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WO2014168210A1 - Dispositif d'injection de produit chimique - Google Patents

Dispositif d'injection de produit chimique Download PDF

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Publication number
WO2014168210A1
WO2014168210A1 PCT/JP2014/060415 JP2014060415W WO2014168210A1 WO 2014168210 A1 WO2014168210 A1 WO 2014168210A1 JP 2014060415 W JP2014060415 W JP 2014060415W WO 2014168210 A1 WO2014168210 A1 WO 2014168210A1
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WO
WIPO (PCT)
Prior art keywords
injection
pattern
chemical
display
screen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2014/060415
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English (en)
Japanese (ja)
Inventor
根本　茂
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nemoto Kyorindo Co Ltd
Original Assignee
Nemoto Kyorindo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nemoto Kyorindo Co Ltd filed Critical Nemoto Kyorindo Co Ltd
Priority to JP2015511299A priority Critical patent/JP6338190B2/ja
Publication of WO2014168210A1 publication Critical patent/WO2014168210A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407—Infusion of two or more substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment
    • A61M2209/084—Supporting bases, stands for equipment

Definitions

  • the present invention relates to a drug solution injection device that injects at least a contrast medium as a drug solution into a patient, and in particular, a single drug solution injection device can use various injection protocol setting methods, and the injection protocol can be simplified and The present invention relates to a chemical injection device that can be created in various ways.
  • CT Computer Tomography
  • MRI Magnetic Resonance Imaging
  • PET PET
  • ultrasound diagnostic devices angiographic imaging devices
  • medical diagnostic imaging devices a patient may be injected with a contrast medium, physiological saline, or the like (hereinafter also simply referred to as “medical solution”).
  • Patent Document 1 relates to a technique for automatically injecting a chemical solution using a chemical solution injection device, and an operator corrects an injection pattern displayed on an injection graph on a screen as needed, and a final injection protocol. Is completed.
  • injection protocol setting methods there are various types of injection protocol setting methods depending on, for example, the examination site and the contrast purpose.
  • which injection protocol setting method is used may be determined depending on the preference of the doctor (operator).
  • An object of the present invention is to provide a chemical solution injection device and the like that can use various injection protocol setting methods with a single chemical solution injection device, and that can easily create various injection protocols. .
  • a chemical solution injection device is as follows: A piston drive mechanism for operating the piston member of the syringe; A control unit for controlling the operation of the piston drive mechanism; A display unit for displaying predetermined information; An input device that receives input from the operator; A chemical injection device comprising: The controller is a: causing the display unit to display a setting initial screen including at least a mode selection display unit for selecting one of a plurality of injection protocol setting modes; b: After a predetermined injection protocol setting mode is selected, one of the vertical axis and the horizontal axis is the injection speed, the other is the injection time, and the input of the injection pattern from the operator to the injection graph including at least one phase.
  • “Chemical solution” refers to, for example, a contrast agent, physiological saline, or a mixture thereof.
  • Specific examples of the “contrast agent” include a contrast agent having an iodine concentration of 240 mg / ml (for example, a viscosity of 3.3 Pa ⁇ s and a specific gravity of 1.268 to 1.296 at 37 ° C.), a contrast agent having an iodine concentration of 300 mg / ml ( For example, a contrast agent having a viscosity of 6.1 mPa ⁇ s and a specific gravity of 1.335 to 1.371 at 37 ° C.
  • physiological saline a physiological saline containing 180 mg of sodium chloride in 20 mL of physiological saline (for example, a viscosity of 0.9595 mPa ⁇ s at 20 ° C., a specific gravity of 1.004 to 1.04). 006) and the like.
  • the “infusion protocol” indicates what kind of chemical solution is to be infused, how much, and at what rate. If multiple injection protocols prepared in advance are stored in the system, the operator can select one of them and make corrections as necessary, and improve the inspection efficiency by setting conditions. Can be planned.
  • the information in the injection protocol may be one or a plurality selected from the type of chemical, the injection speed, the injection time, the injection pressure, and the injection timing (including pause, hold, etc.).
  • the “injection pattern” basically indicates the injection conditions of the chemical solution, and when used in connection with the injection protocol setting screen, a straight line (line segment) or a curve displayed on the injection graph is displayed. May also be shown.
  • “Setting Method” In this specification, “setting method” may be synonymous with “setting mode”.
  • “Patient” As used herein, “patient” may be synonymous with “subject”.
  • “Operator” In this document, “operator” may be synonymous with “user”.
  • Body classification refers to a high-order item representing a classification of the body such as the head, chest, and abdomen.
  • the “imaging part” refers to an imaging target such as a lower item included in the body classification, for example, heart, liver, blood vessel and the like.
  • Data may be synonymous with “information”.
  • Connection when a given device is said to be connected to another device, it may be either wired or wireless. In addition, a configuration in which one-way or two-way connection is made so that other devices can be controlled can also be expressed as “operably connected / linked”. “Electrically connected” means that components are connected so that electrical signals can be transmitted in one direction or in both directions, and may be in either a wired connection or a wireless connection. . In addition to the components directly connected to each other, the case where the components are indirectly connected via other elements is also included.
  • terminal refers to a computer system that performs data processing, connected to a network or used stand-alone, and includes a desktop computer, a laptop computer, a tablet computer, or the like.
  • the “control unit” includes a CPU, a memory, and the like, and performs arithmetic processing.
  • the “controller”, “processor”, “controller unit (control unit)”, “controller circuit (control circuit)”, “controller” It can also be called “module (control module)”, “processor unit”, “processor unit”, “processor module”, and the like.
  • the “controller” can be configured with a microcomputer, a microcontroller, a programmable logic controller, an application specific integrated circuit, and other programmable circuits. In the present specification, the “control unit” may physically have one configuration, but two or more control units functionally cooperate to form one “control unit”. It may be.
  • the basic processing in the control unit is an example.
  • the computer program stored in the memory is read, then data is received from the input device or the storage device according to the instructions of the computer program, and the data is calculated and processed.
  • the data is output to a storage device such as a memory or an output device such as a display.
  • the “computer program” may be a program that reads a storage medium storing the program using a predetermined device, device, mechanism, or the like, and operates the computer with a predetermined function.
  • the storage medium storing the computer program constitutes one aspect of the present invention.
  • the computer program may be provided via a communication network (in the example, the Internet).
  • the computer program may be a so-called differential program that can be realized in combination with a program already recorded in the computer.
  • a nonvolatile memory card flash memory
  • a hard disk an optical disk
  • a magneto-optical disk for example, a CD, a DVD, or the like
  • various media such as a magnetic recording medium and an optical recording medium can be used.
  • “Input device” (input means for the computer system) may be a keyboard, mouse, touch panel, trackball, physical switch operated manually or by machine, microphone, voice input, graphical user interface, etc. Good.
  • the movement of the operator may be recognized (non-contact in one example) and a predetermined input corresponding to the movement may be recognized.
  • Part can also be expressed as“ element ”or“ module ”or the like”) ”— in this specification, for example,“ (function name) ”+“ part ”can be realized as a function of a computer. .
  • Such “parts (elements), modules, etc.” may be provided in any device in the system. In addition, it is not always necessary to have one device, and the corresponding function may be distributed to two or more devices. Furthermore, only one or more predetermined “units” may be provided in an external server or the like via a communication network (for example, the Internet). Such “parts (elements), modules, etc.” may be various functions logically possessed by the computer.
  • the various components do not have to be individually independent, and a plurality of components are formed as a single member.
  • One component is made up of multiple members, one component is a part of another component, and one component is a part of another component , Etc.
  • the various constituent elements may be formed so as to realize their functions, and may be realized by hardware or realized by a computer program.
  • a certain component can be realized as dedicated hardware that exhibits a predetermined function, a processing device in which the predetermined function is realized by a computer program, a combination thereof, or the like.
  • “Graphical user interface” means an interface that can be visually operated by touching an icon, an image button, a pull-down menu, or a numerical input window on the screen with a cursor or in the case of a touch panel. That means.
  • the “icon” is (i) one that displays predetermined information and can be selected by the operator, and (ii) only displays predetermined information and is configured to be selectable. It may include both those that are not. All or some of the icons displayed on the screen can be selected by touching each display location with a touch pen, an operator's finger, or the like, or by a cursor on the screen.
  • the “chemical solution injector” includes the following components: a piston drive mechanism, a control unit (control unit), a display, and the like.
  • these components may be provided in any device constituting the chemical liquid injector. That is, when the chemical liquid injector includes an injection head, a console, and the like, (i) the injection head may be provided with a piston drive mechanism, and the console may be provided with a control unit and a display, or (ii) the injection head A control unit may be provided on both the console and the console. (Iii) A display may be provided on both the injection head and the console.
  • a control unit control unit
  • Such a control unit may be provided as a part of an imaging apparatus such as a CT scanner, an MRI apparatus, a PET apparatus, an ultrasonic diagnostic apparatus, or an angiographic imaging apparatus.
  • the “injection head” includes a syringe holding unit that holds the syringe and a piston drive mechanism that moves the piston of the syringe forward and / or backward.
  • the syringe mounting method mainly includes (i) a so-called side loading type in which the syringe holding portion is formed as a semi-cylindrical concave portion on the upper surface of the head and the syringe is set therein; and (ii) the syringe holding portion is There is a so-called front loading type in which the base end portion of the syringe is held on the front surface of the head.
  • One form of the present invention includes any type of injection head.
  • the chemical injection device may have one or more of the following: one or more pressure sensors, one or more syringe detection sensors (magnet sensors, Hall sensors, etc.), one or Multiple tilt sensors, one or more rotary encoders, one or more motor current detectors, and the like.
  • a pressure sensor is for detecting the pressure which pushes a piston member, for example, By this, the pressure estimated value of a chemical
  • the pressure sensor may be a load cell, for example.
  • the load cell should just be provided in the position which can detect the pressure which the ram member of a piston drive mechanism pushes a piston member.
  • the calculation is performed by calculating the resistance of the injection circuit (eg, the size of the needle), the concentration of the chemical solution, the injection It may be performed in consideration of conditions.
  • a pressure sensor that directly detects the pressure of the chemical solution may be included.
  • Syringe detection sensor detects whether a syringe, adapter, and / or protective case is attached, or what type of syringe, adapter, and / or protective case is attached. It is used for judgment.
  • a sensor may be either a contact type or a non-contact type, and for example, the following can be used: a contact sensor using physical contact, an electric for electrically detecting an object. Sensor, magnetic sensor, Hall sensor, optical sensor, proximity sensor, etc.
  • Tilt sensor detects the tilt of the injection head.
  • this type of injection head performs the suction of the chemical solution into the syringe in such a posture that the front end side (that is, the syringe side) is upward.
  • the chemical liquid injection is performed in such a posture that the front end side of the injection head is relatively downward (a posture in which the tip side is directed slightly downward).
  • Rotary encoder A rotary encoder or the like for detecting the rotation speed and / or rotation direction of the motor of the piston drive mechanism and the feed screw may be provided.
  • Motor current detector It is also possible to calculate the estimated pressure value of the chemical based on the motor current without using a load cell or the like. In this system, the motor current is monitored by the motor current detector during operation of the motor, and the estimated pressure value of the chemical solution is obtained based on the motor current.
  • the chemical injection device may further include one or more of the following: one or more head displays, one or more head status indicators, one or more physical buttons, One or more RFID communication devices, one or more data receivers, one or more data transmitters, etc.
  • a display for displaying predetermined information may be provided in the injection head.
  • the display may be provided, for example, in a part of the casing of the injection head. Alternatively, a sub display prepared separately from the housing may be used.
  • the display is LCD (Liquid A display unit using a crystal display (Organic Electro-Luminescence) display or the like may be used, but an LED (Light It may be a display unit using Emitting Diode).
  • the contents displayed on the display are not particularly limited, but may be as follows: a predetermined state display during the injecting operation, conditions for injecting the liquid to be injected, conditions for injecting the liquid to be injected, liquid chemicals to be injected Injection volume, chemical pressure, injection speed, etc.
