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WO2014162466A1 - Seringue - Google Patents

Seringue Download PDF

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Publication number
WO2014162466A1
WO2014162466A1 PCT/JP2013/059962 JP2013059962W WO2014162466A1 WO 2014162466 A1 WO2014162466 A1 WO 2014162466A1 JP 2013059962 W JP2013059962 W JP 2013059962W WO 2014162466 A1 WO2014162466 A1 WO 2014162466A1
Authority
WO
WIPO (PCT)
Prior art keywords
cylinder
magnetic body
syringe
gasket
magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2013/059962
Other languages
English (en)
Japanese (ja)
Inventor
亜莉紗 山下
昌史 竹本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Corp
Original Assignee
Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Corp filed Critical Terumo Corp
Priority to PCT/JP2013/059962 priority Critical patent/WO2014162466A1/fr
Publication of WO2014162466A1 publication Critical patent/WO2014162466A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8275—Mechanical
    • A61M2205/8287—Mechanical operated by an external magnetic or electromagnetic field

Definitions

  • the present invention relates to a syringe in which a gasket slides by magnetic attraction or repulsion without having a plunger.
  • the syringe is used when injecting a drug solution into a patient or the like.
  • the syringe has a cylinder having an injection needle attached to the distal end and an opening at the proximal end, and a gasket that is inserted into and slides there.
  • a plunger is attached to the gasket. When the plunger protruding from the opening of the syringe is pushed, the gasket slides, and the medicine previously stored in the cylinder can be discharged and injected.
  • This plunger needs to have a length equal to or longer than that of the cylinder so that the gasket can reach the end of the cylinder in order to reliably discharge the chemical solution.
  • Syringes are used not only by medical doctors and nurses in medical practice, but also when self-injecting medicinal solutions by diabetics and rheumatic patients.
  • prefilled syringes are prestored in a cylinder in order to prevent contamination of the bacteria of the chemical and simplify the preparation of the chemical.
  • Patent Document 1 one end of an ampoule containing a drug suspension is closed with a piston, a metal-containing fixing member is provided on the piston, and a magnetic member such as a bead in the suspension is attracted magnetically, and shaken manually. An administration device is then disclosed in which the mixing member is released to diffuse the suspension.
  • syringes and administration devices require a plunger to slide the gasket in the cylinder.
  • the conventional syringe is long due to the plunger.
  • a flange at the base end of the cylinder to which a finger is applied when the plunger is pushed has to be provided, and the entire width of the syringe is large by this flange.
  • Such a syringe requires an operation of pressing the proximal end of the plunger with the thumb and pushing it into the cylinder with force while placing the index finger and the middle finger on the front end of the flange during injection.
  • needles used for self-injection have been devised to reduce the tip of the needle in order to reduce pain during injection.
  • a liquid medicine may be injected with a small-diameter injection needle into the upper layer of the skin such as the epidermis or dermis where many immunocompetent cells are present so that the injection amount of a biologic such as a vaccine may be small.
  • the syringe When a syringe is used for self-injection, it is desired that the syringe be small and light so that the patient can inject it in a timely manner, and can be easily injected with little force even when high injection input is required, and easy to carry.
  • the present invention has been made in order to solve the above-described problems, and has a small size and excellent portability without a plunger, and can discharge a chemical solution with a simple operation or inhale a biological sample such as blood. It aims at providing the syringe which can be performed.
  • the syringe of the present invention which has been made to achieve the above object, has a cylinder tip capable of sucking and discharging liquid at the distal end, a cylinder provided with an opening at the proximal end, and a cylinder inserted into the cylinder to absorb the liquid.
  • a syringe having a gasket for discharging the syringe having an in-cylinder magnetic body that slides along the cylinder, and an in-cylinder magnetic body that is inserted into the cylinder. At least one of the body is a magnet, and the in-cylinder magnetic body is slid by the magnetic attraction or repulsion generated between the magnetic bodies, and the gasket is pulled or pulled. It is pressed and slid.
  • the syringe preferably has the in-cylinder magnetic body integrated with the gasket or inserted between the gasket and the opening in the cylinder.
  • the syringe has a ring shape in which the outer cylinder magnetic body is inserted through the cylinder, the cylinder inner magnetic body has a column shape, and each of the magnetic bodies is the magnet, and the tip and the It is preferable that both end surfaces respectively facing the base end portion are magnetic poles.
  • the extra-cylinder magnetic body is integrated with a cylindrical slider that slides along the cylinder.
  • a guide rail may be provided on an outer peripheral side wall of the cylinder, and a guide that engages with the guide rail may be provided on the slider.
  • outside cylinder magnetic material is connected to a drive source of a syringe pump that is slid along the cylinder.
  • the syringe may have the outer cylinder holder in which the cylinder is removably inserted and slid along the outer cylinder magnetic body.
  • the syringe may have a stopper that stops the movement by locking the gasket and / or the external magnetic body until the external magnetic body is slid.
  • the syringe may be one in which a holder and / or a handle is attached to the extra-cylinder magnetic body and is detachably inserted from the cylinder.
  • the syringe preferably has a fitting hole in which the holder and / or handle fits the in-cylinder magnetic body detachably in accordance with the slide of the out-of-cylinder magnetic body.
  • the syringe liquid sucking and discharging method includes sucking and discharging the liquid with a syringe having a cylinder tip that can absorb and discharge liquid at the distal end, a cylinder having an opening at the proximal end, and a gasket inserted in the cylinder.
  • a cylinder body is slid along the cylinder, and the cylinder magnetic body inserted in the cylinder is moved by a magnetic attractive force or a repulsive force of the cylinder magnetic body.
  • the liquid is discharged and / or sucked in response to pressing and / or pulling the gasket with an inner magnetic body.
