[go: up one dir, main page]

WO2014159498A3 - Système d'analyse automatisé prévu pour la détection et le dépistage de troubles et de déficits neurologiques - Google Patents

Système d'analyse automatisé prévu pour la détection et le dépistage de troubles et de déficits neurologiques Download PDF

Info

Publication number
WO2014159498A3
WO2014159498A3 PCT/US2014/023923 US2014023923W WO2014159498A3 WO 2014159498 A3 WO2014159498 A3 WO 2014159498A3 US 2014023923 W US2014023923 W US 2014023923W WO 2014159498 A3 WO2014159498 A3 WO 2014159498A3
Authority
WO
WIPO (PCT)
Prior art keywords
eye movements
neurological
variety
disease
neurological disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/023923
Other languages
English (en)
Other versions
WO2014159498A2 (fr
Inventor
Paul A. Wetzel
Mark S. BARON
George T. GITCHEL
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Commonwealth University
Original Assignee
Virginia Commonwealth University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Commonwealth University filed Critical Virginia Commonwealth University
Priority to US14/774,152 priority Critical patent/US10575726B2/en
Publication of WO2014159498A2 publication Critical patent/WO2014159498A2/fr
Publication of WO2014159498A3 publication Critical patent/WO2014159498A3/fr
Anticipated expiration legal-status Critical
Priority to US16/745,409 priority patent/US20200146547A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/113—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for determining or recording eye movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Measuring devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
    • A61B5/1103—Detecting muscular movement of the eye, e.g. eyelid movement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7253—Details of waveform analysis characterised by using transforms
    • A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Neurology (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dentistry (AREA)
  • Mathematical Physics (AREA)
  • Human Computer Interaction (AREA)
  • Developmental Disabilities (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Eye Examination Apparatus (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Image Analysis (AREA)

Abstract

Certains objets d'intérêt qui sont projetés devant la fovéa ont une résolution médiocre et manquent d'informations de couleur, ce qui nécessite un mouvement des yeux pour obtenir une image et une perception complètes du monde environnant. Les mouvements des yeux émanent de différentes zones du cerveau, lesquelles peuvent être affectées par une maladie et/ou une lésion. Ainsi, différents troubles neurologiques affecteront une myriade de mouvements des yeux de plusieurs manières différentes. La présente invention concerne un système et une méthode automatisés permettant de détecter, d'analyser et de récapituler les mouvements des yeux d'une personne, qui sont utilisés pour détecter (diagnostiquer) (soit avant soit après l'apparition de symptômes de ladite maladie neurologique), pour confirmer un diagnostic antérieur, et/ou pour surveiller l'efficacité de traitement de diverses maladies neurologiques, de troubles de mouvement neurologiques et de lésions potentielles du cerveau. Les mouvements des yeux analysés et ayant fait l'objet d'une récapitulation sont catalogués, interprétés et utilisés dans une matrice de diagnostic pour mettre en évidence et distinguer des mouvements anormaux des yeux et pour établir un diagnostic clinique ou préclinique/présymptomatique objectif sur la base des procédures de test non invasives.
PCT/US2014/023923 2013-03-14 2014-03-12 Système d'analyse automatisé prévu pour la détection et le dépistage de troubles et de déficits neurologiques Ceased WO2014159498A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US14/774,152 US10575726B2 (en) 2013-03-14 2014-03-12 Automated analysis system for the detection and screening of neurological disorders and defects
US16/745,409 US20200146547A1 (en) 2013-03-14 2020-01-17 Automated analysis system for the detection and screening of neurological disorders and defects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361783156P 2013-03-14 2013-03-14
US61/783,156 2013-03-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/774,152 A-371-Of-International US10575726B2 (en) 2013-03-14 2014-03-12 Automated analysis system for the detection and screening of neurological disorders and defects
US16/745,409 Continuation US20200146547A1 (en) 2013-03-14 2020-01-17 Automated analysis system for the detection and screening of neurological disorders and defects

Publications (2)

Publication Number Publication Date
WO2014159498A2 WO2014159498A2 (fr) 2014-10-02
WO2014159498A3 true WO2014159498A3 (fr) 2014-11-20

Family

ID=51625605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/023923 Ceased WO2014159498A2 (fr) 2013-03-14 2014-03-12 Système d'analyse automatisé prévu pour la détection et le dépistage de troubles et de déficits neurologiques

Country Status (2)

