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WO2014151079A8 - Ratio based biomarkers and methods of use thereof for the detection and prognosis of cancer - Google Patents

Ratio based biomarkers and methods of use thereof for the detection and prognosis of cancer Download PDF

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Publication number
WO2014151079A8
WO2014151079A8 PCT/US2014/024936 US2014024936W WO2014151079A8 WO 2014151079 A8 WO2014151079 A8 WO 2014151079A8 US 2014024936 W US2014024936 W US 2014024936W WO 2014151079 A8 WO2014151079 A8 WO 2014151079A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cancer
determination
disease
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2014/024936
Other languages
French (fr)
Other versions
WO2014151079A2 (en
WO2014151079A3 (en
Inventor
Stephen M. Hewitt
Joon-Yong Chung
Udayan GUHA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/841,176 external-priority patent/US20130210648A1/en
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority to EP14723537.8A priority Critical patent/EP2972374A2/en
Priority to CA2904973A priority patent/CA2904973A1/en
Publication of WO2014151079A2 publication Critical patent/WO2014151079A2/en
Publication of WO2014151079A3 publication Critical patent/WO2014151079A3/en
Publication of WO2014151079A8 publication Critical patent/WO2014151079A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57411—Specifically defined cancers of cervix

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determination of the etiology or risk factors associated with a disease. Sample types analyzed by the disclosed methods include but are not limited to archival tissue blocks that have been preserved in a fixative, tissue biopsy samples, tissue microarrays, and so forth. The methods disclosed herein correlate expression profiles of biomolecules with various disease types, and allow for the determination of relative survival rates; in some embodiments, the methods permit determination of survival rates for a subject with cancer. In other embodiments, the disclosure relates to methods for evaluating therapeutic regimes for the treatment, such as treatment of cancer.
PCT/US2014/024936 2013-03-15 2014-03-12 Ratio based biomarkers and methods of use thereof Ceased WO2014151079A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP14723537.8A EP2972374A2 (en) 2013-03-15 2014-03-12 Ratio based biomarkers and methods of use thereof
CA2904973A CA2904973A1 (en) 2013-03-15 2014-03-12 Ratio based biomarkers and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/841,176 2013-03-15
US13/841,176 US20130210648A1 (en) 2009-01-14 2013-03-15 Ratio based biomarkers and methods of use thereof

Publications (3)

Publication Number Publication Date
WO2014151079A2 WO2014151079A2 (en) 2014-09-25
WO2014151079A3 WO2014151079A3 (en) 2015-03-05
WO2014151079A8 true WO2014151079A8 (en) 2015-04-30

Family

ID=50693967

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/024936 Ceased WO2014151079A2 (en) 2013-03-15 2014-03-12 Ratio based biomarkers and methods of use thereof

Country Status (3)

Country Link
EP (1) EP2972374A2 (en)
CA (1) CA2904973A1 (en)
WO (1) WO2014151079A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008117067A2 (en) 2007-03-27 2008-10-02 Carl Arne Krister Borrebaeck Protein signature/markers for the detection of adenocarcinoma
WO2018201083A1 (en) * 2017-04-28 2018-11-01 University Of Southern California System and method for predicting survival time
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof
CN119199123A (en) * 2024-10-21 2024-12-27 浙江大学 Application of biomarker based on GLS2 function in tumor immunotherapy diagnosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866366A (en) 1997-07-01 1999-02-02 Smithkline Beecham Corporation gidB
US6969615B2 (en) 1999-07-26 2005-11-29 20/20 Genesystems, Inc. Methods, devices, arrays and kits for detecting and analyzing biomolecules
WO2003029480A2 (en) 2001-08-31 2003-04-10 The Government Of The United States Of America, Asrepresented By The Secretary Of The Department Of Health And Human Services Measurements of multiple molecules using a cryoarray
US20130210648A1 (en) * 2009-01-14 2013-08-15 The United States of America, as Represented by the Secretary, Department of Health and Human Services Ratio based biomarkers and methods of use thereof
NZ628463A (en) * 2009-01-14 2015-12-24 Us Health Ratio based biomarkers and methods for use thereof
JP4782854B2 (en) * 2009-03-10 2011-09-28 ナショナル ヤン−ミン ユニバーシティ Methods for predicting potential metastatic potential, prognosis, or overall survival of cancer patients
CN102656458B (en) * 2009-10-26 2016-10-19 雅培分子公司 Diagnostic method for determining the prognosis of non-small cell lung cancer
US20120052508A1 (en) * 2010-08-27 2012-03-01 Rutgers, The State University Of New Jersey Genetic markers and diagnostic methods for resistance of breast cancer to hormonal therapies

Also Published As

Publication number Publication date
WO2014151079A2 (en) 2014-09-25
CA2904973A1 (en) 2014-09-25
EP2972374A2 (en) 2016-01-20
WO2014151079A3 (en) 2015-03-05

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