  • the in-cylinder magnetic body is formed by the magnetic attraction or repulsion generated between the in-cylinder magnetic body inserted into the cylinder and the out-cylinder magnetic body that slides along the cylinder. Therefore, it is not necessary to have a plunger inserted into the cylinder or a flange protruding at the base end of the cylinder. Therefore, since the syringe can be shortened and made small, it is particularly convenient for a patient who performs self-injection to carry.
  • This syringe can discharge and inject a drug solution with a simple operation by simply picking or sliding a slider integrated with an extra-cylinder magnetic body, even for a handicapped patient. Moreover, in a medical institution, it is possible to simply inject and collect blood without malfunction by a quick and simple operation.
  • this syringe does not require a plunger, it is possible to perform a simple suction and discharge operation with one hand without using both hands when discharging a chemical solution such as injection or when inhaling blood such as blood collection.
  • this syringe is small, when adding a small amount of liquid medicine to an infusion solution or continuing to administer only a low dose continuously, the syringe pump that sets this can be reduced in size and weight. Can do. Therefore, it is easy to carry the syringe pump and a small space is enough to install it.
  • the outer cylinder holder, the outer magnetic body and the inner magnetic body are repeatedly inserted into the outer cylinder holder and discharged. It is economical because it can be used.
  • this syringe has a stopper that stops the movement by locking the gasket or the external magnetic body until the external magnetic body is slid, it prevents the gasket from sliding unexpectedly or the desired amount.
  • the chemical solution can be discharged step by step.
  • liquid sucking and discharging method of the present invention it is possible to perform the sucking and discharging of a chemical solution and blood sampling by a simple operation with a simple operation.
  • FIG. 1 shows a perspective view of one embodiment of the syringe 10 of the present invention.
  • the syringe 10 includes a cylinder 30, an injection needle 21 joined to the cylinder tip 31, and a slider 42 that slides along the cylinder 30.
  • the cylinder 30 is molded from a transparent material so that the inside is visible.
  • the tube 30 is formed with a tube tip 31 having a reduced diameter at a distal end portion and an opening 37 provided at a proximal end portion.
  • a gasket 34 is inserted into the cylinder 30.
  • a chemical liquid 33 is accommodated as a liquid between the cylinder tip 31 and the gasket 34.
  • the gasket 34 is in airtight contact with the inner wall surface of the cylinder 30 so that the chemical liquid 33 does not leak from the cylinder 30.
  • the gasket 34 has a recess on the opening 37 side, and an in-cylinder holder 36 in which a cylindrical in-cylinder magnetic body 35 is embedded in this recess is integrated with the in-cylinder holder 36. ing.
  • the in-cylinder magnetic body 35 is a permanent magnet having magnetic poles at both end surfaces, and the surface on the tip side of the tube 30 is an S pole and the surface on the base end side is an N pole.
  • the ring-shaped slider 42 has a ring-shaped magnetic body 41 that is coaxial with the ring-shaped slider 42 embedded therein, and is integrated therewith.
  • the side surface of the slider 42 is recessed in the middle of the outer periphery so that it can be easily picked or pinched with a finger.
  • the slider 42 is inserted into the cylinder 30 from the base end of the cylinder 30 so that the in-cylinder magnetic body 35 enters and is surrounded by the inside of the out-of-cylinder magnetic body 41.
  • the slider 42 can slide along the cylinder 30 together with the extra-cylinder magnetic body 41.
  • the extracylinder magnetic body 41 is a permanent magnet having magnetic poles at both end faces, and the tip side surface of the cylinder 30 is an N pole and the base end side surface is an S pole.
  • the in-cylinder magnetic body 35 and the out-cylinder magnetic body 41 are attracted to each other by magnetic attraction generated between them.
  • the in-cylinder magnetic body 35 can be slid in the cylinder 30 by following the slide of the out-of-cylinder magnetic body 41 and pulling the gasket 34. Therefore, the syringe 10 does not need to have a plunger that presses the gasket 34 and a proximal flange on which a finger is hooked when the plunger is pressed.
  • the tube tip 31 has a diameter smaller than that of the body portion 32.
  • the injection needle 21 protrudes from the tip.
  • the injection needle 21 penetrates the tube tip 31 and communicates the inside and outside of the tube 30.
  • a cap 22 that is an elastic body is attached to the tube tip 31.
  • the cap 22 is stuck with the injection needle 21.
  • a lid 44 is fitted in the opening 37.
  • the lid 44 has a shape in which the base end of the ring portion 44a fitted in the opening 37 is connected to the flange portion 44b having a larger diameter.
  • An air hole 44 c is opened at the center of the lid 44.
  • the air hole 44c is for introducing air into the cylinder 30 on the base end side of the gasket 34 when the gasket 34 slides toward the cylinder tip 31, so that the gasket 34 slides smoothly. is there.
  • the lid 44 is fitted into the opening 37 to securely close the lid 44, and prevents the slider 42 from dropping from the cylinder 30 by the flange 44 b protruding slightly from the side wall of the cylinder 30.
  • the air hole 44 c may be opened near the proximal end of the cylinder 30.
  • FIG. 2 is a schematic partial cross-sectional view showing lines of magnetic force possessed by the in-cylinder magnetic body 35 and the out-cylinder magnetic body 41.
  • the magnetic force lines 35a, 41a to c are virtual lines indicating the direction of magnetism.
  • FIG. 2A shows the magnetic lines of force 35 a of the cylinder-shaped in-cylinder magnetic body 35.
  • the in-cylinder magnetic body 35 has an in-cylinder S pole 35S on the left end surface and an in-cylinder N pole 35N on the right end surface.