Country Link
US (2) US10575726B2 (fr)
WO (1) WO2014159498A2 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9004687B2 (en) 2012-05-18 2015-04-14 Sync-Think, Inc. Eye tracking headset and system for neuropsychological testing including the detection of brain damage
US9238142B2 (en) * 2012-09-10 2016-01-19 Great Lakes Neurotechnologies Inc. Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically
US11975195B1 (en) * 2012-09-10 2024-05-07 Great Lakes Neurotechnologies Inc. Artificial intelligence systems for quantifying movement disorder symptoms and adjusting treatment based on symptom quantification
US9962119B2 (en) 2013-05-31 2018-05-08 Dignity Health System and method for detecting neurological disease
US11317861B2 (en) 2013-08-13 2022-05-03 Sync-Think, Inc. Vestibular-ocular reflex test and training system
US20150051508A1 (en) 2013-08-13 2015-02-19 Sync-Think, Inc. System and Method for Cognition and Oculomotor Impairment Diagnosis Using Binocular Coordination Analysis
US10772554B2 (en) * 2013-09-04 2020-09-15 Joseph Michael Lawless Kelly Methods and systems for the detection of disease
US9958939B2 (en) 2013-10-31 2018-05-01 Sync-Think, Inc. System and method for dynamic content delivery based on gaze analytics
US10376183B2 (en) 2014-04-29 2019-08-13 Dignity Health Systems and methods for non-intrusive drug impairment detection
US10743806B2 (en) * 2014-06-11 2020-08-18 Dignity Health Systems and methods for non-intrusive deception detection
WO2016029019A1 (fr) 2014-08-21 2016-02-25 Dignity Health Systèmes et procédés pour utiliser des mouvements oculaires pour déterminer une lésion cérébrale traumatique
US12151101B2 (en) * 2015-06-02 2024-11-26 Battelle Memorial Institute Non-invasive eye-tracking control of neuromuscular stimulation system
EP3335126A4 (fr) 2015-08-11 2019-05-01 Cognoa, Inc. Procédés et appareil de détermination d'une évolution du développement grâce à l'intelligence artificielle et à une entrée d'un utilisateur
US9788760B2 (en) * 2015-12-08 2017-10-17 BrainStem Biometrics, Inc. Ocular micro tremor (OMT) sensor, system and method
US11972336B2 (en) * 2015-12-18 2024-04-30 Cognoa, Inc. Machine learning platform and system for data analysis
CN118609834A (zh) 2016-11-14 2024-09-06 科格诺亚公司 用于评估发育状况并提供覆盖度和可靠性控制的方法和装置
US20180271364A1 (en) * 2017-03-24 2018-09-27 Osaka University Method and apparatus for detecting ocular movement disorders
CN109276228B (zh) * 2017-07-21 2020-12-25 成都集思鸣智科技有限公司 一种检测大脑功能的系统及其装置
EP3716837A4 (fr) * 2017-11-30 2021-09-08 Viewmind S.A. Système et procédé de détection de troubles neurologiques et de mesure des performances cognitives générales
US11540749B2 (en) * 2018-01-22 2023-01-03 University Of Virginia Patent Foundation System and method for automated detection of neurological deficits
JP7107725B2 (ja) * 2018-04-10 2022-07-27 浜松ホトニクス株式会社 眼球運動特徴量算出システム、眼球運動特徴量算出方法及び眼球運動特徴量算出プログラム
US20220000403A1 (en) * 2018-10-05 2022-01-06 Ocumove Aps Neurotransmitter imbalance detection system and method of detecting a neurotransmitter imbalance
WO2020081799A1 (fr) 2018-10-17 2020-04-23 Battelle Memorial Institute Capteur d'altération des facultés à conduire
WO2020186230A1 (fr) * 2019-03-13 2020-09-17 Eyelab, LLC Systèmes, dispositifs et procédés de détermination de données associées aux yeux d'une personne
CN110151184A (zh) * 2019-04-19 2019-08-23 昆明依利科特科技有限公司 非接触式吸毒人员快速检测系统及方法
US20240065598A1 (en) * 2020-12-23 2024-02-29 Viewmind, Inc. System and method for detecting neurological disorders and for measuring general cognitive performance
CN112890763B (zh) * 2021-01-15 2022-12-27 罗辉 即刻后像视功能检测方法、装置和视功能检测设备
CN112869744B (zh) * 2021-01-20 2024-05-31 上海市精神卫生中心（上海市心理咨询培训中心） 一种精神分裂症辅助诊断方法、系统和存储介质
CA3219279A1 (fr) * 2021-05-18 2022-11-24 Douglas P. Munoz Procedes et appareil de detection de troubles cerebraux
US11896376B2 (en) * 2022-01-27 2024-02-13 Gaize Automated impairment detection system and method
CN115778331B (zh) * 2023-02-08 2023-05-02 四川大学华西医院 一种用于检测偏头痛的生物标志物组及其用途
CN116982932B (zh) * 2023-06-21 2024-09-10 首都医科大学附属北京天坛医院 一种基于眼动双任务的脑疾病预测设备、系统及可读存储介质
WO2025141431A1 (fr) * 2023-12-26 2025-07-03 Alcon Inc. Système et procédé d'évaluation subjective de corps flottants
CN118121152B (zh) * 2024-04-29 2024-07-16 湖南爱尔眼视光研究所 一种视力状况检测方法、装置、设备及介质
CN119649437A (zh) * 2024-11-25 2025-03-18 四川亚欧瑞智科技有限公司 基于眼球运动的涉毒行为鉴别方法、装置以及电子设备

