[go: up one dir, main page]

WO2014167509A3 - Loxoprofen polymorphs and process for preparation of the same - Google Patents

Loxoprofen polymorphs and process for preparation of the same Download PDF

Info

Publication number
WO2014167509A3
WO2014167509A3 PCT/IB2014/060556 IB2014060556W WO2014167509A3 WO 2014167509 A3 WO2014167509 A3 WO 2014167509A3 IB 2014060556 W IB2014060556 W IB 2014060556W WO 2014167509 A3 WO2014167509 A3 WO 2014167509A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
loxoprofen
polymorphs
same
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2014/060556
Other languages
French (fr)
Other versions
WO2014167509A2 (en
Inventor
M Jayamani
Bhuvaneswari SRIDHAR
Saravanan SRINIVASAN
Selvakumar VIRUTHAGIRI
Thanigaiarasu MOHANASUNDARAM
Sankar Arjunan
Santhakumar KUPPUSAMY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shasun Pharmaceuticals Ltd
Original Assignee
Shasun Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shasun Pharmaceuticals Ltd filed Critical Shasun Pharmaceuticals Ltd
Publication of WO2014167509A2 publication Critical patent/WO2014167509A2/en
Publication of WO2014167509A3 publication Critical patent/WO2014167509A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Discloses novel crystalline forms of 2-[4-(2-Oxo-cyclopentylmethyl)-phenyl]-propionic acid (Formula II) and its sodium derivatives (Formula I) and the process for preparation thereof.
PCT/IB2014/060556 2013-04-10 2014-04-09 Loxoprofen polymorphs and process for preparation of the same Ceased WO2014167509A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1628CH2013 2013-04-10
IN1628/CHE/2013 2013-04-10

Publications (2)

Publication Number Publication Date
WO2014167509A2 WO2014167509A2 (en) 2014-10-16
WO2014167509A3 true WO2014167509A3 (en) 2015-04-02

Family

ID=51690081

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/060556 Ceased WO2014167509A2 (en) 2013-04-10 2014-04-09 Loxoprofen polymorphs and process for preparation of the same

Country Status (1)

Country Link
WO (1) WO2014167509A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111360A (en) * 2017-06-26 2019-01-01 江苏瑞科医药科技有限公司 Loxoprofen sodium dihydrate crystal form and preparation method thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108863765B (en) * 2018-08-07 2021-04-13 迪嘉药业集团有限公司 Preparation method of loxoprofen sodium crystal

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161538A (en) * 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
JPS62161740A (en) * 1986-01-09 1987-07-17 Sankyo Yuki Gosei Kk Production of phenylpropionic acid derivative
US20120016158A1 (en) * 2009-02-26 2012-01-19 Ltt Bio-Pharma Co., Ltd. Loxoprofen derivative and pharmaceutical preparation containing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4161538A (en) * 1977-04-05 1979-07-17 Sankyo Company Limited Substituted phenylacetic acid derivatives and process for the preparation thereof
JPS62161740A (en) * 1986-01-09 1987-07-17 Sankyo Yuki Gosei Kk Production of phenylpropionic acid derivative
US20120016158A1 (en) * 2009-02-26 2012-01-19 Ltt Bio-Pharma Co., Ltd. Loxoprofen derivative and pharmaceutical preparation containing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109111360A (en) * 2017-06-26 2019-01-01 江苏瑞科医药科技有限公司 Loxoprofen sodium dihydrate crystal form and preparation method thereof

Also Published As

Publication number Publication date
WO2014167509A2 (en) 2014-10-16

Similar Documents

Publication Publication Date Title
WO2014014835A3 (en) Criystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
PH12016500169A1 (en) Polymorph of syk inhibitors
WO2014028589A3 (en) 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF
HUE037154T2 (en) Substituted benzylindazole derivatives as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases
EA201500875A1 (en) DERIVATIVES OF THE STATE
HUE036887T2 (en) Process for the preparation of bile acid derivatives
WO2011097372A3 (en) Pterostilbene cocrystals
WO2014041565A3 (en) Improved process for preparation of vilanterol and intermediates thereof
AU2014230812A8 (en) Process for making benzoxazepin compounds
CA2899024C (en) Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
EP3063120A4 (en) Process for preparation of herbicidal carboxylic acid salts
WO2013128379A3 (en) Crystalline polymorphic forms of linagliptin
UA111333C2 (en) Method for producing l-arginine salt of perindropryl
HK1205095A1 (en) Methods and intermediates for preparing pharmaceutical agents
WO2015052568A3 (en) Solid forms of curcumin and derivatives thereof
HK1221645A1 (en) Benzoquinolone inhibitors of vmat2
WO2012174229A3 (en) Methods for the synthesis and purification of deoxycholic acid
HK1212978A1 (en) Novel derivatives of sinapinic acid
PH12015502717B1 (en) Anti-fibrogenic compounds, methods and uses thereof
WO2014167509A3 (en) Loxoprofen polymorphs and process for preparation of the same
EP3024326A4 (en) Novel process for the preparation of levothyroxine sodium
EA201491719A1 (en) CRYSTALLIC FORM OF SUCCINION
EA201790522A1 (en) SALT OF DERIVATIVE CEFALOSPORIN, ITS CRYSTAL SOLID MATTER AND METHOD OF ITS PREPARATION
CR20150160A (en) MACRÓLID DERIVATIVES, ITS PREPARATION AND THERAPEUTIC USE
WO2016038622A3 (en) Improved process for the preparation of [[2(s)-[[4(r)-(3-hydroxyphenyl)-3(r),4-dimethyl-1-piperidinyl]methyl]-1 -oxo-3-phenylpropyl]amino]acetic acid dihydrate

Legal Events

Date Code Title Description
122 Ep: pct application non-entry in european phase

Ref document number: 14783506

Country of ref document: EP

Kind code of ref document: A2