  • the magnetic lines of force 35a are emitted from the in-cylinder N pole 35N and are directed to the in-cylinder S pole 35S.
  • FIG. 2B shows the magnetic lines of force 41 a to 41 c of the ring-shaped extra-cylinder magnetic body 41.
  • the left side end face of the extra-cylinder magnetic body 41 is an extra cylinder north pole 41N, and the right end face is an extra cylinder south pole 41S.
  • the magnetic lines of force 41a are emitted from the non-cylinder N pole 41N, suddenly reverse toward the inner space of the outer cylinder magnetic body 41, further reverse through the inner space, and move toward the out-cylinder S pole 41S.
  • the magnetic field lines 41b are emitted from the non-cylinder N pole 41N, the plurality of magnetic field lines 41b approach each other, and the direction of the magnetic field lines 41b changes to the outer periphery of the outer cylinder magnetic body 41, and reverses toward the outer periphery of the ring shape. Heading toward the out-cylinder south pole 41S.
  • the magnetic force line 41c is emitted from the out-cylinder N pole 41N, reverses toward the ring-shaped outer periphery, and moves toward the out-cylinder S pole 41S.
  • FIG. 2 (c) shows a state where the in-cylinder magnetic body 35 is located in the cylinder 30 and in the inner space of the out-cylinder magnetic body 41 as shown in FIG.
  • the magnetic lines of force 41a emitted from the out-cylinder N pole 41N are reversed and drawn into the in-cylinder S pole 35S.
  • the magnetic lines of force 35a emitted from the in-cylinder N pole 35N are reversed and drawn into the out-cylinder S pole 41S.
  • the in-cylinder magnetic body 35 and the out-of-cylinder magnetic body 41 are magnetically attracting each other when the magnetic lines 35a and 41a generated from the N poles 35N and 41N are drawn into the S poles 41S and 35S, respectively. Attracting force is generated.
  • the overall length of the syringe 10 can be shortened compared to the case where a plunger is used. Moreover, since there is no possibility of pulling out the plunger by mistake, the chemical solution 33 is not contaminated while being sealed, and the syringe 10 is safe.
  • FIG. 1 shows an example in which the in-cylinder holder 36 in which the in-cylinder magnetic body 35 is embedded and the gasket 34 are integrated, but both may be separated in an unused state (not shown).
  • the in-cylinder holder 36 is pulled by the outside-cylinder magnetic body 41 and comes into contact with the gasket 34, and then presses and slides the gasket 34. Thereby, the chemical liquid 33 is discharged.
  • the strength of the magnetic attractive force generated between the in-cylinder magnetic body 35 and the out-cylinder magnetic body 41 depends on the surface magnetic flux density of the magnets under the conditions of the shape and surface area of the magnets. The higher the surface magnetic flux density, the stronger the magnetic attractive force, and the lower the magnetic flux density, the weaker the magnetic flux. Therefore, this surface magnetic flux density affects the force that pulls the in-cylinder magnetic body 35 and presses and slides the gasket 34.
  • the surface magnetic flux density of the magnet is preferably from 100 to 30000 G, more preferably from 100 to 20000 G, and even more preferably from 1000 to 10000 G. If the surface magnetic flux density is smaller than this range, the magnetic attractive force is insufficient and the gasket 34 cannot be pressed.
  • the magnet is a strong magnetic force, which makes it expensive and not economically practical, and may cause malfunction in the medical device due to the magnetism of the magnet.
  • the magnetic attractive force of the magnet is preferably 1N or more, and more preferably 5N or more, than the force of sliding the gasket.
  • it has a cylinder 30 having an outer diameter of 8 mm and an inner diameter of 6.5 mm containing pure water, a gasket 34 inserted therein, and an injection needle 21 having an inner diameter of 0.2 mm directly joined to the cylinder tip 31, and a magnet
  • the force required for sliding the gasket 34 at 200 mm / min by the plunger is 3 to 15 N.
  • the magnet has a ring shape with an inner diameter of 10 mm, an outer diameter of 20 mm, and a thickness of 2 mm. Since the difference between these forces is 13.6 N, it is sufficient to smoothly press the gasket 34 by the magnetic bodies 35 and 41.
  • the magnetic flux density of the magnet is appropriately set according to the outer diameter of the cylinder 30, the sliding resistance of the gasket 34, the viscosity of the drug solution 33, the inner diameter and length of the injection needle 21, the site where the drug solution should be injected, and the like.
  • a neodymium magnet, an alnico magnet, a samarium cobalt magnet, or a ferrite magnet can be given.
  • neodymium magnets have the advantage of large attraction or repulsion and large magnetic attraction.
  • Alnico magnets have excellent mechanical strength and can be molded into any shape. Since the surface magnetic flux density hardly changes depending on the temperature, the samarium cobalt magnet can be used at any temperature.
  • the syringe 10 shown in FIG. 1 is manufactured as follows. First, the injection needle 21 is directly joined to the tube tip 31 while the tube 30 is formed by insert molding. The cap 22 that is an elastic body is attached to the tube tip 31 by sticking the injection needle 21 straight, and the needle tip of the injection needle 21 is sealed. This is subjected to sterilization such as high-pressure steam sterilization. Next, a desired chemical solution 33 is filled into the cylinder 30. The in-cylinder holder 36 in which the in-cylinder magnetic body 35 is embedded is fitted into the recess on the proximal end side of the gasket 34. The gasket 34 is pushed into the cylinder 30 to seal the chemical solution 33. The slider 42 embedded with and integrated with the extra-cylinder magnetic body 41 is fitted from the base end portion of the cylinder 30 so that the inner peripheral surface thereof faces the outer peripheral side surface of the cylinder 30.
