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WO2014176785A1 - Dispositif de régulation nerveuse - Google Patents

Dispositif de régulation nerveuse Download PDF

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Publication number
WO2014176785A1
WO2014176785A1 PCT/CN2013/075137 CN2013075137W WO2014176785A1 WO 2014176785 A1 WO2014176785 A1 WO 2014176785A1 CN 2013075137 W CN2013075137 W CN 2013075137W WO 2014176785 A1 WO2014176785 A1 WO 2014176785A1
Authority
WO
WIPO (PCT)
Prior art keywords
shape
electrode
nerve
electrode carrying
carrying member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2013/075137
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English (en)
Chinese (zh)
Inventor
秦杰
汪立
盛卫文
王国辉
吴艳雪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI ANGIOCARE MEDICAL TECHNOLOGY Co Ltd
Original Assignee
SHANGHAI ANGIOCARE MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHANGHAI ANGIOCARE MEDICAL TECHNOLOGY Co Ltd filed Critical SHANGHAI ANGIOCARE MEDICAL TECHNOLOGY Co Ltd
Priority to PCT/CN2013/075137 priority Critical patent/WO2014176785A1/fr
Publication of WO2014176785A1 publication Critical patent/WO2014176785A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation

Definitions

  • the present invention relates to electrosurgery, and more particularly to a device for modulating nerves.
  • Refractory hypertension a condition that is still difficult to control with more than three drugs (both already using a diuretic) (sBP ⁇ 160mmHg), more common in clinical, its pathogenic factors are numerous, the pathogenesis is not clear, the drug treatment effect is very poor, and the diagnosis and treatment techniques are still not mature enough, which has become one of the major problems in the treatment of hypertension.
  • Radiofrequency ablation of the renal artery is an interventional technique that achieves denervation by delivering a lead through a blood vessel into a specific part of the renal artery, releasing radiofrequency currents and causing local coagulative necrosis of the renal artery.
  • the RF current damage range is small and does not cause harm to the body. Therefore, renal artery radiofrequency ablation has become an effective method for removing renal artery sympathetic nerves.
  • kidney-related diseases especially related diseases caused by excessive activation of renal sympathetic nerves.
  • congestive heart failure CHF
  • renin secretion increases renal vasoconstriction, causing a decrease in renal blood flow.
  • the kidney's response to heart failure can prolong the spiral decline in heart failure conditions.
  • the present invention provides a new device for regulating nerves.
  • Apparatus for modulating a nerve comprising an adjustment assembly for modulating the nerve, the adjustment assembly comprising one or more electrodes for delivering modulating energy to the nerve and for carrying the An electrode carrying member of an electrode, characterized in that the electrode carrying member has a first shape and a second shape, the adjusting member being adapted to move in a blood vessel in the first shape, the adjusting in the second shape At least one electrode of the assembly is in a position suitable for transmitting the modulated energy to the nerve; the device further comprising means for delivering the adjustment assembly to a position proximate the nerve and the electrode bearing member at a first A control component that transforms between the shape and the second shape.
  • the nerve is a renal nerve located on a human renal artery, and the 'position close to the nerve' refers to being located in the renal artery .
  • said modulation refers to the removal or reduction of activation of said nerve by means of injury or non-injury.
  • the energy is one or more of heat, cooling, electromagnetic energy, radio frequency, ultrasonic wave, microwave or light energy.
  • the blood vessel is a human renal artery.
  • said 'suitable for moving in a blood vessel' means said adjustment assembly when said adjustment assembly moves in a blood vessel Does not damage the vessel wall.
  • said 'suitable for moving in a blood vessel' refers to said adjustment component
  • the largest dimension in the radial direction of the blood vessel is not greater than the inner diameter of the blood vessel.
  • said 'suitable for moving in a blood vessel' means that the maximum dimension of the adjustment component in the radial direction of the blood vessel is not more than 4 mm .
  • said 'suitable for transferring said modulated energy to said renal nerve' means that when said regulating member is in a blood vessel, At least one of the electrodes is in contact with the vessel wall.