  • a predetermined light emitting unit for notifying an operator of a predetermined state of the injection head may be provided in a part of the casing of the injection head.
  • the light source LED (Light Emitting Diode) can be used.
  • Such a light emitting unit has a function as a head status display unit, and can notify the operator of various situations of the injection head by changing a light emission color or a light emission pattern.
  • the physical button is not particularly limited, but may be as follows. Advance button for advancing the ram member, Treatment button for retracting the ram member, Accelerator button for increasing the moving speed of the ram member by pressing simultaneously with the advance button or the retract button, and a stop for stopping the head operation Buttons etc. These physical buttons can be appropriately arranged on the upper surface, side surface, lower surface, rear end surface and the like of the casing of the injection head. In the case of a two-cylinder injection head, the physical button arrangement for one piston drive mechanism and the physical button arrangement for the other piston drive mechanism may be asymmetric.
  • RFID communication device When a data holding unit such as an IC tag is attached to the syringe, adapter, or protective cover, a wireless communication device that reads information on the tag may be provided.
  • This wireless communication device may be an RFID reader that simply reads data from an IC tag, or may be an RFID reader / writer that can also write data to an IC tag.
  • the data receiver is for receiving data transmitted from the outside to the injection head by wire or wireless.
  • the data receiver may receive data such as the following from the outside: any data generated by the imaging device, any data generated by the hospital system, and so on.
  • the data transmitter is for sending predetermined data from the injection head or the like to the outside by wire or wireless.
  • a suitable protocol may be adopted in consideration of a communication system with another device which is a communication partner.
  • a data transmitter or the like that communicates with an external device may be provided in a console or other device.
  • the data that can be transmitted from the injection head to the outside by the data transmitter may be one or more of the following: the name of the contrast agent used (contrast agent identification information), the total injection amount of the contrast agent Contrast agent injection time, contrast agent injection pressure, contrast agent injection speed, set injection protocol, etc.
  • patient identification information for example, patient ID
  • examination identification information for example, examination ID
  • information regarding imaging time and the like. Such information may be transmitted in combination with the information regarding the contrast agent described above.
  • the injection head and console are provided with a communication unit for communicating with external devices.
  • the piston drive mechanism may be configured to control the operation so as to adjust the injection amount of the contrast agent, the injection speed, and the like according to the injection conditions input from the external device via the communication unit.
  • Abnormality detection It is preferable that one or a plurality of injection abnormalities can be detected using the various sensors as described above. -Injection failure due to malfunction of piston drive mechanism, -Injection abnormalities due to the syringe not being properly mounted on the injection head, -Abnormal injection due to insufficient contrast agent remaining in the syringe to perform the injection operation, -Abnormal injection due to the catheter or needle not being properly inserted in the patient-Abnormal injection due to kinks occurring in the middle of the drug solution path, -An injection abnormality such that the pressure value of the detected chemical is not within a predetermined range (a predetermined range having an upper limit and a lower limit, or a predetermined upper limit, a predetermined lower limit, etc.), etc.
  • a predetermined range having an upper limit and a lower limit, or a predetermined upper limit, a predetermined lower limit, etc.
  • the driving force of the piston drive mechanism exceeds the predetermined range.
  • the driving force falls below a predetermined range.
  • the detection result may be transmitted from the communication unit to the outside.
  • a pressure sensor for measuring pressure may be provided in the middle of the extension tube to detect whether the chemical solution is injected at a predetermined pressure.
  • the following screen may be displayed regarding chemical injection and condition setting.
  • the system may have the following graphical image or may have a storage device in which such a graphical image is stored.
  • the “self-check screen” is a screen for displaying the self-check result of the head immediately after the power is turned on.
  • “Calibration screen” is a screen for calibrating the touch panel.
  • the “service maintenance screen” is a screen that allows the console settings to be changed as necessary.
  • the “part selection screen” is a screen for selecting a protocol registered in each part.
  • “Injection condition setting screen” is a screen for setting the injection conditions of the protocol.
  • “Setting confirmation screen” is a screen for confirming the injection conditions immediately before injection and finely adjusting the injection conditions.
  • the “injection screen” is a screen for displaying the pressure during the injection.
  • “Protocol setting screen” is a screen for creating and editing a protocol.
  • the “environment setting screen” is a screen that displays function setting items that can be adjusted by the operator.
  • the “injection result screen” is a screen for displaying the injection result.
  • the imaging device may be, for example, an X-ray CT scanner or the like.
  • an imaging unit a gantry in one example
  • a bed on which a patient is placed
  • an operation control unit that controls the operations thereof
  • a data collecting unit for collecting fluoroscopic imaging data a main controller for controlling the entire operation, and the like.
  • the main controller may be provided as a console, for example.
  • the imaging device may also have one or more displays that display predetermined information.
  • an X-ray irradiation unit that has an X-ray tube, a collimator, etc.
  • the bed is configured to be movable using, for example, a motor as a drive source, and the movement operation is controlled by the operation control unit.
  • Various communication protocols between devices such as between the imaging device and the chemical injection device, between the other devices of the imaging device, and between the chemical injection device and other devices can be used.
  • CANopen Protocols such as HL7 and DICOM are listed.
  • FIG. 1 It is a figure which shows the relationship between a parameter, a change, and an injection
  • FIG. 10B is a perspective view of a mixing device used in the extension tube of FIG. 10A. It is sectional drawing of the mixing device used for the extension tube of FIG. 10A. It is a figure which shows an example of the screen for confirming the set injection
  • FIG. 3 is a diagram illustrating an example of a graphical user interface for changing an injection pattern.
  • FIG. 6 is a diagram illustrating another example of a graphical user interface for changing an injection pattern.
  • 1 is a block diagram of an example of a computer system according to an embodiment of the present invention. It is a schematic diagram of the system which performs condition setting with the console by the side of an imaging device.
  • the chemical injection system 1000 includes a chemical injection device 100 that injects at least a contrast medium as a chemical into a patient, and an imaging device 300 that captures a fluoroscopic image of the patient.
  • the chemical injection device 100 includes an injection head 110 held on an upper part of a movable stand or a part of a ceiling-suspended arm, and a console 150 connected thereto. Two syringes 200C and 200P may be detachably attached to the injection head 110 in parallel. Note that the injection head and the console may be connected in a wireless manner.
  • the specific configuration of the injection head and the console is not particularly limited, but a specific example as one embodiment will be described later with reference to other drawings (FIG. 7 to FIG. 7). (See FIG. 9B).
  • syringes 200C and 200P may be simply referred to as “syringe 200” without being distinguished.
  • An “injection head” is also called an injector or an injection head.
  • Examples of the chemical solution filled in the syringes 200C and 200P include a contrast medium and physiological saline.
  • one syringe 200C may be filled with a contrast medium
  • the other syringe 200P may be filled with physiological saline.
  • the syringe 200 has a hollow cylindrical cylinder member 221 and a piston member 222 that is slidably inserted into the cylinder member 221.
  • the cylinder member 221 may have a cylinder flange 221a formed at the base end portion thereof and a conduit portion 221b formed at the tip end portion thereof.
  • the extension tube 230 is connected to the conduit portion 221b of each syringe 200.
  • the extension tube 230 may be a so-called T-shaped tube or Y-shaped tube.
  • the tube 231a extends from the conduit portion 221b of one syringe 200C to the branch portion, and the tube extends from the conduit portion 221b of the other syringe 200P to the branch portion. It may have 231b and the tube 231c extended toward a patient from a branch part.
  • an injection needle is connected to the distal end side (not shown) of the tube 231c.
  • This injection needle is punctured into a patient's blood vessel, and the chemical solution is injected into the blood vessel by pushing out the chemical solution in the syringe 200C and / or the syringe 200P.
  • the syringe may be a prefilled type that is pre-filled with a chemical solution, or may be a suction type that sucks and uses a chemical solution in an empty syringe.
  • An IC tag 225 may be attached to a part of the cylinder member 221.
  • the IC tag 225 may store at least one of the following information: -Information about the syringe (one or more of syringe identification information, syringe pressure resistance, cylinder member inner diameter, piston member stroke, etc.), -Information (one or more of name (for example, product name), component information such as iodine amount, expiry date, chemical volume, etc.) of the chemical filled in the syringe.
  • IC tag may have a unique ID unique to the tag.
  • the IC tag may have at least one information selected from a syringe size, a syringe serial number, and a drug standardization code.
  • IC tag 225 for example, an RFID (Radio frequency identification) tag can be used.
  • the position where the IC tag 225 is attached may be, for example, the outer peripheral surface of the cylinder member 221. Specifically, the IC tag 225 may be near the cylinder flange on the outer peripheral surface.
  • the injection head 110 has a casing that extends long in the front-rear direction, and two recesses on which the syringes 200C and 200P are respectively placed are formed on the top end side of the casing. Also good.
  • a recessed part is a part which functions as a syringe holding part.
  • the syringe 200 may be directly attached to the recess, or may be attached via a predetermined syringe adapter.
  • the injection head 110 also has a piston drive mechanism 130 having at least a function of pushing the piston member 222 of the syringe 200.
  • Two systems of piston drive mechanisms 130 are provided, and each mechanism 130 operates independently.
  • the piston drive mechanism 130 may have a function of retracting the piston member 222, for example, for sucking a chemical solution into the syringe.
  • the two piston drive mechanisms 130 may be driven simultaneously, or may be driven at different timings.
  • the piston drive mechanism 130 is connected to a drive motor (not shown), a motion conversion mechanism (not shown) that converts the rotational output of the drive motor into a linear motion, and the motion conversion mechanism. It may have a syringe presser (ram member) for moving the piston member 222 forward and / or backward.
  • a piston drive mechanism a known mechanism generally used in a chemical liquid injector can be used.
  • An actuator other than the motor may be used as the drive source.
  • Typical operation of the piston drive mechanism includes the following: chemical injection (ram member advance) and chemical suction (ram member reverse).
  • chemical solution injection a chemical solution is injected in accordance with a set injection protocol (injection condition) by operating the motor in accordance with a predetermined motor control signal and moving the ram member forward.
  • chemical solution suction a chemical solution is sucked into a syringe by operating a motor in accordance with a predetermined control signal to retract a piston member. In the case of a prefilled syringe, the chemical liquid suction need not be performed.
  • the piston drive mechanism 130 may have a load cell (not shown) for detecting the force with which the syringe press presses the piston member 220.
  • a load cell for detecting the force with which the syringe press presses the piston member 220.
  • the estimated value of the pressure of the chemical solution when the chemical solution is being injected can be obtained using the detection result of the load cell.
  • the calculation of the estimated value is performed in consideration of the needle size, the concentration of the drug solution, the injection conditions, and the like.
  • the pressure may be calculated based on a motor current of a drive motor (not shown).
  • the injection head 110 When the IC tag 225 is attached to the syringe, the injection head 110 includes a reader / writer 145 that reads information from the IC tag 225 and / or writes information to the IC tag 225, as shown in FIG. You may have.
  • the reader / writer 145 may be provided in the recess 120a in which the syringe 200 is mounted. Note that the reader / writer 145 may have only a function of reading information from the IC tag 225.
  • the injection head 110 may have a control unit 144 for controlling operations of the piston drive mechanism 130 and the reader / writer 145.
  • a storage unit 146 that temporarily stores information read from the IC tag 225 may be included.
  • a plurality of physical buttons for causing the injection head 110 to perform various operations are also provided on the top and side surfaces of the casing of the injection head 110.
  • some of these physical buttons may be configured to emit light in order to notify the operator of predetermined information.
  • the console 150 may be used by being placed in an operation room adjacent to the examination room.
  • the console 150 includes a display unit 151 that displays a predetermined image, an operation panel 159 provided on the front surface of the casing, a control circuit (detailed below) arranged in the casing, and the like.
