and spectrum analyzers
WO2020219454A1 (fr) * 2019-04-25 2020-10-29 The Penn State Research Foundation Hybrides de graphène pour la détection biologique et chimique
US12247923B2 (en) 2019-04-25 2025-03-11 The Penn State Research Foundation Graphene hybrids for biological and chemical sensing
US12153045B2 (en) 2020-05-19 2024-11-26 The Texas A&M University System Mid-infrared integrated photonics for biological sensing
CN112683879A (zh) * 2020-12-22 2021-04-20 山东大学 聚合物基多元表面增强拉曼检测基底及其制备方法与癌症诊断应用
CN113418902A (zh) * 2021-03-23 2021-09-21 重庆大学 片上拉曼检测系统
CN113418902B (zh) * 2021-03-23 2023-10-13 重庆大学 片上拉曼检测系统
CN113238065A (zh) * 2021-04-19 2021-08-10 吴志洪 一种污水中微量毒品的全自动检测装置及检测方法
WO2025136394A1 (fr) * 2023-12-21 2025-06-26 Google Llc Spectroscopie raman stimulée différentielle avec une source de lumière d'étalonnage pour détecter un signal sans arrière-plan

Also Published As

Publication number Publication date
WO2014190331A3 (fr) 2015-03-12

Similar Documents

Publication Publication Date Title
WO2014190331A2 (fr) Biocapteurs utilisant la spectroscopie raman nanophotonique
US7444053B2 (en) Integrated electrical and optical sensor for biomolecule analysis with single molecule sensitivity
KR102625081B1 (ko) 도파관 향상 피분석물 검출 스트립을 갖는 도킹 스테이션
JP6659173B2 (ja) マイクロ流体チップ上の蛍光検出アッセイ
US7248771B2 (en) Integrated sensor with electrical and optical single molecule sensitivity
US9057825B2 (en) Optical trapping apparatus, methods and applications using photonic crystal resonators
US9068891B2 (en) Method and apparatus for measuring concentration of biogenic substance
US10444215B2 (en) Method and device for analyzing alcoholic beverages
Dochow et al. Raman-on-chip device and detection fibres with fibre Bragg grating for analysis of solutions and particles
US8509868B2 (en) Method for measuring a concentration of a biogenic substance contained in a living body
Makela et al. Benzene derivatives analysis using aluminum nitride waveguide raman sensors
Coucheron et al. Chip-based resonance Raman spectroscopy using tantalum pentoxide waveguides
Berner et al. Laser-induced fluorescence detection platform for point-of-care testing
Ashok et al. Fiber probe based microfluidic raman spectroscopy
KR20220156555A (ko) 도파관 향상 피분석물 검출 장치
JP4353529B2 (ja) センサ、センサ装置およびデータ伝達処理装置
Levi et al. Sensitivity analysis of a photonic crystal structure for index-of-refraction sensing
CN1838911A (zh) 使用波长路由器从电磁波谱中测量分析物
CN102781325A (zh) 测定生物体中所含的生物体成分的浓度的方法
Xu et al. Single-wavelength water muted photoacoustic system for detecting physiological concentrations of endogenous molecules
Kho et al. Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis
Matthiae et al. Hyperspectral spatially offset Raman spectroscopy in a microfluidic channel
JP2013176436A (ja) 生体成分濃度測定装置
JP5803386B2 (ja) 波長可変干渉フィルター、光フィルターモジュール、および光分析装置
Minas Lab-on-a-chip devices for chemical analysis

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14800922

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 14800922

Country of ref document: EP

Kind code of ref document: A2