  • the in-cylinder N pole 35N of the in-cylinder magnetic body 35 and the out-of-cylinder N pole 41N of the out-of-cylinder magnetic body 41 face each other to generate a magnetic repulsive force. (See the solid-line slider 42 in FIG. 1). Therefore, the gasket 34 receives a pressing force from the in-cylinder magnetic body 35 toward the distal end portion of the cylinder 30, but the chemical liquid 33 at the tip of the gasket 34 and the cap 22 that prevents leakage of the chemical liquid 33, Does not slide.
  • the slider 42 is moved to a position where the inner peripheral surface of the slider 42 and the outer peripheral side surface of the cylinder 30 face each other so that a magnetic attractive force is generated between the outer cylinder magnetic body 41 and the in-cylinder magnetic body 35. It is moved (see the slider 42 indicated by a two-dot broken line in FIG. 1 and FIG. 2C). Then, the cylinder external magnetic body 41 and the cylinder internal magnetic body 35 can move together according to the slide of the slider 42 by the magnetic attractive force between them.
  • the lid 44 is fitted into the opening 37.
  • the syringe 10 is housed in a blister packaging material and sterilized as necessary. Note that the syringe 10 filled with the chemical solution 33 may be sterilized and then stored in the blister packaging material. Alternatively, the slider 42 and the lid 44 may be prepared separately and fitted into the cylinder 30 and the opening 37 immediately before the syringe 10 is used.
  • the injection needle 21 may be joined to a needle base (not shown).
  • the injection needle 21 makes the inside and outside of the cylinder 30 communicate with each other by attaching the needle base to the cylinder tip 31.
  • the syringe 10 is used as described below with reference to FIG.
  • FIG. 3 is a perspective view showing a method of discharging the drug solution 33 stored in the cylinder 30 when the patient himself uses the syringe 10 for self-injection.
  • the patient removes the mount of the blister packaging material, takes out the syringe 10, and removes the cap 22 (see FIG. 1) fitted to the tube tip 31.
  • the body 32 While picking up the slider 42 with a finger, the body 32 is supported and the syringe 10 is held.
  • the injection needle 21 is punctured, for example, subcutaneously at a site to be injected, such as the upper arm, abdomen, or thigh.
  • the slider 42 is slid toward the tube tip 31 while fixing the syringe 10 so that the injection needle 21 does not come out of the site to be injected.
  • the drug solution 33 is discharged from the cylinder 30 through the injection needle 21 and injected into the patient's body.
  • the syringe 10 together with the injection needle 21 is removed from the body.
  • the syringe 10 is discarded as infectious medical waste.
  • the slider 42 may be removed from the cylinder 30 and reused before the syringe 10 is discarded.
  • the syringe 10 is used for self-injection at home as shown in FIG. 3 and injection at a medical institution, and also for infusion administration with a syringe pump at a medical institution.
  • FIG. 4 shows an example in which a syringe 10 similar to that shown in FIG. 1 is set in a syringe pump 50 except that the syringe tip does not have an injection needle.
  • the syringe pump 50 can be reduced in outer dimensions by the amount that does not include a device for pressing the plunger. Therefore, it can be used even in an operating room or an intensive care room where the space for placing the syringe pump 50 is limited.
  • This syringe 10 is used using a syringe pump 50 as follows.
  • a medical worker such as a doctor or nurse places the syringe 10 on the pedestal 51 so that the tip of the tube 30 abuts on the syringe fixing portion 52, and then tilts the syringe clamp 55 to place the syringe 10 on the pedestal 51. Hold.
  • the feeding tool 57 is tilted and the slider 42 is held by the feeding tool 57.
  • the cap 22 (see FIG. 1) is removed and the tube tip connecting portion 54 to which the chemical solution feeding tube 53 is connected is fitted into the tube tip 31.
  • the power supply in the operation unit 56 is turned on to make the syringe pump 50 usable.
  • the operation switch of the operation unit 56 is turned on, and the drive transmission 58 that is screwed to the feeder 57 is rotated by driving a motor (not shown) built in the syringe pump 50. Thereby, the feed tool 57 holding the slider 42 is driven in the direction of the arrow.
  • the gasket 34 is slid by the driving of the feeding tool 57, the chemical liquid feeding pipe 53 is filled with the chemical liquid 33, and air is extracted.
  • the operation switch is turned off.
  • the tip of the drug solution feeding tube 53 is directly connected to an injection needle punctured into a patient's vein, or to a three-way stopcock of an infusion line connected to an injection needle punctured into a patient's vein or to an infusion bag.
  • the operation switch is turned on, and the discharge of the chemical solution 33 from the syringe 10 is started at a predetermined administration speed.
  • FIG. 10 An exploded perspective view of another embodiment of the syringe 10 is shown in FIG.
  • the syringe 10 has a cylinder 30 that is a disposable so-called cartridge that contains the chemical solution 33 in advance, and an outer cylinder holder 45 into which the cylinder 30 can be inserted.
  • the outer cylinder holder 45 has a cylindrical shape with both ends opened, and has a protruding port 46 at the distal end and an insertion / removal port 47 at the proximal end.
  • the outer cylinder holder 45 is made of a transparent material and allows the cylinder 30 to be seen through, but if necessary, a slit 48 that allows the inside to be visually recognized is opened on the outer peripheral side wall.
  • a slider 42 in which the extra-cylinder magnetic body 41 is embedded surrounds the outer peripheral side wall of the outer cylinder holder 45. The slider 42 can slide along the outer cylinder holder 45.