  • the operation panel 159 is a portion where one or a plurality of physical buttons are arranged, and is operated by the user.
  • the display unit 151 may be a touch panel display or a simple display.
  • the console 150 may include a speaker or the like (not shown) for outputting sound and / or sound.
  • the console 150 is depicted as having a control unit 153 that controls the operation of each connected unit and a storage unit 154 that stores various data.
  • the console 150 may have an interface for connection to the injection head 110 and an interface (not shown) for connection to the imaging apparatus.
  • the console 150 may have a hand unit 157 (input device 157 in FIG. 1) that is connected to the console by wire or wirelessly and is operated by the user.
  • the console 150 may have an interface to which an information storage medium is connected.
  • the console 150 has a slot disposed on the front surface, side surface, or rear surface of the housing. You may have.
  • the control unit 153 may include a memory, a processor, and the like, and may perform various processes according to a computer program.
  • a computer program may be stored in advance in a predetermined storage area of the console, downloaded from the outside through a network or the like, and stored in the predetermined storage area, or The information may be read from an information storage medium inserted in the slot.
  • control unit 153 may include a setting screen display unit 153a, an injection protocol creation unit 153b, an injection control unit 153c, a history generation unit 153d, and a history output unit 153e, as shown in FIG.
  • the setting screen display unit 153a may correspond to a function for displaying a screen for setting an injection protocol, specifically, an initial setting screen 360 (see FIG. 4A) as described later. Although the details will be described later, the setting screen display unit 153a displays an initial setting screen 360 including at least a mode selection display unit 363 for selecting one of a plurality of injection protocol setting modes on the display unit 151. It may correspond to the function to be performed. Data relating to the setting initial screen 360 and the like may be stored in a storage device of a chemical liquid injector, an imaging device, a hospital system, or other computers.
  • the protocol creation unit 153b may correspond to, for example, a function of accepting an input operation on the touch panel of the display unit 151 by the user and creating an injection protocol reflecting the contents.
  • the conditions input by the user in this way are, for example, at least one selected from the type of the chemical solution, the injection rate of the chemical solution, the injection amount of the chemical solution, the patient's physical information, the body classification of the patient to be imaged, the imaging region, and the like. It may be one.
  • the protocol creation unit 153b -After a predetermined injection protocol setting mode has been selected, one of the vertical axis and the horizontal axis is the injection rate and the other is the injection time, and the input of the injection pattern from the operator to the injection graph 361 including at least one phase.
  • An injection pattern input receiving unit for receiving;
  • An injection protocol generation unit for creating a chemical liquid injection protocol based on an injection pattern input on the injection graph 361;
  • a pop-up screen display for displaying a pop-up screen 371 on the screen; It may have a protocol change processing unit that accepts protocol changes and reflects the contents thereof.
  • the console computer system -Accept selection of a predetermined injection protocol setting mode, -Displaying an injection graph including at least one phase, one of the vertical and horizontal axes being the injection rate and the other being the injection time; -Accepting the injection pattern input from the operator to the injection graph, -Create a chemical injection protocol based on the injection pattern entered on the injection graph, -Display a pop-up screen (details below) on the screen, -Accept protocol changes and reflect their contents. And have the graphical user interface data required for it or configured to obtain it externally.
  • the injection control unit 153c may correspond to a function of controlling the operation of the piston drive mechanism 130 according to the created injection protocol.
  • the injection control unit 153b may operate only one of the piston drive mechanisms 130 and operate both at the same time.
  • the history generation unit 153d may correspond to a function for generating injection history data.
  • the “injection history data” includes, for example, an injection operation ID that is unique identification information for each injection operation, injection start and end dates and times, identification information of the chemical injection device, and identification of the chemical solution and the imaging region that are the injection conditions described above. It may be information. These may be text data. Further, image data of a time-dependent graph in which one of the horizontal axis and the vertical axis is the elapsed time and the other is the injection rate may be used.
  • the history output unit 153e may correspond to a function of transmitting injection history data to the outside. Specifically, data may be transmitted to a predetermined external device and / or network. Information on the liquid medicine obtained from the IC tag of the syringe or manually input by the operator or input from an external network or the like is transmitted from the liquid injector to the medical information system in the hospital. A system configuration in which a system having an accounting processing function performs accounting processing based on the information is also possible.
  • the storage unit 154 may store, for example, image data displayed on the display unit 151. Further, an algorithm including a calculation formula for setting injection conditions, and data of injection protocol may be stored. The injection rate may be constant or may change with time. In the case of injecting contrast medium and physiological saline, information on the order of injecting these drug solutions is also included in the injection protocol.
  • console 150 may have a slot (not shown), and the console 150 may be inserted into and input from the information storage medium.
  • the imaging apparatus 300 is, for example, an X-ray CT scanner, an MRI apparatus, an angiography apparatus, a PET apparatus, an ultrasonic diagnostic apparatus, or the like. As shown in FIG. 3, an imaging unit 303b that captures a fluoroscopic image of a patient, And a bed 304 on which the robot is placed and a control unit 303a that controls the operation of the bed 304 may be provided.
  • the injection head 110 and the console 150 may be connected by a cable, but as described above, they may be connected via a wireless communication unit or the like.
  • the communication unit may be externally attached to the injection head 110 or may be built therein.
  • the communication unit may be externally attached to the console 150 or may be built therein.
  • A2 In the above description, an injection head to which two syringes are attached is shown, but an injection head to which only one injection head is attached may be used.
  • the chemical injection device 100 is not limited to the CT examination, but may be an apparatus for MR examination, angiography examination, PET examination, ultrasonic diagnosis, or the like.
  • A4 As a contrast agent injection pattern, a variable pattern in which the injection speed is linearly reduced and thereafter the injection speed is kept constant, and / or the injection speed is linearly reduced and thereafter the injection speed is linearized again. It is also possible to use variable patterns that increase in number. Furthermore, you may use what abbreviate
  • A5 In the above description, for example, as shown in FIG. 1, the chemical injection device in which the injection head and the console are configured separately is shown. However, a chemical injection device such as the following may be used: -A chemical injection device in which the injection head and the console are integrated, in other words, a single device is used to set the injection protocol, display various states during chemical injection, and control the operation of the piston drive mechanism.
  • Such as a chemical injection device Such as a chemical injection device.
  • a chemical injection device in which the injection head and the console are integrated as one casing, and further comprising a separate battery unit.
  • a battery unit may be an AC power source, may be installed at any location in the examination room, or may be held in a part of a movable stand.
  • a chemical injection device capable of controlling a predetermined operation of the chemical injection device from the outside of the examination room using, for example, a wired or wireless remote controller.
  • the wireless system may be a system using infrared rays, or a wireless LAN, Wi-Fi (registered trademark), Bluetooth (registered trademark), ZigBee (registered trademark), or the like. Good.
  • the controlled operation may be any operation including, for example, power on / off of the apparatus.
  • the start and / or stop of any operation of the injection head may be controlled with a remote controller.
  • a control unit such as a miniaturized console (e.g. having one or more buttons and / or a display)
  • such a control unit is held on a movable stand together with an injection head.
  • such a control unit is held on a ceiling-suspended arm together with an injection head.
  • it is integrated with the injection head.
  • the controller 144 of the injection head may have at least one of the functions of the units 153a, 153b, and 153c in FIG. That is, in the present invention, the “control unit” responsible for the screen display function and the injection protocol creation function is not particularly limited, and may be a control unit in the injection head or in the console. It may be a control unit or a combination thereof.
  • B1-1) In addition to the configuration in which the setting screen (graphical user interface) for setting the injection protocol is displayed on the console display, the following configuration can also be adopted. -The injection head has a sub-display on which a setting screen (graphical user interface) as described above for setting the protocol is displayed.
  • the injection head 110 may include a component corresponding to the control unit 153.
  • the “chemical injection device” in the present invention includes a device in which at least a part of the function of the console 150 is incorporated in the injection head 110.
  • the setting screen as described above for setting the protocol may be displayed on the display of the imaging apparatus. That is, in this case, the imaging apparatus provides a graphical user interface, and the operator can set conditions via this interface. And it is also preferable that the data of the conditions set on the imaging device side in this way is transmitted to the chemical injection device by wire or wireless, and the setting is performed from the imaging device side.
  • B1-3 As described above for setting a protocol in any device (for example, a chemical injection device, an imaging device, a database server, or other computer system) in the system in order to realize the configuration as described above Data for various setting screens (graphical user interface).
  • the chemical injection device of this embodiment may operate as follows as an example:
  • the user installs the syringes 200 ⁇ / b> P and 200 ⁇ / b> C on the injection head 110 with the power supply of the chemical injection device 100 turned on.
  • the user connects the extension tube to the syringes 200P and 200C via the extension tube 230, and punctures the patient with an injection needle (not shown) provided at the distal end of the extension tube.
  • an injection needle not shown
  • one or a plurality of screens for setting the injection protocol are displayed on the display unit 151.
  • at least one of the following parameters may be entered, selected or changed: -Body segment to be imaged-Region to be imaged (referred to as imaging region) -Information such as patient weight-Type of medicinal solution to be injected, etc.
  • Images for selecting these parameters may be displayed sequentially or collectively.
  • the input, selection, or change of the parameters as described above may be automatically performed according to the function of the apparatus or may be performed by a user operation.
  • a predetermined button for example, a confirmation button
  • creating an injection protocol for example, (i) select one of several basic patterns prepared in advance according to the image for creating the injection protocol displayed on the screen, and confirm or need its contents. (Ii) by creating a desired injection protocol by plotting several reference points in the injection graph displayed on the screen.
  • pharmacokinetic analysis when the patient and contrast medium injection conditions (for example, height, weight, sex, cardiac output, contrast medium concentration, injection speed, injection volume, etc.) are changed
  • This can be implemented using simulation software or the like that can estimate changes in the temporal contrast curve of the aorta (which may be the right heart, left heart, artery, pulmonary circulation, systemic circulation, etc.).
  • a CT value (HU) of 1 mgI / ml may also be set.
  • the injection condition to be changed may be the amount of iodine per body weight, the amount of iodine per body weight per time, or the like.
  • the various conditions in the simulation software may be input / output through two-way data communication with PACS, HIS, RIS, imaging device, workstation, etc.
  • the imaging device may acquire a complex injection protocol, the imaging device may set the injection protocol, or change the speed and / or amount while viewing the CT value.
  • -CANopen standards -HL7 standard, which is the standard for medical information exchange -DICOM (Digital Imaging and Communication in Medicine) standard, etc.
  • DICOM Digital Imaging and Communication in Medicine
  • the operation of the piston drive mechanism 130 is controlled based on the injection protocol, and the drug solution is injected into the patient.
  • FIG. 3 is a flowchart showing an example of an injection protocol setting procedure and the like.
  • 4A to 4H are examples of screens displayed on the display unit 151 of the console 150.
  • FIG. 3 is a flowchart showing an example of an injection protocol setting procedure and the like.
  • a screen 360 as shown in FIG. 4A is displayed on the display unit 151 (step S1).
  • This screen 360 is basically for selecting one of a plurality of injection protocol setting modes, and is also referred to as a setting initial screen 360 in the following description.
  • the console reads the data of the initial setting screen 360 from a storage device (not shown) and displays the image on the display.
  • injection graph 361 (detailed below) is already displayed on the screen of FIG. 4A, this injection graph 361 may appear after selecting the mode selection icon 363 (detailed below), for example. .
  • each display of the setting initial screen 360 of FIG. 4A will be described.
  • an injection graph 361 for creating a protocol is displayed.
  • the horizontal axis represents elapsed time and the vertical axis represents injection speed.
  • the vertical axis displays the speed up to 5.0 ml / sec (in the example, every 1.0 ml / sec), and the horizontal axis includes five phases. It is shown.
  • the number of phases to be displayed is not limited to five, and may be one, two, three, four, or six or more.
  • the scale concerning the speed on the vertical axis and the display mode of the phase on the horizontal axis may be appropriately changed.