  • said 'suitable for transferring said modulated energy to said renal nerve' refers to said adjustment component
  • the largest dimension in the radial direction of the blood vessel is 4-8 mm, and at least one electrode is at the largest dimension.
  • the adjustment assembly includes a plurality of electrodes, the plurality of electrodes of the adjustment assembly being in a position suitable for transmitting the modulated energy to the nerve.
  • the inside of the electrode carrying member is provided with a wire for connecting the electrode to the energy generating device.
  • the electrode is annular or tubular and is sleeved on the outside of the electrode carrying member.
  • the second shape is an shape of the electrode carrying member that is not subjected to an external force.
  • a marking member for displaying the position of the electrode carrying member under X-rays is disposed near the distal end or the distal end of the electrode carrying member.
  • the distal end of the electrode carrying member is provided with a protective member for reducing or avoiding damage to the blood vessel wall. More preferably, the material of the protective member is softer than the material of the electrode carrying member.
  • the first shape of the electrode carrying member is one of an elongated shape, a strip shape, a filament shape or a fiber shape.
  • the second shape of the electrode carrying member is a spiral shape. More preferably, the spiral has a diameter of 4-8 mm.
  • the number of the electrodes is 2-6, when When the electrode carrying member is in the second shape, the distance between adjacent electrodes in the axial direction of the blood vessel is 4-6 mm. More preferably, the number of the electrodes is four.
  • said control component includes means for said a delivery member that is delivered to a position near the nerve, the delivery member being in the form of an elongated, strip, filament or fiber, the distal end of the delivery member and the electrode bearing member The proximal end is connected.
  • the conveying member and the electrode carrying member are made of the same material and integrated.
  • the delivery member preferably has a length that enables delivery of the adjustment assembly from the human iliac artery to the human renal artery. More preferably, the conveying member has a length of from 130 cm to 160 cm.
  • control assembly includes a shape control member for transforming the electrode carrying member between a first shape and a second shape.
  • said The inside of the electrode carrying member and the conveying member has a shape control passage for accommodating the shape control member, the shape control member is located in a shape control passage of the conveying member, the electrode carrying member and the shape control The component is configured to utilize the shape control member to control the passage of the shape of the electrode carrier member to control the passage of the electrode carrier member between the first shape and the second shape.
  • the associated control assembly includes a handle for a user to grip, the delivery member being mounted to the handle, the handle having A shape control passage accommodating the shape control member, the shape control member extending to the outside of the handle through a shape control passage of the handle.
  • the shape control member is sheathed to the conveying member and slidable along the conveying member,
  • the electrode carrying member and the shape controlling member are configured to: when the shape controlling member is sheathed to the electrode carrying member and the electrode, the electrode carrying member is in a first shape when The electrode carrying member is in a second shape when the shape controlling member is detached from the electrode carrying member and the electrode.
  • the control assembly includes a handle for a user to grip, the delivery member being mounted to the handle.
  • the shape control member is disposed near the distal end or the distal end for displaying the shape control member under X-rays Marking component of position.
  • the device for regulating nerves provided by the invention is convenient to operate, and can simultaneously adjust a plurality of nerve sites, thereby improving work efficiency.
  • Figure 1 is a schematic diagram of the structure of human kidney and related tissues.
  • Figure 2 is a schematic view of the structure of the human renal artery.
  • image 3 It is a schematic diagram of a component of a specific embodiment of the apparatus for modulating nerves provided by the present invention, which shows the first shape of the electrode carrying member.
  • Figure 4 is shown in Figure 3.
  • a schematic view of another state of the device for modulating nerves the figure showing the second shape of the electrode carrying member.
  • Figure 5 is a schematic view showing the structure of the device for adjusting nerves shown in Figure 3.
  • FIG. 6 is a schematic structural view of another embodiment of the apparatus for modulating nerves provided by the present invention.
  • the 'proximal end' the end of the device or component that is adjacent to the user (or handle) or away from the nerve site that needs to be adjusted.
  • the 'proximal end' the end of the device or component that is adjacent to the user (or handle) or away from the nerve site that needs to be adjusted.
  • One end of the nerve site that needs to be regulated is called the 'distal'.
