[go: up one dir, main page]

WO2014180857A1 - Dispositif d'inhalateur déterminant un processus d'inhalation - Google Patents

Dispositif d'inhalateur déterminant un processus d'inhalation Download PDF

Info

Publication number
WO2014180857A1
WO2014180857A1 PCT/EP2014/059255 EP2014059255W WO2014180857A1 WO 2014180857 A1 WO2014180857 A1 WO 2014180857A1 EP 2014059255 W EP2014059255 W EP 2014059255W WO 2014180857 A1 WO2014180857 A1 WO 2014180857A1
Authority
WO
WIPO (PCT)
Prior art keywords
inhaler device
inhaler
inhalation
warning
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2014/059255
Other languages
English (en)
Inventor
Ahmet Toksöz
Zafer Toksöz
Onur Mutlu
Ercan Ergenekon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arven Ilac Sanayi ve Ticaret AS
Original Assignee
Arven Ilac Sanayi ve Ticaret AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arven Ilac Sanayi ve Ticaret AS filed Critical Arven Ilac Sanayi ve Ticaret AS
Publication of WO2014180857A1 publication Critical patent/WO2014180857A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3327—Measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/44—General characteristics of the apparatus making noise when used incorrectly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Definitions

  • the present invention relates to the device which enables administration of dry powder inhalation drugs.
  • the present invention comprises at least one electronic system giving a warning signal in order to have the drug in inhaler devices inhaled and/or taken by breathing by the user for a pre-determined duration.
  • inhalation devices for administering inhalation medicaments.
  • These devices are basically classified into two groups, i.e. metered dose inhalers and dry powder inhalers.
  • These types of devices are structurally provided with basic components such as a mechanism, trigger, counter, body, mouthpiece, cap, lock, etc.
  • powder inhalation medicaments are kept in carriers such as blisters, capsules, etc.
  • Blisters are composed of two basic parts, a main layer provided with cavities carrying the medicament, and a strippable protective layer. The users inhale the drug with the help of the mouthpiece on the existing dry powder inhaler devices and by breathing, and the powder drug reaches the target organ: lungs.
  • the drug flowing after the blister is opened or the capsule is burst is directed to the mouthpiece and kept in an area connected to the mouthpiece.
  • the mouthpiece is designed in a volume and length suitable for mouth anatomy. By this way, both administration of the medicament is facilitated and hygiene is provided.
  • Inhaling the air into the lungs is an active action. With contraction of inspiration muscles, the frontal posterior diameter of chest cage widens and lengthens downwards.
  • Boyle-Marriotte Law as volume of gas increases, its pressure decreases. According to this law, atmospheric air fills into the lungs since the pressure of air in the widening lungs shall be lower (than the pressure of atmospheric air).
  • the air flow occurring with atmospheric air and inclining towards the body ensures that the powder drug is taken without needing any other force. With the air flow, the powder in medicament is taken into body. Amount of the air inhaled during this process and how long it takes is very crucial.
  • inhalation devices for administering inhalation medicaments.
  • These devices are basically classified into two groups, i.e. metered dose inhalers and dry powder inhalers.
  • These types of devices are structurally provided with basic components such as a mechanism, trigger, counter, body, mouthpiece, cap, lock, etc.
  • powder inhalation medicaments are kept in carriers such as tanks, blisters, capsules, etc.
  • Blisters are composed of two basic parts, a main layer provided with cavities carrying the medicament, and a strippable protective layer.
  • the inhalers have different methods of use according to their types, and these methods are described visually in the instructions provided with the inhalers.
  • the basic problem in use of inhaler devices relates to the drug which becomes ready to be used after the device is triggered for use. The patient is not able to determine at which level and how long he/she will take the drug. This fact affects psychological state of the patient during treatment negatively. Especially, the problems experienced by the first users, olds and children about use of the device require embodiment of a new device. When the powder drug required to be inhaled at once is taken interruptedly, it is prevented to administer the desired dose amount to the patient, and the amount of loss waste reaches top levels. Use of the existing inhaler devices requires a certain training and practice.
  • the present invention is an inhaler device used for inhalation, with a warning structure eliminating all problems mentioned above and bringing additional advantages to the relevant prior art.
  • the main objective of the present invention is to provide an inhaler device which determines the pre-determined duration of inhalation and/or breathing by means of a warning system during administration.
  • a further objective of the present invention is to facilitate the usage coordinating inhalation process of the user.