  • the cylinder 30 is a so-called cartridge that contains a chemical solution 33 in advance and is sealed with a gasket 34. Since the in-cylinder holder 36 in which the in-cylinder magnetic body 35 is embedded is not integrated with the gasket 34, it can be taken out by removing the lid 44 and directing the opening 37 downward. The cylinder 30 can be easily inserted into or removed from the outer cylinder holder 45 from the insertion / removal port 47. For this reason, the cylinder tip 31 and the injection needle 21 protrude from the protrusion 46 in a state where the cylinder 30 is inserted into the outer cylinder holder 45.
  • the in-cylinder magnetic body 35 is surrounded by the out-of-cylinder magnetic body 41 when the cylinder 30 is inserted into the outer cylinder holder 45 and generates a magnetic attractive force therebetween.
  • a cap 22 is detachably fitted to the tube tip 31.
  • the patient who performs self-injection inserts the cylinder 30 which is a cartridge into the outer cylinder holder 45. It can be visually confirmed from the slit 48 that the cylinder 30 is inserted into the outer cylinder holder 45 and that the chemical liquid 33 is accommodated in the cylinder 30. After the cap 22 is removed, the needle 21 is punctured at the site to be injected, and then the slider 42 is slid toward the projecting port 46, whereby the in-cylinder magnetic body 41 is slid as the out-cylinder magnetic body 41 is slid. As a result of sliding 35 and pulling the gasket 34, the drug solution 33 is discharged from the cylinder 30 and injected.
  • the cylinder 30 from which all of the chemical liquid 33 has been discharged is extracted from the outer cylinder holder 45, the lid 44 is removed, the in-cylinder holder 36 is taken out, and then the entire lid 44 is discarded.
  • the outer cylinder holder 45, the slider 42, the in-cylinder holder 36, the in-cylinder magnetic body 35, and the lid 44 are reused as necessary.
  • the chemical liquid 33 can be replenished only by inserting the cartridge into the outer cylinder holder 45, so that the operation is simple.
  • the syringe 10 can be stored in a small space even if a large amount of medicine is used. conservee space.
  • FIG. 10 An exploded perspective view of another embodiment of the syringe 10 is shown in FIG.
  • the syringe 10 is provided with a cylinder 30 that is a so-called cartridge that has a syringe tip 21 attached to a cylinder tip 31 and stabs a cap 22 and is preliminarily sealed with a gasket 34, and a through hole 42a into which the cylinder 30 can be inserted.
  • a gasket 34 a through hole 42a into which the cylinder 30 can be inserted.
  • an open slider 42 The cylinder 30 has an opening 37 on the proximal end side.
  • An out-of-cylinder magnetic body 41 that can surround the cylinder 30 is embedded in the slider 42.
  • a handle 49 extending in two directions on the base end side of the slider 42 is connected.
  • the handle 49 has a through hole 49a that has the same diameter as the through hole 42a of the slider 42 and can be inserted into the cylinder 30.
  • the slider 42 can be inserted into and removed from the tube 30 together with the handle 49 and can slide along the tube 30.
  • a lid 44 is fitted in the through hole 49a.
  • the lid 44 includes a thin ring portion 44a that fits in the opening 37, a thick cylindrical portion 44d that fits in the through hole 42a of the slider 42 and the through hole 49a of the handle 49 on its proximal end side, and a handle on its proximal end side.
  • 49 has a shape in which a flange 44b having a diameter larger than that of the 49 through hole 49a is connected.
  • An air hole 44 c is opened at the center of the lid 44.
  • the inner space of the small-diameter ring portion 44a of the lid 44 is a fitting hole 44e into which the in-cylinder magnetic body 35 is removably fitted.
  • the in-cylinder magnetic body 41 and the in-cylinder magnetic body 35 are permanent magnets having magnetic poles on both end faces.
  • the surface on the tip side of the cylinder 30 is an N pole
  • the surface on the lid 44 side is an S pole
  • the surface on the tip side of the cylinder 30 is an S pole
  • the surface on the lid 44 side is an N pole.
  • the in-cylinder magnetic body 35 is formed into the cylinder 30 as shown in FIG. In the inside of the cylinder outside magnetic body 41, both the magnetic bodies 35 and 41 attract each other.
  • a self-injecting patient inserts the cylinder 30 as a cartridge from the through hole 42a of the slider 42 into the through hole 49a of the handle 49.
  • the small-diameter ring portion 44a of the lid 44 fits into the cylinder 30 from the opening 37 of the cylinder 30, but the large-diameter cylindrical section 44d of the lid 44 hits the opening 37 of the cylinder 30, so that the ring section 44a is more than the cylinder 30.
  • the injection needle 21 is punctured at the site to be injected, and then the handle 49 is slid together with the slider 42 toward the tube tip 31 so that the cylinder-side magnetic body 41 is slid along with the slide.
  • the chemical solution 33 is discharged from the cylinder 30 and injected.
  • the injection needle 21 is withdrawn from the injection site. If necessary, the injection needle is inserted into the cap 22 again.
  • the handle 49 is moved together with the slider 42 to the opening 37 side.
  • the in-cylinder magnetic body 35 is pulled by the outside-cylinder magnetic body 41 and moves toward the opening 37, and finally fits again into the small-diameter ring portion 44 a that fits in the opening 37.
  • the lid 44 is hooked around the through hole 49 a of the handle 49 by the flange 44 b and detached from the cylinder 30.
  • the in-cylinder magnetic body 35, the slider 42 and the handle 49, and the lid 44 are fitted again in order, so that they can be reused.
  • the opening of the ring portion 44a may be widened so that the in-cylinder magnetic body 35 can be easily fitted again into the ring portion 44a of the lid 44 after the chemical solution 33 is discharged.
  • the cylinder 42 that is a cartridge in which the in-cylinder magnetic body 35 is integrated with the gasket may be used, and the slider 42 and the handle 49 fitted with the out-cylinder magnetic body 41 may be reused. In that case, the lid 44 may not be used.