  • Figures 1 - 5 illustrate a preferred embodiment of the apparatus for modulating nerves and methods of use thereof provided by the present invention. This embodiment is exemplified by a device for regulating human renal nerves.
  • FIG. 1 - Figure 2 shows the relevant tissues and structures of the human kidney.
  • human kidney-related tissue anatomically includes kidney K, kidney K Oxygenated blood is supplied through the renal artery RA.
  • the renal artery RA is connected to the heart via the aorta AA of the abdomen.
  • Deoxygenated blood flows from the kidney to the heart via the renal vein RV and the inferior vena cava IVC.
  • figure 2 A more detailed map of the kidney anatomy. More specifically, the renal anatomy also includes a renal nerve RN extending longitudinally along the axial direction L of the renal artery RA. Renal nerve RN Typically within the outer membrane of the artery.
  • the device is provided for modulating renal nerve RN located on the renal artery RA, said adjustment to remove or reduce renal nerves by injury or non-injury RN Activation.
  • renal nerve RN located on the renal artery RA
  • said adjustment to remove or reduce renal nerves by injury or non-injury RN Activation.
  • nerves at other sites eg, heart-related nerves
  • other modes of adjustment eg, further activation of the nerves is required
  • those skilled in the art can make according to the present invention. Adjustments that are reasonably expected and do not require creative labor.
  • Figures 3 and 4 show the components of the device for modulating nerves in this embodiment.
  • the device first includes an adjustment assembly 100; the adjustment assembly 100 includes an electrode 101 and an electrode carrying member 102. .
  • the electrode When the electrode is close to the nerve site to be regulated, the electrode releases a certain amount of energy and acts on the nerve site, thereby regulating the nerve site (eg, reducing or eliminating the activation of the sympathetic nerve).
  • the electrode can achieve this by transferring heat to the nerve site.
  • a heat transfer heating mechanism for neuromodulation can include thermal ablation and non-ablative thermal changes or damage, for example, the temperature of the target nerve fiber can be raised beyond a desired threshold to achieve a non-ablative thermal change, or more High temperatures to achieve thermal changes in ablation.
  • the target temperature can be around 37 ° C - 45 ° C (for the thermal temperature of non-thermal ablation), or the target temperature may be about 45 ° C or higher for the thermal change of ablation.
  • the electrode can also accomplish this by delivering cooling to the nerve site. For example, reducing the temperature of the target nerve fiber to about 20 Below °C to achieve non-freezing thermal changes, or to lower the temperature of the target nerve fibers to below about 0 °C to achieve the thermal change of freezing.
  • Electrodes can also be achieved by applying an energy field to the target nerve fibers.
  • the energy field may include: electromagnetic energy, radio frequency, ultrasonic waves (including high intensity focused ultrasound), microwave, light energy (including laser, infrared, and near infrared).
  • thermally induced neuromodulation can be achieved by delivering a pulsed or continuous thermal energy field to the target nerve fibers.
  • a more preferred energy mode is a pulsed RF electric field or other types of pulsed thermal energy. Pulsed RF electric fields or other types of pulsed thermal energy can contribute to greater heat levels, longer total duration, and / or better controlled intravascular renal neuromodulation therapy.
  • the electrodes need to be electrically connected to the device that produces the energy (eg, a radio frequency meter) or causes the electrode itself to generate the energy.
  • the device that produces the energy e.g, a radio frequency meter
  • the connection of the electrodes to these devices are prior art well known to those skilled in the art (for example, an interface for connecting these devices is provided in the device of the present invention, which enables plug and play when used), and is no longer here. Detailed description.
  • the electrode 101 The way to close the renal nerve site to be adjusted is to enter the human body through the blood vessel and approach the nerve site through the inner wall of the renal artery. Therefore, when working with the device provided by the specific embodiment, a technical problem to be solved is that it is necessary to realize that the electrode can be closely attached to the inside of the blood vessel to act on the nerve at the corresponding position, and the electrode can be conveniently moved in the blood vessel. And does not damage the vessel wall.
  • This specific embodiment solves this technical problem by adopting the following technical solution: configuring the electrode carrying component 102 has a first shape (as shown in Figure 3) and a second shape (as shown in Figure 4).