  • the vertical axis is speed and the horizontal axis is time, but the vertical axis may be time and the horizontal axis may be speed.
  • various icons 361a, 361b, 362a, 362b, and 363 to 366 are displayed above the injection graph 361 (an example). All or some of the icons displayed on the screen can be selected by touching each display location with a touch pen or an operator's finger or the like, or with a cursor on the screen.
  • Icons 361a and 361b respectively indicate a contrast medium and physiological saline.
  • the contrast medium is represented by “A”
  • the physiological saline is represented by “B”.
  • the icon 361a contrast agent
  • a contrast agent injection pattern can be created in the injection graph 361.
  • the icon 361b saline injection pattern can be created in the injection graph 361.
  • these icons 361a and 361b are for selecting which of the contrast medium and the physiological saline is to be performed.
  • Icons 362a and 362b are for displaying a basic pattern of a predetermined injection protocol.
  • the number of icons for displaying the basic pattern of the injection protocol can be appropriately changed according to the number of selectable injection protocols, and three or more such icons can be displayed. It may be.
  • an image (for example, an image obtained by simplifying the shape of the protocol) may be displayed on the icon so that the injection protocol can be easily recognized visually. . Further, by touching one icon, two or three or more injection protocol candidates may be sequentially displayed.
  • predetermined character information is input or a predetermined target image is operated with a cursor by operating a mouse or the like. Or may be selected.
  • the mode selection icon 363 is basically for an operator to manually create an arbitrary injection pattern (injection profile). In this case, this icon 363 is used to select the injection protocol setting mode. Examples of setting modes for the injection protocol include (i) flow rate mode, (ii) standard / weight input mode, (iii) heart / weight input mode, and the like. Details of each will be described later. When the mode selection icon 363 is pressed, at least two, preferably three of them may be switched sequentially.
  • the icon 364 displays the weight of the patient, and is “60” Kg as an example here. Although not limited, when the icon 364 is pressed, a predetermined pop-up screen (not shown) or pull-down screen (not shown) is displayed, and the weight can be changed by pressing the numeric keypad or the increase / decrease button in the screen. It may be like this.
  • the icon 365 displays the amount of iodine per patient's body weight, and here is “450” mgI / Kg as an example.
  • the numerical value of 450 mg I / Kg is an example of the amount of iodine in the standard / weight input mode. In the case of the heart / weight input mode, for example, 24.5 mg I / Kg / sec may be displayed.
  • a predetermined pop-up screen (not shown) or pull-down screen (not shown) is displayed as described above. By pressing a numeric keypad or an increase / decrease button in the screen, this is displayed.
  • the numerical value may be changeable.
  • the icon 366 may display a pressure limit value, and may be displayed as “10.0” Kg / cm 2 or the like as an example. Although not limited thereto, when the icon 365 is pressed, a predetermined pop-up screen (not shown) or pull-down screen (not shown) is displayed as described above. By pressing a numeric keypad or an increase / decrease button in the screen, this is displayed. The numerical value may be changeable.
  • the screen can also display information such as patient information other than the subject's ID and weight, and information such as the imaging site. Further, a predetermined delete button may be displayed, and a part or all of the injection protocol displayed in the graph 361 may be deleted by pressing this delete button.
  • step S2-1 and S2-2 the patient's weight and iodine amount are input, respectively. Any of the order of step S2-1 and step S2-2 may be first or may be simultaneous. Further, in the flowchart of FIG. 3, such an input is performed after the initial setting screen 360 is displayed. Of course, such an input is performed before the initial setting screen 360 is displayed. Also good. Alternatively, one of step S2-1 and step S2-2 may be performed before step S1, and the other may be performed after step S1.
  • body classification and / or imaging region input may be performed, which will be described later.
  • the input of the patient weight (for example, 60 kg) can be performed by, for example, a conventionally implemented method.
  • the operator may input the weight through a predetermined input (see below) through the display unit 151 (here, a touch panel that also serves as an input device): -Numeric keypad input, -Two, three or more weight category icons are displayed on the screen, and the operator selects one of them, -A preset default value or default weight category is displayed, and the operator changes the value or category as necessary, etc.
  • patient weight data may be automatically input to the console 150 via an external network.
  • patient information including at least body weight data may be obtained from a database server (for example, hospital information system, HIS, Hospital Information System) connected via a LAN (Local Area Network) or the Internet. Good.
  • the chemical injection device is an example, as shown in FIG. 12, such as PACS (Picture Archiving and Communication Systems), HIS (Hospital Information System), RIS (Radiologic Information System, image printer, workstation image, etc.). It may be wired or wirelessly connected to a network to which some or all of them are connected.
  • an electronic weight scale (not shown) to the chemical injection device online, measure the patient's weight with the electronic weight scale, and input the result to the chemical injection device.
  • an electronic weight scale (not shown) to the chemical injection device online, measure the patient's weight with the electronic weight scale, and input the result to the chemical injection device.
  • a bed in the imaging apparatus, for example, it is possible to measure the weight of the subject on the bed and provide data to the drug solution injector.
  • Examples of the input of the iodine amount include the iodine content (for example, 300 mg / ml) of the contrast agent and the iodine amount required per body weight (for example, 450 mg I / Kg).
  • the iodine content of the contrast agent may also be input by the operator making a predetermined input through the display unit 151 (for example, a touch panel) of the console 150, or may be automatically read from the IC tag of the syringe. It may be entered.
  • the amount of iodine required per body weight may also be input by the operator performing numeric keypad input or the like through the display unit 151 (for example, a touch panel). Alternatively, when a body segment or an imaging region is selected, a value set in advance according to the selected body segment or imaging region may be automatically set.
  • an icon 373a displayed as “300” appears in the upper part of the screen (an example), which indicates that the iodine content of the contrast medium is 300 mg / ml.
  • other iodine content candidates for example, 240, 330, 350, 370, etc.
  • a configuration may be adopted in which when this icon is pressed, a small amount is injected in order to confirm in advance the arrival time of the drug solution from the contrast medium or the contrast medium by saline. At that time, the remaining amount may be checked to determine whether the remaining amount necessary for the main plot injection is affected.
  • the icon displayed as “root button” when this icon is pressed, a configuration may be used in which a small amount is injected in order to confirm whether the blood vessel is properly secured with a raw diet or a contrast medium. At that time, the remaining amount may be checked to determine whether the remaining amount necessary for the main plot injection is affected.
  • step S3 When the input of the patient's weight and iodine amount is completed, in step S3, one or both of the injection amount (ml) and the initial velocity (ml / sec) of the contrast medium to be injected into the patient are calculated.
  • This calculation is an example, and is performed by the control unit 153 of the console 150 based on a command of the computer program.
  • the calculation may be performed by a computer system on the imaging apparatus side or another computer system.
  • a predetermined calculation for setting an injection protocol or a predetermined setting screen is displayed, the operation effect thereof is exhibited. Therefore, from such a viewpoint, which computer system performs the calculation or which display monitor displays the screen may be arbitrarily changed.
  • the “heart / weight input mode” is a mode used in the case of cardiography or the like, and the operator inputs an injection pattern in one or a plurality of phases on the injection graph as a whole. This is a setting method for creating a pattern.
  • I A iodine amount required per second unit time (mgI / Kg / sec)
  • I CM Iodine content of contrast agent (mgI / ml)
  • W Weight (Kg)
  • the “iodine amount required per unit time per second” is also input, for example, by an operator inputting a numeric keypad through the display unit 151 (for example, a touch panel), in the same manner as the “iodine amount required per unit weight” described above. Also good. Alternatively, it may be automatically read from the IC tag of the syringe. When selecting a body segment or an imaging region, a preset value corresponding to the selected segment or region may be automatically set.
  • step S4 the operator presses the setting mode selection icon 363 to select the setting mode of the injection protocol.
  • step S5 an example of creating an injection protocol will be described.
  • the operator creates an injection pattern for each phase (a single phase when there is one phase) on the injection graph 361.
  • a pop-up screen 371 appears. Instead of touching the area 374, for example, a pop screen 371 may appear by selecting a predetermined icon (not shown) on the screen.
  • a variable constant display unit 371a In the pop-up screen 371, a variable constant display unit 371a, an injection time display unit 371b, and the like are displayed. Further, a flash button 372a, a dilution button 372b, a final speed fixed pattern button 372c, and the like are displayed. An OK button for confirming the input content and a cancel button for discarding the input content are also displayed.
  • variable constant display unit 371a includes a character display unit that indicates a numerical value of the variable constant and an adjustment button for increasing or decreasing the value.
  • the adjustment button may include an image button (up button) for increasing the numerical value of the variable constant and an image button (down button) for decreasing the numerical value of the variable constant.
  • variable constant is a parameter related to the gradient of the contrast agent injection pattern, and refers to the ratio between the final velocity and the initial velocity in the phase.
  • the display unit 371b indicating the injection time includes a character display unit indicating a numerical value of the injection time of the phase and an adjustment button for increasing or decreasing the value.
  • the adjustment button may have the same configuration as that of the variable constant display unit 371a. By operating the adjustment button, the current injection time (“10” sec in one example) can be changed to, for example, “20” sec or “5” sec.
  • the flush button 372a is a button for creating a constant rate injection of physiological saline in the next phase of the phase.
  • the physiological saline injection speed may be an initial speed of the contrast medium in the phase.
  • the same speed as the sum of the contrast medium injection speed and the physiological saline injection speed may be used.
  • the injection speed at which the effect of flash injection can be obtained for example, ⁇ 20%, preferably ⁇ 10% of the reference speed (the initial speed of the contrast medium or the total speed of the two drug solutions) as described above.
  • the speed may be within a range.
  • the dilution button 372b is a button for creating an injection pattern of physiological saline injected simultaneously with the contrast agent in the phase.
  • the following injection pattern may be created: (I) When the injection speed of the contrast agent is constant, a constant-rate saline injection pattern is displayed. (Ii) A pattern in which the contrast agent injection rate decreases, specifically, a pattern in which the injection rate decreases with time as illustrated in FIG. 4D as an example, and the final rate is zero and not substantially zero. In the case of crossing the contrast agent injection pattern, specifically, the sum of the contrast agent injection rate and the saline injection rate is constant or substantially constant in the phase.
  • the reference line (vertical or horizontal reference line that passes through the approximate center of the line segment of the injection pattern in one example) is displayed as a reference and the contrast medium injection pattern and the physiological saline injection pattern are displayed.
  • a physiological saline injection pattern that crosses the contrast agent injection pattern in a line symmetrical manner is displayed, as in (ii) above.
  • the final speed fixed pattern button 372c is a button for creating an injection pattern having a shape that changes from a predetermined initial speed to a zero or substantially zero final speed in the phase.
  • the injection speed being zero basically means that the motor (not shown) of the piston drive mechanism 130 is not operated. Such speed setting may be performed. However, the operation of the motor is continued by setting the injection rate to substantially zero, for example, in the range of 0.01 ml / sec to 0.5 ml / sec, or in the range of 0.05 ml / sec to 0.2 ml / sec. However, it may be controlled that the chemical liquid injection is not substantially performed.
  • FIG. 4C shows an example of an injection pattern that is displayed when the OK button on the pop-up screen 371 is pressed while the variable constant is 1.0 and the flash button 372a is selected.
  • a constant rate contrast agent injection pattern (line segment) 368a is displayed in the first phase
  • a constant rate saline injection pattern (line segment) 368b is displayed in the second phase.
  • the injection rate is 4.0 ml / sec, which is the same as an example.
  • the amount of contrast medium to be injected into the patient has already been calculated (as a specific example, 80 ml).
  • the injection speed is calculated as 4.0 ml / sec by dividing the injection amount by the injection time.
  • the injection speed is automatically calculated, it is not necessary for the operator to calculate the injection amount and input it.
  • the rate of the physiological saline in the second phase is also 4.0 ml / second as in the example of FIG. 4C. sec.