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020099305A1 (en) * 2000-12-28 2002-07-25 Matsushita Electic Works, Ltd. Non-invasive brain function examination
US20090036755A1 (en) * 2007-07-30 2009-02-05 Neurofocus, Inc. Entity and relationship assessment and extraction using neuro-response measurements
US20100100001A1 (en) * 2007-12-27 2010-04-22 Teledyne Scientific & Imaging, Llc Fixation-locked measurement of brain responses to stimuli
US20100208205A1 (en) * 2009-01-15 2010-08-19 Po-He Tseng Eye-tracking method and system for screening human diseases
US20120059282A1 (en) * 2009-03-17 2012-03-08 Emory University Internet-based cognitive diagnostics using visual paired comparison task

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002087431A1 (fr) * 2001-05-01 2002-11-07 Structural Bioinformatics, Inc. Diagnostic de maladies inapparentes a partir de tests cliniques ordinaires utilisant l'analyse bayesienne
WO2009116043A1 (fr) * 2008-03-18 2009-09-24 Atlas Invest Holdings Ltd. Procédé et système pour déterminer un degréd de familiarité avec des stimuli
GB201200122D0 (en) * 2012-01-05 2012-02-15 Univ Aberdeen An apparatus and a method for psychiatric evaluation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020099305A1 (en) * 2000-12-28 2002-07-25 Matsushita Electic Works, Ltd. Non-invasive brain function examination
US20090036755A1 (en) * 2007-07-30 2009-02-05 Neurofocus, Inc. Entity and relationship assessment and extraction using neuro-response measurements
US20100100001A1 (en) * 2007-12-27 2010-04-22 Teledyne Scientific & Imaging, Llc Fixation-locked measurement of brain responses to stimuli
US20100208205A1 (en) * 2009-01-15 2010-08-19 Po-He Tseng Eye-tracking method and system for screening human diseases
US20120059282A1 (en) * 2009-03-17 2012-03-08 Emory University Internet-based cognitive diagnostics using visual paired comparison task

Also Published As

Publication number Publication date
US20200146547A1 (en) 2020-05-14
US20160022137A1 (en) 2016-01-28
US10575726B2 (en) 2020-03-03
WO2014159498A2 (fr) 2014-10-02

Similar Documents

Publication Publication Date Title
WO2014159498A3 (fr) Système d'analyse automatisé prévu pour la détection et le dépistage de troubles et de déficits neurologiques
JP6975853B2 (ja) 脳機能検査システムおよびそのデバイス
US11903720B2 (en) System and method for detecting neurological disease
US10028694B2 (en) Non-invasive systems and methods to detect cortical spreading depression for the detection and assessment of brain injury and concussion
Frauscher et al. Defining muscle activities for assessment of rapid eye movement sleep behavior disorder: from a qualitative to a quantitative diagnostic level
JP2016523632A5 (fr)
Chen et al. Postural sway in idiopathic rapid eye movement sleep behavior disorder: A potential marker of prodromal Parkinson׳ s disease
WO2013128293A3 (fr) Méthodes, appareils et systèmes permettant de diagnostiquer et de traiter des troubles de l'humeur
Miura et al. An integrated eye movement score as a neurophysiological marker of schizophrenia.
Conte et al. Somatosensory temporal discrimination threshold in Parkinson’s disease parallels disease severity and duration
US10433757B2 (en) Diagnostic method and apparatus for brain injury based on EMG frequency power spectra analysis
Locatelli et al. Differentiating essential tremor and Parkinson's disease using a wearable sensor—A pilot study
Chollet et al. Functional Imaging for neurodegenerative diseases
Komogortsev et al. The application of eye movement biometrics in the automated detection of mild traumatic brain injury
Klingelhoefer et al. Objective measurement and monitoring of nonmotor symptoms in Parkinson's disease
Pham et al. Robust evaluation of time since awakening using force platform posturography
Shokrollahi et al. Chin EMG analysis for REM sleep behavior disorders
CN107847129A (zh) 脑疾病快速筛检装置
Kuzu et al. Apraxic imitation deficits in Alzheimer’s disease are associated with altered dynamic connectivity
Millichap et al. Biological markers in diagnosis of ADHD: EEG theta/beta ratio in diagnosis of ADHD
Wolz et al. P134 Olfactory testing in differential diagnosis of tremor
Schneider et al. P133 Nonmotor fluctuations in Parkinson’s disease: Evaluation of frequency and severity of nonmotor symptoms in off states of advanced Parkinson’s disease
Rawdon et al. ELECTROPHYSIOLOGICAL CORRELATES OF WORKING MEMORY IN ADOLESCENTS AT-RISK OF PSYCHOSIS AND MATCHED CONTROLS
Shammas Objective assessment of motor and gait parameters of patients with multiple sclerosis
Mollenhauer et al. P132 DeNoPa Kassel–A long-term follow-up study on biomarkers and non-motor symptoms for Parkinson disease

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14774543

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 14774152

Country of ref document: US

122 Ep: pct application non-entry in european phase

Ref document number: 14774543

Country of ref document: EP

Kind code of ref document: A2