  • the first shape is a straight or nearly straight strip (or elongated or fibrous or filamentary), the cross section of the strip preferably being circular or approximately circular, with the widest portion of the cross section being less than The inner diameter of the blood vessel.
  • the adjustment assembly 100 when When the adjustment assembly 100 is moved in the blood vessel, the adjustment assembly 100 does not damage the vessel wall.
  • the nerves on the renal artery need to be adjusted, since the inner diameter of the human renal artery is generally 4-7 mm, The maximum dimension of the adjustment component 100 in the radial direction of the renal artery is no more than 4 mm, preferably 1-2 mm.
  • the first shape may also allow for a certain bending or wavy bending, and the cross section may be other shapes as long as the surface is smooth and can be easily moved within the blood vessel without damaging the blood vessel wall. can.
  • the electrodes of the conditioning assembly 100 are in a position suitable for delivering modulated energy to the renal nerves.
  • Figure 4 As shown, in this embodiment, the second shape of the electrode carrying member 102 is entirely helical.
  • the adjustment assembly The widest point of 100 is larger than the first shape so that the electrodes carried can be brought close to or in contact with the vessel wall, thereby being close to the renal nerve.
  • the diameter of the spiral is set to 4-8mm. More suitable.
  • the diameter of the spiral can be set to about 5 mm; for individuals with a large inner diameter of the renal artery (for example, an inner diameter of 7 mm) Left and right), the diameter of the spiral can be set to about 8mm.
  • the second shape may also be other shapes, for example, a random shape having a smooth curvature, as long as the electrode carrying member is in a blood vessel, the electrode It is only in the position of contacting the blood vessel wall.
  • the electrode 101 is annular and sleeved on the outer surface of the electrode carrying member 102.
  • the electrode 101 on the electrode carrying member 102 is in contact with the inner wall of the renal artery (near the renal nerve), so that adjustment work can be performed.
  • an annular recess having a shape matching the electrode 101 may be provided on the outer surface of the electrode carrying member 102, and the electrode 101 Fixed in the corresponding position.
  • the outer surface of the electrode 101 and the adjacent electrode carrying member 102 The outer surface of the area forms a relatively smooth curved surface to reduce damage to the vessel wall.
  • the electrode 101 can also be mounted on the electrode carrying member 102 by other means, for example, an electrode. 101 is block-shaped and embedded in the outer surface of the electrode carrying member 102.
  • the inside of the electrode carrying member 102 is provided with an electrode 101 for A wire (not shown) connected to an energy generating device (for example, a radio frequency meter), when having a plurality of electrodes, requires a plurality of wires each connecting a plurality of electrodes to the energy generating device.
  • Electrode bearing member 102 Elements for measuring temperature (for example, thermocouples) and corresponding wires can also be provided, and the arrangement of wires and thermocouples is a conventional arrangement in the art and will not be described in detail herein.
  • the number of electrodes 101 is four.
  • the distance D of the adjacent electrodes in the axial direction of the blood vessel is 4-6 mm.
  • the positioning of the primary adjustment component (with the electrode contacting the inner wall of the blood vessel) can complete the ablation of the four sites, and the entire ablation procedure requires only two adjustment components to be positioned. can.
  • the number of electrodes can also be set to 2-6 However, if the number is large, the production cost of the entire device will be increased; if the number is small, the work efficiency of the ablation operation can be reduced.
  • the material of the electrode may be a metal or metal alloy which is more biocompatible or relatively stable, such as a platinum group metal such as a platinum rhodium alloy.
  • the distal end of the electrode carrying member 102 is further provided with a marking member 103 and a protective member 104.
  • Marking component The role of 103 is to display the position of the electrode-carrying component under X-ray.
  • the material can be selected from a metal or metal alloy with better biocompatibility or stability, such as a platinum group metal (such as platinum-rhodium alloy).
  • Marking part 103 It may also be annular and sleeved on the outer surface of the distal end of the electrode carrying member 102.