  • the said novelty is characterized in that the said device comprises at least one electronic system giving warning signal in order to ensure inhalation and/or breathing of the user for a pre- determined duration.
  • the said electronic system comprises at least one timer.
  • the said device gives visual and/or audio warning signal at the end of inhalation.
  • the said device gives visual and/or audio warning signal at the beginning of inhalation.
  • the said device gives visual and/or audio warning signal at the beginning and end of inhalation.
  • the said electronic element/system comprises at least one warning receiving component.
  • the said warning receiving component is a sensor.
  • the said warning receiving component is a switch.
  • the said switch is connected to trigger of the device.
  • the said sensor is sensitive to breath of user.
  • the said sensor is sensitive to pressure or molecule or heat or combination of them.
  • the said sensor is positioned at the mouthpiece.
  • the said electronic element/system comprises at least one control element.
  • the said controlling element comprises at least one of microprocessor, processor, chip and time relay.
  • the said warning element comprises a sound or a light unit.
  • the said warning signal element comprises a display panel.
  • the said device is dry powder inhaler device.
  • the said device is a metered dose inhaler device.
  • the said device is a blister dry powder inhaler device.
  • the said device is the capsule dry powder inhaler device.
  • the said device is characterized with giving at least one warning signal for a certain period of time or at the beginning and/or end of the determined time period in order to ensure inhalation and/or breathing of the user for a pre-determined period.
  • Figure 1 is an exemplary illustration of an inhaler device suitable for the present invention.
  • a device is composed of a body having an advancement mechanism for blisters with multiple cavities. There is a mouthpiece immediately upon this body which is structured as an extension of the body.
  • a blister advancement mechanism is placed into inner side of the body to ensure operation of the inhaler. Trigger of the device is locked to the inner side of the body. Therefore, the mechanism starts to operate and powder drug becomes ready for use after one blister is opened.
  • another device suitable for administration is the one with tank(s) into which single or multiple capsules can be placed. The capsule is burst using a pin or a needle. The drug releases.
  • the selected sensor When the user starts to take drug together with the air, the selected sensor senses pressure change, heat or one of the substance molecules. Period of use warns the user by means of a sound or a light indicator.
  • This warning sensor may be continuous as to start with sending of the warning sensor and to finish at the end of the necessary duration, as well as it may be given twice, one at the beginning and one at the end of the process. If the system is activated by means of a lever or trigger which moves the inhaler, a warning of inhalation or breathing is initiated with a delay of 1 -5 seconds considering the period during which the user brings the device to his/her mouth.
  • a system has been developed which warns the user during use of the said inhaler device. Under normal conditions, a human being inhales the air of approximately 4 L at around 4 kPa pressure values. Under normal conditions, a human being breathes 12 - 14 times a minute. The device is adjusted according to suitable respiration durations taking these values into consideration.
  • a warning system has been developed for inhaler devices in order to determine and show how this process shall be healthily.
  • the device is started with an external warning enabling operation of the device.
  • a warning system has been developed which shows breathing duration of the user with triggering of a pressure-sensitive sensor - this sensor can be adjusted to operate at a certain cut-off value. If the sensor is triggered, the user is warned by means of a light, sound or an indicator during or at the beginning and end of the said warning period. In this way, the patient is able to perform inhalation in an optimum duration. Time control of this operation is made by one of the components such as microprocessor, processor, chip and time relay. This triggering operation can also be started by means of a switch to be adapted to the button/trigger which operates the inhaler devices.
  • the first warning can be given immediately after pushing as well as it can be given with a certain period of delay.
  • a delayed warning can be given to allow for duration to bring to the mouth. In that way, the patient determines optimum process of use.
  • Position of the sensor can be around the mouthpiece as well as in or around of drug taking duct.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un dispositif d'inhalateur, caractérisé en ce que le dispositif comprend au moins un système électronique fournissant un signal d'avertissement au début et/ou à la fin de l'inhalation, afin de garantir l'inhalation et/ou la respiration de l'utilisateur pendant une durée prédéfinie.
PCT/EP2014/059255 2013-05-07 2014-05-06 Dispositif d'inhalateur déterminant un processus d'inhalation Ceased WO2014180857A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR201305435 2013-05-07
TR2013/05435 2013-05-07