  • FIG. 4D shows an example of an injection pattern created when the variable constant is 0.5 and the dilution button 372b is selected.
  • the contrast agent injection pattern 368a in which the speed decreases from 4.0 ml / sec to 2.0 ml / sec, and the physiology in which the speed increases from 2.0 ml / sec to 4.0 ml / sec.
  • a saline injection pattern (line segment) 368b is displayed. That is, in this phase, the contrast agent injection rate and the physiological saline injection rate are not constant, but the total rate of both is constant at 4.0 ml / sec.
  • the first phase injection pattern may be combined with the second phase flush injection with physiological saline.
  • the injection speed of the physiological saline of the second phase may be set to be the same as the initial speed of the contrast agent of the first phase.
  • FIG. 4E shows an example of a state in which the dilution button 372b is selected on the pop-up screen 371 when the variable constant is 1.0.
  • the display unit 371c indicating the mixing ratio may appear.
  • a character display portion indicating the numerical value of the ratio and an adjustment button for increasing or decreasing the value are displayed.
  • the adjustment button may have the same configuration as that of the variable constant display unit 371a.
  • FIG. 4F shows an example in which a contrast medium and physiological saline are injected at a constant rate of 50:50 in the first phase.
  • the total injection rate of the contrast medium and the physiological saline is 4.0 ml / sec.
  • the present invention is not limited to such a display mode, and each of the contrast agent injection pattern and the physiological saline injection pattern may be displayed at a height of 2.0 ml / sec.
  • FIG. 4G shows an example of an injection pattern created by selecting the final speed fixed pattern button 372c.
  • a contrast agent injection pattern 368a in which the speed is reduced from 4.0 ml / sec to 0.1 ml / sec (substantially zero) is displayed in the first phase.
  • the end speed fixing pattern button 372c may be as follows: That is, in the case of mixed injection of contrast medium and physiological saline as shown in FIG. 4F, the end speed fixing pattern button 372c. Is selected so that the contrast agent injection pattern changes from a predetermined initial velocity (here, 4.0 ml / sec in the example) to a substantially zero final velocity so that it crosses the injection pattern. In addition, a physiological saline injection pattern that changes from an initial velocity of zero to a predetermined final velocity (here, 4.0 ml / sec as an example) appears.
  • a predetermined initial velocity here, 4.0 ml / sec in the example
  • the predetermined initial speed here, 4.0 ml / sec in this example
  • the predetermined final speed in this example, 4.0 ml / sec
  • An injection pattern of contrast medium to be injected, and an injection of physiological saline that changes from a substantially zero initial speed to a predetermined final speed (in this example, 4.0 ml / sec) so as to cross the injection pattern A pattern may appear.
  • the fixed speed fixed pattern button 372c when the variable constant is less than 1.0, the contrast medium injection pattern changes from a predetermined initial speed to a substantially zero final speed as described above.
  • a pattern to be displayed may appear.
  • the display of the injection graph 361 is not limited to the one illustrated in FIGS. 4A to 4G, and various changes can be made.
  • an interruption icon 369a is displayed at the start point of the phase or at the end point of the phase, and when this icon is operated (for example, long pressing the icon), the chemical solution is interrupted at a predetermined time interval.
  • a phase may be inserted.
  • a time display unit 369b indicating the injection time of each phase may be displayed.
  • the display unit 369b may be a simple character display or a selectable icon.
  • a speed display portion 369 indicating the speed of the end portion of the injection pattern (here, only the initial speed “4.0” is shown as an example) may be displayed.
  • the injection amount display part 369d which shows each injection amount of the contrast agent and chemical
  • the input of one injection pattern is completed as a whole by setting the injection pattern of one or a plurality of phases through the pop-up screen 371 as described above (step S5).
  • step S6 the injection protocol is completed through confirmation by the operator and pattern correction as necessary (details will be described later) (step S6).
  • step S7 the piston drive mechanism 130 is controlled based on the injection protocol, and the medical solution is injected into the patient.
  • a third phase to the injection protocol (for example, consisting of two phases) registered in advance in the icons 362a, 362b, etc. via the operation of the pop-up screen 371.
  • the basic pattern of the registered injection protocol may be appropriately corrected through the operation of the pop-up screen 371.
  • the operator can create an arbitrary injection pattern by operating the pop-up screen 371 on the injection graph 361 as in the standard / weight input mode.
  • the initial velocity of the contrast medium is determined in advance in the heart / weight input mode, the starting point of the first phase injection pattern (segment) is automatically determined, and the operator inputs the initial velocity. There is no need to do.
  • Other procedures for creating the injection pattern can be the same as those in the standard / weight input mode described above.
  • B2-3 Flow rate input mode
  • the operator operates the setting mode selection icon 363 on the screen.
  • the contrast agent injection amount and the initial velocity are not calculated as in the above two setting modes, and the operator inputs an arbitrary injection pattern, so that one injection pattern as a whole is input. Can be created.
  • this mode other procedures for creating the injection pattern can be the same as those in the standard / weight input mode described above.
  • the contrast medium injection amount and the initial velocity are not calculated. Therefore, when the flow rate input mode is selected with the icon 363, the icons 364 and 365 on the screen (FIG. 4A) are displayed. It may be configured to disappear. It will be described later that other input methods may be displayed on the screen and appropriately selected.
  • FIG. 5A shows a case where the injection amount is changed from V to V ′.
  • the injection time t is not changed, and the initial speed f 1 and the final speed f 2 are changed.
  • the weight of the observer is changed (increased) from W to W ′, or the iodine amount is changed (increased) from a to a ′.
  • this corresponds to the case where the weight is changed by pressing the icon 364, or the case where the iodine amount is changed by pressing the icon 365.
  • the displayed injection pattern may be automatically changed. That is, the initial speed of the contrast agent is automatically changed from 4.0 ml / sec to 2.0 ml / sec, for example, while maintaining the injection time and variable constant, and the final speed is 2.0 ml / sec to 1.0 ml. / Sec (see injection patterns 368a and 368a ').
  • the saline injection pattern 368b is automatically changed to the injection pattern 368b '.
  • FIG. 5B shows a case where the variable constant is changed from C to C ′.
  • the contrast agent injection pattern displayed in the injection graph is automatically changed in the manner exemplified above correspondingly. May be. Further, the physiological saline injection pattern may be automatically changed correspondingly.
  • FIG. 5C shows a case where the injection time is changed from t to t ′.
  • the injection pattern of the contrast agent displayed on the injection graph may be automatically changed in the manner illustrated above correspondingly.
  • the physiological saline injection pattern may be automatically changed correspondingly.
  • Figure 5D illustrates the case of changing the f 1 'of the initial velocity from the f 1.
  • the contrast agent injection pattern displayed on the injection graph is automatically changed in the above manner in response to the change.
  • the physiological saline injection pattern may be automatically changed correspondingly.
  • the operation for changing the shape of the injection pattern (line segment) displayed on the injection graph 361 is not particularly limited, and any input method may be used.
  • one or both ends of the injection pattern can be selected by a GUI (Graphical User Interface) function, and the end of the injection pattern is moved by moving the selected end in the vertical direction and / or the horizontal direction.
  • the position of the part may be changed, and at least one of the injection speed and the injection time may be automatically changed accordingly.
  • the injection pattern (line segment) may be moved in any direction (at least one of the vertical direction and the horizontal direction), and the condition may be automatically changed accordingly.
  • an injection pattern once set for example, a pattern in which a contrast agent injection pattern and a physiological saline injection pattern intersect
  • a pop-up screen 371 is displayed, and the pop-up screen 371 may be operated to change the condition.
  • the operator can freely input a desired injection pattern on the injection graph 361.
  • medical solution injection apparatus may be comprised so that the data may be preserve
  • the storage unit may be a storage area of a chemical injection device (for example, in the console), a storage medium inserted into a slot of the console, or a chemical injection by wired or wireless. It may be a storage area of an external network connected to the device.
  • the control unit of the chemical solution injector may be stored in a locked state so that the contents of the injection protocol are not changed or overwritten later. The lock may be released by inputting a password.
  • the chemical injection device performs chemical injection in accordance with an injection protocol created based on such an injection pattern.
  • an injection protocol created based on such an injection pattern.
  • various modes including a conventionally known mode can be taken. .
  • the chemical injection device 100 may have a configuration as shown in FIG.
  • the chemical injection device 100 includes a two-tube injection head 110 that is rotatably held on an upper portion of a movable stand 111.
  • a syringe is attached to each recess 120 a via syringe adapters S 121 and S 122 that hold the cylinder flange of the syringe and the vicinity thereof.
  • the console 150 is connected to the injection head 110 by a cable 102 as an example.
  • the display unit 151 is a touch panel display.
  • a plurality of physical buttons are arranged as the operation panel 159.
  • a home button physical button
  • a home screen on which a plurality of icons are arranged may be displayed on the screen.
  • a “PLOT” icon may be displayed as such an icon, and by selecting this icon, an initial setting screen 360 as shown in FIG. 4A may be displayed.
  • the hand unit 157 is wired to the console 150 and used on a work table.
  • This syringe includes a cylinder member 501 and a piston member 502.
  • a cylinder flange 501a of the cylinder member 501 has an I-cut contour shape, and two notches 505 (only one of them is provided on the outer peripheral portion of the flange 501a. Is formed).
  • the conduit portion 501b at the tip of the cylinder member 501 may be for luer lock connection having two inner and outer cylindrical portions arranged coaxially.
  • a ring-shaped protrusion 501c may be formed on the rear surface of the cylinder flange 501a.
  • the other of the two syringes may be a syringe as shown in FIGS. 8B (a) and (b), and this syringe is for, for example, 200 ml.
  • this syringe also includes a cylinder member 501 and a piston member 502, and the cylinder flange 501a of the cylinder member 501 may have an I-cut contour.
  • Two notches 505 are formed on the outer periphery of the cylinder flange 501a.
  • the conduit portion 501b at the tip of the cylinder member 501 may be for luer lock connection having two inner and outer cylindrical portions arranged coaxially.
  • a ring-shaped protrusion 501c and a plurality of ribs 501d extending outward from the protrusion 501c may be formed on the rear surface of the cylinder flange 501a.
  • the cylinder flange 501a is formed with both the notch 505 and the rib 501d, but only one of them is formed (for example, the notch S505 is formed). May not be).
  • the rib S501d may have a shape in which only two upper and lower ribs are left out of the plurality of ribs arranged in the vertical direction in the figure, and the other ribs are omitted.
  • Such a rib group may be a syringe formed on only one of the left and right sides of the flange portion.
  • two ribs at both upper ends or two ribs at both lower ends may be used.
  • connection connectors 509 and 509 are attached to the end of the tube connected to each syringe, and another form of connection connector 510 is attached to the end of the tube toward the patient.
  • Each connection connector 509 may have a cylindrical portion 509a having a screw portion 509b formed at the tip, and may be connected to the syringe conduit portion 501b by a luer lock method.
  • the connection connector 509 may have a function as a one-way valve, in particular, as disclosed in WO2012 / 060365.
  • the connection connector 510 may be connected to a catheter or an indwelling needle (not shown).
  • the ceiling-suspended holding arm 111 ′ may be a combination of horizontal rotation and vertical movement as shown in FIG. 9A. In this example, it has a base part attached to the ceiling and an articulated arm part extending from the base part, and the injection head 110 has a support bar (in one example, a bar shape extending in the vertical direction) on the terminal side of the arm part. Member).
  • a chemical liquid injection device in which a sub-display 149 is attached to a part of the holding arm 111 ′, specifically, in the vicinity of a part holding the injection head 110 may be used.
  • the sub-display 149 may be electrically connected to the injection head 110 or electrically connected to the console 150, and may be configured to be able to display various information related to the chemical solution injection.
  • the sub display 149 may be a touch panel display, or may be a simple display without a touch panel function.
  • such a sub-display 149 may be provided directly on a part of the injection head 110.
  • such a sub display 149 may be provided on the side or rear of the casing of the injection head 110.