  • the function of the protective member 104 is to reduce or avoid damage to the blood vessel wall, and the protective member 104 It may be connected to the electrode carrying member 102 for a piece of material which is relatively soft (for example, a relatively soft plastic polymer such as Pebax2533, Pebax3533, TPU, etc.).
  • the distal end prevents the distal end of the electrode carrying member 102 from damaging the blood vessel.
  • the apparatus in this embodiment further includes a control assembly 200 that includes an adjustment assembly 100 A delivery member 201 that is delivered to a position near the renal nerve (i.e., delivered into the renal artery) and a shape control member 202 that changes the electrode carrier member 102 between the first shape and the second shape (Fig. 3 and Fig. 3) 4)).
  • Fig. 5 shows the structure of the conveying member 201 and the shape controlling member 202. As shown in Fig. 5, the distal end of the delivery member 201 and the electrode carrying member 102 The proximal ends are connected, and if they are made of the same material, they can be integrally formed.
  • Conveying part 201 The shape is strip (or slender or fibrous or filiform) with rigidity and bendability suitable for movement in blood vessels, the length of which can be set as desired.
  • the delivery member 201 can be configured to have a length of between 80 cm and 130 cm (about 105 cm is most suitable); if the user needs to pass the transarterial artery, the adjustment assembly 100
  • the delivery member 201 can be disposed in the renal artery and has a length of 130 cm to 160 cm (about 155 cm is most suitable).
  • the cross section is preferably circular, and the diameter thereof is not larger than the inner diameter of the blood vessel to be passed, and the diameter is preferably about 1-2 mm. It can satisfy the convenient movement in the blood vessel, has sufficient rigidity and is easy to manufacture, and can reduce the size of the wound of the patient.
  • the electrode carrying member 102 and the conveying member 201 are internally provided for accommodating the shape controlling member 202.
  • the shape control passage 202 has a strip shape (or an elongated shape or a fiber shape or a filament shape), a straight or nearly straight strip shape near the far portion, and the shape control member 202 penetrates the conveying member 201. The entire shape controls the passage and extends beyond the proximal end of the delivery member 201.
  • the second shape of the electrode carrying member 102 is the shape of the electrode carrying member when it is not subjected to an external force, and the electrode carrying member 102 Made of elastic memory material. That is, the electrode carrying member 102 is entirely spiral in shape without being subjected to an external force.
  • the shape control member 202 is made of a material harder than the material of the electrode carrying member, for example, the electrode bearing member 102 is made of a polymer plastic (e.g., Pebax3533, Pebax4033, TPU, etc.), an elastic memory material nickel-titanium wire is provided inside or on the inner wall of the polymer plastic (guarantee electrode carrying member 102)
  • the shape control member 202 is made of stainless steel when it is not subjected to an external force, and the shape control member 202 is made of stainless steel; thus, the user can pinch the proximal end of the shape control member 202 (exposed to the conveying member 201).
  • the outer and outer operations of the push and pull back cause the shape control member 202 to enter and exit the shape control channel of the electrode carrier member 102; when the shape control member 202 enters the electrode carrier member 102
  • the shape control channel is formed, since the hardness of the material of the shape control member 202 is larger than that of the electrode carrying member 102, the shape control member 202 The first shape (straight or nearly straight strip shape) will be exhibited; when the shape control member 202 is disengaged from the shape control passage of the electrode carrying member 102, due to the electrode carrying member 102 With its own elastic force, the electrode carrying member 102 returns to the second shape (helical shape); thereby, the electrode carrying member 102 is changed between the first shape and the second shape.
  • control assembly 200 further includes a handle 203 suitable for the user to hold for the convenience of the user.
  • the conveying member 201 is mounted to the handle 203, and the handle 203 also has a shape control passage for accommodating the shape control member 202, and the shape control member 202 passes through the handle 203.
  • the shape control passage extends to the outside of the handle 203 for the user to push and pull back the shape control member 202.
  • a plurality of wires (such as described above, when the electrode carrying member 102 When carrying a plurality of electrodes thereon, and when an element such as a thermocouple is further provided, when it is necessary to connect the electrodes and the elements to the respective devices with a plurality of wires, a preferred mode is at the electrode carrying member 102 and the conveying member 201.