Publications (1)

Publication Number Publication Date
WO2014180857A1 true WO2014180857A1 (fr) 2014-11-13

Family

ID=49582784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/059255 Ceased WO2014180857A1 (fr) 2013-05-07 2014-05-06 Dispositif d'inhalateur déterminant un processus d'inhalation

Country Status (1)

Country Link
WO (1) WO2014180857A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108778384A (zh) * 2016-03-24 2018-11-09 尼科创业控股有限公司 电子蒸气供应系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5333106A (en) * 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
US20050103337A1 (en) * 2003-10-27 2005-05-19 Anthony James Hickey Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US20070215149A1 (en) * 2006-01-31 2007-09-20 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
US20120247235A1 (en) * 2009-11-03 2012-10-04 Mannkind Corporation apparatus and method for simulating inhalation efforts

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5333106A (en) * 1992-10-09 1994-07-26 Circadian, Inc. Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers
US20050103337A1 (en) * 2003-10-27 2005-05-19 Anthony James Hickey Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances
US20070215149A1 (en) * 2006-01-31 2007-09-20 Oriel Therapeutics, Inc. Dry powder inhalers having spiral travel paths, unit dose microcartridges with dry powder, related devices and methods
US20120247235A1 (en) * 2009-11-03 2012-10-04 Mannkind Corporation apparatus and method for simulating inhalation efforts

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108778384A (zh) * 2016-03-24 2018-11-09 尼科创业控股有限公司 电子蒸气供应系统

Similar Documents

Publication Publication Date Title
US10046121B2 (en) Inhalation device with feedback system
DK2515977T3 (en) DEVICE FOR DELIVERY OF DRY POWDER
EP3117858B1 (fr) Nébuliseur pour nourrissons et les patients ayant des voies respiratoires altérées
EP3650067B1 (fr) Dispositif et procédé d'inhalation
EP2950860B1 (fr) Nébuliseur pour nourrissons et patients atteints de problèmes respiratoires
US20080196716A1 (en) Mouthpiece and Flow Rate Controller for Intrapulmonary Delivery Devices
EP2666501A1 (fr) Inhalateur doté d'un corps interne avec canal d'air
JP2001525710A (ja) 肺を介する医療用エーロゾル剤の投与装置
CN106456914A (zh) 主动干粉吸入器
AU2015357560A1 (en) Inhalation monitoring system and method
WO1994016756A1 (fr) Apport intrapulmonaire d'hormones
CN102470232B (zh) 用于集成节律呼吸和吸入疗法的系统和方法
WO2006048417A1 (fr) Systeme et appareil de suivi de l'observance d'une therapie respiratoire
CN115989408A (zh) 吸入器以及用于施用活性物质的方法和装置
WO2014180857A1 (fr) Dispositif d'inhalateur déterminant un processus d'inhalation
ES3014467T3 (en) Inhaler system providing guidance to its user
WO2005123165A1 (fr) Appareil d'assistance a l'inhalation et methode d'assistance pour des therapies d'inhalation
Smith Inhalation devices for asthma and chronic obstructive pulmonary disease
JP4286498B2 (ja) エアロゾルを管理するための装置
WO2013176638A1 (fr) Inhalateur comportant une embouchure ayant un canal d'air amélioré
AU2013209385B2 (en) Nebulizer for infants and respiratory compromised patients
Leader et al. Product Design Specifications
HK1233559A1 (en) Nebulizer for infants and respiratory compromised patients
HK1216863B (en) Nebulizer for infants and respiratory compromised patients
PL225116B1 (pl) Zestaw do podawania leku w postaci aerozolu dozowanego z pojemnika pod ciśnieniem

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14721415

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 14721415

Country of ref document: EP

Kind code of ref document: A1