  • the cylinder 30 that is a cartridge may be inserted into the outer cylinder holder to discharge the liquid.
  • FIG. 7 shows a syringe 10 that can be self-injected by grasping and sliding a slider 42 as another embodiment of the syringe 10.
  • the slider 42 has an axial length longer than the width of the hand and an outer diameter so that the entire palm can be gripped.
  • the inner end of the tube 30 has a larger inner diameter than the body 32, and the hub 23 is fitted therein.
  • the hub 23 is formed with a ring-shaped annular stabilizing portion 24 at the tip, the injection needle 21 projects from the center thereof, and the injection needle 21 communicates with the inside and outside of the cylinder 30.
  • the patient holds the slider 42.
  • the patient presses the annular stabilizer 24 straight to the site to be injected and punctures the injection needle 21 subcutaneously while stabilizing the syringe 10.
  • the slider 42 is slid toward the hub 23, and the gasket 34 is slid to discharge the drug solution 33 to be administered subcutaneously.
  • the syringe 10 can discharge the liquid medicine 33 by using not only the hand power but also the arm power by picking or sliding the slider 42 and sliding it. Therefore, even patients with rheumatic patients who have difficulty in finger movement or weak grip, they can easily inject themselves without the assistance of family members, etc. The burden at the time of self-injection can be reduced.
  • FIG. 1 shows an example in which the in-cylinder magnetic body 35 and the out-cylinder magnetic body 41 are attracted to each other by magnetic attraction, but the magnetic bodies 35 and 41 may be repelled by magnetic repulsion.
  • Each member of the syringe 10 shown in FIG. 8A is the same as that shown in FIG.
  • the syringe 10 is different from FIG. 1 in the direction of the magnetic pole of the in-cylinder magnetic body 35.
  • the in-cylinder magnetic body 35 is such that the tip side surface of the tube 30 is an N pole and the base end side surface is an S pole.
  • the direction of the magnetic pole of the extra-cylinder magnetic body 41 is the same as in FIG.
  • FIG. 8B is a schematic partial cross-sectional view showing lines of magnetic force acting between the in-cylinder magnetic body 35 and the out-cylinder magnetic body 41 in the state of FIG.
  • the magnetic line of force 41b emitted from the out-cylinder N pole 41N is drawn into the in-cylinder S pole 35S.
  • the magnetic lines 41b emitted from the out-cylinder N pole 41N are repelled on the side of the in-cylinder S pole 35S and the magnetic lines of force 35a emitted from the in-cylinder N pole 35N.
  • the in-cylinder magnetic body 35 and the out-of-cylinder magnetic body 41 are in a state where the magnetic attractive force and the magnetic repulsive force are balanced at a distant position. Due to the magnetic attractive force and the magnetic repulsive force, the gasket 34 integrated with the in-cylinder magnetic body 35 is pressed by the slide of the slider 42 and slides in the cylinder 30.
  • FIG. 9 shows an exploded perspective view of another embodiment of the syringe 10.
  • the syringe 10 includes a cylinder 30, a gasket 34, an in-cylinder magnetic body 35, a slider 42 integrated with an out-cylinder magnetic body 41, and a lid 44, and does not have an in-cylinder holder 36.
  • the in-cylinder magnetic body 35 is inserted into a hole 34 a formed in the gasket 34 and integrated with the gasket 34.
  • a guide rail 38 is provided on the outer peripheral side wall of the cylinder 30, and a guide 43 that engages with the guide rail 38 is provided on the inner periphery of the slider 42.
  • the guide rails 38 are grooves carved into the outer peripheral side wall surface of the cylinder 30, and two are provided symmetrically.
  • the guides 43 are protrusions protruding from the inner periphery of the slider 42 toward the central axis thereof, and two guides 43 are provided symmetrically.
  • the guide rail 38 and the guide 43 are slidably engaged with each other. Thereby, the slider 42 can be smoothly and reliably slid without rotating wastefully.
  • FIG. 10 shows an exploded perspective view and a perspective view of another embodiment of the syringe 10.
  • the description of the configuration of the syringe 10 similar to that in FIG. 1 is omitted.
  • the syringe 10 has a stopper that stops the movement by locking the gasket 34 and / or the external magnetic body 41 until the external magnetic body 41 is slid.
  • the stopper includes a guide rail 38 and a guide 43 of the slider 42.
  • the guide rail 38 provided on the outer peripheral side wall of the cylinder 30 extends in the circumferential direction of the cylinder 30 and slide portions 38 a, 38 c, 38 e extending in a direction parallel to the central axis of the cylinder 30.
  • Two guide rails 38 are provided in line symmetry with the central axis of the cylinder 30 as the axis of symmetry. From the opening 37 side, the guide rail 38 is substantially perpendicular to the first slide portion 38a, the first stopper portion 38b, the second slide portion 38c, the second stopper portion 38d, and the third slide portion 38e in this order. It is linked to.
  • the guide 43 provided on the inner periphery of the slider 42 is slidably engaged with the guide rail 38.
  • the guide 43 of the slider 42 has a lateral width in the circumferential direction slightly smaller than the groove width of the slide portions 38a, 38c, and 38e, and a vertical width in the central axis direction of the cylinder 30 is the length of the stopper portions 38b and 38d. It's rather short for play.
  • the guide 43 engages with the first slide portion 38 a, and the slider 42 slides toward the tube tip 31, thereby coming into contact with the side wall of the first stopper portion 38 b.
  • the slider 42 is prevented from sliding toward the tube tip 31 by the guide 43 being in contact with the first stopper portion 38b.