  • the sub display 149 may be attached to a part of the movable stand 111.
  • a control unit (not shown) may be mounted on the movable stand 111 separately from the injection head 110.
  • the control unit of the chemical injection device may be configured as follows: (S1) The injection graph 361 as illustrated in FIGS. 4A to 4H is displayed on the sub-display 149. (S2) Accepting an injection pattern input from the operator in the injection graph 361; (S3) In the injection graph 361, an input from an operator for correcting the injection pattern created once is received. (S4) A new injection pattern is displayed reflecting the correction contents. Note that only one of s2 and s3 may be performed. That is, the injection pattern created on the console side may be modified only on the sub display side.
  • the mode selection icon 363 is displayed on the initial setting screen 360 as shown in FIG. 4A, and the operator operates the icon 363. Then, you can select the protocol setting mode that you use. Therefore, for example, even when the content of the injection protocol to be set changes according to the imaging purpose or the like, the protocol setting mode can be changed as appropriate, and the conditions can be set in the protocol setting mode suitable for the inspection. .
  • the doctor on site may not use the function if it cannot be changed easily, for example, if a complicated operation is required on the screen.
  • the mode can be changed by simply pressing the display unit (mode selection icon 363 here) displayed on the screen. Can be done intuitively on the screen.
  • a display unit for setting a protocol called “slip injection protocol” may be displayed on the screen.
  • This injection protocol can be suitably used for imaging a wide range, for example, a blood vessel extending from the heart.
  • contrast agent and saline are injected under the following conditions: (I) First phase, from time t 0 to time t 1 : The contrast agent injection rate decreases monotonically from velocity Vc 0 to velocity Vc 1 The diluent injection rate increases monotonically from rate Vp 0 to rate Vp 1 The speed Vc 1 and the speed Vp 1 are substantially the same.
  • the injection rate of the contrast agent is 0 ml / sec.
  • “Monotonically increasing / decreasing” includes not only a mode in which the injection rate increases / decreases linearly but also a mode in which the injection rate is curved or stepped but increases / decreases substantially linearly. Intended. “Substantially the same” is intended to include not only the case where two speeds are the same, but also the case where the difference between one speed and the other speed is within 10%, for example.
  • the time of the first phase basically depends on the imaging speed and the imaging time, but as an example, it may be the same as or slightly shorter than the imaging time (scan time).
  • the time of the second phase may be calculated from the amount of saline injected and the rate of injection. For example, when the injection volume is 30 ml and the speed is 5.0 ml / sec as an example, it is 6.0 sec.
  • the contrast agent velocity decreases linearly from velocity Vc 0 to velocity Vc 1 .
  • the speed Vc 0 may be 2 ml / sec or more, 3 ml / sec or more, or 4 ml / sec or more, for example.
  • the speed Vc 0 may be 4.8 ml / sec.
  • the upper limit speed may be, for example, 6.0 ml / sec.
  • the variable constant (Vc 1 / Vc 0 ) representing the speed change from the speed Vc 0 to the speed Vc 1 is an example, and may be in the range of 0.6 to 0.4.
  • Vc 1 is 2.4 ml / sec.
  • the speed Vp 0 may be 0 ml / sec as an example.
  • the physiological saline velocity Vp from velocity Vp 0 to velocity Vp 1 may gradually increase in response to a decrease in the contrast agent injection rate.
  • the speed Vp is during the time t0 to the time t1
  • the speed Vc + speed Vp may be set to be constant (rate V ttl).
  • the saline velocity Vp 2 after time t 1 may be the same as the velocity Vc 0 at time t 0 of the contrast agent in one example. Alternatively, it may be within the range of +/ ⁇ 20% or +/ ⁇ 10% with respect to this value.
  • the width of the phase to be displayed may be changed corresponding to the injection time (short time) of each phase, or how the injection time of each phase is Even if it is a thing, it is good also as a structure by which the width of a phase is displayed uniformly.
  • the display unit on the screen for changing the protocol setting mode is not limited to the mode of switching with one icon 363. For example, an icon is prepared for each mode candidate, and one of the icons is selected. It is good also as an aspect. (B6) In the above, the example in which the injection pattern of each phase is created through the input to the pop-up screen 371 has been described.
  • an injection pattern (such as an injection pattern 368a as an example) can be created sequentially in sequence. Also good.
  • One or more of the display units 371a to 371c and 372a to 372c in the pop-up screen 371 described above may be displayed in another pop-up screen or on a screen that is not a pop-up screen It may be displayed at a predetermined position. In the pop-up screen 371, it is not always necessary to display all of the display portions 371a to 371c and 372a to 372c, and only one or only a part of them may be displayed.
  • Conversion from a straight line to a curved line is performed by analyzing the input injection pattern shape by the calculation function of the control unit, so that the change rate of the injection rate is equal to or less than the allowable change rate. It may be connected with a curve. In this case, the degree of curvature of the connecting curve may be at least within a range that can be followed by the piston drive mechanism, and is preferably adjusted in consideration of the load and power consumption on the piston drive mechanism. Conversion from a straight line to a curve can be preferably performed by spline curve interpolation.
  • (C1) You may acquire operation conditions (for example, chemical
  • curd medium which is an information storage medium to a chemical
  • Various products can be used as the information storage medium.
  • the injection protocol information or the like stored in an external database server can be downloaded online.
  • the pressure of the injected contrast medium and physiological saline can be calculated from the pressure that presses the piston member of the chemical syringe.
  • a pressure sensitive element is installed inside the chemical syringe or the extension tube to contrast It is also possible to directly detect the injection pressure of an agent or the like.
  • the previous setting of the type of contrast agent is stored, and a liquid injector that can make the type input operation unnecessary can be used as long as the contrast agent is not changed.
  • the previous setting of the imaging part can be stored.
  • the environment where the drug solution injector is used may only capture the brain, and in cardiac surgery, only the heart may be imaged. It is also useful to eliminate input operations until they need to be saved and changed.
  • the basic pattern information of a variable pattern for decreasing the injection rate linearly and maintaining the injection rate constant thereafter, or increasing the injection rate linearly thereafter is stored in advance. The basic pattern may be displayed by selecting a predetermined icon.
  • (C7) In the case of having a region selection function, a schematic image of a plurality of body sections expressed as a horizontal or vertical human body shape may be displayed on the screen.
  • (C8) In the case of having a site selection function, the configuration may be such that the selection of the imaging site and the input operation of the body weight and the type of contrast medium are necessary.
  • the injection rate / total amount / time can be set as data without inputting the type of contrast medium. This may be the case when there is only one type of contrast agent, when there is no substantial difference between the various contrast agents, when the contrast agent to be used is specified and registered in advance, This is effective when imaging only a subject having a proper weight, and can further reduce the work load.
  • the various components (devices, apparatuses, etc.) referred to in this specification do not have to be independent of each other, but a plurality of components are formed as a single member. It is formed of a plurality of members, a certain component is a part of another component, a part of a certain component overlaps a part of another component, etc. May be.
  • the components need only be formed so as to realize their functions, and may be realized by hardware or realized by software.
  • a certain component can be realized as dedicated hardware that exhibits a predetermined function, a processing device in which the predetermined function is realized by a computer program, a combination thereof, or the like.
  • each unit may be logically realized as various functions of the chemical injection device (control unit) by operating the processor in response to the computer program, but various means (each part, each unit) May be formed as unique hardware, or may be a combination of a part realized by software and a part realized by hardware.
  • the chemical liquid injector and the system including the same are not limited to the above contents, and various modifications can be made as follows, for example:
  • the IC tag of the syringe may include information on whether or not to heat the syringe.
  • D1-2 Print at least some items of information read from the IC tag of the syringe using a printer or the like. Alternatively, data including at least some items of information read from the IC tag of the syringe and chemical injection history data is printed using a printer or the like.
  • D2 Information on whether the used syringe has been discarded is managed by a predetermined management server in the system.
  • the controller of the chemical liquid injector may calculate the estimated value of the chemical liquid pressure during the injection using both the load cell and the motor current.
  • a predetermined help button is displayed on the screen, and when this button is pressed, help text on operation and display on the screen, help image as audio, help guidance as these, or these
  • the controller of the chemical liquid injector is configured so that the combination is displayed.
  • the units of various numerical data displayed on the initial setting screen can be changed as appropriate. For example, the pressure may be “psi” instead of “Kg / cm 2 ”.
  • the contrast agent name (product name, etc.) is displayed on a part of the console screen (eg, icon 373, see FIG. 4A).
  • the control unit of the chemical liquid injector has such a function.
  • a status such as whether the console is connected to another device or connected and linked is displayed on a part of the console screen.
  • the control unit of the chemical liquid injector has such a function.
  • the chemical solution injection device may be configured as follows: -With the syringe set in the injection head and the tube connected to a chemical bottle etc., press the predetermined button to advance the gasket and release the air.
  • the predetermined button may be an autofill button as a specific example.
  • the chemical solution is then aspirated. As this step, first, the chemical solution is aspirated halfway (ie, only a part is drawn, not the whole target amount). -Next, the air bleeding operation is performed again. -After that, continue sucking the chemical until the target amount is reached. This suction may be the same as the initial suction speed or may be faster. Thereafter, the preparation is completed by advancing the piston member of the syringe by a small amount.
  • a chemical solution injector in which an inclination sensor is built in the injection head may be used.
  • the control unit performs part or all of the following processing: -It is determined whether or not the injection head is in a substantially vertical state (in other words, the front of the head on which the syringe is mounted faces vertically upward). -Allow the autofill operation to be performed if the injection head is in a substantially vertical state. Otherwise, autofill operation is prohibited. Determine if the injection head is in a horizontal position or a position where the front is relatively low. -In these postures, the liquid injection operation is allowed. Otherwise, the injection operation is prohibited.
  • D8-1 As a device (input device) for an operator to perform a predetermined input, a mouse, a trackball, a desktop controller, a keyboard, a pen tablet, or the like can be used. In addition, a voice input or an input from a touch panel can be used as an input device in combination with or alone.
  • D8-2) As another example, a physical button or the like provided on an injection head, a console, a head display, or the like may be used. Moreover, voice input, a touch sensor, or the like may be used.
  • E1 One mode of extension tube
  • the piston drive mechanism on the A syringe (contrast medium) side may be operated, and then the piston drive mechanism on the B syringe (physiological saline) side may be operated.
  • the piston drive mechanism on the A syringe (contrast medium) side and the piston drive mechanism on the B syringe (physiological saline) side may be operated simultaneously.
  • a liquid pool cap may be provided on the connector 510 at the end of the tube. The liquid storage cap receives the chemical solution from the tube and prevents the chemical solution from dripping on the floor or other medical devices.
  • extension tube (E2: Other embodiment of extension tube)
  • E2 Other embodiment of extension tube
  • FIGS. 10A to 10C an example of an extension tube provided with a mixing device so that two chemical solutions are mixed well will be described.
  • the extension tube includes a first tube 231a that connects the syringe filled with the first drug solution (for example, contrast medium) and the mixing device 241, and a syringe filled with the second drug solution (for example, physiological saline). It has the 2nd tube 231b which connects the mixing device 241, and the 3rd tube 231c which is connected to the liquid outlet (detailed below) of the mixing device 241 and extends to the patient side.
  • the first drug solution for example, contrast medium
  • the mixing device 241 for example, physiological saline
  • first and second tubes 231a and 231b may be connected to the conduit portion of the syringe via the connection connectors 239a and 239b, respectively.
  • the third tube 231c may be connected to a catheter or the like via the connection connector 239c.
  • priming for the purpose of releasing air is performed before the injection of the chemical solution by the chemical solution injection device.
  • the extension tube is filled with either a physiological saline solution or a contrast medium.
  • the contrast agent is pushed out from the contrast agent syringe, and the first tube up to the mixing device is filled with the contrast agent.
  • the physiological saline is pushed out from the physiological saline syringe, and the second tube, the mixing device, the third tube, and the catheter are filled with the physiological saline.