  • Two or more independent channels are provided, and the shape control member 202 uses one of the independent channels, and the wires use one or more other channels (as long as the wires are insulated from each other).
  • shape control component 202 The electrode carrying member 102 can also be varied between the first shape and the second shape by another means.
  • the shape control unit 202 In the form of a strip (or elongated or fibrous or filamentous), the portion near the distal end is a straight or nearly straight strip-shaped tubular body which is jacketed on the outside of the conveying member 201 and slidable along the conveying member 201 .
  • Shape control unit 202 is made of a material that is harder than the material of the electrode carrying member 102.
  • the electrode carrying member 102 is made of a relatively soft polymer plastic (such as Pebax3533, Pebax4033, TPU, etc.)
  • the shape control part 202 is made of relatively hard polymer plastic (such as ABS, PC, etc.); thus, the user can hold the shape control part
  • the proximal end of 202 performs push and pull back operations such that shape control component 202 is overlaid on electrode carrier component 102 and off electrode carrier component 102; when shape control component 202
  • the shape control member 202 is coated on the electrode carrying member 102.
  • the first shape (straight or nearly straight strip shape) is exhibited; when the shape control member 202 is detached from the electrode carrying member 102, the electrode carrying member 102 is due to the elastic force of the electrode carrying member 102 itself.
  • the second shape (spiral shape) is restored; thereby, the electrode carrying member 102 is changed between the first shape and the second shape.
  • the distal end or the distal end of the shape control member 202 can also be set for use in X
  • the marking member at the position of the shape controlling member 202 is displayed under light to prevent the shape controlling member 202 from excessively protruding beyond the electrode carrying member 102 at the time of surgery, thereby damaging the kidney tissue.

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Abstract

La présente invention concerne un dispositif de régulation nerveuse, comprenant un ensemble régulateur pour la régulation nerveuse, l'ensemble régulateur comprenant une ou plusieurs électrodes (101) pour délivrer une énergie régulatrice au nerf et un composant de support d'électrode (102) pour soutenir la ou les électrodes, le composant de support d'électrode (102) ayant une première forme et une seconde forme ; avec la première forme, l'ensemble régulateur est adapté pour se déplacer dans un vaisseau sanguin, tandis qu'avec la seconde forme, au moins une électrode (101) de l'ensemble régulateur est dans une position adaptée pour délivrer l'énergie régulatrice au nerf. Le dispositif comprend en outre un ensemble de commande (200) pour transporter l'ensemble régulateur à une position proche du nerf et permettant au composant de support d'électrode de basculer entre la première forme et la seconde forme. Le dispositif de régulation nerveuse a un fonctionnement commode et est capable de réguler simultanément plusieurs sites nerveux, ce qui améliore l'efficacité de travail.
PCT/CN2013/075137 2013-05-03 2013-05-03 Dispositif de régulation nerveuse Ceased WO2014176785A1 (fr)

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Cited By (10)

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Publication number Priority date Publication date Assignee Title
US9554848B2 (en) 1999-04-05 2017-01-31 Medtronic, Inc. Ablation catheters and associated systems and methods
US9675413B2 (en) 2002-04-08 2017-06-13 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for renal neuromodulation
US9707035B2 (en) 2002-04-08 2017-07-18 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9855096B2 (en) 2012-05-11 2018-01-02 Medtronic Ardian Luxembourg S.A.R.L. Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods
US9888961B2 (en) 2013-03-15 2018-02-13 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
US10076382B2 (en) 2010-10-25 2018-09-18 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods
US10736690B2 (en) 2014-04-24 2020-08-11 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters and associated systems and methods
US11213678B2 (en) 2013-09-09 2022-01-04 Medtronic Ardian Luxembourg S.A.R.L. Method of manufacturing a medical device for neuromodulation
US12408974B2 (en) 2014-12-03 2025-09-09 Medtronic Ireland Manufacturing Unlimited Company Systems and methods for modulating nerves or other tissue
US12478806B2 (en) 2012-03-08 2025-11-25 Medtronic Ireland Manufacturing Unlimited Company Catheter-based devices and associated methods for immune system neuromodulation

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