  • the guide 43 is substantially perpendicular to the first stopper portion 38b and the second slide portion 38c. Move to the department. As a result, the slider 42 can slide in the direction of the tube tip 31. Slide the slider 42 toward the tube tip 31. Then, the guide 43 slides on the second slide portion 38c, moves to a substantially right angle portion where the second slide portion 38d is connected, and stops by contacting the side wall of the stopper portion 38d (FIG. 10 ( c)). At this time, the in-cylinder magnetic body 35 is pulled by the out-cylinder magnetic body 41 and presses the gasket 34. As a result, half of the amount of the chemical solution 33 originally stored in the cylinder 30 is discharged.
  • the guide 43 moves to a substantially right angle portion where the second stopper portion 38d and the third slide portion 38e are connected. As a result, the slider 42 can slide in the direction of the tube tip 31. Slide the slider 42 toward the tube tip 31. Then, the guide 43 slides on the third slide part 38e (FIG. 10 (d)). When the guide 43 reaches the distal end portion of the third slide portion 38e, the gasket 34 reaches the distal end portion of the cylinder 30. Thereby, the discharge of the chemical liquid 33 is completed.
  • the guide rail 38 has a plurality of slide portions and stopper portions, not only can the gasket 34 be prevented from being unexpectedly pressed, but also the chemical solution can be obtained by alternately rotating and sliding the slider 42. 33 can be discharged in stages. As a result, several doses of the drug solution 33 can be stored in the cylinder 30 in advance, and can be discharged and injected for each dose without checking the scale or the like. Furthermore, since one syringe 10 can be used in a plurality of times, medical waste can be reduced.
  • a locking claw 39 is provided on the outer peripheral side wall of the cylinder 30, and a guide 43 that engages with the locking claw 39 is provided on the inner periphery of the slider 42 to prevent the slider 42 from going backward.
  • the locking claw 39 has a sawtooth shape protruding with a slope that gradually increases on the cylinder tip 31 side.
  • a plurality of the locking claws 39 are connected to form a row from the base end portion of the cylinder 30 to the tip portion, and two rows are provided symmetrically.
  • the guide 43 is a groove carved into the inner periphery of the slider 42, and two guides 43 are provided symmetrically.
  • a latching piece 43 a protrudes into the guide 43.
  • the slider 42 is fitted into the cylinder 30 while the locking claw 39 and the guide 43 are engaged.
  • the material of the slider 42 is somewhat more flexible than the material of the cylinder 30.
  • the in-cylinder magnetic body 35 and the out-of-cylinder magnetic body 41 are examples of ferromagnetic bodies that are magnets.
  • one of these magnetic bodies is a magnet, and the other is iron or iron.
  • a ferromagnetic material selected from an alloy, iron oxide, ferrite, cobalt, or nickel may be used.
  • the syringe 10 can be manufactured at low cost.
  • Specific examples of the iron alloy include steel, stainless steel, permendur, sendust, silicon steel, KS steel, and MK steel.
  • Specific examples of the iron oxide include those having a spinel crystal structure such as magnetite and maghematite.
  • the drug solution 33 accommodated in the cylinder 30 includes, for example, a sugar solution injection solution such as glucose, an electrolyte correction injection solution such as sodium chloride and potassium lactate, an antiarrhythmic agent, an anticonvulsant, an insulin preparation, a protein preparation, an antibody drug, Antirheumatic drugs, bronchodilators, contrast agents, steroids, proteolytic enzyme inhibitors, fat emulsions, antibiotics, anticancer agents, heparin calcium, anesthetics, antibody drugs and the like can be mentioned.
  • Influenza, tetanus, pneumococci, polio, Japanese encephalitis, rubella, measles, yellow fever, hives, hepatitis, chickenpox, rabies, rotavirus, mumps, cervical cancer prevention, MQ, DT and DPT vaccines Such biopharmaceuticals.
  • Examples of the biological sample stored in the cylinder 30 include blood, cerebrospinal fluid, and lymph.
  • the inner diameter of the cylinder 30 is preferably 5 to 30 mm. If the inner diameter is smaller than this range, it is difficult to mold the cylinder 30. Further, if it is larger than this range, the force for sliding the gasket 34 is increased, and a strong magnetic attractive force or magnetic repulsive force is required. Therefore, the in-cylinder magnetic body 35 and the out-cylinder magnetic body 41 must be enlarged, The syringe 10 becomes heavy and portability is impaired.
  • the syringe 10 may be sterilized by any of ethylene oxide gas, ⁇ rays, electron beams, and high pressure steam in an autoclave.
  • the sterilization method and procedure are appropriately selected according to the material of the cylinder 30, the type / stability of the drug solution 33 to be injected, the size / shape of the syringe 10, the use of injection and blood collection, and the like.
  • the materials of the cylinder 30, the in-cylinder holder 36, the slider 42, the lid 44, and the outer cylinder holder 45 are selected from the viewpoints of chemical resistance, gas / bacteria barrier properties, safety to living bodies, and the like.
  • polyolefin resin such as polyethylene, polypropylene and cyclic polyolefin; polystyrene; polycarbonate; polyester such as polyethylene terephthalate;
  • a resin having high heat resistance such as polypropylene or polycarbonate, as these materials.
  • the drug solution 33 contained in the cylinder 30 has a high transparency so that the drug solution 33 can be visually recognized from the outside, has little interaction with the drug solution 33, and is strongly gripped when the drug solution 33 is administered. It is preferable to use a cyclic olefin homopolymer or a cyclic olefin copolymer, which is a resin that does not bend and does not collapse even when pressed.
  • a molding method an injection molding method, a blow molding method, a thermoforming method, or the like can be used, and among these, the injection molding method is preferable.