  • the entire street is filled with the chemical solution and the air is removed.
  • the chemical injection device may have a function for automatically performing the priming operation as described above, and the trigger for starting the priming operation may be an input operation by an operator, for example.
  • the mixing device 241 includes a first chamber that is a swirl flow generation chamber 242a that generates a swirl flow, and a second chamber that is a constriction chamber 242b that concentrates the swirl flow in the axial direction.
  • a main body 242 is provided.
  • the swirl flow generation chamber 242a has a cylindrical inner space
  • the constriction chamber 242b has a conical inner space coaxial with the swirl flow generation chamber 242a.
  • the cross-sectional shape in the short direction of the swirl flow generating chamber may be various shapes formed from a circle, an ellipse, or other curves.
  • the swirl flow generation chamber can be configured to have a narrowed shape that narrows as it approaches the narrowed chamber.
  • a conduit portion 243a to which the first tube 231a is connected is provided on the upstream side of the main body portion 242 of the mixing device 241, and a conduit portion 243c to which the third tube 231c is connected is provided on the downstream side.
  • the conduit portion 243b to which the second tube 231b is connected is disposed at a position upstream from the center of the swirl flow generation chamber 242a (details below).
  • the contrast agent flows from the conduit portion 243a and the physiological saline flows from the conduit portion 243b, and both drug solutions are mixed in the mixing device. Thereafter, the mixed drug solution of the contrast medium and physiological saline flows out from the conduit portion 243c as a liquid outlet.
  • the conduit portion 243a into which a high specific gravity chemical solution flows is provided in the central portion of the upstream side wall surface of the swirl flow generation chamber 242a on the upstream side in the flow direction.
  • the conduit portion 243c serving as the liquid outlet is provided so that the center line of the conduit portion 243c and the center line of the conduit portion 243a coincide, that is, both are coaxial.
  • the conduit portion 243b into which the chemical liquid having a small specific gravity flows is disposed on the side surface of the swirl flow generation chamber 242a and extends in the tangential direction of the circumference of the swirl flow generation chamber 242a having a circular cross section.
  • the conduit portion 243b is provided at a position shifted to the peripheral side from the central axis of the cylindrical space included in the swirl flow generation chamber 242a, and thereby, the chemical liquid having a small specific gravity flowing from the conduit portion 243b.
  • the swirl flow is generated. More specifically, as shown in FIG.
  • the flow path 241fb is configured to extend in the circumferential tangential direction of the curved inner surface of the swirl flow generation chamber 242a, and thereby flows from this flow path.
  • the chemical becomes a swirl flow.
  • the constriction chamber 242b has an inclined inner surface that swells toward the downstream side in the flow direction, so that the generated swirling flow is concentrated in the direction of the central axis of the vortex. Become.
  • the conduit portion 243a into which the contrast agent flows is in communication with the swirling flow generation chamber 242a through the flow path 241fa.
  • the chemical liquid having a large specific gravity can be introduced into the swirling flow generating chamber in a direction parallel to the central axis of the swirling flow of the chemical liquid having a small specific gravity. That is, the chemical liquid having a large specific gravity is introduced in a direction parallel to the central axis of the cylindrical space included in the swirl flow generation chamber.
  • the conduit part into which the physiological saline flows is in communication with the swirl flow generation chamber via the flow path 241fb.
  • the inner diameter of the flow path 241fb may be smaller than the inner diameter of the flow path 241fa into which the contrast agent (one example) flows.
  • the flow rate of the chemical solution having a small specific gravity flowing from the flow path 241fb having a relatively small cross-sectional area becomes faster than the flow rate of the chemical solution having a large specific gravity. Therefore, it is possible to avoid a decrease in the mixing efficiency between the chemical solutions due to the attenuation of the inertial force of the swirling flow and the accompanying lack of swirling strength, which can occur when the flow rate of the chemical solution having a small specific gravity is low.
  • the mixing device 241 configured as described above, for example, when a contrast agent and physiological saline are flowed into the device, the contrast agent that has flowed into the swirl flow generation chamber from the flow channel fa flows toward the downstream side in the axial direction. Become.
  • the physiological saline flowing into the swirl flow generation chamber from the flow path 241fb becomes a swirl flow swirling along the curved inner surface of the same chamber, and the swirl flow of the physiological saline is guided to the stenosis chamber and swirls. Concentrate in the direction of the central axis of the flow.
  • a vortex is known as a Rankine vortex, and the inertial force of the swirling flow can be concentrated in the vicinity of the rotation axis of the vortex.
  • both chemicals will be mixed well. That is, in this example, it is possible to obtain a diluted contrast agent in which the contrast agent and physiological saline are well mixed, and as a result, there is no unevenness in the concentration of the contrast agent. Therefore, an excellent contrast effect can be expected.
  • a status bar 721-1 is displayed at the top of the screen, another status bar 721-2 is displayed below it, and a graph of the injection pattern set below it is displayed.
  • an icon 722a for shifting to the timing test screen and an icon 722b for shifting to the route confirmation screen may be displayed.
  • the status bar 721-2 one or more of patient weight information, information on the contrast medium iodine amount required per unit weight, and information on injection time are displayed.
  • a human body-shaped part display icon 723 is displayed so that the part of the patient selected by the part selection can be visually recognized.
  • the part display icon 723 is displayed in the lower status bar 721-2 is shown, but this icon 723 can be displayed at an arbitrary position on the screen.
  • the region display icon 723 When the region display icon 723 is pressed, the screen returns to the screen for selecting the imaging region. Therefore, when the operator wants to change the imaging region on the confirmation screen as shown in FIG. A part can be reselected by pressing the icon 723. Further, the part selection icon 723 can be recognized by highlighting the currently selected part, for example, so that the operator can confirm the selected part when viewing the screen of FIG. Easy to do.
  • the injection pattern (line segment) 368 displayed on the injection graph may be changeable by a method as shown in FIGS. 13A and 13B.
  • FIG. 13A (a) shows an injection pattern 368 with a variable constant of 1.0 and an injection speed of 3.0 ml / sec in the first phase as an example.
  • the operator touches the end 368q of the injection pattern.
  • the touch panel is not a touch panel, the end 368q may be selected by a cursor on the screen.
  • the position of the end 368q can be changed (for example, a marker display surrounding the end 368q may appear).
  • FIG. 13A (c) when the operator touches, for example, the vicinity of a lattice point of 2.0 ml / sec in this state, the position of the end portion 368q is changed, and the terminal velocity of the injection pattern (line segment) 368 is changed. Will be changed. Note that the same change method can be used to change the starting speed of the implantation pattern.
  • the operator can intuitively correct the injection speed on the injection graph.
  • a pop-up window 377 as shown in FIG. 13B (b) may be displayed.
  • the pop-up window 377 has at least one of a numerical value input unit 377a for directly inputting a numerical value and an increase button and a decrease button 377b.
  • the injection rate is “3.0”, but when it is desired to change it to “4.0”, the numerical value input unit 377a is selected as shown in the drawing to 4.0. Enter.
  • This input can be performed via, for example, a numeric keypad on the screen.
  • the injection speed is changed from “3.0” to “4.0”, and although not shown, the display position of the injection pattern (line segment) 368 is changed.
  • the speed may be changed by changing to a predetermined speed with the increase button and the decrease button 377b and touching a return key (decision key).
  • FIG. 14 is a block diagram of a computer system according to one embodiment of this invention.
  • the computer system 1500 constitutes a console of the chemical liquid injector by way of example, but is not limited thereto.
  • the computer system 1500 may include some or all of the following components: a main controller 1510 that performs overall control, a display control unit (screen display circuit) 1530, and the like. , A storage device 1520, an output interface 1512a for outputting data to a display monitor (not shown), an input means 1513 enabling various inputs from an operator, and a slot 1515 for reading data from a computer readable medium And an input interface 1512b for performing communication with an external device.
  • a main controller 1510 that performs overall control
  • a display control unit (screen display circuit) 1530 and the like.
  • a storage device 1520 for a display monitor (not shown)
  • an output interface 1512a for outputting data to a display monitor (not shown)
  • an input means 1513 enabling various inputs from an operator
  • a slot 1515 for reading data from a computer readable medium
  • an input interface 1512b for performing communication with an external device.
  • the main controller 1510 may be a processor unit having a CPU, a memory, a computer program, and the like, and is illustrated as one in the drawing, but may be configured by a plurality of controllers. .
  • the display control unit 1530 may be provided as a software function, may be provided as an electric circuit, or may be a combination thereof.
  • the main controller 1510 gives a predetermined operation signal to the display control unit 1530 as a trigger,
  • the control unit 1530 performs a certain operation to display a predetermined screen, icon, warning message, graphical user interface, etc. on the display monitor.
  • the display monitor may be any display monitor as long as it can display information.
  • a liquid crystal display (LCD) or an organic EL display may be used.
  • the number of monitors is not particularly limited, and may be one or more.
  • One or more monitors may be located at any location, separate from the computer system (at a distance). In this case, the connection between the computer system and these monitors may be, for example, a wired connection or a wireless connection.
  • the input means 1513 may be one or two or more selected from a keyboard, mouse, trackball, voice input, graphical user interface, and the like. A command from a doctor or the like can be input through the input unit 1513.
  • the slot 1515 can be called a medium reading unit. That is, it may be a unit that can read data from a computer-readable medium in a contact type or a non-contact type.
  • the console C150 can also be configured as a common console that controls the operations of both the imaging device C300 and the injection head C110.
  • the storage device 1520 may store various data such as graphical user interface data and data tables and mathematical formulas used when setting the injection protocol.
  • an injection protocol setting screen (graphical user interface) can be provided.
  • an injection protocol setting screen graphical user interface
  • the computer system can be configured to be incorporated in the imaging apparatus or to function as a console of the imaging apparatus.
  • Imaging device console In FIG. 15, an imaging device C300 including a gantry C303 and a bed C304, an imaging device console C150 that controls the operation of the imaging device C300, and an injection head C110 of a chemical injection device are illustrated.
  • the computer system may be an imaging device console C150.
  • the injection protocol set at the imaging device console C150 may be transferred from the imaging device console C150 to the injection head C110, and the injection head C110 may operate accordingly.
  • a piston drive mechanism (130) for operating the piston member of the syringe Control units (144, 153) for controlling the operation of the piston drive mechanism;
  • Input devices (151 and 157) for receiving input from the operator;
  • a chemical injection device (100) comprising: The control units (144, 153) a: causing the display unit to display a setting initial screen (360) including at least a mode selection display unit (363) for selecting one of a plurality of injection protocol setting modes;
  • a flow rate mode in which an injection pattern is created as a whole by inputting an injection pattern in one phase or a plurality of phases on the injection graph;
  • the contrast amount of the drug solution is determined in advance based on at least the weight of the patient, and then an injection pattern is created as a whole by inputting the injection pattern in one phase or a plurality of phases on the injection graph.
  • a first weight input mode (Iii) The initial velocity of the drug solution is determined in advance based on at least the patient's weight, and then an injection pattern is created as a whole by inputting the injection pattern in one phase or a plurality of phases on the injection graph.
  • a second weight input mode The said chemical
  • Two piston drive mechanisms (130) that operate independently, and configured to inject a contrast medium and physiological saline as the drug solution;
  • the control unit (144, 153) displays a pop-up screen (371) for an operator to create an injection pattern in one phase of the injection graph,
  • the pop-up screen (371) A display unit (371a) for inputting parameters relating to the inclination of the implantation pattern in the phase; -A display (371b) for inputting the injection time of the phase, and -A display for entering the injection rate of the phase,
  • medical solution injection device containing at least 1 among these.
