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WO2014155389A3 - Procédé de préparation de ticagrelor - Google Patents

Procédé de préparation de ticagrelor Download PDF

Info

Publication number
WO2014155389A3
WO2014155389A3 PCT/IN2014/000165 IN2014000165W WO2014155389A3 WO 2014155389 A3 WO2014155389 A3 WO 2014155389A3 IN 2014000165 W IN2014000165 W IN 2014000165W WO 2014155389 A3 WO2014155389 A3 WO 2014155389A3
Authority
WO
WIPO (PCT)
Prior art keywords
ticagrelor
preparation
pharmaceutically acceptable
relates
acceptable salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2014/000165
Other languages
English (en)
Other versions
WO2014155389A2 (fr
Inventor
Navin G. BHATT
Samir Naik
Ajay Kumar Sharma
Mahendra CHORAGHE
Shekhar Bhaskar Bhirud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glenmark Pharmaceuticals Ltd
Original Assignee
Glenmark Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd filed Critical Glenmark Pharmaceuticals Ltd
Publication of WO2014155389A2 publication Critical patent/WO2014155389A2/fr
Publication of WO2014155389A3 publication Critical patent/WO2014155389A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un procédé de préparation de ticagrelor et de ses sels pharmaceutiquement acceptables.
PCT/IN2014/000165 2013-03-25 2014-03-14 Procédé de préparation de ticagrelor Ceased WO2014155389A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1111/MUM/2013 2013-03-25
IN1111MU2013 IN2013MU01111A (fr) 2013-03-25 2014-03-14

Publications (2)

Publication Number Publication Date
WO2014155389A2 WO2014155389A2 (fr) 2014-10-02
WO2014155389A3 true WO2014155389A3 (fr) 2015-01-15

Family

ID=51625566

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000165 Ceased WO2014155389A2 (fr) 2013-03-25 2014-03-14 Procédé de préparation de ticagrelor

Country Status (2)

Country Link
IN (1) IN2013MU01111A (fr)
WO (1) WO2014155389A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801583A (zh) * 2014-12-31 2016-07-27 徐州万邦金桥制药有限公司 一种替格瑞洛的纯化方法
CN109633063B (zh) * 2018-12-26 2021-05-04 哈尔滨医科大学 一种人血浆中替格瑞洛及其活性代谢产物浓度的检测方法
CN112394109A (zh) * 2019-08-12 2021-02-23 武汉武药科技有限公司 替格瑞洛中杂质的检测方法
CN110642862B (zh) * 2019-10-29 2021-01-26 株洲千金药业股份有限公司 一种替格瑞洛乙酯化杂质的制备方法
CN119264152B (zh) * 2024-09-30 2025-11-28 江西同和药业股份有限公司 一种二氧杂环戊烷类化合物及其制备方法和应用、替格瑞洛中间体的制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034283A1 (fr) * 1998-12-04 2000-06-15 Astrazeneca Ab Nouveaux composes de triazolo(4,5-d)pyrimidine
CN1432018A (zh) * 2000-06-02 2003-07-23 阿斯特拉曾尼卡有限公司 三唑并[4,5－d]嘧啶化合物的新晶形和非晶形
CN102603751A (zh) * 2012-02-24 2012-07-25 中国药科大学 三唑并(4,5-d)嘧啶衍生物及其制备方法与在制药中的用途
WO2012138981A2 (fr) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. Nouveaux intermédiaires et procédés pour la préparation du ticagrelor
CN102731467A (zh) * 2011-04-15 2012-10-17 博瑞生物医药技术(苏州)有限公司 替卡格雷的中间体及制备替卡格雷的方法
CN102875537A (zh) * 2012-09-10 2013-01-16 常州制药厂有限公司 一种新的抗血栓药物的制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000034283A1 (fr) * 1998-12-04 2000-06-15 Astrazeneca Ab Nouveaux composes de triazolo(4,5-d)pyrimidine
CN1432018A (zh) * 2000-06-02 2003-07-23 阿斯特拉曾尼卡有限公司 三唑并[4,5－d]嘧啶化合物的新晶形和非晶形
WO2012138981A2 (fr) * 2011-04-06 2012-10-11 Teva Pharmaceutical Industries Ltd. Nouveaux intermédiaires et procédés pour la préparation du ticagrelor
CN102731467A (zh) * 2011-04-15 2012-10-17 博瑞生物医药技术(苏州)有限公司 替卡格雷的中间体及制备替卡格雷的方法
CN102603751A (zh) * 2012-02-24 2012-07-25 中国药科大学 三唑并(4,5-d)嘧啶衍生物及其制备方法与在制药中的用途
CN102875537A (zh) * 2012-09-10 2013-01-16 常州制药厂有限公司 一种新的抗血栓药物的制备方法

Also Published As

Publication number Publication date
WO2014155389A2 (fr) 2014-10-02
IN2013MU01111A (fr) 2015-05-01

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