  • the materials for the cap 22 and the gasket 34 are selected from the same viewpoint as described above.
  • rubber materials such as olefin-based, polyurethane-based, polyester-based, polyamide-based or styrene-based thermoplastic elastomers, natural rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, and silicone rubber are used.
  • the syringe 10 can also be used as a so-called blood collection tube in which a doctor or nurse collects blood by inhaling it into the cylinder 30. In this case, the syringe 10 does not contain the chemical solution 33.
  • FIG. 12 shows a method of using the syringe 10 as a blood collection tube.
  • the lid 44 in which the air hole 44 c is a notch that is not blocked by a finger is fitted into the opening 37.
  • the doctor or nurse peels off the mount of the blister packaging material and takes out the syringe 10 that does not contain the drug solution 33.
  • the gasket 34 is positioned at the tip of the tube 30.
  • the injection needle 21 is punctured into a vein of a patient to collect blood.
  • the slider 42 is slid toward the proximal end of the cylinder 30, blood is sucked into the space surrounded by the cylinder tip 31 and the gasket 34 in the cylinder 30.
  • the doctor or nurse completes the inhalation of the required amount of blood, the doctor or nurse removes the injection needle 21 from the patient's skin.
  • the injection needle 21 is punctured into this rubber plug of a sample tube (not shown) with a rubber plug, and the inhaled blood is transferred to the sample tube by sliding the slider 42 toward the tip of the tube 30.
  • the syringe 10 is discarded as infectious medical waste.
  • the syringe 10 can easily inhale liquid with one hand.
  • the syringe of the present invention is used for injecting a medical solution into a patient or inhaling a biological sample such as blood.
  • the liquid suction / discharge method of the present invention is used for self-injection, injection at a medical institution, blood collection, and infusion administration with a syringe pump.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'objectif de la présente invention est de proposer une seringue dépourvue de piston, de petite taille, très facilement transportable et qui permet d'administrer une solution médicamenteuse et d'aspirer un échantillon biologique, par exemple un échantillon de sang, de façon simple. Ladite seringue (10) comprend : un tube (30) qui est équipé d'une buse (31), capable d'aspirer et d'évacuer un liquide (33) au niveau de son extrémité distale, ledit tube comportant également une ouverture (37) au niveau de son extrémité inférieure ; et un joint d'étanchéité (34) qui est placé dans le tube et qui assure l'aspiration et l'évacuation du liquide (33). La seringue (10) comprend, en outre, un corps magnétique extérieur de tube (41) qui coulisse le long du tube (30) et un corps magnétique intérieur de tube (35) qui est placé à l'intérieur du tube. Le corps magnétique intérieur de tube (35) et/ou le corps magnétique extérieur de tube (41) est/sont un/des aimant/s et du fait de l'attraction ou de la répulsion magnétique générée entre lesdits corps magnétiques, le corps magnétique intérieur de tube (35) coulisse quand le corps magnétique extérieur de tube (41) est amené à coulisser de façon à faire coulisser le joint d'étanchéité (34) par traction ou par pression.
PCT/JP2013/059962 2013-04-01 2013-04-01 Seringue Ceased WO2014162466A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2013/059962 WO2014162466A1 (fr) 2013-04-01 2013-04-01 Seringue

Applications Claiming Priority (1)

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PCT/JP2013/059962 WO2014162466A1 (fr) 2013-04-01 2013-04-01 Seringue

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WO2014162466A1 true WO2014162466A1 (fr) 2014-10-09

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017176374A1 (fr) * 2016-04-06 2017-10-12 Flextronics Ap, Llc Dispositif d'injection automatique ayant un système d'entraînement doté d'un ressort à mémoire de forme
WO2018119055A3 (fr) * 2016-12-21 2018-08-02 Dynamic Magnetics, Llc Dispositif d'entraînement magnétique utilisé pour alimenter un injecteur automatique
US11311670B2 (en) 2018-10-12 2022-04-26 Flex Ltd Automatic injection device having a passive drive system with a shape memory spring
US20230044175A1 (en) * 2021-08-06 2023-02-09 Boston Scientific Medical Device Limited Continuous suction and reperfusion mechanism,
CN116492541A (zh) * 2023-03-28 2023-07-28 卓优医疗(苏州)有限公司 一种使用磁驱动式电机的无针注射装置及调节方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060030816A1 (en) * 2004-08-09 2006-02-09 Boris Zubry Medical injection system
US20060173409A1 (en) * 2004-12-28 2006-08-03 Chang-Ming Yang Safety syring

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060030816A1 (en) * 2004-08-09 2006-02-09 Boris Zubry Medical injection system
US20060173409A1 (en) * 2004-12-28 2006-08-03 Chang-Ming Yang Safety syring

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017176374A1 (fr) * 2016-04-06 2017-10-12 Flextronics Ap, Llc Dispositif d'injection automatique ayant un système d'entraînement doté d'un ressort à mémoire de forme
WO2018119055A3 (fr) * 2016-12-21 2018-08-02 Dynamic Magnetics, Llc Dispositif d'entraînement magnétique utilisé pour alimenter un injecteur automatique
US11311670B2 (en) 2018-10-12 2022-04-26 Flex Ltd Automatic injection device having a passive drive system with a shape memory spring
US20230044175A1 (en) * 2021-08-06 2023-02-09 Boston Scientific Medical Device Limited Continuous suction and reperfusion mechanism,
CN116492541A (zh) * 2023-03-28 2023-07-28 卓优医疗(苏州)有限公司 一种使用磁驱动式电机的无针注射装置及调节方法
CN116492541B (zh) * 2023-03-28 2024-06-04 卓优医疗(苏州)有限公司 一种使用磁驱动式电机的无针注射装置及调节方法

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