  • pouring apparatus of the said description whose said parameter regarding the inclination of an injection
  • Two piston drive mechanisms (130) that operate independently, and configured to inject a contrast medium and physiological saline as the drug solution;
  • the control unit (144, 153) displays a pop-up screen (371) for an operator to create an injection pattern in one phase of the injection graph,
  • the pop-up screen (371) A display unit (372a) for creating the physiological saline injection pattern, and when the display unit (372a) is selected when the injection rate of the contrast medium is constant, Including a dilution injection display (372b) in which a constant rate saline injection pattern is displayed within the phase;
  • the above-mentioned chemical injection device is described in which a constant rate saline injection pattern is displayed within the phase.
  • the injection pattern of the contrast medium is an inclined pattern and the dilution injection display section (372b) is selected, the sum of the contrast medium injection speed and the physiological saline injection speed is substantially constant in the phase. As shown, a saline injection pattern (368b) that is symmetrical with the contrast agent injection pattern with respect to a predetermined reference line is displayed.
  • Two piston drive mechanisms (130) that operate independently, and configured to inject a contrast medium and physiological saline as the drug solution;
  • the control unit (144, 153) displays a pop-up screen (371) for an operator to create an injection pattern in one phase of the injection graph,
  • the pop-up screen (371) -Including a flash infusion display (372a) for adding an infusion pattern for flush infusion with saline within the next phase of the phase;
  • Two piston drive mechanisms (130) that operate independently, and configured to inject a contrast medium and physiological saline as the drug solution;
  • the control unit (144, 153) displays a pop-up screen (371) for an operator to create an injection pattern in one phase of the injection graph,
  • the pop-up screen (371) A display unit (372c) for creating an injection pattern of a contrast agent, and when the display unit is selected, injection is performed such that the speed changes from a predetermined initial speed to a zero or substantially zero final speed.
  • the control unit (144, 153) further includes Accepts input of information on at least one of the body category and imaging category of the patient to be examined, Calculate the infusion volume to be infused into the patient based at least on the input body segment or imaging segment information; The above-mentioned chemical injection device.
  • the control unit (144, 153) further includes Accept at least patient weight input from patient physical information, Calculating an infusion volume to be infused into the patient based at least on the inputted weight information; The above-mentioned chemical injection device.
  • the control unit (144, 153) further includes Accept the input of the contrast medium iodine amount, Calculating an infusion volume to be infused into the patient based at least on the input iodine amount information; The above-mentioned chemical injection device.
  • the control unit (144, 153) further includes Accept at least the patient's body weight information and the contrast medium iodine amount information of the patient's physical information, Calculate the initial velocity of the contrast agent based at least on those information entered, The above-mentioned chemical injection device.
  • console has a touch panel display (151) as the display unit that also has a function as the input device.
  • the syringe is It has a hollow cylinder member and a piston member slidably inserted in it,
  • the present invention is not limited to a chemical solution injection device as long as it can set a protocol as exemplified with reference to the drawings, and can be applied to a computer device having no injection function. is there. This means that the above A1.
  • the present invention can be combined with other technical matters disclosed in the present specification as well as the technical matters defined in the above.
  • a system having a graphical user interface for configuring an infusion protocol is a: an initial setting screen including at least a mode selection display (for example, an icon) for selecting one of a plurality of injection protocol setting modes; b: After a predetermined injection protocol setting mode is selected, one of the vertical axis and the horizontal axis is the injection speed, the other is the injection time, and the input of the injection pattern from the operator to the injection graph including at least one phase.
  • a flow rate mode in which an injection pattern is created as a whole by inputting an injection pattern in one phase or a plurality of phases on the injection graph;
  • the contrast amount of the drug solution is determined in advance based on at least the weight of the patient, and then an injection pattern is created as a whole by inputting the injection pattern in one phase or a plurality of phases on the injection graph.
  • a first weight input mode (Iii) The initial velocity of the drug solution is determined in advance based on at least the patient's weight, and then an injection pattern is created as a whole by inputting the injection pattern in one phase or a plurality of phases on the injection graph.
  • a second weight input mode At least two of which are selectable.
  • An injection protocol setting method a: causing the display unit to display a setting initial screen including at least a mode selection display unit for selecting one of a plurality of injection protocol setting modes; b: After a predetermined injection protocol setting mode is selected, one of the vertical axis and the horizontal axis is the injection speed, the other is the injection time, and the input of the injection pattern from the operator to the injection graph including at least one phase. Accepting steps, c: creating an infusion protocol for the medicinal solution based on the infusion pattern input on the infusion graph; Having a method.
  • a flow rate mode in which an injection pattern is created as a whole by inputting an injection pattern in one phase or a plurality of phases on the injection graph;
  • the contrast amount of the drug solution is determined in advance based on at least the weight of the patient, and then an injection pattern is created as a whole by inputting the injection pattern in one phase or a plurality of phases on the injection graph.
  • a first weight input mode (Iii) The initial velocity of the drug solution is determined in advance based on at least the patient's weight, and then an injection pattern is created as a whole by inputting the injection pattern in one phase or a plurality of phases on the injection graph.
  • a second weight input mode The method as described above, wherein at least two of the options are selectable.
  • a step of displaying a pop-up screen for an operator to create an injection pattern in one phase of the injection graph The pop-up screen -A display for inputting parameters relating to the inclination of the implantation pattern in the phase; -A display for entering the injection time of the phase, and -A display for entering the injection rate of the phase,
  • a method comprising at least one of:
  • D1.1 A computer program for causing one or more computers to perform the method according to one aspect of the present invention.
  • a piston drive mechanism for operating the piston member of the syringe; a display unit for displaying predetermined information; a display controller for controlling the content displayed on the display unit; and an input device for receiving input from an operator.
  • a system operating method comprising: a: a step of causing the display controller to display an initial setting screen (360) including at least a mode selection display unit (363) for selecting one of a plurality of injection protocol setting modes on the display unit; , b1: After the predetermined injection protocol setting mode is selected, the display controller displays an injection graph (361) including at least one phase in which one of the vertical axis and the horizontal axis is the injection speed and the other is the injection time.
  • b2 a step in which the input device receives an input of an injection pattern from an operator to the injection graph; A method of operating the system.
  • the method further comprises a step in which the computer (control unit) creates an injection protocol based on the input injection pattern.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne une unité de commande qui est conçue de façon à : (a) amener une unité d'affichage (151) à afficher un écran de paramétrage initial (360) qui contient au moins une section (363) d'affichage de sélection de mode pour sélectionner un mode parmi une pluralité de modes de paramétrage de protocole d'injection ; (b) accepter une entrée de modèle d'injection par un opérateur, après la sélection d'un mode de paramétrage de protocole d'injection donné, par le biais d'un graphique d'injection (361) qui contient au moins une phase, soit l'axe vertical, soit l'axe horizontal dudit graphique d'injection représentant la vitesse d'injection et l'autre axe représentant le temps d'injection ; (c) créer un protocole d'injection de produit chimique sur la base du modèle d'injection entré au moyen du graphique d'injection (361) susmentionné ; et (d) injecter un produit chimique par l'utilisation d'un mécanisme (130) d'entraînement de piston conformément au protocole d'injection créé.
PCT/JP2014/060415 2013-04-11 2014-04-10 Dispositif d'injection de produit chimique Ceased WO2014168210A1 (fr)

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WO2017038575A1 (fr) * 2015-08-28 2017-03-09 株式会社根本杏林堂 Circuit d'injection de liquide médicamenteux, système d'injection de liquide médicamenteux doté dudit circuit d'injection de liquide médicamenteux et système d'imagerie médicale
JP2018064872A (ja) * 2016-10-21 2018-04-26 株式会社メテク 輸液システム
WO2019111995A1 (fr) * 2017-12-08 2019-06-13 株式会社根本杏林堂 Dispositif de perfusion de solution de médicaments
JP2019181165A (ja) * 2018-04-10 2019-10-24 アイルン エルエルシーAilnh, Llc ガス除去装置および関連方法
EP3479856A4 (fr) * 2016-06-30 2020-03-11 Nemoto Kyorindo Co., Ltd. Dispositif de mélange, tube de mélange, système d'injection et procédé de production d'un dispositif de mélange
CN112461980A (zh) * 2019-09-06 2021-03-09 株式会社岛津制作所 分析系统、分析辅助装置、分析方法以及分析辅助方法
EP3831424A1 (fr) * 2019-12-02 2021-06-09 Siemens Healthcare GmbH Organe de commande pour un injecteur d'alimentation en produit de contraste
JP2024040279A (ja) * 2016-08-26 2024-03-25 株式会社根本杏林堂 薬液注入装置
WO2025187842A1 (fr) * 2024-03-08 2025-09-12 株式会社根本杏林堂 Dispositif d'injection de solution médicamenteuse
JP7789388B2 (ja) 2017-12-08 2025-12-22 株式会社根本杏林堂 薬液注入装置

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WO2023106631A1 (fr) * 2021-12-07 2023-06-15 사회복지법인 삼성생명공익재단 Dispositif d'administration de médicament

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WO2017013967A1 (fr) * 2015-07-17 2017-01-26 三菱重工業株式会社 Dispositif d'évacuation
WO2017038575A1 (fr) * 2015-08-28 2017-03-09 株式会社根本杏林堂 Circuit d'injection de liquide médicamenteux, système d'injection de liquide médicamenteux doté dudit circuit d'injection de liquide médicamenteux et système d'imagerie médicale
JPWO2017038575A1 (ja) * 2015-08-28 2018-06-14 株式会社根本杏林堂 薬液注入回路、該薬液注入回路を備えた薬液注入システムおよび医用画像撮像システム
EP3479856A4 (fr) * 2016-06-30 2020-03-11 Nemoto Kyorindo Co., Ltd. Dispositif de mélange, tube de mélange, système d'injection et procédé de production d'un dispositif de mélange
JP7789403B2 (ja) 2016-08-26 2025-12-22 株式会社根本杏林堂 薬液注入装置
JP2024040279A (ja) * 2016-08-26 2024-03-25 株式会社根本杏林堂 薬液注入装置
JP2018064872A (ja) * 2016-10-21 2018-04-26 株式会社メテク 輸液システム
US11819672B2 (en) 2017-12-08 2023-11-21 Nemoto Kyorindo Co., Ltd. Chemical liquid injector
JPWO2019111995A1 (ja) * 2017-12-08 2020-12-03 株式会社根本杏林堂 薬液注入装置
WO2019111995A1 (fr) * 2017-12-08 2019-06-13 株式会社根本杏林堂 Dispositif de perfusion de solution de médicaments
US20210228812A1 (en) * 2017-12-08 2021-07-29 Nemoto Kyorindo Co., Ltd. Drug solution infusion device
JP7789388B2 (ja) 2017-12-08 2025-12-22 株式会社根本杏林堂 薬液注入装置
JP2024010194A (ja) * 2017-12-08 2024-01-23 株式会社根本杏林堂 薬液注入装置
JP7387158B2 (ja) 2017-12-08 2023-11-28 株式会社根本杏林堂 薬液注入装置
JP7006945B2 (ja) 2018-04-10 2022-01-24 アイルン エルエルシー ガス除去装置
JP7137881B2 (ja) 2018-04-10 2022-09-15 アイルン エルエルシー ガス除去装置
JP2022031449A (ja) * 2018-04-10 2022-02-18 アイルン エルエルシー ガス除去装置
JP2019181165A (ja) * 2018-04-10 2019-10-24 アイルン エルエルシーAilnh, Llc ガス除去装置および関連方法
CN112461980B (zh) * 2019-09-06 2023-10-24 株式会社岛津制作所 分析系统、分析辅助装置、分析方法以及分析辅助方法
CN112461980A (zh) * 2019-09-06 2021-03-09 株式会社岛津制作所 分析系统、分析辅助装置、分析方法以及分析辅助方法
EP3831424A1 (fr) * 2019-12-02 2021-06-09 Siemens Healthcare GmbH Organe de commande pour un injecteur d'alimentation en produit de contraste
WO2025187842A1 (fr) * 2024-03-08 2025-09-12 株式会社根本杏林堂 Dispositif d'injection de solution médicamenteuse

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