[go: up one dir, main page]

WO2014170820A3 - A pharmaceutical combination for treating tuberculosis - Google Patents

A pharmaceutical combination for treating tuberculosis Download PDF

Info

Publication number
WO2014170820A3
WO2014170820A3 PCT/IB2014/060722 IB2014060722W WO2014170820A3 WO 2014170820 A3 WO2014170820 A3 WO 2014170820A3 IB 2014060722 W IB2014060722 W IB 2014060722W WO 2014170820 A3 WO2014170820 A3 WO 2014170820A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical combination
isoniazide
treating tuberculosis
nano curcumin
tuberculosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2014/060722
Other languages
French (fr)
Other versions
WO2014170820A2 (en
Inventor
Santosh K KAR
Gobardhan DAS
Mrutyunjay SUAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2014170820A2 publication Critical patent/WO2014170820A2/en
Publication of WO2014170820A3 publication Critical patent/WO2014170820A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A pharmaceutical combination comprising therapeutically effective amounts of nano curcumin and isoniazide, for treating tuberculosis in a subject, is provided herein. Nano curcumin and isoniazide of the pharmaceutical combination of the present invention may be administered simultaneously, separately or sequentially or as a single fixed dose combination. Pharmaceutical compositions comprising nano curcumin and isoniazide are also described herein. The present invention further provides a method of treatment of tuberculosis comprising administering to a subject in need thereof, an effective amount of a pharmaceutical combination comprising nano curcumin and isoniazide.
PCT/IB2014/060722 2013-04-15 2014-04-15 A pharmaceutical combination for treating tuberculosis Ceased WO2014170820A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN413/KOL/2013 2013-04-15
IN413KO2013 2013-04-15

Publications (2)

Publication Number Publication Date
WO2014170820A2 WO2014170820A2 (en) 2014-10-23
WO2014170820A3 true WO2014170820A3 (en) 2015-02-19

Family

ID=51731922

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/060722 Ceased WO2014170820A2 (en) 2013-04-15 2014-04-15 A pharmaceutical combination for treating tuberculosis

Country Status (1)

Country Link
WO (1) WO2014170820A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119970710A (en) * 2025-01-20 2025-05-13 深圳市第三人民医院(深圳市肝病研究所) Application and pharmaceutical composition of isoeilhaemoside

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012017406A1 (en) * 2010-08-05 2012-02-09 Indian Institute Of Technology (Iit), Bombay Exogenous pulmonary surfactant preparation comprising a phospholipid and an adjuvans
WO2012142724A1 (en) * 2011-04-20 2012-10-26 国防教育研究基金会 New low side effect pharmaceutical composition containing antituberculosis drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012017406A1 (en) * 2010-08-05 2012-02-09 Indian Institute Of Technology (Iit), Bombay Exogenous pulmonary surfactant preparation comprising a phospholipid and an adjuvans
WO2012142724A1 (en) * 2011-04-20 2012-10-26 国防教育研究基金会 New low side effect pharmaceutical composition containing antituberculosis drugs

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BHAWANA, RUPESH KUMAR BASNIWAL: "Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 59, no. 5, 2011, pages 2056 - 2061 *
DATABASE DATABASE TKDL "Agnimukhamlava'am", accession no. B/48 *
DATABASE DATABASE TKDL "Kaly'akaavaleha", accession no. G/4827 *
DATABASE DATABASE TKDL "Kaly'valeha", accession no. K/1378 *
DATABASE DATABASE TKDL "Nilakantha Rasa", accession no. K5/396 *
FENG-LIN YEN ET AL.: "Curcumin Nanoparticles Improve the Physicochemical Properties of Curcumin and Effectively Enhance Its Antioxidant and Antihepatoma Activities", J AGRIC FOOD CHEM, vol. 58, no. 12, 2010, pages 7376 - 7382 *
MEGHNA R ADHVARYU ET AL.: "Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs", WORLD J GASTROENTEROL, vol. 13, no. 23, 21 June 2007 (2007-06-21), pages 3199 - 3205 *
MEGHNA R ADHVARYU ET AL.: "Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach", WORLD J GASTROENTEROL, vol. 14, no. 30, 14 August 2008 (2008-08-14), pages 4753 - 4762 *
SINGH M ET AL.: "Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model", HUM EXP TOXICOL, vol. 31, no. 8, August 2012 (2012-08-01), pages 788 - 797 *

Also Published As

Publication number Publication date
WO2014170820A2 (en) 2014-10-23

Similar Documents

Publication Publication Date Title
WO2014062720A3 (en) Methods of treating cancer
IN2015DN00376A (en)
WO2012062925A3 (en) Compounds and methods for treating pain
WO2011099832A3 (en) Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same
WO2012024620A3 (en) Autotaxin inhibitors and uses thereof
GB201118656D0 (en) New compounds
WO2013188847A8 (en) Compositions and methods for transmucosal absorption
UA109991C2 (en) CARBAMATE COMPOUNDS, THEIR PREPARATION AND APPLICATION
MX2013011908A (en) Compositions and therapeutic uses of ikk-related kinase epsilon and tankbinding kinase 1 inhibitors.
IL232308A (en) C0mpounds as modulators of atp-binding cassette transporters, pharmaceutical compositions comprising them and their use in the preparation of medicaments for treating diseases and processes for preparation thereof
MY166014A (en) Combination therapy methods for treating proliferative diseases
MX366899B (en) New compounds.
HK1203356A1 (en) Pharmaceutical combinations comprising a thionucleotide analog
WO2011127333A3 (en) Compounds for treating disease, for administering, and for pharmaceutical compositions
HK1198869A1 (en) Combination treatments for hepatitis c
MX2015010791A (en) Methods of treating cancer and preventing drug resistance.
IN2015DN00450A (en)
HK1217092A1 (en) Therapeutic compounds and uses thereof
TW201613578A (en) Pharmaceutical combinations
PH12016502352A1 (en) Pharmaceutical composition
WO2014107730A3 (en) Use of fatty acid niacin conjugates for treating diseases
HK1218251A1 (en) Treatment of multiple sclerosis with laquinimod
HK1209672A1 (en) Treatment of multiple sclerosis with combination of laquinimod and fampridine
WO2015063613A3 (en) Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
HK1225972A1 (en) Use of laquinimod to delay huntington's disease progression

Legal Events

Date Code Title Description
122 Ep: pct application non-entry in european phase

Ref document number: 14785331

Country of ref document: EP

Kind code of ref document: A2